Algorithm for establishing the time of death of a dog based on temperature measurements in selected sites of the body during the early post-mortem period.

Post-mortem measurements were made of the body temperature of dogs. The aim of the study was to evaluate and verify a reliable mathematical model that can be used to establish the time elapsed since the death of a dog during the initial post-mortem period at room temperature, using the eye (vitreous body), internal organs (heart, liver, kidney and lung), and rectum as sites for temperature measurement. The measurements were performed at six points in the body using an electronic thermometer in conjunction with a temperature probe. The method of temperature measurement is simple and does not cause perceptible macroscopic changes or disfigure the carcass. Multiple regression analysis was shown to be suitable for estimating the time elapsed from death to the discovery of the body for a period up to 12h post-mortem. The proposed multiple regression equation using body weight and the temperature at a specific site reduces manipulation of the carcass to a minimum and thus reduces error in establishing the time of death. The multiple regression model makes it possible to precisely estimate the time elapsed since the death of the animal.

Low intensity, continuous wave photodoping of ZnO quantum dots - photon energy and particle size effects.

The unique properties of semiconductor quantum dots (QDs) have found application in the conversion of solar to chemical energy. How the relative rates of the redox processes that control QD photon efficiencies depend on the particle radius (r) and photon energy (Eλ), however, is not fully understood. Here, we address these issues and report the quantum yields (Φs) of interfacial charge transfer and electron doping in ZnO QDs capped with ethylene glycol (EG) as a function of r and Eλ in the presence and absence of methyl viologen (MV2+) as an electron acceptor, respectively. We found that Φs for the oxidation of EG are independent of Eλ and photon fluence (φλ), but markedly increase with r. The independence of Φs on φλ ensures that QDs are never populated by more than one electron-hole pair, thereby excluding Auger-type terminations. We show that these findings are consistent with the operation of an interfacial redox process that involves thermalized carriers in the Marcus inverted region. In the absence of MV2+, QDs accumulate electrons up to limiting volumetric densities ρe,∞ that depend sigmoidally on excess photon energy E* = Eλ - EBG(r), where EBG(r) is the r-dependent bandgap energy. The maximum electron densities: ρev,∞ ∼ 4 × 1020 cm-3, are reached at E* > 0.5 eV, independent of the particle radius.

Reduced plasma fibrin clot permeability and susceptibility to lysis are associated with increased risk of postthrombotic syndrome.

BACKGROUND: The postthrombotic syndrome (PTS) is a severe complication of deep vein thrombosis (DVT). Reduced plasma clot permeability and lysability have been linked to DVT and residual vein obstruction. OBJECTIVES We investigated whether altered fibrin clot properties are associated with the occurrence of PTS. PATIENTS AND METHODS: Plasma fibrin clot permeability (Ks ) and lysability were investigated in a cohort of 197 consecutive patients aged 18 to 65 years recruited 3 months following the first-ever DVT. Patients with severe thrombophilia or comorbidities known to adversely affect clot phenotype were ineligible. RESULTS: During a 1-year follow-up PTS developed in 48 (24%) patients, who were characterized by lower Ks , prolonged fibrin clot lysis time (CLT) and slower release of D-dimer from clots (D-Drate ), together with higher plasma D-dimer, C-reactive protein and thrombin-activatable fibrinolysis inhibitor (TAFI). No PTS-associated differences in fibrinogen, thrombin generation, factor VIII, other fibrinolysis proteins and the quality of anticoagulation were observed. Ks (r = -0.71), CLT (r = 0.45), D-Drate (r = -0.30) and TAFI activity (r = 0.38) were associated with the Villalta scale (all P < 0.05). Recurrent VTE occurred also more commonly in PTS patients during follow-up and the 26 (13.2%) patients had lower Ks , longer CLT and lower D-Drate (all P < 0.05). A multivariate model adjusted for age, body mass index, fibrinogen and glucose showed that independent predictors of PTS were idiopathic DVT, plasma D-dimer, Ks , D-Drate , tissue plasminogen activator and TAFI activity. CONCLUSIONS: This study demonstrates that formation of more compact fibrin clots displaying impaired susceptibility to lysis predisposes to PTS.

Modulation of the electron transfer processes in Au-ZnO nanostructures.

Plasmonic nanostructures comprising Au and ZnO nanoparticles synthesized by the spontaneous reduction of HAuCl4 in ethylene glycol were used to assess the possibility of modulating the direction of the electron transfer processes at the interface. One electron UV reduction and visible oxidation of the reversible couple TEMPOL/TEMPOL-H was confirmed by EPR spectroscopy. The apparent quantum yield for TEMPOL-H conversion under continuous wave visible excitation depends on the irradiation wavelength, being 0.57% and 0.27% at 450 ± 12 and 530 ± 12 nm, respectively. These results indicate that both the surface plasmon resonance and the interband transition from the 5d to the 6s level of Au nanoparticles contribute to the visible activity of the nanostructure. In addition, by detecting free electron conduction band electrons in ZnO, after the visible excitation of Au/ZnO nanostructures, we provide direct evidence of the photoexcited electron transfer from gold nanoparticles to ZnO.

Paciente con hipertensión arterial y tumor renal / Patient with arterial hypertension and renal tumor

Los tumores renales son causantes de hipertensión arterial en un bajo porcentaje de casos. El más frecuentemente implicado es el feocromocitoma, aunque están descritos otros tumores. Uno de ellos es el hipernefroma, caso que a continuación se describe y que además utilizamos como ejemplo de cronoterapia

Renal tumors cause arterial hypertension in a low percentage of cases. The most frequently involved is pheochromocytoma, although other tumors are described. One of them is hypernephroma, a case is described in the following and is also used as an example of chronotherapy