1.
Bioorg Med Chem Lett
; 22(24): 7672-6, 2012 Dec 15.
Article
in English
| MEDLINE
| ID: mdl-23141913
ABSTRACT
Amido-1,3,4-thiadiazoles have been identified as a novel structural class of potent and selective sphingosine-1-phosphate receptor subtype 1 agonists. Starting from a micromolar HTS hit with the help of an in-house homology model, robust structural-activity relationships were developed to yield compounds with good selectivity and excellent in vivo efficacy in rat models.