ABSTRACT
Scleromyxedema is a generalized cutaneous mucinosis that may cause internal damage. This condition is frequently associated with monoclonal gammopathy. However, its physiopathological implications remains uncertain. The natural development of scleromyxedema is unpredictable and may lead to potentially fatal complications. Although there is no standardized treatment, intravenous immunoglobulins are considered the best method for treating scleromyxedema. The effects of this method of treatment on this condition are not well known, and it could be argued that intravenous immunoglobulins interact with the monoclonal gammopathy. This paper describes a case of scleromyxedema without associated monoclonal gammopathy that was treated effectively using monthly courses of treatment with intravenous immunoglobulins.
Subject(s)
Paraproteinemias , Scleromyxedema , Humans , Immunoglobulins, Intravenous/therapeutic use , Paraproteinemias/complications , Paraproteinemias/drug therapy , Scleromyxedema/drug therapy , SkinSubject(s)
Adenocarcinoma/drug therapy , Antineoplastic Agents, Hormonal/adverse effects , Granuloma, Foreign-Body/diagnosis , Injection Site Reaction/diagnosis , Prostatic Neoplasms/drug therapy , Adenocarcinoma/pathology , Aged, 80 and over , Antineoplastic Agents, Hormonal/administration & dosage , Arm , Delayed-Action Preparations/administration & dosage , Delayed-Action Preparations/adverse effects , Granuloma, Foreign-Body/chemically induced , Granuloma, Foreign-Body/pathology , Humans , Injection Site Reaction/etiology , Injection Site Reaction/pathology , Injections, Subcutaneous/adverse effects , Leuprolide/administration & dosage , Leuprolide/adverse effects , Male , Microspheres , Neoplasm Grading , Prostatic Neoplasms/pathology , Skin/pathologySubject(s)
Antineoplastic Agents, Immunological/adverse effects , Carcinoma, Renal Cell/radiotherapy , Kidney Neoplasms/radiotherapy , Nivolumab/adverse effects , Pemphigoid, Bullous/chemically induced , Pemphigoid, Bullous/pathology , Aged , Carcinoma, Renal Cell/drug therapy , Carcinoma, Renal Cell/secondary , Humans , Kidney Neoplasms/drug therapy , Kidney Neoplasms/pathology , MaleABSTRACT
Syphilis is a worldwide sexually transmitted infection caused by Treponema pallidum subspecies pallidum. Its association with other STIs, including HIV, demands early diagnosis and immediate treatment of patients. We herein report an unusual serpiginous form of secondary syphilis.
Subject(s)
Foot Dermatoses/etiology , Hand Dermatoses/etiology , Syphilis/complications , Adult , Anti-Bacterial Agents/administration & dosage , Foot Dermatoses/diagnosis , Foot Dermatoses/drug therapy , Hand Dermatoses/diagnosis , Hand Dermatoses/drug therapy , Humans , Injections, Intramuscular , Male , Penicillin G Benzathine/administration & dosage , Syphilis/diagnosis , Syphilis/drug therapyABSTRACT
Abstract: Syphilis is a worldwide sexually transmitted infection caused by Treponema pallidum subspecies pallidum. Its association with other STIs, including HIV, demands early diagnosis and immediate treatment of patients. We herein report an unusual serpiginous form of secondary syphilis.
Subject(s)
Humans , Male , Adult , Syphilis/complications , Foot Dermatoses/etiology , Hand Dermatoses/etiology , Penicillin G Benzathine/administration & dosage , Syphilis/diagnosis , Syphilis/drug therapy , Foot Dermatoses/diagnosis , Foot Dermatoses/drug therapy , Hand Dermatoses/diagnosis , Hand Dermatoses/drug therapy , Injections, Intramuscular , Anti-Bacterial Agents/administration & dosageABSTRACT
The lipoid proteinosis is a rare autosomic recessive genodermatosis characterized histologically by deposits of hyaline-like eosinophilic material of characteristic distribution. We herein report the case of a 56-year-old man admitted for progressive aggravated dementia associated with a late-onset dysphonia. Histologic examination of cutaneous and laryngeal biopsies showed deposits of an amorphous and eosinophilic material arranged around vessels, and adnexal structures, stained by PAS and congo red negative. The detection of a mutation in the ECM1 gene confirmed the diagnosis of lipoid proteinosis of atypical clinical presentation.