ABSTRACT
BACKGROUND AND OBJECTIVE: Heart failure (HF) is a frequent condition that deteriorates quality of life and results in high morbidity and mortality. A considerable number of studies have been implemented in recent years to determine the factors that affect the prognosis of HF; however, few studies have assessed the prognosis of patients hospitalised for their first episode of HF. The aim of our study was to analyse the prognostic impact of renal function on patients hospitalised for a first episode of HF. MATERIAL AND METHODS: We recruited 600 patients hospitalised for a first episode of HF in 3 tertiary Spanish hospitals. We analysed the mortality risk during the first year of follow-up according to renal function at the time of admission. RESULTS: The patients with the highest degree of kidney failure at admission were older (P<.001), were more often women (p=.01) and presented a higher degree of dependence (P<.05), as well as a higher prevalence of arterial hypertension (P<.001), chronic renal failure (P<.001) and anaemia (P<.001). In the multivariate analysis, the degree of kidney failure at admission remained an independent predictor of increased mortality risk during the first year of follow-up. CONCLUSIONS: The presence of kidney failure at admission was a marker of poor prognosis in our cohort of patients hospitalised for a first episode of HF.
Subject(s)
Humans , Female , Middle Aged , Multiple Myeloma/complications , Multiple Myeloma/epidemiology , Neoplasms, Second Primary/complications , Neoplasms, Second Primary/diagnosis , Neoplasms, Second Primary/epidemiology , Neoplasm Staging/methods , Neoplasm Staging , Risk Factors , Neoplasm Staging/trends , Melphalan/therapeutic use , Prednisone/therapeutic use , Vincristine/therapeutic use , Carmustine/therapeutic use , Doxorubicin/therapeutic use , Dexamethasone/therapeutic use , Retrospective StudiesABSTRACT
The term cancer of unknown primary site includes metastatic tumours with different histology and behaviour. Although most of them have a poor short-term prognosis, some patients can benefit from a treatment and will achieve a longer survival. The treatable cases are: metastases of squamous carcinoma in cervical or inguinal adenopathies, metastases of adenocarcinoma in axilar adenopathies in women, malignant ascites due to adenocarcinoma in women, osteoblastic bone metastases in men with elevated serum prostatic specific antigen levels, poorly differentiated tumours with features of a germinal extragonadal tumour, poorly differentiated neuroendocrine carcinomas and patients with a single metastasis. Chemotherapy must be considered in the rest of patients, although the optimum regimen is not well established yet.
Subject(s)
Neoplasms, Unknown Primary/pathology , Neoplasms, Unknown Primary/therapy , Humans , Neoplasms, Unknown Primary/classificationABSTRACT
Cancer of unknown primary site (CUPS) is a heterogeneous entity defined by the presence of a histologically-proven metastatic neoplasm, in which the original tumor cannot be identified after a targeted study. The current guidelines for CUPS focus is not based on the search for the primary neoplasm but rather on the identification of patients who may benefit from a treatment that will prolong their survival, based on the clinical and histological characteristics of each case. By improving the diagnostic study, we avoid using fruitless tests in patients with limited therapeutic possibilities and poor short-term prognosis.
Subject(s)
Neoplasms, Unknown Primary/diagnosis , Adenocarcinoma/diagnosis , Biomarkers, Tumor/blood , Carcinoma/diagnosis , Carcinoma, Squamous Cell/diagnosis , Diagnosis, Differential , Female , Humans , Male , Neoplasms, Unknown Primary/diagnostic imaging , Neoplasms, Unknown Primary/mortality , Neoplasms, Unknown Primary/pathology , Neoplasms, Unknown Primary/therapy , Neuroendocrine Tumors/diagnosis , Ovarian Neoplasms/diagnosis , Positron-Emission Tomography , Practice Guidelines as Topic , Prostatic Neoplasms/diagnosisABSTRACT
Objetivos: el carcinoma hepatocelular (CHC) permanece malcaracterizado en pacientes de edad avanzada y comorbilidad, circunstanciaque limita su manejo clínico. Pretendemos analizar lahistoria natural del CHC en mayores de 75 años y determinar losfactores que condicionan su supervivencia.Pacientes y métodos: análisis retrospectivo de 235 pacientescon CHC categorizados según su edad al diagnóstico: ≤ 75 años (n= 186) y > 75 años (n = 49). Tras comparar sus variables clínicas(χ2 y t-Student), realizamos un análisis de regresión logística para determinarlos factores asociados a la recepción de tratamiento locorregional(vs. sintomático); la supervivencia entre ambos grupos fuecomparada mediante el test de log-rank, con posterior análisis multivariante(modelo de riesgos proporcionales de Cox).Resultados: no se obtuvieron diferencias entre ambos gruposen su distribución por sexo, presencia de cirrosis, etiología, Child-Pugh, estadio BCLC, ascitis, trombosis portal, o valores de bilirrubina,AST, ALT, γGT, LDH o hematocrito. Los pacientes de edadavanzada fueron más frecuentemente diagnosticados en presenciade manifestaciones clínicas, con enfermedad multifocal, no localizada,y niveles de α-fetoproteína > 400 ng/ml (todas, p < 0,05). Estegrupo recibió tratamiento exclusivamente sintomático en el 78% delos casos (vs. 33% entre pacientes jóvenes), y sólo tres de ellos fueronsometidos a resección (p < 0,0001). La edad > 75 años actuócomo predictor de la no recepción de terapia locorregional (p <0,0001). La supervivencia del grupo de mayor edad (9,8 ± 1 meses)difirió significativamente respecto a la de los pacientes más jóvenes(25,6 ± 2 meses) (p < 0,00001). En el análisis multivariante, la edadavanzada se mantuvo como factor pronóstico de pobre supervivencia(p = 0,025); sin embargo, pierde su significación al estratificar dichoanálisis por sub-grupos de tratamiento (p = 0,344).Conclusiones: la menor supervivencia demostrada en pacientesancianos con CHC, al margen de diferencias en cuanto a extensióntumoral o insuficiencia hepatocelular, parece condicionada por la aplicaciónde abordajes terapéuticos subóptimos en esta población
Aims: hepatocellular carcinoma (HCC) remains poorly characterizedin elderly patients with comorbid conditions, a fact thatlimits the clinical management of the disease. This study analyzesthe natural history of HCC in patients older than 75, and determinesfactors that condition their survival.Patients and methods: a retrospective analysis of 235 patientswith HCC divided into 2 groups by age at diagnosis: ≤ 75(n = 186) and > 75 (n = 49). After comparing their clinical variables(χ2 and t test), a logistic regression analysis was performed todetermine factors associated with receiving locoregional treatment(versus symptomatic treatment). Survival in the 2 groups wascompared using a log rank test with subsequent multivariateanalysis (Cox proportional hazards model).Results: there were no differences between groups for sex,presence of cirrhosis, etiology, Child-Pugh score, BCLC stage,presence of ascites or portal thrombosis, or bilirubin, AST, ALT,γGT, LDH or hematocrit values. Patients of advanced age weremore frequently diagnosed in the presence of clinical manifestations,and had multifocal, non-localized disease and α-fetoproteinlevels > 400 ng/mL (all p < 0.05). This group received exclusivelysymptomatic treatment in 78% of cases (compared to 33% inyounger patients), and only 3 of them underwent surgical resection(p < 0.0001). Age older than 75 was a predictive factor fornot receiving locoregional therapy (p < 0.0001). Survival in theelderly group (9.8 ± 1 months) differed substantially from that ofyounger patients (25.6 ± 2 months) (p < .00001). Advanced agecontinued to be a prognostic factor of poor survival in the multivariateanalysis (p = 0.025), but lost significance when the analysiswas stratified by treatment subgroups (p = 0.344).Conclusions: the lower survival seen in elderly patients withHCC, beyond differences in tumor extension or liver failure, seemsconditioned by the use of suboptimal treatment in this population
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Carcinoma, Hepatocellular/mortality , Carcinoma, Hepatocellular/therapy , Liver Neoplasms/mortality , Liver Neoplasms/therapy , Survival Analysis , Age Factors , Carcinoma, Hepatocellular/diagnosis , Chi-Square Distribution , Liver Neoplasms/diagnosis , Logistic Models , Multivariate Analysis , Prognosis , Proportional Hazards Models , Retrospective StudiesABSTRACT
BACKGROUND/AIMS: This study aimed to describe the clinical, histological and immunohistochemical characteristics of primary extragastrointestinal stromal tumors (EGISTs) of the omentum and mesentery diagnosed in the Hospital 12 de Octubre, in Madrid, Spain, from 1993-2005. METHODOLOGY: The clinical data and histological and immunohistochemical findings of primary mesenchymal neoplasias were revised using the Department of Pathological Anatomy databases. RESULTS: Six EGISTs were identified. Three were primarily of the omentum and 3 mesenteric. They were found in 4 males and 2 females with an average age of 65.16 years. All were c-KIT positive, and the majority CD34 positive, while 3 were positive for muscle-specific actin. The 3 omentum cases had a mixed spindle/epithelioid pattern and low mitotic rate, while the 3 mesenteric cases had a spindle pattern, with a high mitotic rate in 2 cases, where hepatic metastasis appeared at 6 and 32 months respectively. The 3 omentum cases were alive at the time of writing, and free of disease at 16, 21 and 34 months of follow-up. EGISTs represent 11.9% of GIST cases diagnosed in the hospital over the period 2000-2005. CONCLUSIONS: In this study primary EGISTs of the omentum and mesentery showed clinicopathological and immunohistochemical characteristics similar to those previously in the literature for GISTs of the digestive tract, which supports the hypothesis that these tumors originate from extragastrointestinal c-KIT positive cells. Mesenteric location appears to be associated with a poorer prognosis.
Subject(s)
Gastrointestinal Stromal Tumors/pathology , Mesentery , Omentum , Peritoneal Neoplasms/pathology , Aged , Biomarkers, Tumor/analysis , Female , Follow-Up Studies , Gastrointestinal Stromal Tumors/diagnosis , Gastrointestinal Stromal Tumors/mortality , Gastrointestinal Stromal Tumors/secondary , Gastrointestinal Stromal Tumors/surgery , Humans , Liver Neoplasms/pathology , Liver Neoplasms/secondary , Male , Mesentery/pathology , Middle Aged , Mitotic Index , Omentum/pathology , Peritoneal Neoplasms/diagnosis , Peritoneal Neoplasms/mortality , Peritoneal Neoplasms/surgery , Survival AnalysisABSTRACT
No disponible
Subject(s)
Humans , Male , Aged , Venous Thrombosis/diagnosis , Jugular Veins/injuries , Venous Thrombosis/epidemiologyABSTRACT
No disponible
Subject(s)
Humans , Male , Aged , Bone Neoplasms/secondary , Carcinoma, Hepatocellular/secondary , Femoral Neoplasms/secondary , Humerus , Liver Neoplasms/pathology , Disease ProgressionABSTRACT
Hemoperitoneum due to spontaneous rupture of hepatocellular carcinoma (HCC) constitutes a life-threatening situation if no appropriate therapy is provided. This complication is a well-known form of HCC presentation in countries with high incidence of liver tumours, but is an unusual event in Western countries, where it has been described in 5% or less of cases with HCC. We report three patients admitted to our centre with acute hemoperitoneum secondary to non-traumatic rupture as a first manifestation of not previously diagnosed HCC. A review of the related literature is also performed.
Subject(s)
Carcinoma, Hepatocellular/complications , Hemoperitoneum/etiology , Liver Neoplasms/complications , Aged , Aged, 80 and over , Humans , Male , Rupture, SpontaneousABSTRACT
No disponible
Subject(s)
Humans , Female , Aged , Anemia, Pernicious/etiology , Carcinoid Tumor/complications , Carcinoid Tumor/surgery , Gastroscopy , Stomach Neoplasms/complications , Stomach Neoplasms/surgeryABSTRACT
El hemoperitoneo secundario a la rotura espontánea de un carcinoma hepatocelular (CHC) supone una complicación potencialmente fatal en ausencia de un abordaje terapéutico apropiado. Constituye una forma de presentación tumoral bien establecida en medios con elevada incidencia de CHC, pero resulta infrecuente en países occidentales, donde se describe en menos del 5% de los casos. Presentamos tres pacientes atendidos en nuestro centro por hemoperitoneo agudo secundario a la rotura no traumática de un CHC, en los que dicha complicación constituyó la primera manifestación del proceso neoplásico. Realizamos igualmente una revisión de la literatura relacionada con el tema
Hemoperitoneum due to spontaneous rupture of hepatocellular carcinoma (HCC) constitutes a life-threatening situation if no appropriate therapy is provided. This complication is a well-known form of HCC presentationin countries with high incidence of liver tumours, but is an unusual event in Western countries, where it has been described in 5% or less of cases with HCC. We report three patients admitted to our centre with acute hemoperitoneum secondary to non-traumatic rupture as a first manifestation of not previously diagnosed HCC. A review of the related literature is also performed
Subject(s)
Humans , Male , Aged , Hemoperitoneum/complications , Hemoperitoneum/diagnosis , Carcinoma, Hepatocellular/complications , Carcinoma, Hepatocellular/diagnosis , Chemoembolization, Therapeutic , Rupture, Spontaneous/complications , Atrial Fibrillation/complications , Liver Diseases/complications , Paracentesis/methods , Hypertension, Portal/complications , Hypertension, Portal/therapy , Diabetes Mellitus/complications , Pulmonary Disease, Chronic Obstructive/complications , Adenoma, Liver Cell/complications , Carcinoma, Hepatocellular/physiopathologyABSTRACT
AIMS: Hepatocellular carcinoma (HCC) remains poorly characterized in elderly patients with comorbid conditions, a fact that limits the clinical management of the disease. This study analyzes the natural history of HCC in patients older than 75, and determines factors that condition their survival. PATIENTS AND METHODS: A retrospective analysis of 235 patients with HCC divided into 2 groups by age at diagnosis: < or = 75 (n = 186) and > 75 (n = 49). After comparing their clinical variables (chi2 and t test), a logistic regression analysis was performed to determine factors associated with receiving locoregional treatment (versus symptomatic treatment). Survival in the 2 groups was compared using a log rank test with subsequent multivariate analysis (Cox proportional hazards model). RESULTS: There were no differences between groups for sex, presence of cirrhosis, etiology, Child-Pugh score, BCLCancer stage, presence of ascites or portal thrombosis, or bilirubin, AST, ALT, gammaGT, LDH or hematocrit values. Patients of advanced age were more frequently diagnosed in the presence of clinical manifestations, and had multifocal, non-localized disease and alpha-fetoprotein levels > 400 ng/mL (all p < 0.05). This group received exclusively symptomatic treatment in 78% of cases (compared to 33% in younger patients), and only 3 of them underwent surgical resection (p < 0.0001). Age older than 75 was a predictive factor for not receiving locoregional therapy (p < 0.0001). Survival in the elderly group (9.8 +/- 1 months) differed substantially from that of younger patients (25.6 +/- 2 months) (p < .00001). Advanced age continued to be a prognostic factor of poor survival in the multivariate analysis (p = 0.025), but lost significance when the analysis was stratified by treatment subgroups (p = 0.344). CONCLUSIONS: The lower survival seen in elderly patients with HCC, beyond differences in tumor extension or liver failure, seems conditioned by the use of suboptimal treatment in this population.
Subject(s)
Carcinoma, Hepatocellular/mortality , Carcinoma, Hepatocellular/therapy , Liver Neoplasms/mortality , Liver Neoplasms/therapy , Survival Analysis , Adult , Age Factors , Aged , Aged, 80 and over , Carcinoma, Hepatocellular/diagnosis , Chi-Square Distribution , Female , Humans , Liver Neoplasms/diagnosis , Logistic Models , Male , Middle Aged , Multivariate Analysis , Prognosis , Proportional Hazards Models , Retrospective StudiesABSTRACT
No disponible
