Correction: Gender imbalances in the editorial activities of a selective journal run by academic editors.

[This corrects the article DOI: 10.1371/journal.pone.0294805.].

Gender imbalances in the editorial activities of a selective journal run by academic editors.

The fairness of decisions made at various stages of the publication process is an important topic in meta-research. Here, based on an analysis of data on the gender of authors, editors and reviewers for 23,876 initial submissions and 7,192 full submissions to the journal eLife, we report on five stages of the publication process. We find that the board of reviewing editors (BRE) is men-dominant (69%) and that authors disproportionately suggest male editors when making an initial submission. We do not find evidence for gender bias when Senior Editors consult Reviewing Editors about initial submissions, but women Reviewing Editors are less engaged in discussions about these submissions than expected by their proportion. We find evidence of gender homophily when Senior Editors assign full submissions to Reviewing Editors (i.e., men are more likely to assign full submissions to other men (77% compared to the base assignment rate to men RE of 70%), and likewise for women (41% compared to women RE base assignment rate of 30%))). This tendency was stronger in more gender-balanced scientific disciplines. However, we do not find evidence for gender bias when authors appeal decisions made by editors to reject submissions. Together, our findings confirm that gender disparities exist along the editorial process and suggest that merely increasing the proportion of women might not be sufficient to eliminate this bias. Measures accounting for women's circumstances and needs (e.g., delaying discussions until all RE are engaged) and raising editorial awareness to women's needs may be essential to increasing gender equity and enhancing academic publication.

Impact of Heat Stress on Transposable Element Expression and Derived Small RNAs in Drosophila subobscura.

Global warming is forcing insect populations to move and adapt, triggering adaptive genetic responses. Thermal stress is known to alter gene expression, repressing the transcription of active genes, and inducing others, such as those encoding heat shock proteins. It has also been related to the activation of some specific transposable element (TE) families. However, the actual magnitude of this stress on the whole genome and the factors involved in these genomic changes are still unclear. We studied mRNAs and small RNAs in gonads of two Drosophila subobscura populations, considered a good model to study adaptation to temperature changes. In control conditions, we found that a few genes and TE families were differentially expressed between populations, pointing out their putative involvement in the adaptation of populations to their different environments. Under heat stress, sex-specific changes in gene expression together with a trend toward overexpression, mainly of heat shock response-related genes, were observed. We did not observe large changes of TE expression nor small RNA production due to stress. Only population and sex-specific expression changes of some TE families (mainly retrotransposons), or the amounts of siRNAs and piRNAs, derived from specific TE families were observed, as well as the piRNA production from some piRNA clusters. Changes in small RNA amounts and TE expression could not be clearly correlated, indicating that other factors as chromatin modulation could also be involved. This work provides the first whole transcriptomic study including genes, TEs, and small RNAs after a heat stress in D. subobscura.

The effect of hearing loss on age-related differences in neural distinctiveness.

Age differences in cognitive performance have been shown to be overestimated if age-related hearing loss is not taken into account. Here, we investigated the role of age-related hearing loss on age differences in functional brain organization by assessing its impact on previously reported age differences in neural differentiation. To this end, we analyzed the data of 36 younger adults, 21 older adults with clinically normal hearing, and 21 older adults with mild-to-moderate hearing loss who had taken part in a functional localizer task comprising visual (i.e., faces, scenes) and auditory stimuli (i.e., voices, music) while undergoing functional magnetic resonance imaging. Evidence for reduced neural distinctiveness in the auditory cortex was observed only in older adults with hearing loss relative to younger adults, whereas evidence for reduced neural distinctiveness in the visual cortex was observed both in older adults with normal hearing and in older adults with hearing loss relative to younger adults. These results indicate that age-related dedifferentiation in the auditory cortex is exacerbated by age-related hearing loss.

Isolation of Mixed Compositions of Cellulose Nanocrystals, Microcrystalline Cellulose, and Lignin Nanoparticles from Wood Pulps.

From a circular economy perspective, one-pot strategies for the isolation of cellulose nanomaterials at a high yield and with multifunctional properties are attractive. Here, the effects of lignin content (bleached vs unbleached softwood kraft pulp) and sulfuric acid concentration on the properties of crystalline lignocellulose isolates and their films are explored. Hydrolysis at 58 wt % sulfuric acid resulted in both cellulose nanocrystals (CNCs) and microcrystalline cellulose at a relatively high yield (>55%), whereas hydrolysis at 64 wt % gave CNCs at a lower yield (<20%). CNCs from 58 wt % hydrolysis were more polydisperse and had a higher average aspect ratio (1.5-2×), a lower surface charge (2×), and a higher shear viscosity (100-1000×). Hydrolysis of unbleached pulp additionally yielded spherical nanoparticles (NPs) that were <50 nm in diameter and identified as lignin by nanoscale Fourier transform infrared spectroscopy and IR imaging. Chiral nematic self-organization was observed in films from CNCs isolated at 64 wt % but not from the more heterogeneous CNC qualities produced at 58 wt %. All films degraded to some extent under simulated sunlight trials, but these effects were less pronounced in lignin-NP-containing films, suggesting a protective feature, but the hemicellulose content and CNC crystallinity may be implicated as well. Finally, heterogeneous CNC compositions obtained at a high yield and with improved resource efficiency are suggested for specific nanocellulose uses, for instance, as thickeners or reinforcing fillers, representing a step toward the development of application-tailored CNC grades.

Sight restoration in congenitally blind humans does not restore visual brain structure.

It is unknown whether impaired brain structure after congenital blindness is reversible if sight is restored later in life. Using structural magnetic resonance imaging, visual cortical surface area and cortical thickness were assessed in a large group of 21 sight-recovery individuals who had been born blind and who months or years later gained sight through cataract removal surgery. As control groups, we included 27 normally sighted individuals, 10 individuals with permanent congenital blindness, and 11 sight-recovery individuals with a late onset of cataracts. Congenital cataract-reversal individuals had a lower visual cortical surface area and a higher visual cortical thickness than normally sighted controls. These results corresponded to those of congenitally permanently blind individuals suggesting that impaired brain structure did not recover. Crucially, structural brain alterations in congenital-cataract reversal individuals were associated with a lower post-surgery visual acuity. No significant changes in visual cortex structure were observed in sight-recovery individuals with late onset cataracts. The results demonstrate that impaired structural brain development due to visual deprivation from birth is not fully reversible and limits functional recovery. Additionally, they highlight the crucial importance of prevention measures in the context of other types of aberrant childhood environments including low socioeconomic status and adversity.

Mediadores expressivos na prevenção da doença mental em crianças com long-COVID / Expressive mediators in the prevention of mental illness in children with long-COVID

O presente documento emerge do desenvolvimento do projeto de estágio, no âmbito da Especialização em Enfermagem de Saúde Mental e Psiquiátrica, com vista ao desenvolvimento e consolidação das competências específicas do Enfermeiro Especialista em Enfermagem de Saúde Mental e Psiquiátrica, em articulação com as competências do grau de Mestre. A componente comunitária do Estágio integrou um estudo de investigação alargado com o objetivo geral de avaliar o impacto a longo prazo da infeção por SARS-COV 2 na Saúde Mental da população pediátrica (dos 3 aos 12 anos e 364 dias). Avaliou-se o risco de psicopatologia através de uma triagem telefónica inicial, seguida de um questionário onde constavam questões relativas a três períodos distintos (antes, durante e após a infeção por SARS-COV 2) e um questionário SDQ (Strengths and Difficulties Questionnaire). Após a realização de uma consulta inicial de Enfermagem e de Psiquiatria da Infância e Adolescência às crianças, as crianças que se encontravam em risco de desenvolver psicopatologia iriam integrar uma intervenção terapêutica de prevenção em grupo. O desenvolvimento deste trabalho incidiu, sobretudo, na intervenção terapêutica de prevenção em grupo. Foi formado um grupo terapêutico de crianças com idades compreendidas entre os 4 e os 6 anos, que apresentavam risco de desenvolvimento de psicopatologia e/ou sintomas de Long COVID, em que se aplicou o desenho e a pintura como mediadores da relação e comunicação, entre outros mediadores, nomeadamente o de expressão dramática. Consoante os dados obtidos na primeira consulta médica e de enfermagem, estabeleceram-se os seguintes diagnósticos de enfermagem: comunicação (comprometida), interação social (prejudicada), ansiedade (presente), medo (presente), irritabilidade, inquietação, intolerância à frustração, comportamento de oposição. Assim, tendo em conta as necessidades em saúde mental de cada criança, procurou-se adequar a intervenção no sentido de promover a interação social, a comunicação, a expressão de emoções e sentimentos, e a diminuição dos níveis de inquietação e ansiedade. No final da intervenção, concluiu-se que a utilização do desenho e pintura enquanto mediador na comunicação e relação com crianças que estiveram infetadas por SARS-COV 2, quando mobilizado em terapia de grupo, pode apresentar benefício na prevenção do desenvolvimento de doença mental.

This paper presents the internship's project development, as part of the Mental Health and Psychiatry Nursing course, for the improvement and consolidation of specific capabilities of the specialised Nurse in Mental Health and Psychiatry nursing, to acquire competences and skills through the Master's degree. The internship's community component combined an extended investigation study with the purpose of evaluating the long-term impact of SARS-COV 2 infection in children's Mental Health (from 3 to 12 years-old and 364 days). The risk of psychopathology through an initial trial was evaluated, followed by a questionary that had questions regarding three distinctive periods (before, during and after the SARS-COV 2 infection) and a SDQ (Strengths and Difficulties Questionnaire) questionary. After the first medical and nursing appointment of child and adolescent psychiatry to children, it was identified the risk of having or had developed psychopathology. Considering its results, they were integrated in therapeutic groups. This work's development was mostly focused on its therapeutic group intervention phase. A children therapeutic group was formed (from 4 to 6 years old), that presented risk of developing symptoms of psychopathology and/or of Long-Covid; it was applied drawing and painting as a source of relationship and communication, as well as social drama. According to the acquired data from the first medical and nursing appointment, it was established the following nursing diagnosis: communication (compromised), social interaction (damaged), anxiety (present), fear (present), irritability, restlessness, impatience to frustration, opposition behaviour. Thereby, considering every child's Mental Health needs, it was sought to adequate the intervention in a way to promote social interaction, communication, expression of emotions and feelings, and to decrease the restlessness and anxiety levels. At the end of the intervention, it was concluded that the usage of drawing and painting as a guide in communication and establishing relationship with children that were infected with SARS-COV 2 may be beneficial in preventing Mental disorders.

SchoolAIR: A Citizen Science IoT Framework Using Low-Cost Sensing for Indoor Air Quality Management.

Indoor air quality (IAQ) problems in school environments are very common and have significant impacts on students' performance, development and health. Indoor air conditions depend on the adopted ventilation practices, which in Mediterranean countries are essentially based on natural ventilation controlled through manual window opening. Citizen science projects directed to school communities are effective strategies to promote awareness and knowledge acquirement on IAQ and adequate ventilation management. Our multidisciplinary research team has developed a framework-SchoolAIR-based on low-cost sensors and a scalable IoT system architecture to support the improvement of IAQ in schools. The SchoolAIR framework is based on do-it-yourself sensors that continuously monitor air temperature, relative humidity, concentrations of carbon dioxide and particulate matter in school environments. The framework was tested in the classrooms of University Fernando Pessoa, and its deployment and proof of concept took place in a high school in the north of Portugal. The results obtained reveal that CO2 concentrations frequently exceed reference values during classes, and that higher concentrations of particulate matter in the outdoor air affect IAQ. These results highlight the importance of real-time monitoring of IAQ and outdoor air pollution levels to support decision-making in ventilation management and assure adequate IAQ. The proposed approach encourages the transfer of scientific knowledge from universities to society in a dynamic and active process of social responsibility based on a citizen science approach, promoting scientific literacy of the younger generation and enhancing healthier, resilient and sustainable indoor environments.

Top-down modulation of visual cortical processing after transient congenital blindness.

Early visual experience has been shown to be critical for the development of visual and multisensory functions; however, its impact on functional brain organization remains largely unexplored. Here, we therefore investigated the effect of early visual deprivation on top-down attentional modulation of visual cortical processing within the occipito-temporal cortex. Furthermore, we explored whether early visual deprivation may affect the extent to which typically visual, motion-selective area hMT responds to moving visual stimuli. Using functional magnetic resonance imaging, we compared cortical responses in area hMT and in the fusiform face area (FFA) to moving face stimuli - which were either task relevant or task irrelevant - relative to stationary face stimuli between cataract-reversal participants and normally sighted controls. Although both groups exhibited significantly stronger visual cortical responses in area hMT to moving stimuli than during the stationary baseline, the magnitude of this effect was significantly lower in the cataract-reversal group. In contrast, both groups exhibited significantly enhanced visual cortical responses in area hMT and in the FFA when moving face stimuli were task relevant compared to when they were task irrelevant, with no significant differences between groups in the magnitude of these effects. These results indicate that top-down attentional modulation of visual cortical processing in area hMT and FFA does not depend on early visual experience. Furthermore, the present results suggest that the functional specialization of area hMT for visual motion processing may be partially disrupted by early visual deprivation.

Audiovisual spatial recalibration but not integration is shaped by early sensory experience.

To clarify the role of sensory experience during early development for adult multisensory learning capabilities, we probed audiovisual spatial processing in human individuals who had been born blind because of dense congenital cataracts (CCs) and who subsequently had received cataract removal surgery, some not before adolescence or adulthood. Their ability to integrate audio-visual input and to recalibrate multisensory spatial representations was compared to normally sighted control participants and individuals with a history of developmental (later onset) cataracts. Results in CC individuals revealed both normal multisensory integration in audiovisual trials (ventriloquism effect) and normal recalibration of unimodal auditory localization following audiovisual discrepant exposure (ventriloquism aftereffect) as observed in the control groups. In addition, only the CC group recalibrated unimodal visual localization after audiovisual exposure. Thus, in parallel to typical multisensory integration and learning, atypical crossmodal mechanisms coexisted in CC individuals, suggesting that multisensory recalibration capabilities are defined during a sensitive period in development.

Typical resting-state activity of the brain requires visual input during an early sensitive period.

Sensory deprivation, following a total loss of one sensory modality e.g. vision, has been demonstrated to result in compensatory plasticity. It is yet not known to which extent neural changes, e.g. higher resting-state activity in visual areas (cross-modal plasticity) as a consequence of blindness, reverse, when sight is restored. Here, we used functional MRI to acquire blood oxygen level-dependent resting-state activity during an eyes open and an eyes closed state in congenital cataract-reversal individuals, developmental cataract-reversal individuals, congenitally permanently blind individuals and sighted controls. The amplitude of low frequency fluctuation of the blood oxygen level-dependent signal-a neural marker of spontaneous brain activity during rest-was analyzed. In accordance with previous reports, in normally sighted controls we observed an increase in amplitude of low-frequency fluctuation during rest with the eyes open compared with rest with eyes closed in visual association areas and in parietal cortex but a decrease in auditory and sensorimotor regions. In congenital cataract-reversal individuals, we found an increase of the amplitude of slow blood oxygen level-dependent fluctuations in visual cortex during rest with eyes open compared with rest with eyes closed too but this increase was larger in amplitude than in normally sighted controls. In contrast, congenital cataract-reversal individuals lagged a similar increase in parietal regions and did not show the typical decrease of amplitude of low-frequency fluctuation in auditory cortex. Congenitally blind individuals displayed an overall higher amplitude in slow blood oxygen level-dependent fluctuations in visual cortex compared with sighted individuals and compared with congenital cataract-reversal individuals in the eyes closed condition. Higher amplitude of low-frequency fluctuation in visual cortex of congenital cataract-reversal individuals than in normally sighted controls during eyes open might indicate an altered excitatory-inhibitory balance of visual neural circuits. By contrast, the lower parietal increase and the missing downregulation in auditory regions suggest a reduced influence of the visual system on multisensory and the other sensory systems after restoring sight in congenitally blind individuals. These results demonstrate a crucial dependence of visual and multisensory neural system functioning on visual experience during a sensitive phase in human brain development.

Effects of Low-Intensity and Long-Term Aerobic Exercise on the Psoas Muscle of mdx Mice: An Experimental Model of Duchenne Muscular Dystrophy.

Duchenne muscular dystrophy (DMD) is a muscle disease characterized by the absence of the protein dystrophin, which causes a loss of sarcolemma integrity, determining recurrent muscle injuries, decrease in muscle function, and progressive degeneration. Currently, there is a need for therapeutic treatments to improve the quality of life of DMD patients. Here, we investigated the effects of a low-intensity aerobic training (37 sessions) on satellite cells, peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1α protein (PGC-1α), and different types of fibers of the psoas muscle from mdx mice (DMD experimental model). Wildtype and mdx mice were randomly divided into sedentary and trained groups (n = 24). Trained animals were subjected to 37 sessions of low-intensity running on a motorized treadmill. Subsequently, the psoas muscle was excised and analyzed by immunofluorescence for dystrophin, satellite cells, myosin heavy chain (MHC), and PGC-1α content. The minimal Feret's diameters of the fibers were measured, and light microscopy was applied to observe general morphological features of the muscles. The training (37 sessions) improved morphological features in muscles from mdx mice and caused an increase in the number of quiescent/activated satellite cells. It also increased the content of PGC-1α in the mdx group. We concluded that low-intensity aerobic exercise (37 sessions) was able to reverse deleterious changes determined by DMD.

High Stability of the Epigenome in Drosophila Interspecific Hybrids.

Interspecific hybridization is often seen as a genomic stress that may lead to new gene expression patterns and deregulation of transposable elements (TEs). The understanding of expression changes in hybrids compared with parental species is essential to disentangle their putative role in speciation processes. However, to date we ignore the detailed mechanisms involved in genomic deregulation in hybrids. We studied the ovarian transcriptome and epigenome of the Drosophila buzzatii and Drosophila koepferae species together with their F1 hybrid females. We found a trend toward underexpression of genes and TE families in hybrids. The epigenome in hybrids was highly similar to the parental epigenomes and showed intermediate histone enrichments between parental species in most cases. Differential gene expression in hybrids was often associated only with changes in H3K4me3 enrichments, whereas differential TE family expression in hybrids may be associated with changes in H3K4me3, H3K9me3, or H3K27me3 enrichments. We identified specific genes and TE families, which their differential expression in comparison with the parental species was explained by their differential chromatin mark combination enrichment. Finally, cis-trans compensatory regulation could also contribute in some way to the hybrid deregulation. This work provides the first study of histone content in Drosophila interspecific hybrids and their effect on gene and TE expression deregulation.

Looking at crime-communities and physical spaces: A curated dataset.

This article describes a curated dataset entitled "Looking at Crime: Communities and Physical Spaces", which comprises data from different sources, namely Diagnosis of Local Security (DLS), Diagnosis of School Environment (DSE) and observation of physical spaces. The main topic covered was crime and related variables at the Historic Centre of Porto (HCP), a well-known urban area located in the North of Portugal. It is currently attended by inhabitants, workers, students and tourists. This dataset includes i) data from two different self-reports: i.1) demographics, perception of (in)security, victimization, social control and community cohesion obtained through an inquiry applied to the adult community; and i.2) data from school climate and students behavioural problems, which may be seen as risk factors for juvenile delinquency, collected through a web-survey applied to school personnel; and ii) data from observation of physical spaces, attending to the Crime Prevention through Environmental Design (CPTED) principles. The dataset allows descriptive and inferential statistical analyses, being useful for students, academics, stakeholders, police forces and policy-makers, to better understand crime and its related variables, forecast criminal incidents, and further develop associated preventive and intervention programmes.

Drosophila Evolution over Space and Time (DEST): A New Population Genomics Resource.

Drosophila melanogaster is a leading model in population genetics and genomics, and a growing number of whole-genome data sets from natural populations of this species have been published over the last years. A major challenge is the integration of disparate data sets, often generated using different sequencing technologies and bioinformatic pipelines, which hampers our ability to address questions about the evolution of this species. Here we address these issues by developing a bioinformatics pipeline that maps pooled sequencing (Pool-Seq) reads from D. melanogaster to a hologenome consisting of fly and symbiont genomes and estimates allele frequencies using either a heuristic (PoolSNP) or a probabilistic variant caller (SNAPE-pooled). We use this pipeline to generate the largest data repository of genomic data available for D. melanogaster to date, encompassing 271 previously published and unpublished population samples from over 100 locations in >20 countries on four continents. Several of these locations have been sampled at different seasons across multiple years. This data set, which we call Drosophila Evolution over Space and Time (DEST), is coupled with sampling and environmental metadata. A web-based genome browser and web portal provide easy access to the SNP data set. We further provide guidelines on how to use Pool-Seq data for model-based demographic inference. Our aim is to provide this scalable platform as a community resource which can be easily extended via future efforts for an even more extensive cosmopolitan data set. Our resource will enable population geneticists to analyze spatiotemporal genetic patterns and evolutionary dynamics of D. melanogaster populations in unprecedented detail.

The effect of congenital blindness on resting-state functional connectivity revisited.

Lower resting-state functional connectivity (RSFC) between 'visual' and non-'visual' neural circuits has been reported as a hallmark of congenital blindness. In sighted individuals, RSFC between visual and non-visual brain regions has been shown to increase during rest with eyes closed relative to rest with eyes open. To determine the role of visual experience on the modulation of RSFC by resting state condition-as well as to evaluate the effect of resting state condition on group differences in RSFC-, we compared RSFC between visual and somatosensory/auditory regions in congenitally blind individuals (n = 9) and sighted participants (n = 9) during eyes open and eyes closed conditions. In the sighted group, we replicated the increase of RSFC between visual and non-visual areas during rest with eyes closed relative to rest with eyes open. This was not the case in the congenitally blind group, resulting in a lower RSFC between 'visual' and non-'visual' circuits relative to sighted controls only in the eyes closed condition. These results indicate that visual experience is necessary for the modulation of RSFC by resting state condition and highlight the importance of considering whether sighted controls should be tested with eyes open or closed in studies of functional brain reorganization as a consequence of blindness.

The size-weight illusion is unimpaired in individuals with a history of congenital visual deprivation.

Visual deprivation in childhood can lead to lifelong impairments in multisensory processing. Here, the Size-Weight Illusion (SWI) was used to test whether visuo-haptic integration recovers after early visual deprivation. Normally sighted individuals perceive larger objects to be lighter than smaller objects of the same weight. In Experiment 1, individuals treated for dense bilateral congenital cataracts (who had no patterned visual experience at birth), individuals treated for developmental cataracts (who had patterned visual experience at birth, but were visually impaired), congenitally blind individuals and normally sighted individuals had to rate the weight of manually explored cubes that differed in size (Small, Medium, Large) across two possible weights (350 g, 700 g). In Experiment 2, individuals treated for dense bilateral congenital cataracts were compared to sighted individuals in a similar task using a string set-up, which removed haptic size cues. In both experiments, indistinguishable SWI effects were observed across all groups. These results provide evidence that early aberrant vision does not interfere with the development of the SWI, and suggest a recovery of the integration of size and weight cues provided by the visual and haptic modality.

Linhas de cuidados em saúde às crianças expostas ao HIV / Health care priorities for children exposed to HIV / Prioridades de atención médica para niños expuestos al VIH

Objetivo: identificar na literatura os principais cuidados às crianças expostas ao HIV. Método: estudo bibliográfico, descritivo, tipo revisão integrativa, cuja questão norteadora foi: quais os principais cuidados às crianças expostas ao HIV? A busca ocorreu na biblioteca Scielo e nas bases Lilacs e BDEnf, em que se selecionaram estudos publicados entre 2013 e 2017, de acordo com os critérios de seleção, e avaliados conforme os critérios Agency for Healthcare Research and Quality (AHRQ) para os níveis de evidência, analisando-os de forma descritiva e apresentando-os em forma de figuras. Resultados: amostra final foi composta por treze artigos, constituída por nove (69,2%) estudos com abordagem qualitativa e quatro (30,8%) com enfoque quantitativo. Os principais cuidados se concentraram em quatro grupos norteadores: Cuidados com a prevenção da transmissão vertical; Cuidados relacionados à terapia medicamentosa; Cuidados relacionados aos fatores ambientais e familiar; e Cuidados com a alimentação. Conclusão: o estudo contribui para o entendimento das linhas de cuidados prioritários às crianças expostas ao HIV e expande ideias para novas pesquisas nessa perspectiva.(AU)

Objective: to identify the main health care actions for children exposed to HIV, in the literature. Method: a bibliographic, descriptive, and integrative review study was conducted with the following guiding question: what are the main health care actions for children exposed to HIV? The search took place in the Scielo library and at the Lilacs and BDEnf databases. Studies published from 2013 to 2017 were selected based on selection criteria and evaluated according to the levels of evidence proposed by the Agency for Healthcare Research and Quality (AHRQ). The studies were analyzed descriptively, and results were presented in figures. Results: the final sample consisted of thirteen articles from which nine (69.2%) had a qualitative approach and four (30.8%) had a quantitative approach. The main health care actions were divided in four groups: Prevention of vertical transmission, Drug therapy, Management of environmental and family factors, and Nutrition. Conclusion: the study contributes to understanding the health care priorities for children exposed to HIV and expands ideas for new research in this perspective.(AU)

Objetivo: identificar las principales acciones de atención a la salud de niños expuestos al VIH, en la literatura. Método: se realizó un estudio de revisión bibliográfica, descriptiva e integradora con la siguiente pregunta orientadora: ¿Cuáles son las principales acciones de atención a salud de niños expuestos al VIH? La búsqueda se realizó en la biblioteca Scielo y en las bases de datos Lilacs y BDEnf. Fueron seleccionados estudios publicados de 2013 a 2017 en base a criterios de selección y estos fueron evaluados de acuerdo con los niveles de evidencia propuestos por la Agency for Healthcare Research and Quality (AHRQ). Los estudios se analizaron de forma descriptiva y los resultados se presentaron en figuras. Resultados: la muestra final constó de trece estudios de los cuales nueve (69,2%) tenían un enfoque cualitativo y cuatro (30,8%) tenían un enfoque cuantitativo. Las principales acciones asistenciales se dividieron en cuatro grupos: Prevención de la transmisión vertical, Farmacoterapia, Manejo de factores ambientales y familiares y Nutrición. Conclusión: el estudio contribuye a comprender las prioridades de atención a la salud de niños expuestos al VIH y amplía las ideas para nuevas investigaciones en esta perspectiva.(AU)

Neural mechanisms of visual sensitive periods in humans.

Sensitive periods in brain development are phases of enhanced susceptibility to experience. Here we discuss research from human and non-human neuroscience studies which have demonstrated a) differences in the way infants vs. adults learn; b) how the brain adapts to atypical conditions, in particular a congenital vs. a late onset blindness (sensitive periods for atypical brain development); and c) the extent to which neural systems are capable of acquiring a typical brain organization after sight restoration following a congenital vs. late phase of pattern vision deprivation (sensitive periods for typical brain development). By integrating these three lines of research, we propose neural mechanisms characteristic of sensitive periods vs. adult neuroplasticity and learning.

The Neural Correlates of Visual and Auditory Cross-Modal Selective Attention in Aging.

Age-related deficits in selective attention have been demonstrated to depend on the sensory modality through which targets and distractors are presented. Some of these investigations suggest a specific impairment of cross-modal auditory selective attention. For the first time, this study is taking on a whole brain approach while including a passive perception baseline, to investigate the neural underpinnings of selective attention across age groups, and taking the sensory modality of relevant and irrelevant (i.e., distracting) stimuli into account. Sixteen younger (mean age = 23.3 years) and 14 older (mean age = 65.3 years), healthy participants performed a series of delayed match-to-sample tasks, in which participants had to selectively attend to visual stimuli, selectively attend to auditory stimuli, or passively view and hear both types of stimuli, while undergoing 3T fMRI. The imaging analyses showed that areas recruited by cross-modal visual and auditory selective attention in both age groups included parts of the dorsal attention and frontoparietal control networks (i.e., intraparietal sulcus, insula, fusiform gyrus, anterior cingulate, and inferior frontal cortex). Most importantly, activation throughout the brain did not differ across age groups, suggesting intact brain function during cross-modal selective attention in older adults. Moreover, stronger brain activation during cross-modal visual vs. cross-modal auditory selective attention was found in both age groups, which is consistent with earlier accounts of visual dominance. In conclusion, these results do not support the hypothesized age-related deficit of cross-modal auditory selective attention. Instead, they suggest that the underlying neural correlates of cross-modal selective attention are similar in younger and older adults.