The effect of heat-treated single-file systems on dentinal crack formation.

OBJECTIVES: The aim of this study was to compare the formation of dentinal crack after root canal preparation performed with different heat treated single-file systems. MATERIALS AND METHODS: Forty mandibular premolar teeth were randomly divided into four groups according to the file system to be used during the preparation (n = 10): Group 1: Reciproc Blue; group 2: One Curve; group 3: HyFlex EDM; group 4: (control group) hand files. During the cleaning and shaping, irrigation was performed with a total of 10 ml of 5.25% sodium hypochlorite and 2 mL of distilled water. Then sections were taken from the roots (3, 6 and 9 mm). Sections were examined on a stereomicroscope to determine the presence of cracks. Chi-square test was used for data analysis. RESULTS: There was a significant difference between the groups in dentinal crack frequency (P <.05). HyFlex EDM (13.3%) caused less dentinal crack than One Curve (26.7%) and Reciproc Blue (30%). No cracks were observed in the control group. When 3, 6, and 9 mm were evaluated within themselves, dentinal crack formation did not differ according to the groups (P > 0.05). A statistically higher mean value was obtained in the control group compared to the other groups in terms of working time (P < 0.001). CONCLUSIONS: All the files used during root canal preparation formed dentin crack. Hy-Flex EDM caused less dentinal cracks than other file systems. The flexibility of nickel-titanium instruments because of heat treatment seems to have a significant influence on dentinal crack formation.

Investigation of the cortical activity during episodic future thinking in schizophrenia: A functional near-infrared spectroscopy study.

Episodic future thinking (EFT) refers to mental simulation of possible future events, a process that mostly depends on episodic memory (EM). EFT impairment in schizophrenia was proposed to disturb continuity in self-functioning. Schizophrenia patients are also impaired in EM as well as executive functions (EFs). In the present study, we aimed to clarify the relationship between EFT and memory functions in schizophrenia by assessing (a) whether a group of individuals with schizophrenia (schizophrenia group [SG]) who have relatively intact long-term memory functions differ from healthy controls (control group [CG]) in terms of EFT performance, and (b) whether such difference is biologically represented in terms of cortical activity. We also aimed to clarify the role of EFs in EFT in 3 task conditions: past remembering with a single cue (PR), future imagination with a single cue (FI-1C), and future imagination with 3 given cues (FI-3C). Cortical activity was monitored by functional near-infrared spectroscopy. Although the two groups showed a comparable performance in the PR, the SG performed worse than the CG in the two future-imagination conditions. In the CG, mental flexibility predicted EFT, and EM predicted PR. No such relationship was observed in the SG. In the CG only, activity was higher in the FI-1C than the PR in the middle and superior temporal cortices. In the SG, activity in the rostral prefrontal cortex (rPFC) was negatively correlated with performance in FI-3C. These results suggest that EFT is still observed but not associated with EFs in individuals with schizophrenia having relatively intact memory functions. Altered activity in the rPFC may be associated with EFT impairment in schizophrenia. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

ASSESSMENT OF WARFARIN TREATMENT EFFICACY BY MEANS; OF USING COAGULATION TEST RESULTS WITHIN THE THERAPEUTIC RANGE.

Time in Therapeutic Range (TTR) is a value used to assess the efficacy of Warfarin treatment. The aim of our study is to determine the effective INR levels and the rate of TTR in patients on Warfarin regimen due to Atrial Fibrillation (AF) or Mechanical Prosthetic Valve (MPV). A total of 94 patients (58 female, and 36 male, mean age: 64.9±11years) on Warfarin treatment due to AF or MPV with at least 10 INR levels measurements in the last 6 months were included in this retrospective study. The patients were divided into 2 groups. Group 1 consisted of the patients with Valvular AF (n=47); Group 2 included the patients with Non-Valvular AF (n=47); TTR and INR levels were compared. The average of INR values were found as 2,4 (min: 1,3, max: 4,3) in all patients; 2,3 (min: 1,3, max: 4,2) in Group 1; 2,6 (min: 1,3, max: 4,3) in Group 2. The average of TTR values was found 40.3% (min: 10%, max: 80%) in all patients; 43.8% (min: 10%, max: 80%) in Group 1; 36,8% (min: 10%, max: 80%) in Group 2. INR and TTR values are needed to assess the effectiveness of the Warfarin treatment. The patients in treatment with Warfarin should be well trained and frequently monitored. On the other hand, the underlying factors of the TTR values being determined as lower in the Turkish patient population might be due to the lower socio-economic and socio-cultural status, inadequate education levels, and the insufficient information on use of the medication provided by the doctors to the patients.

HEMATOLOGICAL MARKERS OF THE NO-REFLOW PHENOMEN ON IN-PATIENTS UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION.

The study aims to investigate hematological parameters of the no-reflow phenomenon (NRP) developed in patients underwent primary percutaneous coronary intervention (pPCI) due to diagnosis of ST elevation myocardial infarction (STEMI). The study sample consisted of a total of 90 patients, of which 44 patients who underwent pPCI and developed NRP without anemia and chronic renal failure (mean age was 64; 34 males and 10 females) were included in the experimental group, and the control group consisted of 46 patients with normal reperfusion flow (mean age was 58; 34 males and 12 females). In both groups, Red blood-cell Distribution Width (RDW), Mean Platelet Volume (MPV), plateletcrit (PCT), Platelet Distribution Width (PDW), and neutrophil count were observed. The demographic characteristics of both groups were similar, except the higher mean age of the experimental group (age; 64.0±12.6; 58.0±12.5). No correlation was found between development of no-reflow and incidence of risk factors such as hypertension, diabetes mellitus, dyslipidemia, smoking, family history and gender. In the no-reflow group, RDW level (16.2%±2.1; 14.2%±0.7, p<0.001), MPV level (7.9±1.2; 7.3±0.8, p<0.05), PDW level (18.1±1.2; 17.4±1.2, p<0.05), PCT level (0.2±0.06 vs 0.17±0.05) and neutrophil count (9.9±3.7; 7.1±3.3, p<0.001) was found to be higher than the control group. According to logistic regression analysis, RDW (OR; 23.4, <95% Cl 4.6-118.9, p<0.001), PDW (OR; 2.8, <95% Cl 1.2-6.4, p<0.05) and neutrophil count (OR; 1.4, Cl 1.1-1.9, p<0.05) were found to be the predictors of NRP development. Hemogram is a cheap and easy to apply test. In our study, a relationship between the NRP development and RDW, PDW, MPV, PCT, and neutrophil counts was found in patients who underwent pPCI. At the same time, RDW, PDW, and the neutrophil count were found to be predictors of no-reflow development.

Comparison of apically extruded debris after root canal instrumentation using Reciproc(®) instruments with various kinematics.

AIM: To assess the amount of apically extruded debris using Reciproc(®) instruments with different kinematics (150° counter clockwise [CCW]-30° clockwise [CW], 270° CCW-30° CW, 360° CCW-30° CW and continuous rotation). METHODOLOGY: Forty-eight maxillary central incisors were selected and assigned to four root canal shaping groups as follows (n = 12): 150° CCW-30° CW, 270° CCW-30° CW, 360° CCW-30° CW and continuous rotation. Reciproc R25 and R50(®) instruments were used in all groups. Apically extruded debris was collected and dried in preweighed Eppendorf tubes. The weight of extruded debris was assessed with an electronic balance. The data were analysed with one way analysis of variance and LSD post hoc tests (P = 0.05). RESULTS: The 150° CCW-30° CW and 270° CCW-30° CW reciprocating motions extruded significantly less debris than continuous rotation (P < 0.05). However, no significant differences were found between the 360° CCW and 30° CW reciprocating motion and the continuous rotation (P > 0.05). CONCLUSIONS: All instrument movements were associated with apically extruded debris. However, the 150° CCW-30° CW and 270° CCW-30° CW reciprocating motions were associated with less extrusion than continuous rotation.

Incidence of dentinal cracks after root canal preparation with ProTaper Gold, Profile Vortex, F360, Reciproc and ProTaper Universal instruments.

AIM: To assess the effect of root canal preparation using ProTaper Gold, Profile Vortex, F360, Reciproc and ProTaper Universal instruments on dentinal crack formation. METHODOLOGY: Ninety mandibular central incisor teeth with mature apices and straight canals (<5° ) were selected and stored in distilled water. Fifteen teeth were left unprepared (control group) and the remaining 75 teeth were assigned to the five root canal shaping groups (n = 15): ProTaper Gold, ProFile Vortex, F360, Reciproc and ProTaper Universal. All the roots were sectioned perpendicular to the long axis at 3, 6 and 9 mm from the apex with a low-speed saw under water cooling. The slices were then viewed through a stereomicroscope at 25×  magnification. The presence of dentinal cracks was determined by photographing all samples using a digital camera. RESULTS: All the experimental groups, except F360, produced significantly more cracks than the control group (P < 0.05). No significant difference was observed amongst the groups at the 6 and 9 mm levels (P > 0.05). The ProTaper Universal group produced significantly more cracks than the control, ProTaper Gold, ProFile Vortex, F360 and Reciproc groups at the apical section (3 mm) (P < 0.05). CONCLUSION: All the systems that were tested produced dentinal cracks. There was no significant difference between the control and F360 groups in terms of dentinal crack formation.

Immediate primary transcatheter closure of left ventricular free wall rupture after myocardial infarction.

Left ventricular free wall rupture due to acute myocardial infarction (MI) is an infrequent but fatal complication that occurs especially during the 1st week of MI. Emergency surgical intervention is essential but conveys significant operative mortality. Most of the patients die before they reach the operating room. We present a case of percutaneous left ventricular free wall rupture closure complicating acute inferior MI to bridge the time until the patient can be transferred to the surgical department and subjected to surgery.

Slow ventricular response atrial fibrillation related to mad honey poisoning.

Mad honey poisoning which is induced by Grayanotoxin (Andromedotoxin), is also known to have adverse effects in the cardiovascular system leading to different clinical entities. This toxin is produced by a member of the Rhododendron genus of plants of two R. Luteum and R. Panticum. In this article, we presented a case of slow ventricular response atrial fibrillation complaints with nausea, vomiting, dizziness and chest pain about an hour after eating honey produced in the Black Sea Region.

Natural radiation monitoring and control treatment in the Hantepe beach.

This work has been carried out to monitor and decrease the natural radiation exposure at the Hantepe beach (Çanakkale, Turkey). A 0.25- to 0.30-m-thick layer of sand was scraped, removed and deposited in a safe place in order to decrease people's exposure to radiation and to relieve relevant radiophobia. The original mean value of dose rate on the beach was 1.38 µGy h(-1) at the contact and 1.0 µGy h(-1) at 1 m above the ground. After the scraping process, the mean value of dose rate decreased to 0.98 µGy h(-1) at the contact and to 0.78 µGy h(-1) at 1 m above the ground. One year later, these values decreased to 0.70 µGy h(-1) at the contact and to 0.56 µGy h(-1) at 1 m above the ground. The effective original dose rate of 1.2 mSv y(-1) decreased to 0.95 mSv y(-1) after the surface treatment and to 0.69 mSv y(-1) one year later.

Dose evaluation in criticality accidents using response of Panasonic TL personal dosemeters (UD-809/UD-802).

This study gives the results of dosimetry measurements carried out in the Silène reactor at Valduc (France) with neutron and photon personal thermoluminescence dosemeters (TLDs) in mixed neutron and gamma radiation fields, in the frame of the international accident dosimetry intercomparison programme in 2002. The intercomparison consisted of a series of three irradiation scenarios. The scenarios took place at the Valduc site (France) by using the Silène experimental reactor. For neutron and photon dosimetry, Panasonic model UD-809 and UD-802 personal TLDs were used together.

Occupational exposure to ionising radiation with thermoluminescence dosimetry system in Turkey, in 2003.

The individual annual dose information on classified workers who are occupationally exposed to extended radiation sources by using thermoluminescence dosimetry system, in Turkey, was assessed and analysed by the Ankara Nuclear Research and Training Centre (ANAEM) dosimetry service at the Turkish Atomic Energy Authority (TAEK) for the year 2003. A total of 3721 persons were monitored with TLD and the data presented in this report were obtained by using TLD technology in 2003. The annual mean effective doses received from external radiation in different fields of activities and the distribution of the annual effective dose by dose intervals are presented. The collective annual dose by field of activity is estimated and the contribution to the total annual collective dose is determined.

Cardiac emergencies caused by honey ingestion: a single centre experience.

An unusual type of food poisoning is commonly seen in the Black Sea coast of Turkey attributable to andromedotoxin containing toxic honey ingestion. This study is a retrospective case series of 19 patients admitted to an emergency department in 2002, poisoned by "mad" honey. All of the patients had the complaints of nausea, vomiting, sweating, dizziness, and weakness, several hours after ingesting "mad" honey. Physical examination showed hypotension in 15 patients, sinus bradycardia in 15, and complete atrioventricular block (AVB) in four patients on admission. Two patients with bradycardia and two with AVB fell and injured their heads. Three of them presented with local haematoma. One patient had a 6 cm cut on his head without any neurological deficit and his cranial computed tomography imaging was normal. Hypotension and conduction disorders resolved with atropine treatment, resulting in complete recovery within 24 hours.

Atrial fibrillation after electrical shock: a case report and review.

A 52 year old man was admitted to an emergency department with a fast ventricular rate atrial fibrillation after an electrical shock. Electrical cardioversion was attempted after echocardiographic examination. This failed, but the heart rate slowed. Successful pharmacological cardioversion was achieved after 16 hours of amiodarone infusion. Pre-excitation syndrome was detected on baseline echocardiograph. Serum cardiac specific markers were all within normal limits. No abnormal findings were detected by chest radiography, echocardiographic, or coronary angiographic investigations. Acute onset atrial fibrillation after electrical injury is discussed.

Occupational exposure to ionising radiation in the region of Anatolia, Turkey for the period 1995-1999.

For this study, the individual annual dose information on classified workers who are occupationally exposed to extended radiation sources in Turkey, was assessed and analysed by the Ankara Nuclear Research and Training Centre dosimetry service at the Turkish Atomic Energy Authority for the years 1995-1999. The radiation workers monitored are divided into three main work sectors: conventional industry (8.24%), medicine (90.20%) and research-education (1.56%). The average annual dose for all workers in each particular sector was 0.14, 0.38 and 0.08 mSv, respectively, in 1995-1999. This paper contains the detailed analysis of occupational exposure. The statistical analysis provided includes the mean annual dose, the collective dose, the distributions of the dose over the different sectors and the number of workers who have exceeded any of the established dose levels.

Effects of Nigella sativa L. and Urtica dioica L. on lipid peroxidation, antioxidant enzyme systems and some liver enzymes in CCl4-treated rats.

This study was designed to investigate the effects Nigella sativa L. (NS) and Urtica dioica L. (UD) on lipid peroxidation, antioxidant enzyme systems and some liver enzymes in carbon tetrachloride (CCl4)-treated rats. A total of 60 healthy male Sprague-Dawley rats were utilized in this study. The rats were randomly allotted into one of four experimental groups: A (CCl4-only treated), B (CCl4 + UD treated), C (CCl4 + NS treated) and D (CCl4 + UD + NS treated), each containing 15 animals. All groups received CCl4 [0.8 ml/kg of body weight, subcutaneously, twice a week for 90 days starting day 1]. In addition, B, C and D groups also received daily intraperitoneal injections of 0.2 ml/kg NS or/and 2 ml/kg UD oils for 45 days starting day 46. Group A, on the other hand, received only 2 ml/kg normal saline solution for 45 days starting day 46. Blood samples for the biochemical analysis were taken by cardiac puncture from five randomly chosen rats in each treatment group at beginning, at 45th and at 90th day of the experiment. The CCl4 treatment for 45 days increased the lipid peroxidation and liver enzymes, and also decreased the antioxidant enzyme levels. NS or UD treatments (alone or combination) for 45 days starting day 46 decreased the elevated lipid peroxidation and liver enzyme levels and also increased the reduced antioxidant enzyme levels. Live weights of the rats decreased in group A, and increased in groups B, C and D. It is concluded that NS and UD decrease the lipid peroxidation and liver enzymes, and increase the antioxidant defence system activity in the CCl4-treated rats.

Serum trace elements status of rabbits supplemented with Nigella sativa, vitamins C and E, and selenium against damage by N-methyl-N'-nitro-N-nitrosoguanidine.

In this study, we investigated the effects of Nigella sativa, vitamins C and E, and selenium on the levels of trace elements in the serum of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-injected rabbits. The rabbits were separated into one control and three experimental groups, each consisting of eight rabbits. MNNG was administered to all rabbits at a dose of 20 mg/kg. Group A received a suspension of N. sativa, group B received a combination of vitamins C and E and selenium, and group C received MNNG without any additional treatment. Group D did not receive any treatment and acted as control. The concentrations of serum zinc, copper, and iron were determined for groups A, B, C, and D. The zinc levels were 155.3+/-25.8, 304.7+/-14.22, 117.2+/-27.9, and 87.0+/-8 ng/dL for groups A-D, respectively; copper was measured at 234.8+/-31.9, 214.3+/-14.2, 196.5+/-19.3, and 359.2+/-19.9 ng/dL and iron levels were 276.3+/-10.71, 260.8+/-7.15, 211.2+/-13.47, and 223.4+/-9.5 ng/dL, in the stated group order. There were statistically significant differences between groups (p<0.05). The results obtained in this work may be of use for monitoring and preventing the nocive effects of N-methyl-N'-nitro-N-nitrosoguanidine and similar carcinogens.

The effects of growing conditions on oil content, fatty acid composition and tocopherol content of some sunflower varieties produced in Turkey.

The properties of some extensively cultivated sunflower seed varieties in Turkey and their oils were investigated. 1991-1992 crop year sunflower varieties harvested from Trakya University, Tekirdag Agricultural Faculty, Experiment field of Crop Science Department were used as research materials. The oil content, fatty acid composition and tocopherol content of sunflower seeds in 1991 and 1992 crop years were determined as 44.2-51.2% (on dry weight basis), 43.0-51.5% (on dry weight basis); oleic acid 14.8-18.5%, 32.9-40.1%; linoleic acid 69.5-74.5%, 49.7-55.7% and tocopherol content (as alpha-tocopherol) 648-860 mg/kg, 524-880 mg/kg, respectively. It was determined that the growing conditions significantly affected the fatty acid compositions of sunflower varieties studied. While the oleic acid content of the 1992 crop increased, the linoleic acid content of the same crop decreased compared to the 1991 crop.

Obstetric complications predict treatment response in first-episode schizophrenia.

BACKGROUND: Understanding the role of obstetric complications (OCs) in schizophrenia could potentially shed light on the heterogeneity in the aetiology and course of schizophrenia. Many investigators have reported an association between OCs and schizophrenia, but few have examined the association between OCs and treatment outcome. We investigated this question in a sample of patients studied during their first episode of schizophrenia, schizoaffective or schizophreniform disorder. METHOD: OC histories were obtained for 59 patients participating in the Hillside First Episode Study. Cox proportional hazards regression analysis was used to estimate the effect of OCs on treatment response during the first episode of schizophrenia. RESULTS: Twelve of the 59 patients (20%) had positive histories of OCs. This group exhibited lower rates of treatment response than those with negative OC histories (hazard ratio controlling for sex = 0.28; 95% CI = 0.13, 0.62). The positive OC group also had significantly greater lateral ventricle volume, baseline disorganization and number of live births. The effect of OC history on treatment response held when these three variables were controlled for. CONCLUSION: A history of obstetric complications predicted poor response to treatment in the first episode of schizophrenia. This large effect was based on a small sample of 59 patients. Thus, replication is called for.