1.
J Pharm Pharmacol
; 28(10): 758-61, 1976 Oct.
Article
in English
| MEDLINE
| ID: mdl-10369
ABSTRACT
Two crystal forms of disopyramide have been characterized using X-ray diffraction, differential scanning calorimetry and infrared spectroscopy. The kinetics of the solid state transformation of Form I to Form II has been analysed using the Prout-Tompkins theory. An activation energy of 144 kJ mol-1 is calculated for the system. Dissolution and plasma concentrations show no significant differences in bioavailability between the two polymorphs.
Subject(s)
Disopyramide/analysis , Pyridines/analysis , Biological Availability , Biotransformation , Chemical Phenomena , Chemistry, Physical , Disopyramide/metabolism , Female , Humans , Hydrogen-Ion Concentration , Isomerism , Kinetics , Male , Solubility , X-Ray Diffraction
2.
Pharm Acta Helv
; 49(9-10): 298-302, 1974.
Article
in English
| MEDLINE
| ID: mdl-4618350