Suanzaoren decoction exerts its antidepressant effect via the CaMK signaling pathway.

Calmodulin-dependent protein kinases (CaMKs) are widely regarded as "memory molecules" due to their role in controlling numerous neuronal functions in the brain, and the CaMK signaling pathway plays a crucial role in controlling synaptic plasticity. Suanzaoren decoction (SZRD) can improve depression-like behavior and thus has potential benefits in the clinical treatment of depression; however, its mechanism of action is not fully understood. In this study, we found that key proteins in the CaMK signaling pathway were regulated by the decoction used to treat depression. The purpose of this research was to ascertain if the SZRD's therapeutic efficacy in the treatment of depression is associated with the modulation of key proteins in the CaMK signaling pathway. A rat model of depression was created by exposing the animals to chronic, unexpected, mild stress. Model rats were given intragastric administration of SZRD or fluoxetine every morning once a day. Protein and mRNA relative expression levels of CaM, CaMK I, and CaMK IV in the hippocampus were measured by Western blot, quantitative polymerase chain reaction, and immunohistochemistry in the hippocampus. Our findings demonstrated that SZRD significantly improved the mood of depressed rats. This indicates that SZRD, by modulating the CaMK signaling system, may alleviate depressive symptoms and lessen work and life-related pressures.

Yinchen gongying decoction mitigates CCl4-induced chronic liver injury and fibrosis in mice implicated in inhibition of the FoxO1/TGF-ß1/ Smad2/3 and YAP signaling pathways.

ETHNOPHARMACOLOGICAL RELEVANCE: Liver fibrosis (LF) is a common reversible consequence of chronic liver damage with limited therapeutic options. Yinchen Gongying decoction (YGD) composed of two homologous plants: (Artemisia capillaris Thunb, Taraxacum monochlamydeum Hand.-Mazz.), has a traditionally application as a medicinal diet for acute icteric hepatitis. However, its impact on LF and underlying mechanisms remain unclear. AIM OF THE STUDY: This study aims to assess the impact of YGD on a carbon tetrachloride (CCl4) induced liver fibrosis and elucidate its possible mechanisms. The study seeks to establish an experimental foundation for YGD as a candidate drug for hepatic fibrosis. MATERIALS AND METHODS: LC-MS/MS identified 11 blood-entry components in YGD, and network pharmacology predicted their involvement in the FoxO signaling pathway, insulin resistance, and PI3K-AKT signaling pathway. Using a CCl4-induced LF mouse model, YGD's protective effects were evaluated in comparison to a positive control and a normal group. The underlying mechanisms were explored through the assessments of hepatic stellate cells (HSCs) activation, fibrotic signaling, and inflammation. RESULTS: YGD treatment significantly improved liver function, enhanced liver morphology, and reduced liver collagen deposition in CCl4-induced LF mice. Mechanistically, YGD inhibited HSC activation, elevated MMPs/TIMP1 ratios, suppressed the FoxO1/TGF-ß1/Smad2/3 and YAP pathways, and exhibited anti-inflammatory and antioxidant effects. Notably, YGD improved the insulin signaling pathway. CONCLUSION: YGD mitigates LF in mice by modulating fibrotic and inflammatory pathways, enhancing antioxidant responses, and specifically inhibiting FoxO1/TGF-ß1/Smad2/3 and YAP signal pathways.

Robust photogalvanic effect, full spin polarization and pure spin current in the BiC photodetector by vacancy- and substitution-doping.

The photogalvanic effects (PGEs) in low-dimensional devices have attracted great interests recently. Herein, based on non-equilibrium Green's function combined with density functional theory, we investigated spin-dependent PGE phenomena in the BiC photodetector for the case of linearly polarized light and zero bias. Due to the presence of strong spin-orbital interaction (SOI) and C3v symmetry for the BiC monolayer, the armchair and zigzag BiC photodetectors produce robust spin-dependent PGEs which possess the cos(2θ) and sin(2θ) relations on the photon energies. Especially, the armchair and Bi-vacancy armchair BiC photodetector can produce fully spin polarization, and pure spin current was found in the armchair and zigzag BiC photodetector. Furthermore, after introducing the Bi-vacancy, C-vacancy, Bi-doping and C-doping respectively, corresponding armchair and zigzag BiC photodetector can produce higher spin-dependent PGEs for their Cs symmetry. Moreover, the behaviors of spin-dependent photoresponse are highly anisotropic and can be tuned by the photon energy. This work suggested great potential applications of the BiC monolayer on PGE-driven photodetectors in low energy-consumption optoelectronics and spintronic devices. .

Theoretical prediction of 2D biphenylene as a potential anchoring material for lithium-sulfur batteries.

Searching for good anchoring materials that can suppress the shuttle effect is critical to large-scale commercialization of lithium-sulfur (Li-S) batteries. In this work, the adsorption behavior of lithium polysulfides (LiPSs, such as S8 and Li2Sn, n = 1, 2, 4, 6, and 8), the sulfur reduction reaction (SRR), the decomposition processes of Li2S and the diffusion behavior of Li atoms on intrinsic and doped 2D biphenylene (BIP) are systematically investigated by employing the first-principles calculation method. Calculations show that the adsorption energies of LiPSs on the electrolyte (DOL and DME) are smaller than those on the intrinsic/B doped BIP. The moderate anchoring strength (0.8-2.0 eV) between LiPSs and the BIP can effectively suppress the shuttle effect. Moreover, the Gibbs free energy barrier for SRR is 0.72/0.64 eV on intrinsic/B doped BIP. The dissociation energy barrier of Li2S on intrinsic/B doped BIP is 1.35 eV, while the diffusion energy barrier of Li atoms on intrinsic/B doped BIP is 0.18 eV/0.30 eV. Lower energy barriers are conducive to enhancing the discharging and charging efficiency. Therefore, intrinsic and B doped BIP are predicted as good anchoring materials for Li-S batteries.

Investigation of the anchoring and electrocatalytic properties of pristine and doped borophosphene for Na-S batteries.

Designing an anchoring layer on the sulfur electrode has been considered one of the effective approaches to promoting the real application of room-temperature sodium-sulfur (RT-Na-S) batteries. In this work, based on the first-principles calculation method, the potential of pristine and doped borophosphene (BP) as anchoring materials for Na-S batteries has been investigated. The calculated adsorption energies of sodium polysulfides (NaPSs) adsorbed on pristine and doped substrates are higher than those of NaPSs adsorbed with the electrolytes (DOL&DME), indicating that the shuttle effect could be well alleviated. Meanwhile, the projected density of states (PDOS) suggests that the metallic characteristics of the adsorption systems are still well preserved, which is in favor of improving the electronic conductivity. More importantly, excellent electrocatalytic properties of the substrates are exhibited by reducing the catalytic decomposition energy barriers of Na2S, in which 0.27/0.79/1.02 eV is found on the pristine/N-doped/C-doped BP, indicating that the electrochemical processes could be improved smoothly. Therefore, it could be expected that pristine and doped BP are excellent anchoring materials for sodium-sulfur batteries.

A graphene-like semiconducting BC2P monolayer as a promising material for a Li-ion battery and CO2 adsorbent.

Searching for high-performance anode materials and CO2 adsorption materials are key factors for next-generation renewable energy technologies and mitigation of the greenhouse effect. Herein, we report a novel two-dimensional (2D) BC2P monolayer with great potential as an anode material for lithium-ion batteries (LIBs) and as a material for CO2 adsorption. The adsorption energies of Li atoms and CO2 molecules on the BC2P supercell are negative enough to assure stability and safety under operating conditions. More intriguingly, the BC2P monolayer possesses a very high theoretical capacity of 1018.8 mA g h-1 for LIBs. In addition, the diffusion energy barriers of Li on the BC2P supercell are 0.26 and 0.87 eV, showing good charge/discharge capability, and the electrode potential of Li is beneficial to their performance as an anode material. Moreover, four chemical and three physical adsorption sites were verified, indicating that the CO2 molecule was effectively adsorbed on the BC2P supercell. These desirable properties make the BC2P monolayer a promising 2D material for application in LIBs and for CO2 adsorbents aimed at highly efficient CO2 capture.

Plant protein-coding gene families: Their origin and evolution.

Steady advances in genome sequencing methods have provided valuable insights into the evolutionary processes of several gene families in plants. At the core of plant biodiversity is an extensive genetic diversity with functional divergence and expansion of genes across gene families, representing unique phenomena. The evolution of gene families underpins the evolutionary history and development of plants and is the subject of this review. We discuss the implications of the molecular evolution of gene families in plants, as well as the potential contributions, challenges, and strategies associated with investigating phenotypic alterations to explain the origin of plants and their tolerance to environmental stresses.

Identification and molecular mapping of YrBm for adult plan resistance to stripe rust in Chinese wheat landrace Baimangmai.

KEY MESSAGE: A new adult plan resistance gene YrBm for potentially durable resistance to stripe rust was mapped on wheat chromosome arm 4BL in landrace Baimangmai. SSR markers closely flanking YrBm were developed and validated for use in marker-assisted selection. The wheat stripe rust pathogen Puccinia striiformis f. sp. tritici (Pst) frequently acquires new virulences and rapidly adapts to environmental stress. New virulences in Pst populations can cause previously resistant varieties to become susceptible. If those varieties were widely grown, consequent epidemics can lead to yield losses. Identification and deployment of genes for durable resistance are preferred method for disease control. The Chinese winter wheat landrace Baimangmai showed a high level of adult plant resistance (APR) to stripe rust in a germplasm evaluation trial at Langfang in Hebei province in 2006 and has continued to confer high resistance over the following 15 years in field nurseries in Hebei, Sichuan and Gansu. A recombinant inbred line population of 200 F10 lines developed from a cross of Baimangmai and a susceptible genotype segregated for APR at a single locus on chromosome 4BL; the resistance allele was designated YrBm. Allelism tests of known Yr genes on chromosome 4B and unique closely flanking marker alleles Xgpw7272189 and Xwmc652164 among a panel of Chinese wheat varieties indicated that YrBm was located at a new locus. Moreover, those markers can be used for marker-assisted selection in breeding for stripe rust resistance.

In-situ synthesis of NiS2 nanoparticles/MoS2 nanosheets hierarchical sphere anchored on reduced graphene oxide for enhanced electrocatalytic hydrogen evolution reaction.

As an important energy storage and transportation carrier, hydrogen has the advantages of high combustion heat, non-toxic, and pollution-free energy conversion process. Bimetallic sulfide composites are one of the emerging catalysts for hydrogen evolution reactions (HER) during water splitting. Herein, a hydrothermal method has been employed for the in-situ synthesis of NiS2 nanoparticles/MoS2 nanosheets (NiS2/MoS2) hierarchical sphere anchored on reduced graphene oxide (RGO) for enhanced electrocatalytic HER activity. The NiS2/MoS2/RGO composite displays improved HER activity compared to MoS2/RGO and NiS2/RGO. The optimized NiS2/MoS2/RGO-9 requires only an overpotential of 136 mV at a current density of 10 mA cm-2, a small Tafel slope of 53.4 mV dec-1, and good stability in acid solution. The synergetic effect between NiS2 nanoparticles and MoS2 nanosheets is responsible for enhanced HER performance. Moreover, RGO provides the substrate for NiS2/MoS2 species and maintains the overall conductivity of NiS2/MoS2/RGO composites. Finally, density functional theory (DFT) calculations justify and approve the efficient HER activity of NiS2/MoS2/RGO in terms of lower Gibbs free energy (0.07 eV) and lower work function (3.98 eV) that subsequently enhance the dissociation of H2O.

Synonymous Codon Usage Analysis of Three Narcissus Potyviruses.

Narcissus degeneration virus (NDV), narcissus late season yellows virus (NLSYV) and narcissus yellow stripe virus (NYSV), which belong to the genus Potyvirus of the family Potyviridae, cause significant losses in the ornamental value and quality of narcissus. Several previous studies have explored the genetic diversity and evolution rate of narcissus viruses, but the analysis of the synonymous codons of the narcissus viruses is still unclear. Herein, the coat protein (CP) of three viruses is used to analyze the viruses' phylogeny and codon usage pattern. Phylogenetic analysis showed that NYSV, NDV and NLSYV isolates were divided into five, three and five clusters, respectively, and these clusters seemed to reflect the geographic distribution. The effective number of codon (ENC) values indicated a weak codon usage bias in the CP coding region of the three narcissus viruses. ENC-plot and neutrality analysis showed that the codon usage bias of the three narcissus viruses is all mainly influenced by natural selection compared with the mutation pressure. The three narcissus viruses shared the same best optimal codon (CCA) and the synonymous codon prefers to use codons ending with A/U, compared to C/G. Our study shows the codon analysis of different viruses on the same host for the first time, which indicates the importance of the evolutionary-based design to control these viruses.

Promising application of a SiC2/C3B heterostructure as a new platform for lithium-ion batteries.

Constructing heterostructures via the van der Waals coupling effect has provided an effective method for developing novel electrode materials. In this work, based on the first-principles calculation method, we proposed to construct a hexagonal SiC2/C3B heterostructure and confirmed its stability by analyzing its structural properties. Meanwhile, the electrochemical performances of the SiC2/C3B heterostructure as a new platform for lithium-ion batteries were evaluated. The calculated results illustrate that the pristine SiC2/C3B heterostructure is a semiconductor with a small bandgap of 0.15 eV and the lithiated heterostructure exhibits metallic properties which ensure superior electrical conductivity for fast electron transfer. Moreover, the low diffusion barriers of the heterostructure are acceptable to guarantee a high-rate performance for the batteries. Compared with the anode properties of isolated SiC2 and C3B monolayers, an enhancement of the storage capacity of Li ions on the SiC2/C3B heterostructure is observed, which could reach up to 1489.72 mA h g-1. In addition, the ab initio molecular dynamics simulations reveal that the SiC2/C3B heterostructure could maintain excellent structural stability during the lithiation processes even at a temperature of 350 K. All these encouraging results show that the SiC2/C3B heterostructure has fascinating potential to be an advanced platform for lithium-ion batteries.

New loci for refractive errors and ocular biometric parameters in young Chinese Han adults.

Myopia has become a major public health issue with an increasing prevalence. There are still individuals who experience similar environmental risk factors and, yet, remain non-myopic. Thus, there might be genetic factors protecting people from myopia. Considering the opposite ocular characteristics of primary angle closure glaucoma (PACG) to myopia and possible common pathway between them, we propose that certain risk genes for PACG might act as a protective factor for myopia. In this study, 2,678 young adults were genotyped for 37 targeted single nucleotide polymorphisms. Compared with emmetropia, rs1401999 (allele C: OR=0.795, P=0.03; genotype in dominant model: OR=0.759, P=0.02) and rs1258267 (allele A: OR=0.824, P=0.03; genotype in dominant model: OR=0.603, P=0.01) were associated with low to moderate myopia and high myopia, respectively. Genotype under recessive model of rs11024102 was correlated with myopia (OR=1.456, P=0.01), low to moderate myopia (OR=1.443, P=0.02) and high myopia (OR=1.453, P=0.02). However, these associations did not survive Bonferroni correction. Moreover, rs1401999, rs1258267, and rs11024102 showed associations with certain ocular biometric parameters in different groups. Our study suggests that ABCC5, CHAT and PLEKHA7 might be associated with refractive errors by contributing to the regulation of ocular biometry, in terms of uncorrected results and their biological functions.

Effect of Age and Refractive Error on Local and Global Visual Perception in Chinese Children and Adolescents.

PURPOSE: This study investigated the impact of age and myopia on visual form perception among Chinese school-age children. METHODS: This cross-sectional study included 1,074 students with a mean age of 12.1 ± 4.7 (range = 7.3-18.9) years. The mean spherical equivalence refraction (SER) of the participants was -1.45 ± 2.07 D. All participants underwent distance visual acuity (VA), refraction measurement and local and global visual form perception test including orientation, parallelism, collinearity, holes and color discrimination tasks. RESULTS: The reaction times of emmetropes were slower than those of myopic and high myopic groups on both local (orientation, parallelism, and collinearity) and global discrimination tasks (all p < 0.05). A reduction in reaction times was found with increasing age on both local and global discrimination tasks (all p < 0.05). Age was significantly associated with both local and global visual perception performance after adjusting for gender, visual acuity and SER (orientation, ß = -0.54, p < 0.001; parallelism, ß = -0.365, p < 0.001; collinearity, ß = -0.28, p < 0.001; holes, ß = -0.319, p < 0.001; color, ß = -0.346, p < 0.001). CONCLUSIONS: This study revealed that both local and global visual perception improve with age among Chinese children and that myopes seem to have better visual perception than emmetropes.

Penta-BCN monolayer with high specific capacity and mobility as a compelling anode material for rechargeable batteries.

With the increasing demand for sustainable and clean energies, seeking high-capacity density electrode materials applied in rechargeable metal-ion batteries is urgent. In this work, using first-principles calculations, we evaluate the ternary pentagonal BCN monolayer as a compelling anode material for metal ion batteries. Calculations show that the penta-BCN monolayer has favorable metallic behaviors after adsorbing Li (Na) atoms. More interestingly, the saturated adsorption systems provide a large storage capacity of 2183.12 (1455.41) mA h g-1 for Li (Na) ions. A low energy barrier of 0.14 (0.16) eV for Li (Na) diffusion is observed, being smaller than the reported other two-dimensional anode materials. Also, the wrinkled structure of penta-BCN has been demonstrated to be very beneficial to improve the energy density and cycle life of batteries. The calculated low open-circuit voltage and peculiar surface area expansion together with the thermal stability of saturated intercalation structures, further indicate that the penta-BCN monolayer has great potential as the anode material for Li (Na) ion batteries.

Distribution of IOP and its relationship with refractive error and other factors: the Anyang University Students Eye Study.

AIM: To investigate the distribution of intraocular pressure (IOP) and its relationship with refractive error and other factors in university students from Anyang, China. METHODS: A university-based study was conducted. Subjects were invited to complete ophthalmic examinations, including visual acuity, noncontact tonometry (NCT), cycloplegic autorefraction, and ocular biometry. Univariable and multivariable analyses were used to evaluate the associations between IOP and other factors. Only data from right eyes were used in analysis. RESULTS: A total of 7720 subjects aged 16 to 26 years old were included, and 2834 (36.4%) of the participants were male. The mean IOP of the right eye for all subjects was 15.52±3.20 mm Hg (95%CI: 15.45, 15.59). Using multivariate linear regression analysis, IOP was found to correlate significantly with younger age (P<0.001; standardized regression coefficient ß, -0.061; regression coefficient ß, -0.139; 95%CI: -0.18, -0.09), higher myopic refractive error (P=0.044; standardized ß, -0.060; regression coefficient ß, -0.770; 95%CI: -0.15, -0.002), higher central corneal thickness (P<0.001; standardized ß, 0.450; regression coefficient ß, 0.044; 95%CI: 0.04, 0.05), and shorter axial length (AL; P<0.001; standardized ß, -0.061; regression coefficient ß, -0.163; 95%CI: -0.25, -0.07). CONCLUSION: This study described the normal distribution of IOP. In Chinese university students aged 16-26y, higher IOP is associated with younger age, higher myopic refractive error, higher thickness of the central cornea, and shorter AL.

Effect of body stature on refraction and ocular biometry in Chinese young adults: The Anyang University Students Eye Study.

CLINICAL RELEVANCE: Large-scale data on the association between body stature with biometry parameters and refraction in young adults facilitates an understanding of myopia development. Taller persons have eyes with more negative refractions, longer axial lengths, deeper anterior chambers, flatter corneas, and higher axial length-corneal radius ratio. BACKGROUND: To determine the relationship between body stature with ocular biometry and refraction in young adults. METHODS: This was a cross-sectional university-based study of 16- to 26-year-old students in China. Cycloplegic refraction and corneal curvature were measured using an autorefractor. Ocular parameters, including axial length, anterior chamber depth and lens thickness, were measured using a Lenstar LS900. Data on height and weight were acquired from an annual standardised physical examination and body mass index was calculated. RESULTS: Of 7,971 participants examined in the school clinics, 5,657 (71.0 per cent) were available in the analysis. After adjusting for age, gender, parental myopia, time outdoors, near work and weight, each centimetre of height increase was associated with more negative refraction of -0.023-D, a 0.032-mm increase in axial length, a 0.003-mm increase in anterior chamber depth, a 0.008-mm increase in corneal curvature, and a 0.001 increase in axial length-corneal radius ratio. With regard to weight, a 1-kg heavier person was more likely to have less negative refraction of 0.011-D, a 0.001-mm increase in anterior chamber depth and a 0.002-mm increase in corneal curvature. A similar pattern of significant associations was also found in body mass index. CONCLUSION: Taller, young adults tended to have longer eyes, deeper anterior chambers, flatter corneas, higher axial length-corneal radius ratio, and more negative refraction, adjusted for potential confounders. In contrast, heavier and higher body mass index persons are more hyperopic. The differences in stature may partially explain the variation in refraction and ocular biometric parameters.

Distribution of ocular biometry in young Chinese eyes: The Anyang University Students Eye Study.

PURPOSE: To investigate the distribution of ocular biometric parameters and its association to refraction in university students in central China. METHODS: Ocular biometric parameters including axial length (AL), central corneal thickness (CCT), keratometry power (K), anterior chamber depth (AQD) and lens thickness (LT) were measured by an optical biometry in a cohort of university students. Corneal radius of curvature (CR), lens position (LP), lens power (PBennett ), vitreous chamber depth (VCD) and AL to corneal radius ratio (AL/CR) were calculated. Cycloplegic refraction was measured using an autorefractor. RESULTS: A total of 7650 undergraduate students participated in this study, with a mean age of 20.0 ± 1.4 years. The following ocular biometric parameters were measured: AL (24.78 ± 1.21 mm), CCT (539.83 ± 33.03 µm), AQD (3.23 ± 0.25 mm), LT (3.47 ± 0.18 mm), CR (7.79 ± 0.27 mm), LP (4.97 ± 0.23 mm), VCD (17.55 ± 1.15 mm), PBennett (25.00 ± 1.07 dioptres) and AL/CR (3.18 ± 0.15). Male subjects were found to have longer AL, thicker CCT, flatter CR, thinner lens, deeper AQD and VCD than female ones. Myopic subjects were found to have longer AL, thinner CCT, steeper CR, thinner and posterior lens, deeper AQD and VCD, lower PBennett and larger AL/CR than emmetropes and hyperopes. Spherical equivalent (SE) showed a negative correlation with AL/CR (r = -0.914), AL (r = -0.755) and VCD (r = -0.751). CONCLUSIONS: This study provided a range of reference values for the main ocular biometric parameters in young adults and reported their distributions based on gender and refractive status. Our study indicates that SE has a strong correlation with AL/CR ratio, AL and VCD.

Multidimensional B4N materials as novel anode materials for lithium ion batteries.

Based on first-principles calculations and ab initio molecular dynamics simulations, multidimensional B4N materials are investigated as anode materials for lithium ion batteries. The present results show that the monolayer B4N can reach a remarkably high specific capacity of 1874.27 mA h g-1 and possesses a low diffusion barrier (0.29 eV). Testing of bilayer B4N and bulk B4N reveals that the materials exhibit irreversible structural phase transformation. They are transformed from a layered structure to the more stable cavity-channel structure due to the adsorption of Li atoms. The volume expansions of their saturated lithiation cavity-channel structures are about 12%, which is close to that of graphite (10%). Moreover, it is found that the energy barriers of the bilayer and bulk B4N are less than 0.5 eV in the cavity-channel. The saturated adsorption of bulk B4N yields a specific capacity of 468.57 mA h g-1, which is higher than that of commercial graphite (372 mA h g-1). More importantly, all the lithiation structures in the monolayer, bilayer, and bulk B4N are verified to be thermodynamically stable at 350 K. These findings may encourage further experimental investigation in the design of multidimensional B4N materials as novel candidate anode materials for lithium ion batteries.

Gallium Oxide Nanowire with Twinning Structure and Its Photoluminescence Property.

In this paper, ß-Ga2O3 nanowires were synthesized by vapor transport method at different temperatures. The as-prepared samples were analyzed for crystal structure by X-ray diffraction (XRD), transmission electron microscopy (TEM) and selected area electron diffraction (SAED), and for morphology using scanning electron microscopy (SEM). The results show that the Ga2O3 nanowires present a monoclinic structure, the length and diameter of the Ga2O3 nanowires increased with the growth temperature. A majority of the Ga2O3 nanowires present longitudinal twinning structures. A broad photoluminescence emission band was observed from the Ga2O3 nanowires at room temperature, which is caused by different kinds of vacancy defects. Our study shows an unusual twinning structure of ß-Ga2O3 nanowires, which may be helpful to understand the growth mechanism of nanowires.

Visual Impairment and Spectacle Use in University Students in Central China: The Anyang University Students Eye Study.

PURPOSE: To investigate the prevalence and associations of visual impairment and spectacle use in university students in central China. DESIGN: Cross-sectional study. METHODS: This study included students aged 16-26 years in China. Study subjects from 2 universities underwent distance visual acuity (VA) assessment in both eyes with a logarithm of the minimum angle of resolution chart and their refractions were measured by cycloplegic autorefraction. Blindness was defined as presenting VA less than three-sixtieth in the better eye (World Health Organization definition), and visual impairment was defined as presenting VA less than six-twelfths. RESULTS: Overall, 9710 undergraduates were enumerated, 7704 (79.3%) subjects were included in this study. The prevalence of uncorrected VA less than six-twelfths and less than three-sixtieth in the better eye were 69.9% and 0.9%, respectively. Only 77.0% (4148/5388) of subjects with uncorrected VA in the better eye of less than six-twelfths wore glasses. For presenting VA, the prevalence of mild (VA <6/12 to 6/18), moderate (VA <6/18 to 6/60), and severe (VA <6/60 to 3/60) visual impairment was 6.3%, 11.2%, and 0.7%, respectively. Overall, 71.7% (4300/6001) of students with myopia (spherical equivalent ≤-0.5 diopters) wore spectacles. In multiple logistic regression analysis, visual impairment was associated with female sex (P < .001) and lower year level of education (P = .006) when presenting with VA. CONCLUSIONS: This study has documented a relatively high prevalence of visual impairment and relatively low spectacle coverage in Chinese university students. Given the potential impact of visual impairment, target education and accessible refraction services are highly important to solve the problem.