ABSTRACT
Choline diet promotes improvement of the brain cognitive functions in rats with moderate-to-severe traumatic brain injury. In previous studies, the rats received choline being standard (0.2%) or choline-supplemented (2%) diet for 2 weeks prior to and 2 weeks after experimental brain injury. To the end of the experiments (in 4 weeks), the post-traumatic disturbances in the cognitive functions were observed in both groups, although they were less pronounced than in the rats kept on the choline-supplemented diet. Based on original mathematical model, this paper proposes a method to calculate the most efficient use of choline to correct the brain cognitive functions. In addition to evaluating the cognitive functions, the study assessed expression of α7 nicotinic acetylcholine receptors, the amount of consumed food and water, and the dynamics of body weight.
Subject(s)
Brain Injuries/drug therapy , Choline/therapeutic use , Cognition/drug effects , Neuroprotective Agents/therapeutic use , alpha7 Nicotinic Acetylcholine Receptor/drug effects , Administration, Oral , Animals , Body Weight/drug effects , Brain/drug effects , Brain/metabolism , Brain Injuries/metabolism , Choline/metabolism , Diet , Dietary Supplements , Neuroprotective Agents/metabolism , Rats , alpha7 Nicotinic Acetylcholine Receptor/agonists , alpha7 Nicotinic Acetylcholine Receptor/metabolismABSTRACT
A mathematical model was developed based on the analysis of body response to variations in choline content in the ration of growing rats. The peculiarities of choline metabolism and the expression of α7-nicotinic receptors in the brain were studied. The information obtained can be useful for comparative analysis of choline administration for correction of certain cerebral pathologies.