ABSTRACT
La enfermedad pulmonar avanzada (EPAV) es la principal causa de morbimortalidad en pacientes con Fibrosis Quística (FQ). Objetivo: describir características clínicas de pacientes con FQ con EPAV y mortalidad en el seguimiento. Método: Estudio descriptivo, retrospectivo de pacientes con FQ y EPAV: VEF1 4 años de vida. Un 75% era portador de infección crónica por Pseudomonas. Un 68% era dependiente de oxígeno y un 18% de ventilación mecánica no invasiva. El 70 % tuvo 2 o más hospitalizaciones el último año de seguimiento. De 27 pacientes derivados a trasplante, 7 se trasplantaron, 3 fallecieron en lista para trasplante, 9 presentaron alguna contraindicación: 4 de ellos por desnutrición y 5 por mala adherencia y escasa red de apoyo. En el seguimiento un 32% (n = 14) falleció, 93% de causa respiratoria. Conclusión: Un 39% de los pacientes tenían EPAV cuyo diagnóstico de FQ en promedio fue a los 11,2 años (SD ± 13 a). Las barreras de ingreso a lista para trasplante fueron: desnutrición, mala adherencia y falta de red de apoyo. Esta es una población con una elevada mortalidad.
Advanced cystic fibrosis lung disease (ACFLD) is the leading cause of morbidity and mortality in patients with Cystic Fibrosis (CF). Objective: to describe clinical characteristics of patients with CF with ACFLD and mortality during follow-up. Method: Descriptive, retrospective study of patients with CF and ACFLD: FEVi < 40%, oxygen dependent, and/or referred to a lung transplantprogram. Clinical, microbiological, functional, genetic and mortality characteristics were collected. Results: Of 111 controlled patients, 39% met criteria for ACFLD. 52% were men and the mean age was 29,8 years- old. The average BMI was 19.9 kg/m2, 72% had pancreatic insufficiency and 87% had a genetic study, being the DF508 mutation the most frequent (67%). The average age of diagnosis was 11.2 years (SD ± 13 years), being in 54,5% over the age of 4 years. 75% had chronic Pseudomonas infection. 68% were oxygen dependent and 18% on noninvasive mechanical ventilation. In the last year of follow-up 70% had 2 or more hospitalizations. Of 27 patients who have been referred for transplantation, 7 underwent lung transplantation, 3 died waiting on the transplant list, 9 had contraindications: 4 due to malnutrition and 5 to poor adherence and poor support network. 32% (n = 14) of the ACFLD patients died, 93% due to respiratory causes. Conclusion: 39% of the patients had ACFLD. The average age for CF diagnosis was 11.2 years (SD ± 13 years) Barriers to entering the transplant list are: malnutrition, poor adherence, and lack of a support network. This is a population with a high mortality.
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Young Adult , Cystic Fibrosis/physiopathology , Cystic Fibrosis/mortality , Comorbidity , Survival Analysis , Retrospective Studies , Analysis of Variance , Follow-Up Studies , Lung Transplantation , Cystic Fibrosis/surgery , Cystic Fibrosis/diagnosis , Cystic Fibrosis/microbiology , MalnutritionABSTRACT
Modified titanium dioxide (m-TiO2NPs) is a novel photocatalytic nanomaterial. Its level of toxicity was evaluated to be used in photodynamic treatment for cervical cancer. In the toxicity studies (Irwin test, acute and repeated doses (10 days)), female albino Swiss Webster (CFW) mice, 28 days old were used; the m-TiO2NPs was administered in single 300, 600 and 5,000 mg/kg of body weight (b.w) doses injected in the peritoneal zone. No adverse events or mortality were produced. Daily intraperitoneal doses of 300 and 600 mg/kg b.w every 24 h for 10 days did not produce adverse effects or mortality. There were no abnormal clinical signs or behavioral changes (neurological or physiological) in any of the mice. All organs exhibited normal architecture, and histological studies determined that m-TiO2NPs does not produce changes in the cells or tissues. Based on the test results, it is concluded that the m-TiO2NPs has not a toxic effect in doses equal to or less than 5,000 mg/kg b.w.
ABSTRACT
Caso clínico en el que se presenta un paciente con una quemadura solar en una pierna. El paciente presenta psoriasis en placas y está recibiendo tratamiento con corticoide tópico combinado con análogo de la vit D
In this case, a situation arises in which, in the presence of a skin pathology such as psoriasis, it may appear another health problem associated to the use of medication for the psoriasis treatment without the necessary care to minimise the sun effects
Subject(s)
Humans , Male , Middle Aged , Psoriasis/complications , Sunburn/complications , Sunburn/diagnosis , Psoriasis/chemically induced , Betamethasone/adverse effects , Sunscreening Agents , Psoriasis/diagnosis , Vitamin D/analogs & derivativesABSTRACT
No disponible
Subject(s)
Humans , Female , Child , Taeniasis/diagnosis , Taeniasis/drug therapy , Taenia saginata , Taenia saginata/parasitology , Paromomycin/therapeutic use , Praziquantel/therapeutic use , Niclosamide/therapeutic use , Taeniasis/parasitology , Feces/cytology , Feces/parasitology , Cestoda , Cestoda/isolation & purification , Cestode Infections/drug therapy , Cestode Infections/parasitologySubject(s)
Taeniasis/diagnosis , Child , Female , Humans , Spain , Taeniasis/drug therapy , Taeniasis/parasitologyABSTRACT
Objetivos: En este trabajo se realiza una revisión de la evidencia científica sobre las pautas de cuidado de la herida umbilical del recién nacido recomendadas en la actualidad con el objetivo de determinar cuál es el mejor cuidado posible. Metodología: En mayo de 2015 se realizó una revisión, siguiendo los criterios PRISMA, de la literatura científica que se completó con una revisión manual. La herramienta utilizada para la evaluación de los trabajos seleccionados fueron las «Fichas de Lectura Crítica» de OSTEBA del Servicio de Evaluación de Tecnologías Sanitarias del Gobierno Vasco. Resultados: Incluimos en la revisión 9 artículos, de los cuales 5 son revisiones previas y 4 ensayos clínicos aleatorizados y controlados. La mayoría de los trabajos comparan la utilización de un antiséptico para la cura del ombligo (generalmente clorhexidina) frente al cuidado seco de la herida. Conclusiones: De acuerdo a la evidencia científica resumida en esta revisión sobre las recomendaciones para la cura del ombligo del recién nacido el método a recomendar será diferente según el país en el que nos encontremos ya sea desarrollado o en vías de desarrollo
Objectives: This paper presents a review of the scientific evidence about the recommended care for newborn umbilical wound in order to establish the best care possible. Methodology: The search was conducted in May 2015, following the PRISMA criteria of scientific literature searches and completed with a manual review. We used the tool «Critical Reading Sheets» of OSTEBA Service for Health Technology Assessment of the Basque Government for the scientific evaluation of the selected works. Results: We included 9 articles in this s review: 5 of them were previous revisions and 4 randomized controlled clinical trials. Most of them compared the use of an antiseptic (mainly clorhexidine) versus dry care. Conclusions: Accordingly to the scientific evidence summarized In this manuscript about the care of newborns umbilical cord, the method to recommend will differ depending on whether we are in a developed country or in a developing one
Subject(s)
Humans , Male , Female , Infant, Newborn , Umbilical Cord/physiology , Evidence-Based Medicine/methods , Evidence-Based Practice/methods , Evidence-Based Practice/trends , Antisepsis/instrumentation , Antisepsis/methods , Antisepsis/standards , Chlorhexidine/therapeutic use , Anti-Infective Agents, Local/metabolism , Anti-Infective Agents, Local/therapeutic useABSTRACT
Objetivos: Comprobar si la tasa de partos instrumentales varía al cambiar el número de varones entre los médicos residentes de tercer y cuarto año. Material y métodos: Se recogió la proporción de partos instrumentales sobre 54.961 partos atendidos en un mismo hospital desde 1990 hasta 2006. Las tasas anuales se agruparon de acuerdo con el sexo de los médicos residentes de tercer y cuarto año. Para la comparación de las tasas se recurrió al cálculo del intervalo de confianza (IC) del 95% de la diferencia de porcentajes y a la prueba de la χ2. Resultados: Al aumentar la proporción de varones se incrementa también la tasa de partos instrumentales. Las diferencias son significativas para los años en los que el número de residentes varones es de tres o más. Conclusiones: Parece que el sexo de los residentes de tercer y cuarto año se relaciona con el porcentaje de partos instrumentales (AU)
Objective: To determine whether the instrumental delivery rate changes according to the number of men among third- and fourth-year resident physicians. Materials and methods: The proportion of instrumental deliveries was determined among 54,961 births in a single hospital from 1990 to 2006. Annual rates were calculated based on the gender of third- and fourth-year resident physicians. For each annual rate, a 95% confidence interval was calculated and the χ2 test was performed to verify the significance of differences. Results: When the number of male physicians increased so did the rate of instrumental deliveries. Differences were significant for years in which the number of male physicians was equal to three or more. Conclusions: The instrumental delivery rate seems to be related to the gender of third-and fourth-year resident physicians (AU)
Subject(s)
Humans , Female , Pregnancy , Delivery, Obstetric/statistics & numerical data , Medical Staff, Hospital/statistics & numerical data , Obstetric Labor Complications/epidemiology , Labor, Induced/statistics & numerical data , Obstetrical Forceps , Internship and Residency/statistics & numerical data , Sex Distribution , Multivariate Analysis , Cesarean Section/statistics & numerical data , Surgical InstrumentsABSTRACT
El Hamartoma folicular basaloide es un tumor anexial benigno de clínica variable. Se han descrito formas solitarias y generalizadas. Presentamos un nuevo caso de hamartoma folicular basaloide lineal unilateral, congénito, en una mujer de 28 años con una lesión localizada en palma de la mano (AU)
