Subject(s)
Sarcoidosis/diagnosis , Splenic Diseases/diagnosis , Splenomegaly/pathology , Female , Humans , Middle AgedABSTRACT
Waldenström's macroglobulinemia is a rare disease with an indolent clinical course. The median age of the affected patient is 65 years. Nevertheless, we report a case of Waldenström's macroglobulinemia revealed by a splenomegaly and severe pancytopenia, in a 51-year-old man without previous medical history. According to the recent consensus recommendations for the clinicopathological definition of Waldenström's macroglobulinemia, diagnosis was made through morphological and immunophenotypic data of medullary cells. The reduced survival of the patient is associated with the importance of the cytopenia.
Subject(s)
Waldenstrom Macroglobulinemia/diagnosis , Chromosome Mapping , Chromosomes, Human, Pair 14 , Chromosomes, Human, Pair 9 , Diagnosis, Differential , Humans , Male , Middle Aged , Pancytopenia/etiology , Splenomegaly/etiology , Translocation, Genetic , Waldenstrom Macroglobulinemia/blood , Waldenstrom Macroglobulinemia/genetics , Waldenstrom Macroglobulinemia/pathologyABSTRACT
INTRODUCTION: Cancer of the prostate in HIV-infected patients has rarely been reported in the literature. OBSERVATION: A 40 year-old man presented with an adenocarcinoma of the prostate and bone and glandular metastases. The patient exhibited HIV seropositivity stage B1, the immune-virology of which was well controlled by antiretroviral tritherapy. COMMENTS: The relationship between cancer and HIV has been established for certain cancers such as Hodgkin's disease, non-Hodgkin malignant lymphoma, Kaposi's sarcoma and invasive cancers of the uterine neck in women. The significant increase in some cancers in patients infected by HIV (lung, penis, soft tissue, lips, seminoma) suggests the potential association with immunodepression unless it corresponds to a risk induced by antiretroviral treatments in the long term.
Subject(s)
Adenocarcinoma/complications , HIV Infections/complications , Prostatic Neoplasms/complications , Adenocarcinoma/pathology , Adult , Humans , Male , Neoplasm Metastasis , Prostatic Neoplasms/etiology , Prostatic Neoplasms/pathologyABSTRACT
INTRODUCTION: Cancer of the prostate in HIV-infected patients has rarely been reported in the literature. OBSERVATION: A 40-year-old man presented with an adenocarcinoma of the prostate and bone and glandular metastases. The patient exhibited HIV seropositivity stage B1, the immune-virology of which was well controlled by antiretroviral tritherapy. COMMENTS: The relationship between cancer and HIV has been established for certain cancers such as Hodgkin's disease, non-Hodgkin malignant lymphoma, Kaposi's sarcoma and invasive cancers of the uterine neck in women. The significant increase in some cancers in patients infected by HIV (lung, penis, soft tissue, lips, seminoma) suggests the potential association with immunodepression unless it corresponds to a risk induced by antiretroviral treatments in the long term.
Subject(s)
Adenocarcinoma/secondary , Bone Neoplasms/secondary , HIV Infections/complications , Neoplasms, Glandular and Epithelial/secondary , Prostatic Neoplasms/pathology , Adenocarcinoma/virology , Adult , Antiviral Agents/therapeutic use , Bone Neoplasms/virology , HIV Infections/drug therapy , Humans , Male , Prostatic Neoplasms/virology , Risk FactorsSubject(s)
Lymphoma, B-Cell, Marginal Zone/pathology , Prostatic Neoplasms/pathology , Aged , Aged, 80 and over , Biomarkers, Tumor/analysis , Clone Cells , DNA, Neoplasm/analysis , Diagnosis, Differential , Gene Rearrangement, B-Lymphocyte, Heavy Chain/genetics , Humans , Keratins/analysis , Ki-67 Antigen/analysis , Lymphoma, B-Cell, Marginal Zone/chemistry , Lymphoma, B-Cell, Marginal Zone/surgery , Male , Polymerase Chain Reaction , Prostatic Neoplasms/chemistry , Prostatic Neoplasms/surgery , Prostatitis/pathologySubject(s)
Breast Neoplasms/diagnosis , Carcinoma, Small Cell/diagnosis , Neuroendocrine Tumors/diagnosis , Aged , Breast Neoplasms/pathology , Breast Neoplasms/surgery , Carcinoma, Small Cell/pathology , Carcinoma, Small Cell/surgery , Female , Humans , Immunohistochemistry , Mitotic Index , Neuroendocrine Tumors/pathology , Neuroendocrine Tumors/surgeryABSTRACT
Sarcomas of the breast are relatively rare and account for 1% of all primary malignant tumors of the breast. Only 4 cases of pure chondrosarcoma of the breast have been published. We report an additional case in a fifty-seven-year-old woman. Histological and immunohistological characteristics were similar to those described in other localizations. Differential diagnosis involves cystosarcoma phyllodes and breast metaplastic carcinoma with chondroid differentiation. The prognosis is likely to be the same as in other chondrosarcomas.
Subject(s)
Breast Neoplasms/pathology , Chondrosarcoma/pathology , Breast Neoplasms/chemistry , Chondrosarcoma/chemistry , Diagnosis, Differential , Female , Humans , Immunohistochemistry , Middle Aged , PrognosisABSTRACT
Clear cell sarcoma (malignant melanoma of soft parts) is a rare malignancy that is found in the young adult, and is generally located in the extremities of the limbs. In this study, a new case has been reported in a 24-year old male with no previous history of cutaneous melanoma. The tumor consisted of fusiform or round cells with clear or granulocytic cytoplasm and vesicular nuclei. The patient was treated by surgical resection of the tumor and postoperative radiotherapy. Eight years later, metastatic nodes were detected in the inguinal region. The histogenesis of this tumor has not yet been determined, and it poses a diagnostic problem for pathologists as it can be mistaken for a malignant metastatic cutaneous melanoma.
Subject(s)
Leg , Sarcoma, Clear Cell , Soft Tissue Neoplasms , Adult , Combined Modality Therapy , Follow-Up Studies , Humans , Lymphatic Metastasis , Male , Radiotherapy Dosage , Sarcoma, Clear Cell/pathology , Sarcoma, Clear Cell/radiotherapy , Sarcoma, Clear Cell/surgery , Soft Tissue Neoplasms/pathology , Soft Tissue Neoplasms/radiotherapy , Soft Tissue Neoplasms/surgery , Time FactorsABSTRACT
Primary hypertrophic antro-pyloric stenosis in adults is a misleading anatomic and radioclinical entity. It consists of hypertrophy of the internal muscular layer. Distal gastrectomy is the only effective treatment of the symptomatic form and allows a pathologic study of the gastrectomy, thus ruling out most causes of obstruction, including neoplastic ones. Its congenital origin has not been established. We report the case of a 59 year-old man who had primary hypertrophic pyloric stenosis.
Subject(s)
Gastric Outlet Obstruction/pathology , Pyloric Stenosis/pathology , Adult , Gastrectomy , Gastric Outlet Obstruction/surgery , Humans , Hypertrophy , Male , Middle Aged , Muscle, Smooth/pathology , Pyloric Stenosis/surgery , Pylorus/pathology , Stomach/pathologyABSTRACT
The pancreas is an uncommon site of metastasis for renal cell carcinoma. We report 2 cases of patients who underwent total and subtotal pancreatectomy 13 and 10 years after resection of the primary tumor. One of the patients already had liver and cerebellum metastasis, the second one had a solitary metastasis to the pancreas. In both cases, tumoral proliferation invaded the lumen of the Wirsung, and in one case was prominent through the papillae.