Subject(s)
Anemia, Iron-Deficiency/drug therapy , Drug Hypersensitivity/etiology , Iron/adverse effects , Irritable Bowel Syndrome/drug therapy , Administration, Intravenous , Anemia, Iron-Deficiency/etiology , Europe , Federal Government , Humans , Iron/administration & dosage , Irritable Bowel Syndrome/complicationsABSTRACT
The human pharmacokinetics of 5-aminosalicylic acid (5-ASA), the active moiety of salazosulphapyridine (SASP), is only known from studies in which rapid absorption has been deliberately avoided. The present investigation demonstrates that pure 5-ASA is absorbed extremely quickly when given as an instillation in the proximal part of the small bowel, and acetylation follows immediately. The metabolite is excreted very rapidly by the liver in small amounts, while the major part is eliminated renally.
Subject(s)
Aminosalicylic Acids/metabolism , Acetylation , Adult , Aminosalicylic Acids/administration & dosage , Female , Humans , Intestinal Absorption , Jejunum/metabolism , Kinetics , Male , MesalamineABSTRACT
When jejunal juice is obtained by means of open pernasal tubes, the risk of the aspirates being contaminated is presumably high. The present study compares jejunal aspirates obtained from an open and from a closed tube system. Ten patients suspected of having abnormal jejunal flora and five healthy human volunteers were investigated. The pH values of aspirates obtained from the open tubes were significantly lower than the values registered in aspirates from the closed tube system, with a median difference of 0.70 (p less than 0.02). No differences between the two types of aspirate were registered with regard to total number of bacteria, number of bacterial species, lipase, total protein, total amylase or its fractions of pancreatic and salivary isoamylases. For the investigation of pH-sensitive substances in jejunal juice, a closed tube system is therefore recommended, whereas the use of such a device does not seem necessary for the study of bacterial microflora and pancreatic enzymes.
Subject(s)
Intestinal Secretions , Intubation, Gastrointestinal/methods , Jejunum , Specimen Handling/methods , Adult , Aged , Amylases/metabolism , Biopsy, Needle/methods , Female , Humans , Hydrogen-Ion Concentration , Intestinal Secretions/metabolism , Intestinal Secretions/microbiology , Isoamylase/metabolism , Jejunum/metabolism , Jejunum/microbiology , Male , Middle Aged , Proteins/metabolismABSTRACT
A tube system for the collection of uncontaminated small-bowel juice is described. It consists of an outer guide tube, its distal end being closed by a membrane, and an inner aspiration tube. When the outer tube is placed at the desired site of aspiration, the membrane is perforated by advancing the sterile inner tube. The device was tested in 90 healthy human volunteers. The procedure was completely or partly unsuccessful in 9 cases (95% confidence limits, 4.7-18.0). Median intubation time was 12 min; range, 5-14 min. The time used for aspiration of 5 ml of intestinal juice varied from 1 to 30 min; median, 10 min. The site of aspiration in jejunum distal to the ligament of Treitz varied from 0 to 14 cm; median, 3 cm. No complications of the procedure were registered.
