ABSTRACT
UNLABELLED: Obesity leads to a deterioration of glucose tolerance and the action of insulin. The purpose of this study was to determine insulin resistance (IR) by indirect methods, and its correlation with clinical, anthropometric and biochemical variables in obese normoglycemic school children. This was a descriptive-correlational study of 72 school prepubescent children, who attended the ambulatory "El Concejo" of the University of Carabobo (UC) and at the Gastroenterology and Pediatric Nutrition service of the city hospital "Enrique Tejera" (CHET), in Valencia, Venezuela, between January-April 2011. INCLUSION CRITERIA: exogenous obesity. We assessed personal and family history, presence of Acanthosis Nigricans and nutritional and biochemical status. We found a higher percentage of IR, through the use of the QUICKI method (66.7%), followed by the HOMA (55.6%) and basal insulin (45.9%). The mean (chi) indexes of body mass and waist circumference were significantly greater (p < 0.05) in patients with IR, by HOMA and QUICKI techniques. The QUICKI method detected significant differences (p < 0.05) in the values of glycemia, basal insulin and postprandial insulin, among patients with diminished and normal insulin sensitivities. While HOMA, detected these differences (p < 0.05) in the values of glycemia and basal insulin. A statistically significant relationship was observed (p < 0.05), between the presence of Acanthosis Nigricans and IR, by the HOMA, QUICKI and basal insulin methods. In conclusion, the evaluated techniques, QUICKI, HOMA and basal insulin indexes, were most effective for detecting the IR.
Subject(s)
Insulin Resistance , Obesity/blood , Acanthosis Nigricans/blood , Acanthosis Nigricans/epidemiology , Blood Glucose/analysis , Body Composition , Body Mass Index , Checklist , Child , Diabetes Mellitus, Type 2/genetics , Fasting/blood , Female , Homeostasis , Humans , Insulin/blood , Insulin/metabolism , Insulin Secretion , Lipids/blood , Male , Models, Biological , Nutritional Status , Postprandial Period , Thigh/anatomy & histology , Venezuela/epidemiology , Waist CircumferenceABSTRACT
El incremento de la adiposidad, conduce a un deterioro de la tolerancia a la glucosa y de la acción de la insulina. Se determinó la resistencia a la insulina (RI) por métodos indirectos y se correlacionó con variables clínicas, antropométricas y bioquímicas en escolares obesos normoglicémicos. Estudio descriptivo-correlacional, realizado en 72 escolares, que acudieron al ambulatorio El Concejo de la Universidad de Carabobo (UC) y al servicio de Gastroenterología y Nutrición Pediátrica de la Ciudad Hospitalaria Enrique Tejera (CHET), de Valencia, Venezuela, entre enero y abril de 2011. Criterio de Inclusión: obesidad exógena. Se evaluaron antecedentes personales y familiares, presencia de acantosis nigricans y valoración nutricional y bioquímica. Se encontró mayor porcentaje de RI, a través de la utilización del método QUICKI (66,7%), seguido del HOMA (55,6%) y la insulina basal (45,9%). Las medias de índice de masa corporal y circunferencia de cintura, fueron significativamente mayores (p<0,05), en pacientes con RI, estimadas por los métodos HOMA y QUICKI. El método QUICKI, detectó diferencias significativas (p<0,05), entre las glicemias e insulinas basales y entre las insulinas postprandiales, de los pacientes con sensibilidades insulínica disminuida y normal; mientras que el HOMA, detectó estas diferencias (p<0,05), en las glicemias e insulinas basales. Se observó una correlación estadísticamente significativa (p<0,05), entre la presencia de acantosis nigricans y la RI, estimada por los métodos HOMA, QUICKI e insulina basal. En conclusión, de los métodos evaluados, los índices QUICKI, HOMA y la insulina basal, fueron los más eficaces para detectar la RI.
Obesity leads to a deterioration of glucose tolerance and the action of insulin. The purpose of this study was to determine insulin resistance (IR) by indirect methods, and its correlation with clinical, anthropometric and biochemical variables in obese normoglycemic school children. This was a descriptive-correlational study of 72 school prepubescent children, who attended the ambulatory El Concejo of the University of Carabobo (UC) and at the Gastroenterology and Pediatric Nutrition service of the city hospital Enrique Tejera (CHET), in Valencia, Venezuela, between January-April 2011. Inclusion criteria: exogenous obesity. We assessed personal and family history, presence of Acanthosis Nigricans and nutritional and biochemical status. We found a higher percentage of IR, through the use of the QUICKI method (66.7%), followed by the HOMA (55.6%) and basal insulin (45.9%). The mean (c) indexes of body mass and waist circumference were significantly greater (p < 0.05) in patients with IR, by HOMA and QUICKI techniques. The QUICKI method detected significant differences (p < 0.05) in the values of glycemia, basal insulin and postprandial insulin, among patients with diminished and normal insulin sensitivities. While HOMA, detected these differences (p < 0.05) in the values of glycemia and basal insulin. A statistically significant relationship was observed (p < 0.05), between the presence of Acanthosis Nigricans and IR, by the HOMA, QUICKI and basal insulin methods. In conclusion, the evaluated techniques, QUICKI, HOMA and basal insulin indexes, were most effective for detecting the IR.