Mitral valve dysplasia in eight English Springer Spaniels.

INTRODUCTION: To describe the signalment, physical examination, and echocardiographic findings of a series of English Springer Spaniels (ESSs) diagnosed with congenital mitral valve dysplasia (MD). ANIMALS: Eight client-owned ESSs with congenital MD referred for murmur investigation and/or suspected congestive heart failure (CHF). MATERIALS AND METHODS: Retrospective case series. Medical records and echocardiograms were reviewed to collect relevant data. Echocardiograms were assessed for the following abnormalities consistent with MD: thickened valve leaflets or leaflet tips, a 'hockey stick' appearance to the valve leaflets, abnormal length of one leaflet with respect to the other, and tethering of one or both leaflets to the papillary muscles. RESULTS: All eight dogs showed the typical echocardiographic lesions associated with MD: thickened leaflet tips (5/8), 'hockey stick' appearance (5/8), elongated anterior leaflet (4/8), tethering of one or both leaflets (7/8). Seven of the eight dogs presented in CHF. Six of the eight dogs had left ventricular dilation in both systole and diastole. Two of the eight dogs had reduced systolic function as assessed by ejection fraction/fractional shortening; however end-systolic volume index was increased in 6/8 dogs. Two dogs subsequently developed atrial fibrillation. CONCLUSIONS: Congenital MD should be considered in ESSs with a left-sided apical systolic murmur, particularly in younger dogs. The valve changes seen are similar to those reported in other breeds with MD (thickened leaflet tips, hockey stick appearance to open leaflet tips, abnormal leaflet tethering, abnormally shaped leaflets) and may result in marked remodeling and CHF.

White blood cell differentials in dogs with congestive heart failure (CHF) in comparison to those in dogs without cardiac disease.

OBJECTIVES: To determine if dogs with congestive heart failure have different white blood cell differential cell counts than dogs without cardiac disease. MATERIALS AND METHODS: In total, 72 dogs with congestive heart failure and 143 controls were included in this retrospective study. Signalment, white blood cell differential counts and echocardiography data were retrieved. Basic statistical analysis was performed on white blood cell differential counts, and principal component analysis was used to compare these counts between cases and controls, with age, gender and case/control status as supplementary variables. Cases and controls were compared with binary logistic regression for the principal components identified and individual white blood cell differential counts. Principal component analysis of cases alone was conducted with age, gender, weight and mitral E wave:isovolumic relaxation time as supplementary variables. Linear regression analysis was used to explore the association between mitral E wave:isovolumic relaxation time and the principal components, weight, gender, age and diagnosis (mitral valve disease or dilated cardiomyopathy). RESULTS: Among cases and controls, the largest variance in data (component 1) was associated with neutrophils, band neutrophils, monocytes and case status (P<0·01). The odds of an individual being a case increased 2·5-fold (95% confidence interval: 1·4 to 4·4) for each unit increase in component 1. Among the cases, mitral E wave:isovolumic relaxation time was associated with neutrophil count and case/control category. CLINICAL SIGNIFICANCE: Dogs with congestive heart failure had a statistically significant increase in neutrophils, band neutrophils and monocytes in comparison with those without cardiac disease but the cell counts remained within normal reference intervals.