1.
Chem Pharm Bull (Tokyo)
; 64(7): 800-4, 2016.
Article
in English
| MEDLINE
| ID: mdl-27373634
ABSTRACT
Conversion of readily available vindoline to 11-mesyloxytabersonine, a versatile synthetic intermediate for indole alkaloids, has been achieved by a 9-step sequence in 39% overall yield.
Subject(s)
Indole Alkaloids/chemical synthesis , Vinblastine/analogs & derivatives , Indole Alkaloids/chemistry , Molecular Conformation , Vinblastine/chemistry
2.
J Am Chem Soc
; 136(18): 6598-601, 2014 May 07.
Article
in English
| MEDLINE
| ID: mdl-24749477
ABSTRACT
The first asymmetric total synthesis of lepenine has been accomplished. The synthesis features a tethered intramolecular Diels-Alder reaction, an intramolecular Mannich reaction, and a Diels-Alder reaction between an ortho-quinone monoketal and ethylene, resulting in stereoselective construction of the unique hexacyclic system.
Subject(s)
Alkaloids/chemical synthesis , Alkaloids/chemistry , Stereoisomerism
3.
Angew Chem Int Ed Engl
; 50(21): 4884-7, 2011 May 16.
Article
in English
| MEDLINE
| ID: mdl-21500330
