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Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome.
de Smith, Adam J; Walsh, Kyle M; Morimoto, Libby M; Francis, Stephen S; Hansen, Helen M; Jeon, Soyoung; Gonseth, Semira; Chen, Minhui; Sun, Hanxiao; Luna-Fineman, Sandra; Antillón, Federico; Girón, Verónica; Kang, Alice Y; Smirnov, Ivan; Shao, Xiaorong; Whitehead, Todd P; Barcellos, Lisa F; Jolly, Kent W; Healy, Jasmine; Laverdière, Caroline; Sinnett, Daniel; Taub, Jeffrey W; Birch, Jillian M; Thompson, Pamela D; Pombo-de-Oliveira, Maria S; Spector, Logan G; DeWan, Andrew T; Mueller, Beth A; Chiang, Charleston; Metayer, Catherine; Ma, Xiaomei; Wiemels, Joseph L.
Leukemia ; 33(11): 2746-2751, 2019 11.
Article in English | MEDLINE | ID: mdl-31296947

Subject(s)
Down Syndrome/genetics , Polymorphism, Single Nucleotide , Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics , Adolescent , California/epidemiology , California/ethnology , Case-Control Studies , Child , Child, Preschool , Chromosomes, Human, Pair 21/genetics , Down Syndrome/complications , Down Syndrome/ethnology , Female , Genetic Predisposition to Disease , Genome-Wide Association Study , Guatemala/epidemiology , Guatemala/ethnology , Haplotypes , Hispanic or Latino , Humans , Infant , Infant, Newborn , Male , Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications , Precursor Cell Lymphoblastic Leukemia-Lymphoma/ethnology , Principal Component Analysis , Risk Factors , Transcriptional Regulator ERG/genetics
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