ABSTRACT
The first cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection were identified at the end of 2019 and, in the next few months, coronavirus disease (COVID-19) spread throughout the world. Initially, it was believed that this disease mainly affected elderly individuals with comorbidities, in whom respiratory failure often occurs. It was believed that children fell ill from the infection more often, although the course of infection in the vast majority of pediatric cases has been asymptomatic or mildly symptomatic. In April and May 2020, the first report of a rapidly progressing disease, similar to Kawasaki syndrome, was found in children who had been infected with SARS-CoV-2. Shortly thereafter, children with symptoms of pediatric inflammatory multisystem syndrome (PIMS-ST [temporally associated with SARS-CoV-2 infection]) began presenting to pediatric hospitals around the world. The syndrome has a mortality rate of up to 2%. Symptoms of PIMS-TS include those that may suggest the need for surgical treatment (severe abdominal pain with the presence of peritoneal symptoms, ascites, high levels of inflammatory markers, intestinal inflammation, and appendages revealed on ultrasound examination). However, there are few reports addressing surgical cases associated with this condition. The authors present a case involving an 11-year-old boy who was admitted to hospital with severe abdominal pain and underwent surgery for symptoms of peritonitis and was diagnosed with PIMS in the post-operative period. Due to the large number of illnesses caused by SARS-CoV-2 infection in recent months, the diagnosis of PIMS-TS/MISC should be considered in the differential diagnosis of acute abdominal symptoms, especially in atypical courses and interviews indicating exposure to SARS-CoV-2.
ABSTRACT
AIM: Assessment of the etiology of urinary tract infections and pathogen drug sensitivity in hospitalized children. MATERIALS AND METHODS: We analyzed 156 medical records of patients admitted to the Clinical Department of Pediatrics, Bielanski Hospital in Warsaw in 2012, with a suspected UTI. Positive urine culture results were found in 113 (72.4%) children (68; 60.2% of girls and 45; 39.8% of boys), aged from 2 months to 17.9 years (the average age was 2 years and 3 months). RESULTS: E. coli was the most frequent isolated pathogen - 92.0% of patients (104/113). The greatest sensitivity of pathogens showed to cephalosporins of the second and third generation (80.5-90.3%). The sensitivity to amoxicillin with clavulanic acid was 71.7% and 41.6% for ampicillin. The length of hospital stay and treatment ranged from 2 to 16 days (average 8.6 days). In 60.2% (68/113) of patients were treated with second cephalosporin, in 17.7% (20/113) with third generation cephalosporins. Only 11.5% of them (13/113) received amoxicillin with clavulanic acid. Before the treatment, 69.9% (79/113) of children had a fever from 38 up to 41,7ºC, and the fever persisted for the average of 2.5 days (1-8 days). We found significantly higher levels of CRP in children aged between 2-4 in comparison to other age groups (p= 0.0290). In 44.2% (50/113) of children the cystourethrography was performed and in 22% (11/50) cases we recognized a unilateral or bilateral vesicoureteral-ureter of a I to IV degree, on one or both sides. CONCLUSION: The most common etiological agent of UTIs in children remains E. coli. The sensitivity of urinary pathogens to the commonly used antibiotics is still high, however, finds a large percentage of strains resistant to ampicillin and to amoxicillin with clavulanic acid. The antibiotic recommended for empiric therapy of UTIs in children should be cephalosporins, if there is such a possibility, the treatment should be based on drug sensitivity tests of the organisms grown. Because of the relatively long hospitalization of children with UTIs and the possibility of hospital complications, sequential treatment should also be considered sequential.
Subject(s)
Anti-Bacterial Agents/administration & dosage , Cross Infection/drug therapy , Drug Resistance, Bacterial , Escherichia coli Infections/drug therapy , Urinary Tract Infections/drug therapy , Adolescent , Amoxicillin/administration & dosage , Cephalosporins/administration & dosage , Child , Child, Preschool , Clavulanic Acid/administration & dosage , Cross Infection/microbiology , Drug Therapy, Combination , Escherichia coli Infections/diagnosis , Female , Humans , Infant , Male , Microbial Sensitivity Tests , Poland , Treatment Outcome , Urinary Tract Infections/microbiologyABSTRACT
UNLABELLED: Poland is a destination country or temporary living place for many refugees from Chechnya. Refugees are provided with full, free of charge, health care including the vaccination programme according to the present National Vaccination Programme (NVP). AIM OF STUDY: To assess the implementation of vaccinations in Chechen refugees' children in Poland. MATERIALS: The group comprised 310 children from the Centre for Foreigners in Warsaw-Bielany. The mean age of the examined children was 7.5 years. The investigations were performed three times during the study--the first was conducted in a group of 220 children in June, the second one in 303 children in August and the third in 310 children in October 2008 (the differences in the numbers resulted from the changes in the size of the Chechen population living in the Centre). METHODS: The vaccination records were assessed paying special attention to the implementation of vaccinations. During the consecutive two examinations the implementation of vaccination recommendations was analyzed as well as the availability of this information in the records. At every visit the history was obtained on the reasons for not having the vaccination programme implemented. RESULTS: The information on vaccination programme implementation was available in 19, 30 and 45%, of analyzed records from the Centre at the first, second and third visit, respectively. The majority of the obtained data regarded the implementation of vaccinations in children in the first year of life (85%), while the least data was on vaccinations in children over 12 years of age (30%). Similar results were obtained when analyzing a group of 168 children at the all three visits (18, 32 and 48%, respectively). The reasons for non-implementation of vaccinations were as follows: (a) low parents' awareness of the necessity of vaccinations; (b) lack of self-discipline (every other child did not report for a scheduled appointment); (c) relocation of refugees to other Centres; (d) exceedingly frequent postponing of vaccinations (in every fourth child). Substantially better implementation of vaccinations was found in refugees' children born in Poland. CONCLUSIONS: On account of the differences in the Polish and Chechen vaccination programmes and the low awareness among the Chechen parents' regarding the need of vaccinations, implementation of health care programmes and monitoring of the sanitary-epidemiologic situation in the Centres for Foreigners is necessary in order to prevent local outbreaks of an epidemic.