Colorectal cancer in a region of western of Algeria: results of 581 cases in 5 years.

Aims: The objective of this work is to evaluate the epidemiological profile of colorectal cancers, histologically proven over a 5-year period (2012-2016) in the Tlemcen region. Methods: A retrospective study of 581 cases of colorectal cancer collected at the epidemiology department of the University Hospital Center (UHC) of Tlemcen between January 2012 and December 2016 was performed. Epidemiological data were processed using SPSS version 25 and Microsoft Excel 2010. Results: The epidemiological profile has shown that colorectal cancer in our region ranks 3rd in both sexes. There were 322 men (55.4%) affected compared to 259 women (44.6%) with a sex ratio of 1.2. A predominance of males is noted in 50-60 age group, while for the female sex, the dominance is between 60-70 years old. The mean age of CRC occurrence was 60±13 years, with an extremity ranging from16 to 90. A significantly higher rate was recorded for rectal cancer (43.7%) followed by sigmoid colon (5.7%). Variable rates were recorded during the 5 years with a peak in 2014 (27.9%). Conclusion: Regular analysis of these data, if supplemented with additional data on diagnostic modalities like circular RNA diagnostic, will contribute to the assessment of the impact over time of public policies on nationally organized CRC screening.

Erratum to: colorectal cancer in a region of western of Algeria: results of 581 cases in 5 years.

[This corrects the article DOI: 10.1111/agc.123.].

Retrospective epidemiological study on stomach cancer in a region of western Algeria: about 394 cases between 2011 and 2015.

PURPOSE: Stomach cancer is a major global health problem; it is one of the ten most common cancers with poor survival, and its incidence is characterized by wide variation. The aim of this work is to carry out a retrospective epidemiological study on gastric cancer in the wilaya of Tlemcen (West Algeria) over a period of 5 years (2011-2015). METHODS: The data set was provided by the cancer registry of the Tlemcen wilaya. The statistical analysis was performed using software SPSS.21. RESULTS: During this period, 394 cases of gastric cancers were collected, including 199 patients with gastric adenocarcinoma (50.50%); gastric cancer was ranked in 5th rank of the ten most answered cancers in the wilaya. The average age of the patients was 60.5 ±  14.208 years (60.618 ±  13.556 men, 56.654 ±  14.8761 women) with an extremity ranging from 18 to 91 years. A predominance of men has been observed with 60.4% against 39.6% of women, with a sex ratio of 1.5 and a significant difference between the two sexes (p = 0.08). Patients over 50 years of age represented the predominant age group (73.4%). The tumor topography was antropyloric in 6.09% of the cases, and the vast majority of the diagnosed cases was in the local stage (17.01%). CONCLUSION: Stomach cancer remains one of the top ten cancers in the Tlemcen willaya, so extensive research on the risk factors for gastric cancer remains important to plan effective preventive and curative strategies to reduce this burden.

Bacteriological water quality and biofilm formation in the treatment system of the hemodialysis unit in Tlemcen, Algeria.

OBJECTIVE: To evaluate and compare the microbiological quality of osmosis water at the distribution loop, at the dialysis generator inlet and to study the prevalence of biofilm in the tubing. METHODS: Microbiological analysis of 20 water loop samples, 10 water samples were taken at the machine entry and 10 pipe segments from tubing connecting the machines to the loop was done. RESULTS: The bacterial enumeration results of the loop water vary from 90 to 150 CFU/mL, while the average number of bacteria at the entry of the machines was 182 CFU/mL. The counts of the adhered bacteria in the tubing were worrying with rates ranging from 4.30 to 6.74 Log CFU/ cm2 . Fifty percentage of the strains isolated were Bacillus, followed by Enterobacter cloacae 23.52%, Staphylococcus, and others such as Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumanii. More than half of the tubing strains were highly formative of biofilm, 13 strains with medium capacity and 10 were weakly. CONCLUSION: This study indicates bacterial water contamination. The formation of a biofilm will certainly harm the effectiveness of the various disinfection methods in this unit. Water quality is influenced not only by the high rate of bacterial colonization, but also differences in standards for dialysis water.

[HPV DNA genotyping: A study of anogenital, head and neck and skin cancers in a population from west Algerian. HPV detection in different cancers from an Algerian population]. / Le génotypage d'ADN d'HPV : une étude de cancers ano-génitaux, de cancers des VADS et de cancers cutanés dans la population de l'ouest algérien. Détection d'HPV dans différents cancers dans la population de l'ouest algérien.

OBJECTIVES: To investigate the prevalence of human papillomaviruses (HPV) in cancers located at different sites in patients from west Algerian and collected between 2010 and 2014. MATERIAL AND METHODS: Extracted DNA from archival formaldehyde-fixed and paraffin-embedded tissues was provided from 39 anogenital cancers, 10 head and neck cancers and 36 skin cancers. The viral DNA was detected using the INNO-LiPA HPV Genotyping Extra(®) kit. RESULTS: The prevalence of HPV was 100% in cervical cancers, 40% in vaginal cancers, 17% in vulvar cancers, 33% in anal cancers, 0% in tonsil and larynx cancers and 6.4% in skin squamous cell carcinoma. In cervical cancers, the most prevalent genotypes were HPV16 (52%) and HPV18 (12%) as single infection. CONCLUSION: The overall results agree partially with literature. Extensive research is necessary to promote HPV vaccine to reduce in particular the burden of cervical cancer in Algeria.

Comparisons between geographically diverse samples of carried Staphylococcus aureus.

Approximately one-third of the human population is asymptomatically colonized by Staphylococcus aureus. However, much of the global diversity within the carriage populations remains uncharacterized, and it is unclear to what degree the variation is geographically partitioned. We isolated 300 carriage isolates from 1,531 adults contemporaneously in four countries: France, Algeria, Moldova, and Cambodia. All strains were characterized by multilocus sequence typing. Six clonal complexes (CCs) were present in all four samples (CC30, -45, -121, -15, -5, and -8). Analyses based on the genotype frequencies revealed the French and Algerian samples to be most similar and the Cambodian sample to be most distinct. While this pattern is consistent with likely rates of human migration and geographic distance, stochastic clonal expansion also contributes to regional differences. Phylogenetic analysis revealed a highly divergent and uncharacterized genotype (ST1223) within Cambodia. This lineage is related to CC75, which has previously been observed only in remote aboriginal populations in northern Australia.

Diversity of staphylococcal cassette chromosome mec structures in methicillin-resistant Staphylococcus epidermidis and Staphylococcus haemolyticus strains among outpatients from four countries.

In staphylococci, methicillin (meticillin) resistance (MR) is mediated by the acquisition of the mecA gene, which is carried on the size and composition variable staphylococcal cassette chromosome mec (SCCmec). MR has been extensively studied in Staphylococcus aureus, but little is known about MR coagulase-negative staphylococci (MR-CoNS). Here, we describe the diversity of SCCmec structures in MR-CoNS from outpatients living in countries with contrasting environments: Algeria, Mali, Moldova, and Cambodia. Their MR-CoNS nasal carriage rates were 29, 17, 11, and 31%, respectively. Ninety-six MR-CoNS strains, comprising 75 (78%) Staphylococcus epidermidis strains, 19 (20%) Staphylococcus haemolyticus strains, 1 (1%) Staphylococcus hominis strain, and 1 (1%) Staphylococcus cohnii strain, were analyzed. Eighteen different SCCmec types were observed, with 28 identified as type IV (29%), 25 as type V (26%), and 1 as type III (1%). Fifteen strains (44%) were untypeable for their SCCmec. Thirty-four percent of MR-CoNS strains contained multiple ccr copies. Type IV and V SCCmec were preferentially associated with S. epidermidis and S. haemolyticus, respectively. MR-CoNS constitute a widespread and highly diversified MR reservoir in the community.