ABSTRACT
Background: Deep inspiration breath-hold (DIBH) has been established to decrease normal tissue radiation dose in breast cancer. Methods: Forty-nine patients had two CT scans during DIBH or free breathing. Chest-wall position, setup verification and breath-hold monitoring were performed. Cone-beam CT and a surface image system were used for verification. Results: A total of 1617 breath-holds were analyzed in 401 fractions. The mean time bit was 6.01 min. The mean breaths-holds per fraction was 4.96. The median for intra-breath hold variability was 3 mm. No patient stopped treatment for intolerance. Clinical target volume margins were calculated as 0.36, 0.36 and 0.32 for the three translational positions. The mean saved volume was 26.3%. Conclusion: Voluntary DIBH is feasible, tolerable and easy to apply for children with Hodgkin lymphoma involving the mediastinum.
Deep inspiration breath-hold (DIBH) is a radiotherapy maneuver to decrease the exposure of normal tissues during the radiation of the target organ. It was developed for the treatment of breast cancer, both intact breast and chest wall, after mastectomy. For mediastinal Hodgkin lymphoma, especially in children and adolescents, DIBH will benefit in decreasing the radiation dose to the lungs and heart in this category of patients who still have normal growing tissues. We treated 49 pediatric and adolescent patients with DIBH and precise radiotherapy (volumetric modulated arc therapy) to augment the benefit of lowering the dose to normal tissues. All patients were trained and coached to breath-hold for more than 20 s. No patient stopped treatment due to poor tolerance or discomfort. Only one breath-hold was required for CT simulation in all populations (100%). The mean number of breath-holds per treatment fraction was 5.1 ± 1.8. The mean treatment time was 6 ± 1.8 min. DIBH is feasible, tolerable and easy to apply for children and adolescents with Hodgkin lymphoma involving the mediastinum. A considerable dose volume could be saved, hence decreasing the rate of side effects.
Subject(s)
Breath Holding , Hodgkin Disease , Inhalation , Mediastinal Neoplasms , Radiotherapy, Intensity-Modulated , Hodgkin Disease/diagnostic imaging , Hodgkin Disease/radiotherapy , Mediastinal Neoplasms/diagnostic imaging , Mediastinal Neoplasms/radiotherapy , Cone-Beam Computed Tomography , Humans , Male , Female , Child , AdolescentABSTRACT
The objective of this study was to evaluate the outcome of semi-open reduction and minimal internal fixation through a single small lateral approach as a minimally invasive technique for treatment of displaced intra-articular calcaneal fractures. This prospective study was conducted on eighteen patients (16 men and 2 women). The average age was 37.7 (22-55). The most common cause of injury was a fall from height in fourteen patients. Patients were operated on within a mean time of 4.8 days of admission (1-11 days) and were followed up for an average period of 24.1 months (6-39 months). Patients were evaluated clinically using the Creighton-Nebraska Heath Foundation Assessment score of Crosby and Fitzgibbons (J Bone Joint Surg (Am) 72-A:852-859, 1990). The scoring system proposed by Knirk and Jupiter was used for radiological assessment of the posterior subtalar joint (Knirk and Jupiter in J Bone Joint Surg (Am) 68-A: 647-659, 1986). The skin incision healed in all cases without necrosis, infection, or sural nerve injury. All fractures healed after an average of 8 weeks (7-10 weeks), and patients returned to the routine daily activities after an average time of 4.3 months (3-7 months). In conclusion, semi-open reduction and minimal internal fixation through a small lateral approach is an effective treatment for carefully selected cases of displaced intra-articular calcaneal fractures.
ABSTRACT
Twenty two patients with intra-articular fractures of the distal humerus were operatively treated using the extensor mechanism-sparing paratricipital approach as described by Schildhauer et al. All fractures were AO type C (six AO type C1, 11 C2 and five C3). There were 16 males and six females with a mean age of 32.5 years. Internal fixation was achieved with bilateral plates and screws. The results were evaluated after a mean follow-up period of 30 months using Mayo Elbow Score. The results were graded as excellent in 13 patients (59.2%), good in six (27.3%), fair in two patients (9%) and poor in one (4.5%). The average range of flexion was 120 degrees +/- 8 degrees (range: 100 to 140), extension 6 degrees (range: 0 to 15). Eighty-two percent of patients had normal muscle strength in comparison to the contralateral side and 18% had good muscle strength. The average time to union was 2.4 +/- 1.6 months (range: 2 to 4). No implant failure, neurovascular deficit or nonunion was noted. There was one deep infection. The extensor mechanism-sparing paratricipital approach is an invaluable approach for fixation of intercondylar fractures of the humerus without negative effects on triceps strength; however it is not recommended for multifragmentary type C3 fractures.
