Quantitative magneto-optical investigation of superconductor/ferromagnet hybrid structures.

We present a detailed quantitative magneto-optical imaging study of several superconductor/ferromagnet hybrid structures, including Nb deposited on top of thermomagnetically patterned NdFeB and permalloy/niobium with erasable and tailored magnetic landscapes imprinted in the permalloy layer. The magneto-optical imaging data are complemented with and compared to scanning Hall probe microscopy measurements. Comprehensive protocols have been developed for calibrating, testing, and converting Faraday rotation data to magnetic field maps. Applied to the acquired data, they reveal the comparatively weaker magnetic response of the superconductor from the background of larger fields and field gradients generated by the magnetic layer.

A scanning Hall probe microscope for high resolution, large area, variable height magnetic field imaging.

We present a scanning Hall probe microscope operating in ambient conditions. One of the unique features of this microscope is the use of the same stepper motors for both sample positioning as well as scanning, which makes it possible to have a large scan range (few mm) in the x and y directions, with a scan resolution of 0.1 µm. Protocols have been implemented to enable scanning at different heights from the sample surface. The z range is 35 mm. Microstructured Hall probes of size 1-5 µm have been developed. A minimum probe-sample distance <2 µm has been obtained by the combination of new Hall probes and probe-sample distance regulation using a tuning fork based force detection technique. The system is also capable of recording local B(z) profiles. We discuss the application of the microscope for the study of micro-magnet arrays being developed for applications in micro-systems.

Observation of the Meissner-Ochsenfeld effect and the absence of the Meissner state in UCoGe.

We present low field magnetization and susceptibility measurements made on a single crystal of the ferromagnetic superconductor UCoGe. The interplay between ferromagnetism and superconductivity comes into view in the study of hysteresis along the c axis (easy magnetization axis). The Meissner state (perfect diamagnetism) could not be observed in very low magnetic fields for all three crystallographic directions, implying that the sample is always in the mixed state. Notwithstanding, the Meissner-Ochsenfeld effect (reversible flux expulsion) occurs and is found to be anisotropic. For the c axis in low fields, it is proportional to the bulk magnetization M (and thus to the population of domains) and not to the applied magnetic field H. On a microscopic level, our interpretation of these results implies that flux is expelled independently from each domain proportional to its volume.

Observation of vortex coalescence in the anisotropic spin-triplet superconductor Sr2RuO4.

We present direct imaging of magnetic flux structures over the ab face of the anisotropic, spin-triplet superconductor Sr2RuO4 using a scanning microSQUID force microscope. Individual vortices with a single flux quantum were observed at low magnetic fields applied along the out-of-pane direction. At intermediate fields, the direct imaging revealed coalescing of vortices and the formation of flux domains. Our observations imply the existence of a mechanism in this material for bringing vortices together overcoming the conventional repulsive vortex-vortex interaction.

Persistent currents in mesoscopic connected rings.

We report measurements of the low temperature magnetic response of a line of 16 GaAs/GaAlAs connected mesoscopic rings whose total length is much larger than l(straight phi). Using an on-chip micro-SQUID technology, we have measured a periodic response, with period h/e, corresponding to persistent currents in the rings of a typical amplitude of 0.40+/-0.08 nA per ring. Direct comparison with measurements on the same rings but isolated is presented.

6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships.

Starting from the recently reported nonpeptidic angiotensin II (AII) receptor antagonists DuP753 (1) and Exp 7711 (2), we have designed and investigated novel substituted benzimidazoles. Systemic variation of several substituents at the benzimidazole ring positions 4-7 led to the finding that substitution in position 6 with acylamino groups results in highly active AII antagonists. Compounds with 6-membered lactam or sultam substituents in position 6 of benzimidazole showed receptor activities in the low nanomolar range but were only weakly active when given orally to rats. In contrast, analogous substitution of the benzimidazole moiety with basic heterocycles resulted in potent AII antagonists which were also well absorbed after oral application. The most active compound of this series, 33 (BIBR 277), was selected as a candidate for clinical development. On the basis of molecular modeling studies a binding model of this new class of AII antagonists to the AT1 receptor is proposed.

Prediction of the three-dimensional structure of the enzymatic domain of t-PA.

Tissue plasminogen activator (t-PA), an enzyme of the fibrinolytic system, is responsible for lysis of fibrin via activation of plasminogen, and therefore for degradation of blood clots. There are currently no X-ray crystal structure data of the t-PA molecule available either in whole or in part. We therefore predicted the three-dimensional structure of the protease domain by means of computer-graphical methods*. The model obtained forms a basis for understanding the binding of plasminogen to the active site of t-PA. In addition, the interactions of various inhibitors with t-PA were studied by modeling them into the active site. The model also yields an explanation for the observed amidolytic activity of t-PA in the single chain form.