Individual differences in emerging adults' spatial abilities: What role do affective factors play?

Spatial ability is defined as a cognitive or intellectual skill used to represent, transform, generate, and recall information of an object or the environment. Individual differences across spatial tasks have been strongly linked to science, technology, engineering, and mathematics (STEM) interest and success. Several variables have been proposed to explain individual differences in spatial ability, including affective factors such as one's confidence and anxiety. However, research is lacking on whether affective variables such as confidence and anxiety relate to individual differences in both a mental rotation task (MRT) and a perspective-taking and spatial orientation task (PTSOT). Using a sample of 100 college students completing introductory STEM courses, the present study investigated the effects of self-reported spatial confidence, spatial anxiety, and general anxiety on MRT and PTSOT. Spatial confidence, after controlling for effects of general anxiety and biological sex, was significantly related to performance on both the MRT and PTSOT. Spatial anxiety, after controlling for effects of general anxiety and biological sex, was not related to either PTSOT or MRT scores. Together these findings suggest some affective factors, but not others, contribute to spatial ability performance to a degree that merits advanced investigation in future studies.

Caregiver Distress and Child Behavior Problems in Children with Developmental Delay from Predominantly Minoritized Backgrounds.

IMPORTANCE: Child behavior problems have been shown to contribute to caregiver distress and vice versa among youth with developmental delay (DD). However, studies have not examined these associations among children and caregivers from underrepresented ethnic/racial backgrounds. Furthermore, research has not explored how associations function differently following internet-delivered treatment or based on the level of acculturation and enculturation. OBJECTIVE: We examined bidirectional associations between caregiver distress (i.e. symptoms of depression, anxiety, and stress) and externalizing and internalizing behavior problems in 3- to 5-year-old children with DD from underrepresented ethnic/racial backgrounds. We also examined the impact of internet-delivered Parent-Child Interaction Therapy (iPCIT) and the moderating role of acculturation and enculturation on these bidirectional associations. METHOD: Children aging out of early intervention services (n = 150) and their primary caregiver were randomized to receive iPCIT or referrals as usual (RAU) in the community. RESULTS: Findings provide support for bidirectional associations between child internalizing behavior problems and caregiver depressive symptoms, although there were fewer significant associations among families randomized to iPCIT compared to RAU. Weaker associations were observed among families with higher levels of enculturation, whereas stronger associations were observed among families with higher levels of acculturation. CONCLUSIONS: Results highlight a sensitive period from age 3.5 to 4 years old for bidirectional associations between caregiver distress and child behavior problems and highlight the importance of addressing family cultural values during treatment. Findings also suggest the utility of internet-delivered behavioral parenting interventions in weakening the effect of child behavior problems on caregiver distress and vice versa.

Direct and indirect effects of mother's spatial ability on child's spatial ability: What role does the home environment play?

Individual differences in spatial thinking are predictive of children's math and science achievement and later entry into Science, Technology, Engineering, and Mathematics (STEM) disciplines. Little is known about whether parent characteristics predict individual differences in children's spatial thinking. This study aims to understand whether, and to what extent, mother's intrinsic (i.e., mental rotation) and extrinsic (i.e., spatial scaling) spatial ability directly and indirectly, via the variation in home spatial environment, predicts children's intrinsic and extrinsic spatial ability. A total of 165 mothers and their 4-6-year-old children were recruited to participate in a remote video session with an experimenter. Mothers were administered a forced-choice Intrinsic Spatial Toy Preference Task gauging their preference for highly spatial versus less spatial toys and asked questions with the Home Intrinsic Spatial Environmental Questionnaire about the frequency with which they engage their child in spatial activities at home. Mothers completed a Mental Rotations Test and a Spatial Scaling Task adapted for adults. Children were administered the Picture Rotation Task, the Spatial Scaling Task, and the Peabody Picture Vocabulary Test. Structural equation modeling was used to examine direct and indirect, via home spatial environment and toy choices, influences of mother spatial ability on child spatial ability. Contrary to our predictions, we did not find direct, nor indirect, relations between mother and child spatial ability. These findings suggest that researchers should consider alternative conceptualizations of the early home spatial environment beyond the frequency of spatial play in the home. RESEARCH HIGHLIGHTS: The identification of factors that predict individual differences in children's spatial ability is important in order to maximize STEM learning outcomes. Data collection was conducted remotely rather than in traditional preschool or laboratory settings. Contrary to our pre-registered hypotheses, no significant relations between mother spatial ability, the early home spatial environment, and children's development of spatial skills were found. Future research should consider examining the amount of spatial language used in the home or the quality of parent-child interactions during spatial play as potential explanations for individual differences in children's spatial ability.

Individual-level probabilities and cluster-level proportions: Toward interpretable level 2 estimates in unconflated multilevel models for binary outcomes.

Multilevel models allow researchers to test hypotheses at multiple levels of analysis-for example, assessing the effects of both individual-level and school-level predictors on a target outcome. To assess these effects with the greatest clarity, researchers are well-advised to cluster mean center all Level 1 predictors and explicitly incorporate the cluster means into the model at Level 2. When an outcome of interest is continuous, this unconflated model specification serves both to increase model accuracy, by separating the level-specific effects of each predictor, and to increase model interpretability, by reframing the random intercepts as unadjusted cluster means. When an outcome of interest is binary or ordinal, however, only the first of these benefits is fully realized: In these models, the intuitive cluster mean interpretations of Level 2 effects are only available on the metric of the linear predictor (e.g., the logit) or, equivalently, the latent response propensity, yij∗. Because the calculations for obtaining predicted probabilities, odds, and ORs operate on the entire combined model equation, the interpretations of these quantities are inextricably tied to individual-level, rather than cluster-level, outcomes. This is unfortunate, given that the probability and odds metrics are often of greatest interest to researchers in practice. To address this issue, I propose a novel rescaling method designed to calculate cluster average success proportions, odds, and ORs in two-level binary and ordinal logistic and probit models. I apply the approach to a real data example and provide supplemental R functions to help users implement the method easily. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Speech-language pathologists' perceptions of childhood bilingualism.

The value of learning multiple languages has increased in the past 20 years. Despite this, some professionals continue to provide misinformation about bilingualism to many families around the United States, resulting in recommendations of implementing a monolingual approach for children. This study investigated the perceptions held by speech-language pathologists (SLPs) regarding childhood bilingualism. A total of 320 SLPs completed a survey stating their perceptions on childhood bilingualism for typically developing children and children with disabilities. Based on the number of responses, 292 participants were analysed quantitatively utilising a binary logistic regression to identify whether SLPs thought childhood bilingualism was advantageous or neutral, while incorporating the predictors of bilingual status and bilingualism education received. Additionally, a qualitative content analysis was conducted on 173 participants' responses to an open-ended question about their perceptions on childhood bilingualism. Results revealed that SLPs' bilingual status did not predict the probability of an advantageous perception for typically developing children, but it did for children with disabilities; however, SLPs who had received bilingualism education had a higher probability of having advantageous perceptions in both populations. Qualitative results revealed the use of appraisals related to multiple themes. This study served to understand the thoughts of SLPs in relation to the education they are providing to parents and the services they are providing to different populations - whether it be typically developing children or children with disabilities. There are implications for bilingual and cultural-linguistic education to be implemented across graduate programmes to ensure that optimal services are provided to the diverse groups in our case loads.

Beyond generalized anxiety: the association of anxiety sensitivity with disordered eating.

BACKGROUND: Anxiety and eating disorders (EDs) are rising at alarming rates. These mental health disorders are often comorbid, yet the factors associated with their comorbidity are not well understood. The present study examined a theoretical model of the pathways and relative associations of anxiety sensitivity (AS) with different dimensions of ED risk, controlling for generalized anxiety. METHODS: Participants (N = 795) were undergraduate students with an average age of 21 (SD = 4.02), predominantly female (71%), and Hispanic (71.8%). Participants completed an online survey with established measures of AS (i.e., Anxiety Sensitivity Index-3; ASI-3), general anxiety (i.e., Beck Anxiety Inventory; BAI), and eating behaviors (i.e., Eating Attitudes Test-26; EAT-26). RESULTS: The results of our structural equation models indicated that AS subscales were significantly associated with dimensions of the EAT-26, even when controlling for generalized anxiety. Specifically, the ASI-3 factors reflecting cognitive and social concerns provided the most consistent significant associations with EDs. Whereas reporting higher cognitive concerns was associated with higher ED symptoms (e.g., reporting the urge to vomit after a meal), reporting higher social concerns was associated with fewer ED symptoms. These differential results may suggest risk and resilience pathways and potential protective or buffering effects of social concerns on ED risk. DISCUSSION: Findings advance understanding of the role of AS in the comorbidity of anxiety and EDs, demonstrating the strong association of AS with ED pathology. These findings provide cognitive indicators for transdiagnostic therapeutic intervention in order to reduce the risk of EDs.

Many people with anxiety disorders also have high rates of eating pathology, and vice versa. Teasing apart the factors that may contribute to this co-morbidity can provide important information for psychotherapeutic prevention and intervention. In this study we examine the contributions of anxiety sensitivity, also known as the 'fear of fear,' beyond that of generalized anxiety in its associations with eating disorder outcomes. Our findings show that the cognitive concerns of anxiety (i.e., thinking about being anxious) are associated with higher urges to purge after eating. Higher social concerns with anxiety (i.e., concerns that others will know one is anxious) related to fewer symptoms of eating disorders. Taken together our findings illuminate that considering anxiety sensitivity may be helpful for the diagnosis and treatment of eating disorders.

Early intervention for families experiencing homelessness: A pilot randomized trial comparing two parenting programs.

OBJECTIVE: As part of a larger community-based, service-driven research project, the primary purpose of this pilot randomized study was to examine the feasibility and acceptability of delivering time-limited adaptations of parent-child interaction therapy (PCIT) and child-parent psychotherapy (CPP) within a sample of children experiencing homelessness. The secondary goal was to examine the promise of both interventions in improving parent/child outcomes. METHOD: One hundred forty-four young children (18 month-5 years old; Mage = 3.48, SD = 1.09; 43.1% female; 78.5% Black/African American; 27.1% Hispanic) and their mothers were recruited from a women's homeless shelter and randomly assigned to 12 weeks of either PCIT or CPP delivered by shelter clinicians on-site. Attendance, fidelity, and program satisfaction were obtained. Families completed pre- and postintervention assessments, including observational data on maternal verbalizations during a child-led play session. RESULTS: Both time-limited PCIT and time-limited CPP were successfully implemented with similarly high levels of intervention fidelity (>90%) and satisfaction by mothers (85%). Completion rates were similar across both time-limited PCIT (76.6%) and time-limited CPP (71.4%). Both time-limited CPP and PCIT resulted in decreases in children's posttraumatic stress, parental stress, and increases in maternal positive verbalizations. Only time-limited PCIT resulted in significant improvements in externalizing behavior problems in children and reductions in maternal negative verbalizations. CONCLUSIONS: Time-limited PCIT and CPP are acceptable, feasible, and hold significant promise for helping families within a homeless shelter environment and by extension, other transitional and/or shelter environments. A full randomized trial is warranted to determine which program may offer a more effective intervention. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Effects of English versus Spanish language exposure on basic multisensory attention skills across 3 to 36 months of age.

Recent research has demonstrated that individual differences in infant attention to faces and voices of women speaking predict language outcomes in childhood. These findings have been generated using two new audiovisual attention assessments appropriate for infants and young children, the Multisensory Attention Assessment Protocol (MAAP) and the Intersensory Processing Efficiency Protocol (IPEP). The MAAP and IPEP assess three basic attention skills (sustaining attention, shifting/disengaging, intersensory matching), as well as distractibility, deployed in the context of naturalistic audiovisual social (women speaking English) and nonsocial events (objects impacting a surface). Might children with differential exposure to Spanish versus English show different patterns of attention to social events on these protocols as a function of language familiarity? We addressed this question in several ways using children (n = 81 dual-language learners; n = 23 monolingual-language learners) from South Florida, tested longitudinally across 3-36 months. Surprisingly, results indicated no significant English language advantage on any attention measure for children from monolingual English versus dual English-Spanish language environments. Second, for dual-language learners, exposure to English changed across age, decreasing slightly from 3-12 months and then increasing considerably by 36 months. Furthermore, for dual-language learners, structural equation modeling analyses revealed no English language advantage on the MAAP or IPEP as a function of degree of English language exposure. The few relations found were in the direction of greater performance for children with greater Spanish exposure. Together, findings indicate no English language advantage for basic multisensory attention skills assessed by the MAAP or IPEP between the ages of 3 to 36 months. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Measurement invariance in the assessment of parenting practices: A cross-cultural comparison of China and the United States.

Assessing parenting practices in a culturally informed manner is critical to clinical practice when working with families. Although many parenting measures have been translated into Chinese, limited evidence for measurement invariance is available. The present study aims to assess the measurement invariance of positive and negative parenting practices across Mandarin-speaking families living in Mainland China and English-speaking families living in the United States. Three thousand seven parents of children ages 6-12 years (770 English-speaking: parent Mage = 35.15 years, SD = 7.96; child Mage = 9.50 years, SD = 4.27; 2,237 Chinese-speaking: parent Mage = 38.46 years, SD = 4.42; child Mage = 9.40 years, SD = 1.78) completed the Multidimensional Assessment of Parenting Scale as a part of two separate research protocols. Multiple-group confirmatory factor analyses (CFAs) were used, and the source of invariance at the factor and item levels was examined. CFA revealed that a seven-factor solution was feasible across both samples, as evidenced by configural and metric invariance. We found a lack of scalar invariance; thus, we constructed a partial scalar invariance model and presented latent means, correlations, and variances of the seven subscales. Item-level parameter estimates and content analyses revealed potentially different item interpretations of the measure. The lack of scalar invariance suggests that researchers should not use mean differences (e.g., from simple t tests) for cross-cultural comparisons using common parenting questionnaires. Instead, we recommend analyzing data utilizing latent variable modeling (e.g., structural equation modeling) and future directions for improving measures as part of larger efforts for promoting inclusive parenting science. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Unpacking Inequities in ADHD Diagnosis: Examining Individual-Level Race/Ethnicity and State-Level Online Information-Seeking Patterns.

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent, persistent, and costly mental health condition. The internet is an increasingly popular source for information related to ADHD. With a nationally representative sample (2018 NSCH), we aimed to separate individual- and state-level effects to examine inequities in ADHD diagnoses. We extracted state-level relative search volumes using "ADHD," "ADHD treatment," "ADHD medication," and "ADHD therapy" from Google Trends, and sociodemographic and clinical variables from the 2018 National Survey of Children's Health (N = 26,835). We examined state variation in ADHD-related information-seeking and applied multilevel modeling to examine associations among individual-level race/ethnicity, state-level information-seeking patterns, and ADHD diagnoses. Online information seeking related to ADHD varies by state and search term. Individual-level racial/ethnic background and state-level information-seeking patterns were associated with ADHD diagnoses; however, their cross-level interaction was not significant. This study adds to the strong body of evidence documenting geographical variation and diagnostic disparity in mental health and the growing literature on the impact of the digital divide on population health, indicating an urgent need for addressing inequities in mental health care. Increasing public interest in and access to empirically supported online information may increase access to care, especially among people of color.

Sleep fails to depotentiate amygdala-reactivity to negative emotional stimuli in youth with elevated symptoms of anxiety.

Sleep-related problems often precede escalating anxiety in early adolescence. Pushing beyond broad sleep-mental health associations and toward mechanistic theories of their interplay can inform etiological models of psychopathology. Recent studies suggest that sleep depotentiates neural (e.g., amygdala) reactivity during reexposure to negative emotional stimuli in adults. Persistent amygdala reactivity to negative experiences and poor sleep characterize anxiety, particularly at the transition to adolescence. We propose that sleep depotentiates amygdala reactivity in youth but fails to do so among youth with anxiety. Participants (n = 34; 18 males; age, mean [M] = 11.35, standard deviation [SD] = 2.00) recruited from the community and specialty anxiety clinics viewed valenced images (positive, negative, and neutral) across two fMRI sessions (Study, Test), separated by a 10-12-hour retention period of sleep or wake (randomized). Mixed linear models regressed basolateral amygdala (BLA) activation and BLA-medial prefrontal cortex (mPFC) functional connectivity to negative images on Time, Condition, and Anxiety Severity. There were greater reductions in BLA activations to negative target images from Study to Test in the Sleep Condition, which was blunted with higher anxiety (b = -0.065, z = -2.355, p = 0.019). No such sleep- or anxiety-related effects were observed for BLA-mPFC functional connectivity (ps > 0.05). Sleep supports depotentiation of amygdala reactivity to negative stimuli in youth, but this effect is blunted at higher levels of anxiety. Disruptions in sleep-related affective habituation may be a critical, modifiable driver of anxiety.

Risk factors for early use of e-cigarettes and alcohol: Dimensions and profiles of temperament.

Adolescent e-cigarette use has been labeled an epidemic and alcohol use during this developmental period is associated with deleterious outcomes. Though specific temperamental dimensions have been shown to predict substance use, profiles of temperament have rarely been examined as predictors. This study examines dimensions and profiles of adolescent temperament as predictors of early use of e-cigarettes and alcohol. The sample was comprised of adolescent (62.07% female, 87.59% White, 82.76% Hispanic/Latinx)/caregiver dyads (N = 146) who completed the first two timepoints (M age at second timepoint = 16.16, SD = 0.68) of a longitudinal adolescent substance use study. Models showed parent-reported effortful control predicted protection against adolescent use of e-cigarettes, whereas adolescent report of effortful control predicted protection against alcohol use. Though dissimilar in temperamental pattern, three profiles emerged from both parent- and adolescent-report-based latent profile analysis models. Adolescents characterized by parents as displaying a Resilient profile had greater odds of e-cigarette use than those characterized by a Reserved profile, whereas adolescents who self-characterized as Mixed-type had markedly greater odds of alcohol use than those who self-characterized as Resilient. Utilization of temperamental profiles may aid in identification of particularly vulnerable subgroups of adolescents who may benefit from relevant preventative programing.

The Ethnic Identity Scale: Affirmation, really?

OBJECTIVE: The Ethnic Identity Scale (EIS) was developed to distinguish between process and content components of ethnic-racial identity (ERI). However, the affirmation subscale is composed entirely of negatively worded items, measuring negative feelings about one's ethnic-racial group, rather than positive feelings as widely conceptualized. Addressing this gap, the present study examined the psychometric validity of a revised EIS with positively and negatively worded items to determine whether affirmation is best represented as a unidimensional construct, a bidimensional construct, or a combination of the two. METHOD: The sample consisted of 280 college students (75.5% female; Mage = 20.95 years; SD = 1.98 years). The largest ethnic-racial group consisted of Black or African Americans (68.2%), followed by Asian/Asian Americans (12.1%), Hispanic/Latinos (9.6%), and other ethnic-racial groups (10%). RESULTS: Confirmatory factor analysis provided evidence for both unidimensionality and multidimensionality. Indeed, although positively worded and negatively worded items of "affirmation" loaded onto a general factor representing affirmation, there was still a significant amount of variance captured by the negative ERI affect specific factor, indicating the presence of multidimensionality. In addition, results indicated that negative ERI affect, over and above the general ERI affirmation factor, predicted psychosocial functioning. CONCLUSIONS: The present study expands our understanding of the multidimensionality of ERI, highlighting the need for examination of how we measure ERI affect at the very least, and possibly how we conceptualize it within the broader ERI literature. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

A measure of functioning in adults With ADHD: Psychometric properties of the general life functioning scale-parent version.

OBJECTIVE: The General Life Functioning Scale (GLF) was developed to provide a complementary alternative to existing measures of impairment. We examined the psychometric properties of the GLF-Parent version (GLF-P), given the known value of informant ratings. METHODS: The GLF-P was administered to parents of adults with attention-deficit/hyperactivity disorder (ADHD) diagnosed in childhood and a nonADHD comparison group in the Pittsburgh ADHD Longitudinal Study. GLF-P ratings described 334 participants (ADHD = 186; comparison = 148) rated at age 25 (Mage = 24.80 years, SDage = 0.46, range = 24-26) and 401 participants (ADHD = 237; comparison = 164) rated at age 30 (Mage = 29.30, SDage = 0.64, range = 28-33). Exploratory (EFA) and confirmatory (CFA) factor analyses were used. RESULTS: EFAs suggested and CFAs confirmed a five-factor solution. We found measurement invariance across diagnostic and age groups, satisfactory internal consistency, construct validity, and known-group validity. CONCLUSION: Psychometric results suggest the GLF-P as a helpful adjunctive measure of functioning. Further research is needed to determine the utility of the GLF across diverse settings.

Twenty-year trends in elementary teachers' beliefs about best practices for students with ADHD.

In an effort to understand teachers' perceptions of best practices for treatment of students with attention-deficit/hyperactivity disorder (ADHD) and how those may have shifted over the past 20 years, general education elementary school teachers completed surveys regarding their opinions of evidence-based interventions in the classroom. Two independent and anonymous samples of general education, elementary school teachers were collected: One in 1999 (n = 598) and a second in 2019 (n = 661). Teachers responded to questions about their interactions with students with ADHD as well as their beliefs about best practices for these students. Across survey samples, teachers generally agreed that behavioral classroom management, medications, and the combination of the two are effective treatments for students with ADHD. Comparisons of the 1999 and 2019 survey samples suggest that teachers in 2019 perceive the use of behavioral classroom management somewhat less favorably than did teachers in 1999. Teacher perceptions of best practices for students with ADHD in 1999 and 2019 were generally consistent with professional practice guidelines. Teacher responses also highlight a critical need for training and support related to evidence-based strategies for students with ADHD in the classroom. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

A school-based parenting program for children with attention-deficit/hyperactivity disorder: Impact on paternal caregivers.

Engaging male caregivers within school settings is a major need within the educational field. Paternal engagement may be particularly important for children with attention-deficit/hyperactivity disorder (ADHD). Children with ADHD have increased risk for a number of poor educational outcomes, which may be attenuated by the benefits of positive male caregiver involvement. The Coaching Our Acting Out Children: Heightening Essential Skills (COACHES) program has been illustrated to be an effective approach for engaging, retaining, and improving the parenting of male caregivers of children with ADHD in clinical settings. The present study reports on the efficacy of the COACHES in Schools program, an adaptation intended for deployment in elementary school settings. Sixty-one male caregivers were randomly assigned to COACHES in Schools or a waitlist control. Results indicated that male caregivers in COACHES in Schools used significantly more praise and less negative talk in a parent-child activity relative to male caregivers in the waitlist control at post-treatment and one-month follow-up. Distal outcomes related to child behavior at home and at school were not significantly different. Implications of the results for future studies and continued efforts to engage male caregivers within school settings are discussed.

R-squared change in structural equation models with latent variables and missing data.

Researchers frequently wish to make incremental validity claims, suggesting that a construct of interest significantly predicts a given outcome when controlling for other overlapping constructs and potential confounders. Once the significance of such an effect has been established, it is good practice to also assess and report its magnitude. In OLS regression, this is easily accomplished by calculating the change in R-squared, ΔR2, between one's full model and a reduced model that omits all but the target predictor(s) of interest. Because observed variable regression methods ignore measurement error, however, their estimates are prone to bias and inflated type I error rates. As a result, researchers are increasingly encouraged to switch from observed variable modeling conducted in the regression framework to latent variable modeling conducted in the structural equation modeling (SEM) framework. Standard SEM software packages provide overall R2 measures for each outcome, yet calculation of ΔR2 is not intuitive in models with latent variables. Omitting all indicators of a latent factor in a reduced model will alter the overidentifying constraints imposed on the model, affecting parameter estimation and fit. Furthermore, omitting variables in a reduced model may affect estimation under missing data, particularly when conditioning on those variables is essential to meeting the MAR assumption. In this article, I describe four approaches to calculating ΔR2 in SEMs with latent variables and missing data, compare their performance via simulation, describe a set of extensions to the methods, and provide a set of R functions for calculating ΔR2 in SEM.

Prolonged Cardiopulmonary Bypass is Associated With Endothelial Glycocalyx Degradation.

BACKGROUND: The endothelial glycocalyx (EG) is involved in critical regulatory mechanisms that maintain endothelial vascular integrity. We hypothesized that prolonged cardiopulmonary bypass (CPB) may be associated with EG degradation. We performed an analysis of soluble syndecan-1 levels in relation to duration of CPB, as well as factors associated with cell stress and damage, such as mitochondrial DNA (mtDNA) and inflammation. METHODS: Blood samples from subjects undergoing cardiac surgery with CPB (n = 54) were obtained before and during surgery, 4-8 h and 24 h after completion of CPB, and on postoperative day 4. Flow cytometry was used to determine subpopulations of white blood cells. Plasma levels of mtDNA were determined using quantitative polymerase chain reaction and plasma content of shed syndecan-1 was measured. To determine whether syndecan-1 was signaling white blood cells, the effect of recombinant syndecan-1 on mobilization of neutrophils from bone marrow was tested in mice. RESULTS: CPB is associated with increased mtDNA during surgery, increased syndecan-1 blood levels at 4-8 h, and increased white blood cell count at 4-8 h and 24 h. Correlation analysis revealed significant positive associations between time on CPB and syndecan-1 (rs = 0.488, P < 0.001) and level of syndecan-1 and neutrophil count (rs = 0.351, P = 0.038) at 4-8 h. Intravenous administration of recombinant syndecan-1 in mice resulted in a 2.5-fold increase in the number of circulating neutrophils, concurrent with decreased bone marrow neutrophil number. CONCLUSIONS: Longer duration of CPB is associated with increased plasma levels of soluble syndecan-1, a signal for EG degradation, which can induce neutrophil egress from the bone marrow. Development of therapy targeting EG shedding may be beneficial in patients with prolonged CPB.

Factor Score Regression in the Presence of Correlated Unique Factors.

Recently, quantitative researchers have shown increased interest in two-step factor score regression (FSR) approaches to structural model estimation. A particularly promising approach proposed by Croon involves first extracting factor scores for each latent factor in a larger model, then correcting the variance-covariance matrix of the factor scores for bias before using this matrix as input data in a subsequent regression analysis or path model. Although not immediately obvious, Croon's bias correction formulas are predicated upon the standard assumption of conditionally independent uniquenesses (measurement residuals). To our knowledge, the method's performance has never been evaluated under conditions in which this assumption is violated. In the present research, we rederive Croon's formulas for the case of correlated uniqueness and present the results of two Monte Carlo simulations comparing the method's performance with standard methods when the unique factors were correlated in the population model. In our simulations, our proposed Croon FSR approaches outperformed methods that blindly assumed conditionally independent uniquenesses (e.g., uncorrected FSR, traditional Croon FSR, structural equation modeling [SEM] using standard specification), performed comparably to a correctly specified SEM, and outperformed SEMs that correctly specified the unique factor covariances but misspecified the structural model. We discuss the implications of our results for substantive researchers.