Men's Sleep Quality and Assisted Reproductive Technology Outcomes in Couples Referred to a Fertility Clinic: A Chinese Cohort Study.

Background: Poor sleep quality has been linked to lower semen quality, but it is unclear whether this result in decreased fertility. To address this question, we retrospectively evaluated the relationship between men's sleep quality and treatment outcomes in subfertile couples receiving assisted reproductive technology (ART). Patient Enrollment and Methods: From September 2017 to November 2019, 282 subfertile couples referred to a Chinese fertility clinic and eligible for ART procedures were enrolled in our study. Sociodemographic characteristics, life habits, and sleep habits in the year prior to ART were recorded. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI). We first divided the patients into two groups based on sleep quality (good sleep: PSQI < 5 and poor sleep: PSQI ≥ 5). Then, the ART outcomes (fertilization rate, good quality embryo rate, implantation rate, positive pregnancy rate, clinical pregnancy rate, live birth rate, miscarriage rate, and birth weight) of each group were analyzed. Finally, multivariate linear and logistic regression analysis were used to examine the relationship between sleep quality (discrete variable or dichotomous variable) and ART outcomes. Results: The participants in the poor sleep group showed a lower fertilization rate of 60.13% (543/903) when compared with 67.36% for the good sleep group (902/1339), P < 0.001. The global PSQI score had a significant influence on birth weight (ß, -63.81; 95% CI, -119.91- -8.52; P = 0.047), and live birth rate (OR, 0.88; 95% CI, 0.78- 0.99; P = 0.047) after adjusting for the interfering factors. Men's sleep quality was unrelated to good quality embryos rate, implantation rate, positive pregnancy rate, clinical pregnancy rate, or miscarriage rate. Conclusion: Men's sleep quality was positively associated with fertilization rate, birth weight, and live birth rate among couples undergoing ART.

Aqua-bis(2-amino-1,3-thia-zole-4-acetato-κO,N)nickel(II).

In the crystal structure of the title compound, [Ni(C(5)H(5)N(2)O(2)S)(2)(H(2)O)], the Ni(II) cation is located on a twofold rotation axis and chelated by two 2-amino-1,3-thia-zole-4-acetate (ata) anions in the basal coordination plane; a water mol-ecule located on the same twofold rotation axis completes the distorted square-pyramidal coordination geometry. Inter-molecular O-H⋯O and N-H⋯O hydrogen bonding, as well as π-π stacking between parallel thia-zole rings [centroid-centroid distance 3.531 (8) Å], helps to stabilize the crystal structure.

Aqua-(2,2'-bipyrimidine-κN,N')(succin-ato-κO,O)copper(II) dihydrate.

In the crystal structure of the title compound, [Cu(C(4)H(4)O(4))(C(8)H(6)N(4))(H(2)O)]·2H(2)O, the Cu(II) atom is chelated by a 2,2'-bipyrimidine (bpm) ligand and a succinate anion in the basal plane; a water mol-ecule in the apical position completes the slightly distorted square-pyramidal coordination geometry. Another carboxyl-ate O atom from an adjacent complex is located in the opposite apical direction, with a Cu⋯O distance of 2.706 (3) Å, and is not considered as a bridging atom. Extensive O-H⋯O and O-H⋯N hydrogen bonding is present in the crystal structure.

catena-Poly[[(2,2'-bipyridine-κN,N')copper(I)]-µ-cyanido-κC:N-[(2,2'-bipyridine-κN,N')copper(I)]-µ-thio-cyanato-κS:N].

The title compound, [Cu(2)(CN)(SCN)(C(10)H(8)N(2))(2)](n), contains two crystallographically independent Cu(I) atoms, each in a distorted tetra-hedral geometry. Each Cu atom is coordinated by a bidentate chelating 2,2'-bipyridine ligand. A bridging cyanide anion links the two Cu(2,2'-bipyridine) units to form a binuclear unit. Adjacent binuclear units are connected by a thio-cyanate anion into a one-dimensional helical chain along [010]. The cyanide anion is disordered, with each site occupied by both C and N atoms in an occupancy ratio of 0.61 (5):0.39 (5). The S atom of the thio-cyanate anion is also disordered over two sites, with occupancy factors of 0.61 (3) and 0.39 (3). There are π-π inter-actions between the pyridyl rings of neighbouring chains [centroid-centroid distance = 3.82 (1) Å].