1.
Org Biomol Chem
; 15(2): 333-337, 2017 Jan 04.
Article
in English
| MEDLINE
| ID: mdl-27924330
ABSTRACT
Thienopyridines and related heterocycles were prepared in a straightforward manner in moderate to good yields and under mild conditions by palladium-catalysed cross-coupling of ortho-fluorinated iodopyridines and terminal alkynes, followed by a reagent-capsule-assisted thiolation cyclization process. By applying paraffin wax capsules to prevent catalyst poisoning and undesired side reactions, the separation and purification processes were reduced.