ABSTRACT
La sialometaplasia necrotizante (SN) es una afección inflamatoria, autoresolutiva, que afecta a las glándulas salivales, más frecuentemente a las menores. Si bien su etiopatogenia permanece aún desconocida, diversos autores sugieren que una agresión fisico-química o biológica sobre los vasos sanguíneos produciría isquemia, la cual conduciría al infarto de la glándula y su posterior necrosis. Su aspecto clínico e histológico tiene apariencias de malignidad. Clínicamente puede presentarse como una úlcera de bordes irregulares, ligeramente elevados y lecho necrótico, mientras que histopatológicamente se caracteriza por presentar metaplasia escamosa de conductos y acinos e hiperplasia pseudoepiteliomatosa del epitelio mucoso, características éstas que pueden inducir a un diagnóstico incorrecto de neoplasia maligna anexial. Es fundamental realizar un correcto diagnóstico a los efectos de evitar tratamientos quirúrgicos mutilantes, debido a que se trata de una patología autoresolutiva. En el presente trabajo se describen cinco casos de (SN) en pacientes de sexo femenino, ubicados en glándulas salivales menores del paladar (AU)
Necrotizing sialometaplasia (NS) is a self-limiting inflammatory disease, that involves salivary glands, more frequently the minor ones. Although its etiopathogenesis remains still unknown some authors suggest that a physicochemical or biological injury on the blood vessels may produce ischemic changes, leading to infarction of the gland and its further necrosis. Its clinical and histologic feature resemble malignancy. Clinically it may appear like an ulcer with slightly elevated irregular borders and necrotic base. Histologic features are squamous metaplasia of ducts and acini and a pseudoepitheliomatous hyperplasia of the overlying mucosa. These characteristics may induce to an inapropiated diagnosis of malignant neoplasia. A correct diagnosis to avoid mutilant surgical treatments is essential, considering that it is a self-limiting disease. In this report we describe five cases of NS in females, located in minor glands of the palate (AU)
Subject(s)
Adult , Aged , Female , Humans , Middle Aged , Sialometaplasia, Necrotizing/diagnosis , Oral Ulcer/diagnosis , Salivary Gland Diseases/diagnosis , Diagnosis, Differential , Salivary Glands, Minor/pathologyABSTRACT
Necrotizing sialometaplasia (NS) is a self-limiting inflammatory disease, that involves salivary glands, more frequently the minor ones. Although its etiopathogenesis remains still unknown some authors suggest that a physico-chemical or biological injury on the blood vessels may produce ischemic changes, leading to infarction of the gland and its further necrosis. Its clinical and histologic feature resemble malignancy. Clinically it may appear like an ulcer with slightly elevated irregular borders and necrotic base. Histologic features are squamous metaplasia of ducts and acini and a pseudoepitheliomatous hyperplasia of the overlying mucosa. These characteristics may induce to an inapropiated diagnosis of malignant neoplasia. A correct diagnosis to avoid mutilant surgical treatments is essential, considering that it is a self-limiting disease. In this report we describe five cases of NS in females, located in minor glands of the palate.