Processing and Physicochemical Properties of Magnetite Nanoparticles Coated with Curcuma longa L. Extract.

In this work, Curcuma longa L. extract has been used in the synthesis and direct coating of magnetite (Fe3O4) nanoparticles ~12 nm, providing a surface layer of polyphenol groups (-OH and -COOH). This contributes to the development of nanocarriers and triggers different bio-applications. Curcuma longa L. is part of the ginger family (Zingiberaceae); the extracts of this plant contain a polyphenol structure compound, and it has an affinity to be linked to Fe ions. The nanoparticles' magnetization obtained corresponded to close hysteresis loop Ms = 8.81 emu/g, coercive field Hc = 26.67 Oe, and low remanence energy as iron oxide superparamagnetic nanoparticles (SPIONs). Furthermore, the synthesized nanoparticles (G-M@T) showed tunable single magnetic domain interactions with uniaxial anisotropy as addressable cores at 90-180°. Surface analysis revealed characteristic peaks of Fe 2p, O 1s, and C 1s. From the last one, it was possible to obtain the C-O, C=O, -OH bonds, achieving an acceptable connection with the HepG2 cell line. The G-M@T nanoparticles do not induce cell toxicity in human peripheral blood mononuclear cells or HepG2 cells in vitro, but they can increase the mitochondrial and lysosomal activity in HepG2 cells, probably related to an apoptotic cell death induction or to a stress response due to the high concentration of iron within the cell.

Lentil sprouts: a nutraceutical alternative for the elaboration of bread.

The pro-health action of germinated lentils could be useful to be added with wheat flour in the production of box bread. In this work, we spectroscopically evaluate the germinated and non-germinated lentils, and use them at the concentrations of 5 and 10% for the production of box bread. The chemical and physical tests of the bread and its determination of phenolic acids and flavonoids (by HPLC) were also performed. As well as the evaluation of the quality of flour and dough used to produce the bread and the acceptance of the germinated lentil bread with a population of 20 people with diabetes or with diabetic relatives It is shown that: (1) The amplitude of photoacoustic signal obtained by photoacoustic spectroscopy is modified as a function of the percentage of germinated lentil (GL) flour (0, 5 or 10%) add to the bread; being higher the photoacoustic amplitude to higher concentration of GL in the absorption band of 300-425 nm, which is related to higher content of phenols and flavonoids. (2) The contents of phenolic acids (Sinapinic, ß- resorcylic, Chlorogenic and Ferulic) and flavonoids (Quercetin and Isorhamnetin) tended to increase in the germinated lentil bread with 10% concentration of germinated lentil flour with respect to the control bread (0% GL). (3) The addition of germinated lentils flour to 5 and 10% into wheat flour to produce bread with higher hardness and less cohesiveness than bread based on wheat flour only. The Falling number indicate that there is no significant difference between the control sample and the 5% GL flour, while in the 10% GL flour there was a reduction of 21 s, with respect to the control. The effect of the germinated lentil flour percentage on the pasting properties of the flours was significant between the control and 10% GL flour. In general, the quality of the dough and flour are modified due to the addition of germinates lentils, and this affectation increases with the increase in the concentration of GL. (4) The bread added with germinated lentil has sensory acceptance with a group of people with diabetes and/or diabetic relatives in their attributes in general. The obtained results thus support the production of wheat bread with mixed germinated lentils flour, as a nutraceutical option for human consumption.

Terapia electroquímica: relación del patrón espacial del daño tisular con la forma del arreglo de electrodos / Electrochemical therapy: relationship of the tissular damage space pattern with the form of electrodes repair

Se realizó una investigación en la Escuela Superior de Ingeniería Mecánica y Eléctrica del Instituto Politécnico Nacional de Ciudad de México, desde mayo hasta junio de 2016, con el objetivo de determinar cómo cambia el patrón espacial del daño tisular con la forma del arreglo de electrodos en piezas tridimensionales de papa (Solanum tuberosum L) bajo la acción de 10 mA durante 30 min para los arreglos de electrodos con formas colineal, circular, elíptica, parabólica e hiperbólica). Los resultados mostraron la estrecha relación entre el daño tisular y la forma del arreglo de electrodos, así como algunos hallazgos que se observan también en tumores, tales como: necrosis circular alrededor de todos los electrodos, daño tisular extensivo en espacio y en tiempo, burbujeo alrededor del cátodo, zona blanca alrededor del ánodo; igualmente, se observó que las regiones alejadas de los electrodos no se afectarona(AU)

An investigation in the Mechanical and Electric Engineering Higher School of the National Polytechnic Institute of Mexico City, was carried out from May to June, 2016, aimed at determining how the tissue damage space pattern changes with the electrodes position form in three-dimensional pieces of potato (Solanum tuberosum L) under the 10 MA action during 30 minutes for electrodes position with cholineal, round, elliptic, parabolic and hyperbolic forms). The results showed a close relationship between the tissue damage and the electrodes position form, as well as some findings that are also observed in tumors, such as: circular necrosis around all the electrodes, extensive tissue damage in space and time, bubbling around the cathode, white area near the anode; likewise, it was observed that the regions far from the electrodes were not affected(AU)

Terapia electroquímica: relación del patrón espacial del daño tisular con la forma del arreglo de electrodos / Electrochemical therapy: relationship of the tissular damage space pattern with the form of electrodes repair

Se realizó una investigación en la Escuela Superior de Ingeniería Mecánica y Eléctrica del Instituto Politécnico Nacional de Ciudad de México, desde mayo hasta junio de 2016, con el objetivo de determinar cómo cambia el patrón espacial del daño tisular con la forma del arreglo de electrodos en piezas tridimensionales de papa (Solanum tuberosum L) bajo la acción de 10 mA durante 30 min para los arreglos de electrodos con formas colineal, circular, elíptica, parabólica e hiperbólica). Los resultados mostraron la estrecha relación entre el daño tisular y la forma del arreglo de electrodos, así como algunos hallazgos que se observan también en tumores, tales como: necrosis circular alrededor de todos los electrodos, daño tisular extensivo en espacio y en tiempo, burbujeo alrededor del cátodo, zona blanca alrededor del ánodo; igualmente, se observó que las regiones alejadas de los electrodos no se afectaron

An investigation in the Mechanical and Electric Engineering Higher School of the National Polytechnic Institute of Mexico City, was carried out from May to June, 2016, aimed at determining how the tissue damage space pattern changes with the electrodes position form in three-dimensional pieces of potato (Solanum tuberosum L) under the 10 MA action during 30 minutes for electrodes position with cholineal, round, elliptic, parabolic and hyperbolic forms). The results showed a close relationship between the tissue damage and the electrodes position form, as well as some findings that are also observed in tumors, such as: circular necrosis around all the electrodes, extensive tissue damage in space and time, bubbling around the cathode, white area near the anode; likewise, it was observed that the regions far from the electrodes were not affected

Quantum mechanical model for the anticarcinogenic effect of extremely-low-frequency electromagnetic fields on early chemical hepatocarcinogenesis.

Using the conventional Haberkorn approach, it is evaluated the recombination of the radical pair (RP) singlet spin state to study theoretically the cytoprotective effect of an extremely-low-frequency electromagnetic field (ELF-EMF) on early stages of hepatic cancer chemically induced in rats. The proposal is that ELF-EMF modulates the interconversion rate of singlet and triplet spin states of the RP populations modifying the products from the metabolization of carcinogens. Previously, we found that the daily treatment with ELF-EMF 120 Hz inhibited the number and area of preneoplastic lesions in chemical carcinogenesis. The singlet spin population is evaluated diagonalizing the spin density matrix through the Lanczos method in a radical pair mechanism (RPM). Using four values of the interchange energy, we have studied the variations over the singlet population. The low magnetic field effect as a test of the influence over the enzymatic chemical reaction is evaluated calculating the quantum yield. Through a bootstrap technique the range is found for the singlet decay rate for the process. Applying the quantum measurements concept, we addressed the impact toward hepatic cells. The result contributes to improving our understanding of the chemical carcinogenesis process affected by charged particles that damage the DNA.

Female breast symptoms in patients attended in the family medicine practice.

BACKGROUND: there are few studies on breast symptoms (BS) in patients attended at primary care units in Mexico. The aim was to determine the frequency and types of BS overall and by age-group and establish which BS were related to diagnosis of breast cancer. METHODS: data from all female patients with a breast-disease-related diagnosis, attended from 2006 to 2010, at the Family Medicine Unit 38, were collected. The frequencies of BS were determined by four age-groups (< 19, 20-49, 50-69, > 70 years) and likelihood ratios for breast cancer for each breast-related symptom patient, with a 95 % confidence interval (CI). RESULTS: the most frequent BS in the study population were lump/mass (71.7 %) and breast pain (67.7 %) of all breast complaints, and they were more noted in women age group of 20-49 years. Overall, 120 women had breast cancer diagnosed with a median age of 53.51 + 12.7 years. Breast lump/mass had positive likelihood ratios for breast cancer 4.53 (95 % CI = 2.51-8.17) and breast pain had increased negative LR = 1.08 (95 % CI = 1.05-1.11). CONCLUSIONS: breast lump/mass was the predominant presenting complaint among females with breast symptoms in our primary care unit, and it was associated with elevated positive likelihood of breast cancer.

Introducción: en México, en las unidades del primer nivel hay pocos estudios sobre los síntomas mamarios. El objetivo fue determinar la frecuencia de los síntomas y los más asociados con el diagnóstico de cáncer. Métodos: se recabó información de las pacientes atendidas de 2006 a 2010 con enfermedad de mama de una unidad de medicina familiar. Se determinaron las frecuencias de los síntomas mamarios en los grupos etarios < 19, 20-49, 50-69, > 70 años y los cocientes de probabilidad (LR) de cáncer de mama para cada síntoma, con un intervalo de confianza (IC) de 95 %. Resultados: casi todas las quejas derivaron de una masa o tumoración (71.7 %) y dolor mamario (67.7 %). Presentaron cáncer de mama 120 mujeres, con un promedio de edad de 53.51 + 12.7 años. La tumoración/masa en el seno tuvo un LR+ para cáncer de mama de 4.53 (IC 95 % = 2.51-8.17) y un LR+ para dolor mamario de 1.08, 95 % (IC 95 % = 1.05-1.11). Conclusiones: la presentación de la tumoración/masa predominó como queja en nuestra unidad y estuvo asociada con un LR+ para cáncer de mama.