1.
Amino Acids
; 27(2): 153-9, 2004 Oct.
Article
in English
| MEDLINE
| ID: mdl-15365909
ABSTRACT
Hepatitis C, Dengue and West Nile virus are some of the most important flaviviruses, that share one important serine protease enzyme. Serine proteases are the most studied class of proteolytic enzyme and, in these cases, a primary target for drug discovery. In this paper, we describe the synthesis and preliminary molecular modeling studies of a novel class of N- t-Boc amino acid esters derived of isomannide as potential serine proteases inhibitors.
Subject(s)
Amino Acids/chemistry , Bridged Bicyclo Compounds, Heterocyclic/chemistry , Enzyme Inhibitors/pharmacology , Mannitol/chemistry , Serine Endopeptidases/chemistry , Carbon/chemistry , Dengue Virus/metabolism , Flavivirus/metabolism , Hydrogen Bonding , Magnetic Resonance Spectroscopy , Mannose/chemistry , Models, Chemical , Models, Molecular , Peptides/chemistry , Protein Conformation , Temperature , Viral Nonstructural Proteins/chemistry
2.
Rev Cubana Med Trop
; 35(3): 290-302, 1983.
Article
in Spanish
| MEDLINE
| ID: mdl-6379774
3.
Rev. cuba. med. trop
; 35(3): 290-302, 1983.
Article
in Spanish
| LILACS
| ID: lil-19455