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1.
Exp Brain Res ; 237(8): 2135, 2019 Aug.
Article in English | MEDLINE | ID: mdl-31280355

ABSTRACT

In the manuscript, we write that saccadic reaction time was determined as the time between the offset of the last fixation on the central stimulus and the onset of the peripheral stimulus (the target).

2.
Infant Behav Dev ; 57: 101316, 2019 11.
Article in English | MEDLINE | ID: mdl-31128517

ABSTRACT

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that affects social communication skills and flexible behaviour. Developing new treatment approaches for ASD requires early identification of the factors that influence later behavioural outcomes. One fruitful research paradigm has been the prospective study of infants with a first degree relative with ASD, who have around a 20% likelihood of developing ASD themselves. Early findings have identified a range of candidate neurocognitive markers for later ASD such as delayed attention shifting or neural responses to faces, but given the early stage of the field most sample sizes are small and replication attempts remain rare. The Eurosibs consortium is a European multisite neurocognitive study of infants with an older sibling with ASD conducted across nine sites in five European countries. In this manuscript, we describe the selection and standardization of our common neurocognitive testing protocol. We report data quality assessments across sites, showing that neurocognitive measures hold great promise for cross-site consistency in diverse populations. We discuss our approach to ensuring robust data analysis pipelines and boosting future reproducibility. Finally, we summarise challenges and opportunities for future multi-site research efforts.


Subject(s)
Autism Spectrum Disorder/physiopathology , Autism Spectrum Disorder/psychology , Electroencephalography/methods , Mental Status and Dementia Tests , Siblings/psychology , Attention/physiology , Autism Spectrum Disorder/diagnosis , Autism Spectrum Disorder/epidemiology , Communication , Europe/epidemiology , Female , Humans , Infant , Longitudinal Studies , Male , Predictive Value of Tests , Prospective Studies , Reproducibility of Results
3.
Exp Brain Res ; 235(12): 3585-3592, 2017 12.
Article in English | MEDLINE | ID: mdl-28884226

ABSTRACT

Attentional disengagement is important for successful interaction with our environment. The efficiency of attentional disengagement is commonly assessed using the gap paradigm. There is, however, a sharp contrast between the number of studies applying the gap paradigm to clinical populations and the knowledge about the underlying developmental trajectory of the gap effect. The aim of the present study was, therefore, to investigate attentional disengagement in a group of children aged 9-15. Besides the typically deployed gap and the overlap conditions, we also added a baseline condition in which the fixation point was removed at the moment that the target appeared. This allowed us to reveal the appropriate experimental conditions to unravel possible developmental differences. Correlational analyses showed that the size of the gap effect became smaller with increasing age, but only for the difference between the gap and the overlap conditions. This shows that there is a gradual increase in the capacity to disengage visual attention with increasing age, but that this effect only becomes apparent when the gap and the overlap conditions are compared. The gradual decrease of the gap effect with increasing age provides additional evidence that the attentional system becomes more efficient with increasing age and that this is a gradual process.


Subject(s)
Adolescent Development/physiology , Attention/physiology , Eye Movements/physiology , Visual Perception/physiology , Adolescent , Age Factors , Child , Female , Humans , Male , Photic Stimulation , Reaction Time/physiology
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