ABSTRACT
DRLs 2020 has been revised, and Ka,r and PKA for each procedure have been set for IVR along with the reference fluoroscopic dose rate. The total dose of IVR includes fluoroscopic and digital acquisition (DA) doses, but in actual clinical practice, the ratio varies greatly depending on the procedure (diagnosis/treatment purpose and procedure content), and there are not many detailed data on the ratio. Therefore, we evaluated previous efforts that optimized radiation protection through examining dose for each procedure and the ratio of fluoroscopic and DA doses to total dose, and reviewing protocols. Since the ratio of fluoroscopy and DA dose differs depending on the procedure, it was suggested that the radiation dose exposed to patients can be optimized by sharing the dose information with physicians and constructing a protocol while considering the image quality for each procedure.
Subject(s)
Radiation Protection , Humans , Fluoroscopy , Radiation DosageABSTRACT
Mitochondria of the yeast Saccharomyces cerevisiae contain enzymes Crd1p and Psd1p, which synthesize cardiolipin (CL) and phosphatidylethanolamine respectively. A previous study indicated that crd1Δ is synthetically lethal with psd1Δ. In this study, to identify novel genes involved in CL metabolism, we searched for genes that genetically interact with Psd1p, and found that deletion of FMP30 encoding a mitochondrial inner membrane protein results in a synthetic growth defect with psd1Δ. Although fmp30Δ cells grew normally and exhibited a slightly decreased CL level, fmp30Δpsd1Δ cells exhibited a severe growth defect and an about 20-fold reduction in the CL level, as compared with the wild-type control. We found also that deletion of FMP30 caused a defect in mitochondrial morphology. Furthermore, FMP30 genetically interacted with seven mitochondrial morphology genes. These results indicated that Fmp30p is involved in the maintenance of mitochondrial morphology and required for the accumulation of a normal level of CL in the absence of mitochondrial phosphatidylethanolamine synthesis.