1.
Bioorg Med Chem Lett
; 8(15): 2045-50, 1998 Aug 04.
Article
in English
| MEDLINE
| ID: mdl-9873483
ABSTRACT
The synthesis and in vitro antibacterial activity of new derivatives and analogues of nematophin are described. It was shown that the unsubstituted amide NH-group is essential for bioactivity. Alkyl- or arylsubstitution at the 1-position results in a distinct increase of antibacterial activity. Addition of protein (blood or serum) to the culture media reduces the inhibitory activity on bacteria.