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Bioorg Med Chem Lett
; 11(3): 327-9, 2001 Feb 12.
Article
in English
| MEDLINE
| ID: mdl-11212102
ABSTRACT
Four Leu-enkephalin (Enk) analogues containing 2',6'-dimethyphenylalanine (Dmp) in position 4 were prepared and tested for their receptor binding and biological activities. Among the analogues prepared, [2', 6'-dimethyltyrosine, D-Dmp4]Enk was found to be an antagonist toward mu and delta opioid receptors with pA2 values of 6.90 and 5.57, respectively.