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1.
World Neurosurg ; 182: e400-e404, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38030073

ABSTRACT

OBJECTIVE: To evaluate the relationships between Doximity rankings (Doximity, Inc.) of residency programs and 2 new ranking systems based on publication rates and academic pursuits. METHODS: We collected data on 550 neurosurgery graduates over 3 years. We analyzed the median number of published manuscripts per resident and the percentage of residents pursuing academic careers and compared them across the Doximity Research Productivity and Reputation Rankings. We used logistic regression to evaluate the relationships among the rankings, publication rates, and academic pursuits. RESULTS: Neurosurgery residents published a median of 10 manuscripts per person (IQR: 6-17), and 50% (IQR: 33%-67%) of residents in a given program pursued an academic career. The distributions of the median number of published manuscripts across the Doximity Research Productivity Ranking and the Doximity Reputation Ranking tiers differed significantly (all P < 0.001). Similarly, the distribution of the percentage of residents pursuing an academic career across both published Doximity ranking systems' tiers differed significantly (all P = 0.02). Moreover, we found moderate agreement between the 2 Doximity rankings, fair agreement between the publication and the other 3 rankings, and slight agreement between the academic pursuit and the Doximity rankings. CONCLUSIONS: We introduced 2 new methods to rank residency programs based on the number of graduates pursuing an academic position and the median number of published manuscripts per resident. By taking a comprehensive approach, neurosurgery applicants can ensure that they select a residency program that meets their needs and offers them the best opportunity for success.


Subject(s)
Internship and Residency , Neurosurgery , Humans , Neurosurgery/education , Reproducibility of Results , Efficiency
2.
World Neurosurg ; 163: e384-e390, 2022 07.
Article in English | MEDLINE | ID: mdl-35390497

ABSTRACT

BACKGROUND: To describe the use of intraoperative anteroposterior long cassette radiographs (APLCRs) to guide kickstand rod application in adult spinal deformity. METHODS: A retrospective chart review was performed to identify patients with adult thoracolumbar and coronal plane deformity undergoing open segmental decompression with spinopelvic fixation and deformity correction between October 2017 and June 2019 who had APLCRs after rod placement. In patients with persistent intraoperative coronal deviations, a kickstand rod was placed. This supplemental rod was anchored to an iliac screw and to the construct via a pair of side-to-side connectors. A distractor was expended between a vice grip plyer on the kickstand and side-to-side connector to apply a lateralizing force to reduce the degree of deviation. RESULTS: Of 15 patients who underwent T3-ilium fusion with spinal deformity correction with intraoperative APLCRs, 7 underwent kickstand placement. Mean preoperative coronal deviation was similar between cohorts (4.3 cm vs. 2.2 cm, P = 0.09), but was greater intraoperatively in the kickstand cohort (4.3 cm vs. 0.6 cm, P < 0.001). Postoperative coronal deviation was similar between groups (2.1 cm vs. 1.8 cm, P = 0.37). Preoperative fractional lumbar curve was significantly greater in patients requiring a kickstand (23° vs. 35°, P = 0.02), but the major thoracolumbar curve was similar between groups (43° vs. 35°, P = 0.14). CONCLUSIONS: Intraoperative APLCRs can help guide application of a kickstand rod in adult thoracolumbar deformity correction. Patients with a greater fractional lumbar curve may derive greater benefit of kickstand usage, independent of major curve magnitude.


Subject(s)
Scoliosis , Spinal Fusion , Adult , Bone Screws , Humans , Ilium/surgery , Lumbar Vertebrae/diagnostic imaging , Lumbar Vertebrae/surgery , Radiography , Retrospective Studies , Scoliosis/surgery , Thoracic Vertebrae/diagnostic imaging , Thoracic Vertebrae/surgery , Treatment Outcome
3.
Front Neurol ; 12: 610434, 2021.
Article in English | MEDLINE | ID: mdl-33959086

ABSTRACT

Lack of blood flow to the brain, i.e., ischemic stroke, results in loss of nerve cells and therefore loss of function in the effected brain regions. There is no effective treatment to improve lost function except restoring blood flow within the first several hours. Rehabilitation strategies are widely used with limited success. The purpose of this study was to examine the effect of electrical stimulation on the impaired upper extremity to improve functional recovery after stroke. We developed a rodent model using an electrode cuff implant onto a single peripheral nerve (median nerve) of the paretic forelimb and applied daily electrical stimulation. The skilled forelimb reaching test was used to evaluate functional outcome after stroke and electrical stimulation. Anterograde axonal tracing from layer V pyramidal neurons with biotinylated dextran amine was done to evaluate the formation of new neuronal connections from the contralesional cortex to the deafferented spinal cord. Rats receiving electrical stimulation on the median nerve showed significant improvement in the skilled forelimb reaching test in comparison with stroke only and stroke with sham stimulation. Rats that received electrical stimulation also exhibited significant improvement in the latency to initiate adhesive removal from the impaired forelimb, indicating better sensory recovery. Furthermore, axonal tracing analysis showed a significant higher midline fiber crossing index in the cervical spinal cord of rats receiving electrical stimulation. Our results indicate that direct peripheral nerve stimulation leads to improved sensorimotor recovery in the stroke-impaired forelimb, and may be a useful approach to improve post-stroke deficits in human patients.

4.
Neurodiagn J ; 61(1): 2-10, 2021 Mar.
Article in English | MEDLINE | ID: mdl-33945449

ABSTRACT

Multimodal intraoperative neurophysiologic monitoring (IONM) can be utilized as an adjunct to lumbar spinal instrumentation in order to aid with avoidance of neurologic complications. The most commonly utilized modalities include somatosensory-evoked potentials, motor-evoked potentials, and electromyography. Somatosensory-evoked potentials (SSEPs) allow for continuous assessment of the dorsal columns of the spinal cord and are therefore most useful during procedures with a posterior approach to the cervical and thoracic spine. Motor-evoked potentials (MEPs) and electromyography (EMG) can be applied intermittently to assess motor nerve function. The utility of each individual modality can be largely dependent on the surgical approach. Approaches to lumbar spinal instrumentation can be generally categorized as anterior, lateral, and posterior. For lateral approaches, electromyography can be helpful in identifying neural structures crossing the surgical field to prevent injury. In posterior and anterior approaches, somatosensory-evoked potentials and motor-evoked potentials can be used to assess nerve injury during and after maneuvers for decompression and instrumentation. Additionally, during the placement of pedicle screws, direct stimulation with triggered electromyography can be used to detect the pedicle cortex's breach. The efficacy of intraoperative neuromonitoring is dependent on prompt and accurate recognition of changes in signals. This is then followed by accurate recognition of the cause for these changes and appropriate responses by the surgeon, anesthesiologist, and monitoring personnel to correct the change.


Subject(s)
Intraoperative Neurophysiological Monitoring , Spinal Fusion , Electromyography , Evoked Potentials, Motor , Evoked Potentials, Somatosensory , Humans , Neurosurgical Procedures , Spine
5.
Spine J ; 21(9): 1473-1478, 2021 09.
Article in English | MEDLINE | ID: mdl-33848689

ABSTRACT

BACKGROUND CONTEXT: C5 palsy is a well-known complication following cervical laminectomy, however the cause of this complication remains elusive, with many studies providing conflicting reports on prognosis and the impact of specific risk factors. PURPOSE: To describe the natural history of and risk factors for C5 palsy after first time cervical laminectomy involving C4 and/or C5, in a large series with a high rate of postoperative palsy. STUDY DESIGN/SETTING: This is a retrospective case series. PATIENT SAMPLE: Patients undergoing first time cervical laminectomy for degenerative spine pathologies at a single institution between January 2008 and July 2018. Adult patients were included if a complete laminectomy was performed at C4 or C5 for degenerative pathology and pre- and postoperative upright lateral x-rays were performed. OUTCOME MEASURES: The primary outcome measure was postoperative C5 palsy, defined as a decrease in strength of at least one point in deltoid and/or biceps within 30 days of operation. The secondary outcome measure was recovery of function. METHODS: A retrospective database of patients who underwent posterior cervical spine surgery was created and further focused by utilizing specific Common Procedural Technology (CPT) codes associated with our desired patient population. Patients were excluded from our study if they had inadequate pre- and postoperative imaging, as well as patients with a history of prior cervical spine surgery, concurrent anterior surgery, intradural pathology, spinal tumor, or spinal trauma. Patient history, surgical specifics, and neurologic function were recorded. RESULTS: A total of 190 patients were treated by 13 surgeons. 53 (27.9%) developed C5 palsy postoperatively. Of patients with C5 palsy, 40 (75.5%) recovered to baseline strength, 46 (86.6%) had at least grade 4 strength at last follow up, and 4 (7.5%) had strength worse than baseline and motor grade less than 4. Median time to recovery was 2.0 (IQR: 0.18 to 8.24) months. Age, gender, preoperative motor score, number of levels decompressed, smoking history, and comorbidities were not associated with a significant increase in the odds of C5 palsy. Risk of C5 palsy increased by 35% for every additional level fused below C4. CONCLUSION: The risk of C5 palsy is increased with instrumentation caudal to C5 in operations addressing degenerative cervical pathology. This should be taken into consideration during operative planning. Overall prognosis of C5 palsy is good; however, incidence of this condition may be greater than previously reported.


Subject(s)
Cervical Vertebrae , Laminectomy , Adult , Cervical Vertebrae/diagnostic imaging , Cervical Vertebrae/surgery , Decompression, Surgical , Humans , Laminectomy/adverse effects , Paralysis/epidemiology , Paralysis/etiology , Postoperative Complications/epidemiology , Postoperative Complications/etiology , Retrospective Studies
6.
World Neurosurg ; 141: e453-e460, 2020 09.
Article in English | MEDLINE | ID: mdl-32474094

ABSTRACT

BACKGROUND: Many treatment options for osteoporotic vertebral fractures are available. However, limited and variable findings have been reported on the efficacy of the individual therapies. The objective of the present study was to systematically review the reported data for evidence of efficacy of spinal orthoses for osteoporotic vertebral fractures. METHODS: A systematic review of the PubMed database was performed. Two reviewers evaluated the studies found for eligibility. Randomized controlled trails (RCTs) and prospective nonrandomized, prospective single-arm, and retrospective comparative studies of the treatment of acute osteoporotic vertebral fractures with spinal orthoses were included. RESULTS: A total of 16 studies were included: 5 RCTs, 6 nonrandomized prospective comparative studies, 1 retrospective case-control study, and 4 prospective single-arm studies. Of the 16 studies, 4 (3 single-arm studies and 1 nonrandomized study) provided low-quality evidence that bracing, with or without bedrest, was safe. Also, 1 nonrandomized and 1 single-arm study provided low-quality evidence that bracing improved pain and disability. In addition, 4 studies demonstrated that the use of a rigid brace was equivalent to the use of a soft brace or no brace (2 high-quality RCTs, 2 nonrandomized studies, 1 low-quality RCT). Two nonrandomized and one case-control study demonstrated a benefit of kyphoplasty compared with bracing alone (all low quality). Two RCTs had provided low-quality evidence that bracing was superior to no brace and one nonrandomized study provided low-quality evidence that a dynamic brace was superior to rigid orthosis. CONCLUSIONS: Limited evidence has suggested the safety of spinal orthoses for the treatment of osteoporotic compression fractures. At present, compelling evidence is not available to suggest that a rigid brace is superior to a soft brace or no brace. Kyphoplasty might be of benefit for select patients.


Subject(s)
Fractures, Compression/therapy , Osteoporotic Fractures/therapy , Spinal Fractures/therapy , Aged , Aged, 80 and over , Braces , Female , Humans , Male , Middle Aged
7.
J Neurosurg Spine ; : 1-7, 2020 Apr 24.
Article in English | MEDLINE | ID: mdl-32330888

ABSTRACT

OBJECTIVE: The authors conducted a study to determine whether a change in T1 tilt results in a compensatory change in the cervical sagittal vertical axis (SVA) in a cadaveric spine model. METHODS: Six fresh-frozen cadavers (occiput [C0]-T1) were cleaned of soft tissue and mounted on a customized test apparatus. A 5-kg mass was applied to simulate head weight. Infrared fiducials were used to track segmental motion. The occiput was constrained to maintain horizontal gaze, and the mounting platform was angled to change T1 tilt. The SVA was altered by translating the upper (occipital) platform in the anterior-posterior plane. Neutral SVA was defined by the lowest flexion-extension moment at T1 and recorded for each T1 tilt. Lordosis was measured at C0-C2, C2-7, and C0-C7. RESULTS: Neutral SVA was positively correlated with T1 tilt in all specimens. After increasing T1 tilt by a mean of 8.3° ± 2.2°, neutral SVA increased by 27.3 ± 18.6 mm. When T1 tilt was reduced by 6.7° ± 1.4°, neutral SVA decreased by a mean of 26.1 ± 17.6 mm.When T1 tilt was increased, overall (C0-C7) lordosis at the neutral SVA increased from 23.1° ± 2.6° to 32.2° ± 4.4° (p < 0.01). When the T1 tilt decreased, C0-C7 lordosis at the neutral SVA decreased to 15.6° ± 3.1° (p < 0.01). C0-C2 lordosis increased from 12.9° ± 9.3° to 29.1° ± 5.0° with increased T1 tilt and decreased to -4.3° ± 6.8° with decreased T1 tilt (p = 0.047 and p = 0.041, respectively). CONCLUSIONS: Neutral SVA is not a fixed property but, rather, is positively correlated with T1 tilt in all specimens. Overall lordosis and C0-C2 lordosis increased when T1 tilt was increased from baseline, and vice versa.

8.
Cureus ; 12(12): e12065, 2020 Dec 13.
Article in English | MEDLINE | ID: mdl-33489485

ABSTRACT

Objective The objective of the study is to identify specific population groups that may benefit from intraoperative motor evoked potentials (MEP) and to assess positive predictive value (PPV) and negative predictive value (NPV) changes during operation by correlating these with postoperative motor outcomes. Methods We retrospectively reviewed 1,043 consecutive patient cases undergoing spine surgery with and without intraoperative monitoring (IOM) at a single institution from January 1, 2016 to December 31, 2017. Demographic and clinical outcome data were collected at multiple time points. An MEP amplitude decrease of 50% or greater was correlated with a motor deficit for this study. Results On multivariate analysis, patients with coronary artery disease and who received IOM were more likely to experience no new deficit (p=0.047) than those who did not receive IOM. Additionally, patients with hyperlipidemia and coronary artery disease (CAD) were less likely than those without to experience no new deficit (p=0.001 and p=0.02, respectively). MEP accounted for 244 cases, of which 15 had alert MEP criteria but no deficit for a PPV of 21.05% at day 1 post-operation. Day 7-30 PPV declined to 14.29%, and by day 90, there was no association. Conclusion Among patients in our study with CAD, IOM use was associated with significantly better outcomes. Patients with higher intraoperative blood loss, hyperlipidemia, and those with CAD were at increased risk of new neurological deficit. The use of motor evoked potentials was associated with low sensitivity and low PPV.

9.
World Neurosurg ; 129: e754-e760, 2019 Sep.
Article in English | MEDLINE | ID: mdl-31203081

ABSTRACT

BACKGROUND: Evolving technologies and health care quality metrics have altered treatment algorithms for acoustic neuromas (ANs), increasing trends toward observation and radiosurgery, with proportionate declines in use of microsurgery. A correlation between increasing surgical volumes and superior outcomes has been investigated previously in numerous surgical diseases, including AN. OBJECTIVE: To re-evaluate the volume-outcome relationship of AN resection in a changing health care system, with evolving treatment strategies. METHODS: Patients who underwent AN resection between 2009 and 2013 were retrospectively identified in the State Inpatient Database subset of the Healthcare Cost and Utilization Project. Generalized linear mixed-effect models were used to assess odds of various outcome measures (length of stay [LOS], discharge disposition, and facial nerve or severe clinical complications). Institutions were grouped into low-volume centers (1-6 cases/year) and high-volume centers (HVC; ≥31 cases/year) for analysis. RESULTS: A total of 1873 patients underwent AN resection between 2009 and 2013 with a mean age of 50.1 ± 14.1 years (±standard deviation). For each additional case treated annually, patients were 2% (odds ratio [OR], 0.98; 95% confidence interval, 0.96-0.99) less likely to experience a severe complication (P = 0.004). Each additional case also trended toward a decreased rate of facial nerve complications and nonroutine discharge. Inpatient LOS was also shorter for patients at HVCs (median, 4 vs. 5 days; P < 0.001). CONCLUSIONS: Despite a relative decline in microsurgery compared with previous eras, care at HVCs is still associated with superior short-term outcomes, such as decreased LOS, facial nerve or other severe complications, and nonroutine discharges.


Subject(s)
Microsurgery , Neuroma, Acoustic/therapy , Radiosurgery , Adult , Aged , Databases, Factual , Delivery of Health Care , Female , Humans , Male , Middle Aged , Neuroma, Acoustic/radiotherapy , Neuroma, Acoustic/surgery , Outcome Assessment, Health Care , Treatment Outcome
10.
J Stroke Cerebrovasc Dis ; 28(7): e104-e105, 2019 Jul.
Article in English | MEDLINE | ID: mdl-31103550

ABSTRACT

Remote cerebellar hemorrhage is rare but potentially fatal complication of cranial and spinal surgeries. The pathophysiology of this condition following spinal surgery is thought to be related to venous bleeding from cerebellar sagging and cerebrospinal fluid (CSF) hypotension. Most reported cases in the literature following spinal surgery involve intraoperative CSF leakage. We present a case of remote cerebellar hemorrhage following uncomplicated lumbar spinal decompression and fusion without CSF leakage.


Subject(s)
Decompression, Surgical/adverse effects , Intracranial Hemorrhages/etiology , Spinal Fusion/adverse effects , Spinal Stenosis/surgery , Decompressive Craniectomy , Female , Humans , Intracranial Hemorrhages/diagnostic imaging , Intracranial Hemorrhages/surgery , Middle Aged , Spinal Stenosis/diagnosis , Tomography, X-Ray Computed , Treatment Outcome
11.
World Neurosurg ; 122: e512-e515, 2019 02.
Article in English | MEDLINE | ID: mdl-31060199

ABSTRACT

BACKGROUND: Postoperative ileus is not uncommon after spinal surgery. Although previous research has focused on the frequency of ileus formation, little has been done to investigate the clinical sequelae after development. We investigated the effect of postoperative ileus on patients' length of stay and rates of deep vein thrombosis (DVT) formation, myocardial infarction (MI), aspiration pneumonia, sepsis, and death. METHODS: The Healthcare Cost and Utilization Project National Inpatient Sample was queried to identify adult patients who underwent any spinal fusion procedure. Patient characteristics and outcomes for discharges involving spinal fusion surgery were compared between patients with and without postoperative ileus. The Rao-Scott χ2 test of association was used for categorical variables, and a t test for equality of means was used for continuous variables. Among discharges with postoperative ileus, a multivariate linear regression model was used to assess how fusion approach and fusion length were associated with length of hospital stay, controlling for sex, age, and race. RESULTS: A total of 250,221 patients were included. The mean length of stay was 3.75 days for patients without postoperative ileus and 9.40 days for patients with postoperative ileus. Patients with postoperative ileus are more likely to have DVT (4.1% vs. 20.8%, P < 0.001), MI (2.5% vs. 7.1%, P < 0.001), aspiration pneumonia (6.6% vs. 34.3%, P < 0.001), sepsis (5.7% vs. 35.7%, P < 0.001), and death (2.6% vs. 11.4%, P < 0.001). CONCLUSIONS: This study demonstrates that patients with postoperative ileus are significantly more likely to have DVT, experience MI, acquire aspiration pneumonia, develop sepsis, and die.


Subject(s)
Ileus/etiology , Spinal Fusion/adverse effects , Adolescent , Adult , Aged , Female , Hospital Mortality , Humans , Ileus/mortality , Length of Stay/statistics & numerical data , Male , Middle Aged , Myocardial Infarction/etiology , Myocardial Infarction/mortality , Pneumonia, Aspiration/etiology , Pneumonia, Aspiration/mortality , Postoperative Complications/etiology , Postoperative Complications/mortality , Retrospective Studies , Sepsis/etiology , Sepsis/mortality , Spinal Diseases/surgery , Spinal Fusion/methods , Spinal Fusion/mortality , Treatment Outcome , United States/epidemiology , Venous Thrombosis/etiology , Venous Thrombosis/mortality , Young Adult
12.
World Neurosurg ; 126: e181-e189, 2019 Jun.
Article in English | MEDLINE | ID: mdl-30797921

ABSTRACT

OBJECTIVE: Management of adolescent idiopathic scoliosis (AIS) in neurosurgery residency training may have a significant impact on resident experience, even though few trainees are likely to pursue careers in the field of AIS. The impact of this exposure on resident knowledge in adult spinal disease management is the subject of our retrospective analysis. METHODS: An analysis was performed of all adolescent patients undergoing surgical correction of spinal deformity between 2006 and 2016. Patient characteristics, including age at operation, Cobb angles, length of stay, operative time, blood loss, and complications, were collected. Objective benchmarks were created for resident education in the management of AIS. A survey was sent to the last 7 years of graduates to assess the impact of exposure to AIS during neurosurgery training on their current practice. RESULTS: Nine male and 37 female patients ages 11 to 22 years were identified. Neurosurgical residents assisted in all procedures without fellows or surgical assistants. Average operative time was 336 minutes (range, 215-575 minutes), and blood loss per procedure was 603 mL (range, 200-4000 mL). The average Cobb angle correction was 72.2% (range, 35.3%-90.9%). Zero of the past 7 graduates currently treat AIS surgically. All 7 graduates agreed that exposure to AIS during residency enhanced their knowledge of adult spinal disease management. CONCLUSIONS: Treatment of AIS by surgeons with specialized training can be effective and safe. Resident exposure to these patients enhances their understanding of spinal biomechanics and deformity correction, which is applicable to treating AIS and adult spinal deformity.


Subject(s)
Neurosurgical Procedures/education , Neurosurgical Procedures/methods , Scoliosis/surgery , Adolescent , Age Factors , Blood Loss, Surgical , Child , Female , Humans , Internship and Residency , Length of Stay , Male , Operative Time , Postoperative Care , Postoperative Complications/epidemiology , Retrospective Studies , Scoliosis/diagnostic imaging , Spinal Fusion/methods , Treatment Outcome , Young Adult
13.
World Neurosurg ; 126: e125-e135, 2019 Jun.
Article in English | MEDLINE | ID: mdl-30790735

ABSTRACT

BACKGROUND: Atlantoaxial instability (AAI) is a common cause of neurologic dysfunction and pain in patients with Down syndrome (DS), frequently requiring instrumented fusion of the upper cervical spine. Despite this, optimal treatment strategy is controversial. METHODS: A systematic review of the literature was performed according to the Preferred Reporting Items for Systemic Reviews and Meta-Analysis statement to identify patients with AAI and DS were treated with upper cervical spine fusion. Patient demographics, preoperative symptoms, fixation type, and outcome measures including complications, neurologic outcomes, and bony fusion status were gathered for patients in the included publications. Meta-analysis was performed to compare outcomes of different types of fixation constructs. RESULTS: Of the 1191 publications retrieved, 51 met inclusion criteria, yielding 137 patients. Six fixation strategies were identified: noninstrumented (n = 6), wiring (n = 77), wiring with rods (n = 14), screw fixation (n = 33), hook and rod fixation (n = 2), and screw and wire fixation (n = 5). Constructs with screws and rods had greater bony union (P = 0.003) and a lower rate of revision surgery (P = 0.047), loss of reduction or pseudoarthrosis (P = 0.009), halo utilization (P < 0.001), and early neurologic decline (P = 0.004) compared with wiring alone. Constructs with wires and rods had greater bony union (P = 0.036) than wiring alone. CONCLUSIONS: Numerous fixation strategies exist for AAI in patients with DS. Using a combination of screws, rods, and wiring in appropriately selected patients may help reduce the high rate of surgical complications in these patients.


Subject(s)
Atlanto-Axial Joint/surgery , Down Syndrome/complications , Joint Instability/complications , Joint Instability/surgery , Neurosurgical Procedures/methods , Orthopedic Procedures/methods , Humans , Internal Fixators , Treatment Outcome
14.
J Neurosurg Spine ; 30(2): 175-181, 2018 11 23.
Article in English | MEDLINE | ID: mdl-30497148

ABSTRACT

OBJECTIVEAtlantoaxial instability is an important cause of pain and neurological dysfunction in patients with Down syndrome (DS), frequently requiring instrumented fusion of the upper cervical spine. This study provides a quantitative analysis of C2 morphology in DS patients compared with their peers without DS to identify differences that must be considered for the safe placement of instrumentation.METHODSA retrospective chart review identified age-matched patients with and without DS with a CT scan of the cervical spine. Three-dimensional reconstructions of these scans were made with images along the axis of, and perpendicular to, the pars, lamina, facet, and transverse foramen of C2 bilaterally. Two of the authors performed independent measurements of anatomical structures using these images, and the average of the 2 raters' measurements was recorded. Pedicle height and width; pars axis length (the distance from the facet to the anterior vertebral body through the pars); pars rostrocaudal angle (angle of the pars axis length to the endplate of C2); pars axial angle (angle of the pars axis length to the median coronal plane); lamina height, length, and width; lamina angle (angle of the lamina length to the median coronal plane); and transverse foramen posterior distance (the distance from the posterior wall of the transverse foramen to the tangent of the posterior vertebral body) were measured bilaterally. Patients with and without DS were compared using a mixed-effects model accounting for patient height.RESULTSA total of 18 patients with and 20 patients without DS were included in the analysis. The groups were matched based on age and sex. The median height was 147 cm (IQR 142-160 cm) in the DS group and 165 cm (IQR 161-172 cm) in the non-DS group (p < 0.001). After accounting for variations in height, the mean pars rostrocaudal angle was greater (50.86° vs 45.54°, p = 0.004), the mean transverse foramen posterior distance was less (-1.5 mm vs +1.3 mm, p = 0.001), and the mean lamina width was less (6.2 mm vs 7.7 mm, p = 0.038) in patients with DS.CONCLUSIONSPatients with DS had a steeper rostrocaudal trajectory of the pars, a more posteriorly positioned transverse foramen posterior wall, and a narrower lamina compared with age- and sex-matched peers. These variations should be considered during surgical planning, as they may have implications to safe placement of instrumentation.


Subject(s)
Cervical Vertebrae/pathology , Cervical Vertebrae/surgery , Down Syndrome , Age Distribution , Bone Screws , Female , Humans , Male , Middle Aged , Retrospective Studies , Sex Factors , Spinal Fusion/methods , Tomography, X-Ray Computed/methods
15.
World Neurosurg ; 120: e194-e202, 2018 Dec.
Article in English | MEDLINE | ID: mdl-30114540

ABSTRACT

BACKGROUND: Pseudoarthrosis after spinal fusion is an important cause of pain, neurologic decline, and reoperation. METHODS: The Healthcare Cost and Utilization Project State Inpatient Databases were queried in New York, California, Florida, and Washington for adult patients who had undergone new spinal fusion from 2009 to 2011. In accordance with the Healthcare Cost and Utilization Project methods series and analysis guidelines, generalized linear mixed effects models were used to estimate the odds of experiencing postoperative pseudoarthrosis as a function of multivariable patient characteristics, comorbidities, and surgical approach. RESULTS: Of the 107,420 patients who had undergone cervical fusion, 1295 (1.2%) developed pseudoarthrosis requiring reoperation. On multivariable analysis, the risk factors included posterior (odds ratio [OR], 4.47; 95% confidence interval [CI], 3.92-5.10) and combined (OR, 1.77; 95% CI, 1.33-2.36) approaches, fusion of ≥9 vertebrae (OR, 2.54; 95% CI, 1.38-4.68), smoking (OR, 1.19; 95% CI, 1.05-1.34), and long-term steroid use (OR, 1.89; 95% CI, 1.18-3.00). Of the 148,081 patients who underwent thoracic or lumbar fusion, 2665 (1.8%) developed pseudoarthrosis. Posterior (OR, 0.58; 95% CI, 0.51-0.56) and combined (OR, 0.46; 95% CI, 0.40-0.54) approaches resulted in reduced rates. Fusion of 4-8 vertebrae (OR, 1.52; 95% CI, 1.39-1.67), ≥9 vertebrae (OR, 1.87; 95% CI, 1.49-2.34), hypertension (OR, 1.18; 95% CI, 1.09-1.28), sleep apnea (OR, 1.48; 95% CI, 1.26-1.72), smoking (OR, 1.22; 95% CI, 1.12-1.33), and long-term steroid use (OR, 1.53, 95% CI, 1.08-2.18) resulted in increased rates. CONCLUSIONS: These findings strongly associate several diagnoses with the development of pseudoarthrosis. However, further prospective studies are warranted to establish causation.


Subject(s)
Adrenal Cortex Hormones/therapeutic use , Hypertension/epidemiology , Lumbar Vertebrae/surgery , Postoperative Complications/epidemiology , Pseudarthrosis/epidemiology , Sleep Apnea Syndromes/epidemiology , Smoking/epidemiology , Spinal Fusion/methods , Thoracic Vertebrae/surgery , Adult , Age Factors , Aged , Databases, Factual , Female , Humans , Linear Models , Male , Middle Aged , Multivariate Analysis , Odds Ratio , Risk Factors
17.
J Child Neurol ; 32(10): 871-875, 2017 Sep.
Article in English | MEDLINE | ID: mdl-28604158

ABSTRACT

Dystonia is a movement disorder characterized by involuntary muscle contractions, which cause twisting movements or abnormal postures. Deep brain stimulation has been used to improve the quality of life for secondary dystonia caused by cerebral palsy. Despite being a viable treatment option for childhood dystonic cerebral palsy, deep brain stimulation is associated with a high rate of infection in children. The authors present a small series of patients with dystonic cerebral palsy who underwent a stepwise approach for bilateral globus pallidus interna deep brain stimulation placement in order to decrease the rate of infection. Four children with dystonic cerebral palsy who underwent a total of 13 surgical procedures (electrode and battery placement) were identified via a retrospective review. There were zero postoperative infections. Using a multistaged surgical plan for pediatric patients with dystonic cerebral palsy undergoing deep brain stimulation may help to reduce the risk of infection.


Subject(s)
Cerebral Palsy/surgery , Deep Brain Stimulation , Dystonia/surgery , Globus Pallidus/surgery , Neurosurgical Procedures , Cerebral Palsy/complications , Cerebral Palsy/physiopathology , Child , Deep Brain Stimulation/methods , Dystonia/etiology , Dystonia/physiopathology , Female , Humans , Male , Neurosurgical Procedures/methods , Retrospective Studies , Surgical Wound Infection/prevention & control
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