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Objective@#To construct and implement a calculation model of clinical nursing post classification.@*Methods@#Between October to December 2018, head nurses of the hospital were screened as consultants, and Delphi method was used to determine the indicators, while the weights were assigned from the aspects of nursing workload, work quality, patient satisfaction and number of nursing night shifts. Combined with HIS data, the calculation model of clinical nursing post classification was constructed to classify clinical nursing units into different categories and levels.@*Results@#After two rounds of expert enquiry, 82 nursing work items were identified and the objective weight assignment was determined ranging from 0.80 to16.14. According to the established calculation model and HIS data, nursing posts in clinical departments were classified into 6 levels and 3 categories, and the accurate management of clinical nursing post classification was achieved.@*Conclusions@#The construction of a calculation model is scientific and rigorous, which provides a scientific basis for dynamic nurse performance management and rational allocation of human resources. In addition, it provides a useful reference for accurate nursing management.
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Objective To study the effect of ventolin combined with pulmicort in the treatment of children with asthma and its influence on inflammatory cytokines .Methods 100 children with asthma were randomly divided into observation group(50 cases) and control group(50 cases) according to the digital table.The control group was given pulmicort treatment ,the observation group was given 0.5％ ventolin combined with pulmicort .The course of treatment was 3-5 days.The remission time,the levels of inflammatory cytokines (IL-17 and TGF ) and adverse reactions were compared between the two groups .Results After treatment,the VC,FVC and PEFC of the observation group were significantly better than those of the control group ,the differences were statistically significant (t=2.412, 9.806,3.922,all P<0.05).The remission time of clinical symptoms of the observation group was better than those of the control group(t=5.182,4.576,4.166,5.761,all P<0.05 ).There was no statistically significant difference in the side effects between the two groups (18.00％vs.16.00％,χ2 =2.153,P>0.05).The levels of IL-6 and TGF in the observation group were lower than those in the control group (t =8.234,25.075,all P <0.05). Conclusion Ventolin combined with pulmicort in the treatment of children with asthma can effectively relieve clinical symptoms,reduce the inflammatory cytokines ,improve pulmonary function ,so it is worthy of further clinical application .
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Objective To investigate the clinical effects and the degree of satisfaction of areola margin small incision and conventional incision in the treatment of patients with benign tumor of mammary glands. Methods 338 patients were selected and randomly divided into the observation group and the control group according to the digital table,169 patients in each group. The clinical effects and the degree of satisfaction of the patients were compared. Results Compared with the control group, the operation time was slightly longer in the observation group[(26. 2 ± 4. 8) min vs. (24. 5 ± 3. 7) min,t =13. 178,P =0. 000];The incidence rate of postoperative complications was significantly reduced (2. 37% vs. 34. 55%,χ2 =57. 911,P=0. 000);The scar score wassignificantlylower[(1.11±0.47)pointsvs.(4.14±0.45)points,t= -60.387,P=0.000];Thepostoperative satisfaction rate was significantly higher (98. 82% vs. 62. 13%,χ2 =72. 379,P =0. 000). Conclusion Areola margin small incision has high degree of satisfaction and small scar,provides safe and reliable effect in treatment of benign tumor of mammary glands. This method can be suitable for popularization and application in clinic.
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Objective To investigate the clinical effects and the degree of satisfaction of areola margin small incision and conventional incision in the treatment of patients with benign tumor of mammary glands. Methods 338 patients were selected and randomly divided into the observation group and the control group according to the digital table,169 patients in each group. The clinical effects and the degree of satisfaction of the patients were compared. Results Compared with the control group, the operation time was slightly longer in the observation group[(26. 2 ± 4. 8) min vs. (24. 5 ± 3. 7) min,t =13. 178,P =0. 000];The incidence rate of postoperative complications was significantly reduced (2. 37% vs. 34. 55%,χ2 =57. 911,P=0. 000);The scar score wassignificantlylower[(1.11±0.47)pointsvs.(4.14±0.45)points,t= -60.387,P=0.000];Thepostoperative satisfaction rate was significantly higher (98. 82% vs. 62. 13%,χ2 =72. 379,P =0. 000). Conclusion Areola margin small incision has high degree of satisfaction and small scar,provides safe and reliable effect in treatment of benign tumor of mammary glands. This method can be suitable for popularization and application in clinic.
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Objective:To discuss the curative effect of bifid triple viable capsules in the patients after laparoscopic cholecystecto-my ( LC) . Methods:Totally 100 cases of patients with LC were selected and divided into the observation group and the control group at random. The patients in the two groups underwent LC under the general anesthesia, and were given routine medical treatment after the operation. The patients in the observation group were additionally given bifid triple viable capsules, 630mg per time, twice a day for 1 week as the treatment course. The changes in the occurrence of diarrhea, alteration of intestinal flora and plasma D-lactic acid of the patients and drug adverse reactions in the two groups were observed and compared after the medical treatment. Results:One week after the operation, the occurrence of diarrhea and alteration of intestinal flora of the patients in the observation group were lower than those in the control group (P0. 05). Conclusion: The application of bifid triple viable capsules in the pa-tients after LC can effectively reduce the plasma D-lactic acid levels, occurrence of diarrhea and alteration of intestinal flora with prom-ising security, which is good for the postoperative recovery of the patients.
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Objective To discuss curative effect of Octreotide on early inflammatory intestinal obstruction after abdomi-nal operation and its influence on serum LPS and High sensitive C-reactive protein (hs-CRP) levels. Methods All 64 cases of patients with early inflammatory intestinal obstruction after abdominal operation were selected and divided into observation group (n=32) and control group (n=32) at random. The patients in two groups were given routine medical treatment, such like fasting, instant gastrointestinal decompression, anti-infection, intravenous nutrition,maintenance of water-electrolyte and acid-base balance and etc. The patients in observation group were additionally given 0.1mg Octreotide by hypodermic injection,q8h,while the patients in control group were given the same medical treatment as that in observation group except for Octreotide. The changes of serum LPS and hs-CRP levels of patients in two groups before and 6 days after the medical treatment,and the curative effect and untoward effect was compared as well. Results After 6 days' medical treatment, serum LPS and hs-CRP levels of patients in two groups were obvi-ously declined than before(P<0.05 or P<0.01),and the declining rate of patients in observation group was much higher than that in control group (P<0.05), and the total clinical efficiency in observation group (93.75%) was much higher than that in control group (75.00%)(χ2=4.27,P<0.05). 1 and 3 cases of untoward effect were appeared on patients in control group and observation group during treatment with light symptom, and after comparing the occurrence rates of untoward effect of patients in two groups,no differences were appeared(χ2=0.27,P>0.05). Conclusion Octreotide has reliable curative effect on early inflammatory intestinal obstruction after abdominal operation with high security, whose mechanism of action has close effect on obvious reducing serum LPS and hs-CRP levels of patients.
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Long non-coding RNAs (lncRNAs) are a group of endogenous RNA molecules which exceed 200 nt in length, lack complete specific open reading frame, and completely lack or possessvery limited protein-coding capacity. Recent studies have revealed that lncRNAs participate in critical processes such as genomic imprinting, cell differentiation, and immune reaction, etc. lncRNAs regulate gene expression at the epigenetic, transcriptional and post-transcriptional levels by modulating chromatin remodeling and histone modifications, interfering the transcription, regulating patterns of alternative splicing, generating small RNAs, and modulating protein activation and localization. Through their numerous functions, lncRNAs play critical roles in the growth, development, senescence, death, and other important physiological and pathological processes. Further investigation into the regulation of gene expression mediated by lncRNAs will be of great value in the thorough understanding of pathogenies and provide new molecular markers and drug targets of diseases.
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Alternative Splicing , Chromatin Assembly and Disassembly , Gene Expression , Open Reading Frames , Proteins , RNA, Long NoncodingABSTRACT
Objective To study the clinical effect of pedicle screw fixation in treatment of unstable upper and middle thoracic vertebrae fractures. Methods A retrospective study was performed on 17 cases of unstable upper and middle thoracic vertebrae fractures treated with vertebral pedicle screw system (GSS 全称in 11 cases and USS 全称in six) fixation, posterolateral bone grafting and fusion from March 2001 on. There were one case of T_3, two T_4, two T_5, four T_6, six T_7 and two T_8. Of all, nine cases were with compression fractures, five with fracture-dislocation and three with burst fractures. Results All cases were followed up for 10-38 months (average 21.1 months). During the follow up, the anterior vertebral body height was restored from preoperative 40% to postoperative 91%. Except for four screw malpositions, there was no postoperative neurologic deterioration, screw loose or breakage of the internal fixation, or loss of the normal spine curve and the spinal height of the injured vertebra. Conclusions Pedicle screw fixation is an effective way for treating unstable upper and middle thoracic vertebrae fractures. Correct placement depend on a comprehensive familiarity of pedicle anatomy, appropriate pedicle diameter and entry point and depth can avoid potential risks in placing pedicle screws into the upper and middle thorax.