ABSTRACT
OBJECTIVE: This study aimed to measure changes in disease-specific quality of life in children following tonsillectomy or adenotonsillectomy. METHODS: A multicentre prospective cohort study was performed involving seven ENT departments in England. A total of 276 children entered the study over a 2-month period: 107 underwent tonsillectomy and 128 adenotonsillectomy. Forty-one children referred with throat problems initially managed by watchful waiting were also recruited. The follow-up period was 12 months. Outcome measures were the T14, parental impressions of their child's quality of life and the number of days absent from school. RESULTS: One-year follow-up data were obtained from 150 patients (52 per cent). The mean baseline T14 score in the non-surgical group was significantly lower (T14 = 23) than in the tonsillectomy group (T14 = 31) or the adenotonsillectomy group (T14 = 35; p < 0.001). There was a significant improvement in the T14 scores of responders in all groups at follow up. The effect size was 1.3 standard deviations (SD) for the non-surgical group, 2.1 SD for the tonsillectomy group and 1.9 SD for the adenotonsillectomy group. Between-group differences did not reach statistical significance. A third of children in the non-surgical group underwent surgery during the follow-up period. CONCLUSION: Children who underwent surgical intervention achieved a significant improvement in disease-specific quality of life. Less severely affected children were managed conservatively and also improved over 12 months, but 1 in 3 crossed over to surgical intervention.
Subject(s)
Adenoidectomy , Health Status , Quality of Life , Sleep Apnea Syndromes/surgery , Tonsillectomy , Tonsillitis/surgery , Adolescent , Child , Child, Preschool , Cohort Studies , England , Female , Humans , Infant , Infant, Newborn , Male , Pharyngeal Diseases/surgery , Prospective Studies , Recurrence , Watchful WaitingABSTRACT
OBJECTIVE: We present the case of a rare cause of epistaxis in a paediatric patient, together with the diagnostic and management challenges associated with this condition. CASE REPORT: A previously well nine-year-old boy presented with a six-month history of intermittent unilateral epistaxis. Radiological investigation and endoscopic biopsy confirmed a highly malignant nasopharyngeal mass consistent with carcinoma. The tumour continued to grow rapidly. Whilst awaiting intervention, the patient experienced a further significant haemorrhage requiring surgical intervention. CONCLUSION: Nasopharyngeal carcinoma is a rare cause of epistaxis amongst children in the UK. Early flexible nasendoscopy can help delineate both benign and sinister causes of symptoms in this region.
Subject(s)
Epistaxis/diagnosis , Nasopharyngeal Neoplasms/diagnosis , Nasopharynx/pathology , Carcinoma , Child , Diagnosis, Differential , Epistaxis/diagnostic imaging , Epistaxis/pathology , Humans , Male , Nasopharyngeal Carcinoma , Nasopharyngeal Neoplasms/physiopathology , Radiography , RecurrenceABSTRACT
OBJECTIVES: We modified and abbreviated a pre-existing research questionnaire, the Tonsil and Adenoid Health Status Instrument, to make it suitable for rapid completion as a disease-specific, health-related quality of life research tool for children with tonsil and adenoid disease in the UK. We determined the main psychometric properties of the resulting 14-item Paediatric Throat Disorders Outcome Test. DESIGN, SETTING AND PARTICIPANTS: Pre- and post-operative questionnaires were completed by the parents of children with throat disorders referred to two large hospitals. We included children with recurrent tonsillitis and with obstructive sleep apnoea. A separate cohort of healthy children of comparable age range was also studied. MAIN OUTCOME MEASURES: The test's internal consistency and responsiveness were analysed and its construct validity documented via known-group differences. RESULTS: A total of 126 completed questionnaires were received from the hospital referral group. The children's mean age was 6.5 years (range one to 16). The 40 unaffected children were well matched in age to the study population (mean 6.1 years, range two to 15). Cronbach's alpha coefficient for the pre-operative assessment total score was 0.84. The test-retest reliability coefficient for the total score was 0.98, indicating very high reproducibility. The 14-item Paediatric Throat Disorders Outcome Test discriminated well between children known to suffer with throat problems and a group of healthy controls (p < 0.0001; t = 24.016). Six months after surgical intervention, parentally reported questionnaire scores had improved (i.e. were lower) (p < 0.0001; t = 7.01). The standard effect size (i.e. change in mean divided by baseline standard deviation) for children for whom post-operative questionnaires were completed was 1.53; this is very large. CONCLUSIONS: The 14-item Paediatric Throat Disorders Outcome Test is an appropriate, disease-specific, parent-reported outcome measure for children with throat disorders, for which we have demonstrated internal consistency, reliability, responsiveness to change and two forms of construct validity.
Subject(s)
Outcome Assessment, Health Care/standards , Surveys and Questionnaires , Tonsillectomy/statistics & numerical data , Tonsillitis/surgery , Adenoidectomy/statistics & numerical data , Adenoids , Adolescent , Child , Child, Preschool , Health Status Indicators , Humans , Infant , Parents , Psychometrics , Quality of Life , Recurrence , Severity of Illness Index , Sleep Apnea, Obstructive/etiology , Statistics as Topic , Tonsillitis/complications , United KingdomABSTRACT
INTRODUCTION: Embryological remnants of third or fourth branchial pouches are a rare but important cause of recurrent neck abscesses in children. They are characterised by an internal opening in the piriform fossa. Traditional management involves surgical excision of the entire tract. We present our experience with the use of monopolar diathermy applied to the internal sinus opening as a treatment modality for this condition. MATERIALS AND METHODS: A retrospective, case report review was performed. RESULTS: Four cases of piriform fossa sinus were treated with monopolar diathermy to the sinus opening via an endoscopic approach. The first three cases were treated in this way for recurrence, following external tract excision, while the fourth case had simultaneous excision of the tract and diathermy to the piriform fossa opening. There were no serious complications and no recurrence within a follow-up period ranging from nine to 27 months. DISCUSSION: Obliteration of the internal opening of these sinuses by endoscopic diathermy is a safe and effective management option for this condition, either as an alternative to or as an adjunct to external surgical excision of the tract.
Subject(s)
Abscess/therapy , Branchial Region/abnormalities , Diathermy/methods , Neck , Abscess/surgery , Branchial Region/surgery , Child , Endoscopy , Female , Humans , Infant , Male , Recurrence , Treatment OutcomeABSTRACT
OBJECTIVE: Epidermolysis Bullosa encompasses a group of inherited disorders characterized by excessive susceptibility of the skin and mucosa to separate from underlying tissues following mechanical trauma. Information in the literature and guidance on the management of Ear, Nose and Throat problems in such children is scarce. The aim of this study is to report the experience of an Ear, Nose and Throat department in a tertiary paediatric hospital linked to a national Epidermolysis Bullosa unit, describing how children have presented and the care that has been given including a theatre protocol aimed at reducing shearing forces. METHODS: Retrospective case note review of Epidermolysis Bullosa patients referred to Otolaryngology over an 8-year period. RESULTS: Reviewing notes of 307 EB patients identified 15 that had been referred to the ENT department. Four children with middle ear effusions were effectively treated by watchful waiting or grommets. Three children with otitis externa had some relief from careful microsuction but reinfection from ulcers on other parts of the children's bodies tended to occur. One child with profound sensorineural hearing loss benefited from cochlear implantation but later passed away from unrelated sepsis. One child with intrinsic rhinitis was treated with steroid and then a salt-water nasal spray. Five children had nasal crusting documented, although this was not a specific reason for referral. When severe this had been treated with topical steroids by the dermatology team. One patient with obstructive sleep aponea had tonsillectomy and examination of the post-nasal space. Of the five patients referred with glottic or supraglottic scarring, the management of four included a tracheostomy. When carried out tracheostomy sites healed well in each case. With repeated endoscopic procedures it was subsequently possible to remove the tracheostomy in the two of the children. Using a special theatre protocol no new ulcers were recorded as being precipitated by any of the procedures children underwent. CONCLUSIONS: Optimal management depends on the support of a multidisciplinary team, including otolaryngologists, pediatricians, dermatologists, anaesthetists, and specialist nurses. Adherence to a protocol for theatre management can help avoid intraoperative complications.
Subject(s)
Anti-Inflammatory Agents/therapeutic use , Epidermolysis Bullosa/drug therapy , Epidermolysis Bullosa/epidemiology , Otorhinolaryngologic Diseases/epidemiology , Otorhinolaryngologic Diseases/therapy , Rhinitis/drug therapy , Rhinitis/epidemiology , Adolescent , Child , Child, Preschool , Dermatology/methods , Female , Hearing Loss, Sensorineural/epidemiology , Hearing Loss, Sensorineural/surgery , Humans , Laryngostenosis/epidemiology , Laryngostenosis/surgery , Male , Otitis Externa/epidemiology , Otitis Externa/therapy , Otitis Media with Effusion/epidemiology , Otitis Media with Effusion/therapy , Otolaryngology/methods , Otorhinolaryngologic Diseases/drug therapy , Patient Care Team , Retrospective Studies , Sleep Apnea, Obstructive/epidemiology , Sleep Apnea, Obstructive/surgery , TonsillectomyABSTRACT
BACKGROUND: Oral antihistamines are recommended by a World Health Organisation working group as a first-line pharmacological treatment in mild persistent allergic rhinitis. There is, however, uncertainty with respect to their effectiveness for a common symptom, that of nasal obstruction. OBJECTIVE: To test the null hypothesis that oral antihistamines have no effect on the symptom of nasal obstruction in a clinical setting in patients with persistent allergic rhinitis. METHODS: Protocol based review of double-blind randomized controlled trials of oral antihistamine (i.e. drugs considered to act as a histamine receptor type-1 antagonist) vs. placebo. A search was carried out for published and unpublished trials. Individuals had to be age 12 years or older (with a diagnosis confirmed by skin prick tests, IgE blood tests or nasal allergen challenge), experiencing their normal allergen exposure. A symptom score for nasal obstruction had to be recorded. Predetermined quality criteria were applied. Treating their data as 4-point scores, a meta-analysis was carried out for studies, which provided enough data to be pooled. RESULTS: Meta-analysis found a weighted mean difference of -0.52 in favour of treatment for patient-assessed symptom scores (95% confidence interval (CI)-0.73,-0.31, P<0.00001), and of -0.33 in favour of treatment for healthcare worker assessed scores (95% CI -0.49, -0.16, P = 0.0001). CONCLUSION: Oral antihistamines cause statistically significant improvement in the symptom of nasal obstruction in patients with persistent allergic rhinitis.
Subject(s)
Histamine H1 Antagonists/administration & dosage , Nasal Obstruction/drug therapy , Rhinitis, Allergic, Perennial/drug therapy , Administration, Oral , Adolescent , Adult , Double-Blind Method , Histamine H1 Antagonists/therapeutic use , Humans , Middle Aged , Nasal Obstruction/immunology , Patient Selection , Randomized Controlled Trials as Topic , Rhinitis, Allergic, Perennial/complications , Treatment OutcomeABSTRACT
Lower oesophageal foreign body meat bolus obstruction is potentially life-threatening. We report a case in a 94-year-old woman in which conservative measures and flexible oesophagoscopy were unsuccessful. Rigid oesophagoscopy was considered technically difficult and so clearance by interventional radiology was attempted. Through the mouth a radiologically guided balloon catheter was introduced. It was passed beyond the bolus to dilate the site of obstruction, before being withdrawn and inflated above the bolus, pushing it into the stomach. Although successful in this case, the technique is previously unreported and so its complication rate is unknown. It is therefore presented only to be considered when other treatments are neither effective nor possible.
Subject(s)
Catheterization/methods , Esophagus , Foreign Bodies/therapy , Aged , Aged, 80 and over , Endoscopy, Gastrointestinal , Female , HumansABSTRACT
The NHS Cancer Plan sets out targets for the diagnosis and treatment of cancer. Ideally, there should be a maximum of a 2-week wait from a referral for suspected cancer to an outpatient appointment. A fast track referral system has been established nationally, with general practitioners given guidelines as to appropriate referrals. In the South Essex region, we audited all such referrals using this system for a 12-month period and also all new patients diagnosed with head and neck cancer during the same period. We found that 71% of patients diagnosed with cancer were not referred using the fast track system and that only 15% of patients who were referred by the fast track system were subsequently found to have cancer. For patients with cancer who were referred using standard letters, the time from referral to initial consultation was generally much longer than the recommended period of 2 weeks. We conclude that improvements in utilizing the fast track system need to be made if it is to bring about an improvement in early diagnosis of head and neck cancer. As things stand, it may actually be detrimental for most cancer patients.
Subject(s)
Ambulatory Care , Head and Neck Neoplasms/diagnosis , Referral and Consultation , Early Diagnosis , Humans , Medical Audit , Reproducibility of Results , Time Factors , United KingdomABSTRACT
Epithelial-myoepithelial carcinoma (EMC) is a rare biphasic tumour of the salivary glands typically arising in the parotid. Fine needle aspiration cytology is widely used in the initial investigation of salivary gland swellings and whilst the cytological features of this tumour have been described they are not well recognized. This report describes the clinicopathological features of a case of epithelial-myoepithelial carcinoma of the parotid gland and highlights the importance of awareness of this tumour in the differential diagnosis of biphasic tumours on fine needle aspiration cytology.
Subject(s)
Carcinoma/pathology , Myoepithelioma/pathology , Parotid Neoplasms/pathology , Biopsy, Needle/methods , Carcinoma/diagnosis , Carcinoma/surgery , Diagnosis, Differential , Epithelial Cells/pathology , Female , Humans , Middle Aged , Myoepithelioma/diagnosis , Myoepithelioma/surgery , Parotid Neoplasms/diagnosis , Parotid Neoplasms/surgery , Tomography, X-Ray Computed/methodsABSTRACT
We report a case of Pott's puffy tumour in a 12-year-old. Owing to the late development of the frontal sinuses, frontal sinus infection in children is rare. When present it can lead to osteomyelitis associated with forehead swelling. Early diagnosis and active treatment prevent progression to life-threatening intracranial spread.
Subject(s)
Edema/etiology , Frontal Sinusitis/complications , Child , Edema/diagnostic imaging , Female , Forehead , Humans , Osteomyelitis/diagnostic imaging , Osteomyelitis/etiology , Tomography, X-Ray ComputedSubject(s)
Adenocarcinoma, Follicular/pathology , Mucins/metabolism , Thyroid Neoplasms/pathology , Adenocarcinoma, Follicular/metabolism , Adenocarcinoma, Follicular/surgery , Biomarkers, Tumor/metabolism , Biopsy, Needle , Calcitonin/metabolism , Humans , Immunohistochemistry , Lymph Nodes/pathology , Lymphatic Metastasis/pathology , Male , Middle Aged , Neoplasm Proteins/metabolism , Reproducibility of Results , Thyroid Neoplasms/metabolism , Thyroid Neoplasms/surgeryABSTRACT
Langerhans' cell histiocytosis is a rare disorder of unknown aetiology in which pathological Langerhans' cells accumulate and destroy local tissue. We report a 38-year-old female who presented with a sudden onset of left sensorineural hearing loss. Magnetic resonance imaging (MRI) revealed a contrast-enhancing lesion in the left mastoid and a second lesion in the hypothalamus. Following left mastoid exploration and biopsy a definitive diagnosis of Langerhans' cell histiocytosis was made and the patient was treated with external beam radiotherapy. Subsequent right femur and right mastoid involvement were successfully treated with steroids and cytotoxic chemotherapy. At one year follow-up the patient had residual left-sided sensorineural hearing loss with normal hearing in the right ear. To our knowledge, Langerhans' cell histiocytosis has not been previously reported as a cause of unilateral sudden onset sensorineural hearing loss. It should be considered in the differential diagnosis of this condition.