ABSTRACT
OBJECTIVES: Biliary complications are common after living-donor liver transplant. This retrospective study reviewed our experience with biliary complications in recipients of living-donor liver transplant. MATERIALS AND METHODS: Over our 9-year study period, 120 patients underwent living-donor liver transplant. Patients were divided into 2 groups, with group A having biliary complications and group B without biliary complications. Both groups were compared, and different treatment modalities for biliary complications were evaluated. RESULTS: Group A included 45 patients (37.5%), whereas group B included 75 patients (62.5%). Biliary complications included bile leak in 17 patients (14.2%), biliary stricture in 11 patients (9.2%), combined biliary stricture with bile leak in 15 patients (12.5%), and sphincter of Oddi dysfunction and cholangitis in 1 patient each (0.8%). Cold ischemia time was significantly longer in group A (P = .002). External biliary drainage was less frequently used in group A (P = .031). Technical success rates of endoscopic biliary drainage and percutaneous transhepatic biliary drainage were 68.3% and 41.7%. Survival rate following relaparotomy for biliary complications was 62.5%. CONCLUSIONS: Graft ischemia is an important risk factor for biliary complications. Bile leaks can predispose to anastomotic strictures. The use of external biliary drainage seems to reduce the incidence of biliary complications. Endoscopic and percutaneous trans-hepatic approaches can successfully treat more than two-thirds of biliary complications. Relaparotomy can improve survival outcomes and is usually reserved for patients with intractable biliary complications.
Subject(s)
Anastomotic Leak/etiology , Biliary Tract Surgical Procedures/adverse effects , Cholangitis/etiology , Cholestasis/etiology , Liver Transplantation/adverse effects , Living Donors , Sphincter of Oddi Dysfunction/etiology , Adolescent , Adult , Aged , Anastomotic Leak/diagnostic imaging , Anastomotic Leak/mortality , Anastomotic Leak/therapy , Biliary Tract Surgical Procedures/methods , Biliary Tract Surgical Procedures/mortality , Child , Child, Preschool , Cholangiopancreatography, Endoscopic Retrograde , Cholangitis/diagnostic imaging , Cholangitis/mortality , Cholangitis/therapy , Cholestasis/diagnostic imaging , Cholestasis/mortality , Cholestasis/therapy , Cold Ischemia/adverse effects , Drainage/methods , Egypt , Female , Humans , Infant , Liver Transplantation/methods , Liver Transplantation/mortality , Male , Middle Aged , Reoperation , Retrospective Studies , Risk Factors , Sphincter of Oddi Dysfunction/diagnostic imaging , Sphincter of Oddi Dysfunction/mortality , Sphincter of Oddi Dysfunction/therapy , Time Factors , Treatment Outcome , Young AdultABSTRACT
AIM: Portal hypertension has recently been implicated in the pathogenesis of small-for-size syndrome (SFSS) in adult-to-adult living-donor liver transplantation (A-LDLT). The aim of our study is to compare the portal venous pressure (PVP) cut-off values of 15 mmHg and 20 mmHg in terms of prevention of SFSS in A-LDLT. METHODS: Seventy-six patients underwent A-LDLT. A PVP <20 mmHg at the end of the operation was targeted using graft inflow modulation. Patients were divided into two groups: group A, final PVP <15 mmHg; and group B, final PVP 15-19 mmHg. Peak serum bilirubin and peak international normalized ratio in the first month after A-LDLT, as well as hepatic encephalopathy, SFSS, 90-day morbidity, and mortality were observed in both groups. RESULTS: Final PVP was well controlled below 20 mmHg in all patients (group A, n = 39; group B, n = 37). Six patients suffered SFSS in group B (16.2%) compared to one patient (2.6%) in group A (P = 0.04). Nine patients died in group B (24.3%), four of whom died of SFSS, compared to three patients in group A (7.7%) (P = 0.047). CONCLUSION: A PVP cut-off of 15 mmHg seems to be a more appropriate target level than a cut-off of 20 mmHg for prevention of postoperative SFSS in A-LDLT.
