Preliminary nomogram model for predicting irreversible organ damage of patients with systemic sclerosis.

OBJECTIVE: To investigate predictive factors for irreversible organ damage in systemic sclerosis (SSc) and establish a nomogram model. METHODS: This retrospective study included patients with SSc who were treated at our hospital between March 2013 and March 2023. Irreversible organ damage included heart failure, respiratory failure, renal failure, and gangrene of the hands and feet. Cox and LASSO regression analyses were performed to determine the predictive factors. Based on the results, a nomogram model was developed. The model was evaluated using the C-indices, calibration plots, and DCA. RESULTS: A total of 361 patients with systemic sclerosis were randomly divided into the development (n = 181) and validation (n = 180) groups. Multivariate Cox regression analysis showed that age ≥65 years, weight loss, digital ulcers, mRSS ≥16, elevated creatinine, elevated myoglobin, elevated C-reactive protein, renal involvement, and cardiac involvement were independent risk factors. Based on the LASSO analysis, a nomogram model of irreversible organ damage was established. The C-indices of the development group at 24, 60, and 96 m were 96.7, 84.5, and 85.7, whereas those of the validation group at 24, 60, and 96 m were 86.6, 79.1, and 78.5, respectively. The results of the DCA showed that the nomogram can be used as a valuable tool to predict irreversible organ damage in patients with SSc. CONCLUSION: We included commonly used clinical indicators. According to the nomogram, the probability of irreversible organ damage can be calculated and high-risk patients can be identified.

Hydrothermal synthesis of high surface area CuCrO2 for H2 production by methanol steam reforming.

Hydrogen (H2) is viewed as an alternative source of renewable energy in response to the worldwide energy crisis and climate change. In industry, hydrogen production is mainly achieved through steam reforming of fossil fuels. In this research, hydrothermally-synthesized delafossite CuCrO2 nanopowder were applied in methanol steam reforming. Reducing the size of the CuCrO2 nanopowder significantly improved the efficiency of hydrogen production. The prepared CuCrO2 nanopowder were characterized by X-ray diffraction, Brunauer-Emmett-Teller (BET) analysis, field emission scanning electron microscopy, and transmission electron microscopy. The calculated BET surface area of the hydrothermally synthesized CuCrO2 nanopowder was 148.44 m2 g-1. The CuCrO2 nanopowder displayed high catalytic activity, and the production rate was 2525 mL STP per min per g-cat at 400 °C and a flow rate of 30 sccm. The high specific area and steam reforming mechanism of the CuCrO2 nanopowder catalyst could have vital industrial and economic effects.