Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 37
Filter
Add more filters











Publication year range
1.
Environ Sci Technol ; 2024 Sep 13.
Article in English | MEDLINE | ID: mdl-39271452

ABSTRACT

Acid mine drainage (AMD) raises a global environmental concern impacting the iron cycle. Although the formation of Fe(III) minerals in AMD-impacted waters has previously been reported to be regulated by biological processes, the role of abiotic processes remains largely unknown. This study first reported that a photochemical reaction coupled with O2 significantly accelerated the formation of Fe(III) flocculates (i.e., schwertmannite) in the AMD, as evidenced by the comparison of samples from contaminated sites across different natural conditions at latitudes 24-29° N. Combined with experimental and modeling results, it is further discovered that the intramolecular oxidation of photogenerated Fe(II) with a five-coordinative pyramidal configuration (i.e., [(H2O)5Fe]2+) by O2 was the key in enhancing the photooxidation of Fe(II) in the simulated AMD. The in situ attenuated total reflectance-Fourier transform infrared spectrometry (ATR-FTIR), UV-vis spectroscopy, solvent substitution, and quantum yield analyses indicated that, acting as a precursor for flocculation, [(H2O)5Fe]2+ likely originated from both the dissolved and colloidal forms of Fe(III) through homogeneous and surface ligand-to-metal charge transfers. Density functional theory calculations and X-ray absorption spectroscopy results further suggested that the specific oxidation pathways of Fe(II) produced the highly reactive iron species and triggered the hydrolysis and formation of transient dihydroxo dimers. The proposed new pathways of Fe cycle are crucial in controlling the mobility of heavy metal anions in acidic waters and enhance the understanding of complicated iron biochemistry that is related to the fate of contaminants and nutrients.

2.
Small ; : e2404307, 2024 Sep 06.
Article in English | MEDLINE | ID: mdl-39240072

ABSTRACT

Free-standing micro-supercapacitor (MSC) devices without substrate or current collectors are promising for practical applications. However, it is still difficult to prepare high-performance free-standing MSC devices because of the requirement of optimized active sites, conductivity, ion diffusion, controlled patterns, moisture susceptibility, etc. Here, it is proposed that the optimization of oxygen level on graphene is promising to solve these requirements because of the balance of sp2 and sp3 hybridization. Using the medium-oxidized graphene, the flexible, conductive, hydro-stable, easy-processing film can be facilely obtained, which facilitates the preparation of free-standing MSC electrodes. After constructing with gel electrolyte, the free-standing MSC device shows a high capacitance of 898.4 mF cm-2 using aqueous-gel electrolyte and 383.6 mF cm-2 using ion-gel electrolyte with mass loading of ca. 10 mg cm-2. Correspondingly, the MSC device can achieve a landmark energy density of 42.6 µWh cm-2 at 0.85 mW cm-2 (7.1 mWh cm-3 at 141.7 mW cm-3). The advantages of high performance, facile preparation, and low inactive components make the free-standing MSC device promising for practical applications.

3.
Water Res ; 263: 122195, 2024 Oct 01.
Article in English | MEDLINE | ID: mdl-39116713

ABSTRACT

Iron minerals in nature are pivotal hosts for heavy metals, significantly influencing their geochemical cycling and eventual fate. It is generally accepted that, vivianite, a prevalent iron phosphate mineral in aquatic and terrestrial environments, exhibits a limited capacity for adsorbing cationic heavy metals. However, our study unveils a remarkable phenomenon that the synergistic interaction between sulfide (S2-) and vivianite triggers an unexpected sulfidation-reoxidation process, enhancing the immobilization of heavy metals such as cadmium (Cd), copper (Cu), and zinc (Zn). For instance, the combination of vivianite and S2- boosted the removal of Cd2+ from the aqueous phase under anaerobic conditions, and ensured the retention of Cd stabilized in the solid phase when shifted to aerobic conditions. It is intriguing to note that no discrete FeS formation was detected in the sulfidation phase, and the primary crystal structure of vivianite largely retained its integrity throughout the whole process. Detailed molecular-level investigations indicate that sulfidation predominantly targets the Fe(II) sites at the corners of the PO4 tetrahedron in vivianite. With the transition to aerobic conditions, the exothermic oxidation of CdS and the S sites in vivianite initiates, rendering it thermodynamically favorable for Cd to form multidentate coordination structures, predominantly through the Cd-O-P and Cd-O-Fe bonds. This mechanism elucidates how Cd is incorporated into the vivianite structure, highlighting a novel pathway for heavy metal immobilization via the sulfidation-reoxidation dynamics in iron phosphate minerals.


Subject(s)
Metals, Heavy , Oxidation-Reduction , Metals, Heavy/chemistry , Sulfides/chemistry , Water Pollutants, Chemical/chemistry , Phosphates/chemistry , Minerals/chemistry , Iron/chemistry , Adsorption
4.
Ren Fail ; 46(2): 2386146, 2024 Dec.
Article in English | MEDLINE | ID: mdl-39091091

ABSTRACT

The significance of glomerular IgM deposit intensity in IgA Nephropathy (IgAN) remained ambiguous and requires further research. Patients with biopsy-proven IgAN in our hospital from January 2018 to May 2023 were recruited into this retrospective single-center study. Patients who presented with positive IgM deposit were included in IgM + cohort while patients with negative IgM deposit were included in IgM- cohort. Of the IgM+, patients whose IF intensity of IgM deposits exceeded 1+ formed IgM-H cohort while patients whose IF intensity of IgM deposits was equal to 1+ consisted IgM-L cohort. Pairwise comparisons were performed among these cohorts to determine clinical disparities, following the propensity score matching process. Among 982 IgAN patients, 539 patients presented with positive IgM deposit. The Kaplan-Meier analysis showed that the IgM deposit did not contribute adversely to the outcomes (eGFR decreased from the baseline ≥ 50% continuously or reached end-stage renal disease). However, the Cox regression analysis showed that increased intensity of IgM deposit was an independent risk factor (p = 0.03) in IgM+. The IgM-H exhibited more pronounced segmental glomerulosclerosis (p = 0.02) than the IgM-L, which may also be associated more directly with higher urine protein levels (p = 0.02). Moreover, our generalized linear mixed model demonstrated a remarkably higher urine albumin/creatinine ratio (p < 0.01) and serum creatinine (p = 0.04) levels as well as lower serum albumin (p < 0.01) level in IgM-H persistently during the 5-year follow-up. This study concluded that increased intensity of glomerular IgM deposits may contribute adversely to clinicopathologic presentation and outcome in those IgM + patients.


Subject(s)
Glomerular Filtration Rate , Glomerulonephritis, IGA , Immunoglobulin M , Kidney Glomerulus , Humans , Immunoglobulin M/blood , Male , Glomerulonephritis, IGA/immunology , Female , Retrospective Studies , Adult , Follow-Up Studies , Kidney Glomerulus/pathology , Kidney Glomerulus/immunology , Middle Aged , Risk Factors , Kidney Failure, Chronic/etiology , Kidney Failure, Chronic/immunology , Kaplan-Meier Estimate , Disease Progression , Biopsy , Clinical Relevance
5.
Environ Sci Technol ; 58(29): 13145-13156, 2024 Jul 23.
Article in English | MEDLINE | ID: mdl-38980824

ABSTRACT

Electrode scaling poses a critical barrier to the adoption of electrochemical processes in wastewater treatment, primarily due to electrode inactivation and increased internal reactor resistance. We introduce an antiscaling strategy using tip-enhanced electric fields to redirect scale-forming compounds (e.g., Mg(OH)2 and CaCO3) from the electrode-electrolyte interface to the bulk solution. Our study utilized Cu nanowires (Cu NW) with high-curvature nanostructures as the cathode, in contrast to Cu nanoparticles (Cu NP), Cu foil (CF), and Cu mesh (CM), to evaluate the electrochemical nitrate reduction reaction (NO3RR) performance in hard water conditions. The Cu NW/CF cathode demonstrated superior NO3RR efficiency, with an apparent rate constant (Kapp) of 1.04 h-1, significantly outperforming control electrodes under identical conditions (Kapp < 0.051 h-1). Through experimental and theoretical analysis, including COMSOL simulations, we show that the high-curvature design of Cu NW induced localized electric field enhancements, propelling OH- ions away from the electrode surface into the bulk solution, thus mitigating scale formation on the cathode. Testing with real nitrate-contaminated wastewater confirms that the Cu NW/CF cathode maintained excellent denitrification efficiency over a 60-day period. This study offers a promising perspective on preventing electrode scaling in electrochemical wastewater treatment, paving the way for more efficient and sustainable practices.


Subject(s)
Electrodes , Wastewater , Wastewater/chemistry , Copper/chemistry , Water Purification/methods , Nitrates/chemistry
6.
Water Res ; 252: 121232, 2024 Mar 15.
Article in English | MEDLINE | ID: mdl-38309068

ABSTRACT

Magnetite is a reductive Fe(II)-bearing mineral, and its reduction property is considered important for degradation of contaminants in groundwater and anaerobic subsurface environments. However, the redox condition of subsurface environments frequently changes from anaerobic to aerobic owing to natural and anthropogenic disturbances, generating reactive oxygen species (ROS) from the interaction between Fe(II)-bearing minerals and O2. Despite this, the mechanism of ROS generation induced by magnetite under aerobic conditions is poorly understood, which may play a crucial role in As(III) oxidation. Herein, we found that magnetite could activate O2 and induce the oxidative transformation of As(III) under aerobic conditions. As(III) oxidation was attributed to the ROS generated via structural Fe(II) within the magnetite octahedra oxygenation. The electron paramagnetic resonance and quenching tests confirmed that O2•-, H2O2, and •OH were produced by magnetite. Moreover, density function theory calculations combined with experiments demonstrated that O2•- was initially formed via single electron transfer from the structural Fe(II) to the adsorbed O2; O2•- was then converted to •OH and H2O2 via a series of free radical reactions. Among them, O2•-and H2O2 were the primary ROS responsible for As(III) oxidation, accounting for approximately 52 % and 19 % of As(III) oxidation. Notably, As(III) oxidation mainly occurred on the magnetite surface, and As was immobilized further within the magnetite structure. This study provides solid evidence regarding the role of magnetite in determining the fate and transformation of As in redox-fluctuating subsurface environments.


Subject(s)
Ferrosoferric Oxide , Oxygen , Ferrosoferric Oxide/chemistry , Reactive Oxygen Species , Oxygen/chemistry , Hydrogen Peroxide , Oxidation-Reduction , Minerals , Ferric Compounds/chemistry
7.
Ren Fail ; 45(2): 2267138, 2023.
Article in English | MEDLINE | ID: mdl-37850851

ABSTRACT

BACKGROUND: Both primary IgA nephropathy (IgAN) with and without nephrotic syndrome (NS) can present massive proteinuria (24-h urinary protein ≥3.5 g/d). The clinical significance of massive proteinuria may be different in the two entities and needs further research. METHODS: Data of 1870 patients with biopsy-proven IgAN in our hospital from January 2011 to December 2022 was retrospectively reviewed. A total of 242 IgAN patients with massive proteinuria were enrolled. Patients who presented with nephrotic syndrome at renal biopsy were included in the IgAN with NS cohort (IgAN-NS). The IgAN with nephrotic-range proteinuria cohort (IgAN-NR) consisted of 1:1 matched cases from the remaining according to age, gender, estimated glomerular filtration rate (eGFR) at baseline, and follow-up time. The clinical and pathological characteristics between the two cohorts were analyzed. RESULTS: The IgAN-NS had a significantly higher proteinuria level than the IgAN-NR (p < .001). Cluster analysis revealed that proteinuria was associated with lipids in IgAN-NS, while it was associated with inflammatory indicators in IgAN-NR. When the complete remission of proteinuria (CR) was not achieved, the Kaplan-Meier analysis showed the prognosis of IgAN-NS was significantly worse than that of IgAN-NR (p = .04). Then, our GLMM model and line chart showed that the serum albumin level of the IgAN-NR was always evidently higher than that of the IgAN-NS while the significant difference in urinary albumin/creatinine ratio between the two cohorts gradually disappeared during the short-term follow-up (1 year). Moreover, the Cox regression analysis showed that the increased serum albumin was an independent protective factor for the poor outcomes (eGFR decreased from the baseline ≥ 30% continuously or reached end-stage renal disease [ESRD]). CONCLUSION: The IgAN-NS had poorer clinicopathologic manifestation than IgAN-NR, including severer massive proteinuria. When the CR was not achieved, the prognosis of IgAN-NS was inferior to that of the IgAN-NR.


Subject(s)
Glomerulonephritis, IGA , Nephrotic Syndrome , Humans , Nephrotic Syndrome/complications , Glomerulonephritis, IGA/complications , Glomerulonephritis, IGA/pathology , Cohort Studies , Retrospective Studies , Clinical Relevance , Proteinuria/complications , Prognosis , Glomerular Filtration Rate , Serum Albumin
8.
IEEE Trans Pattern Anal Mach Intell ; 45(10): 12408-12426, 2023 Oct.
Article in English | MEDLINE | ID: mdl-37819806

ABSTRACT

Natural untrimmed videos provide rich visual content for self-supervised learning. Yet most previous efforts to learn spatio-temporal representations rely on manually trimmed videos, such as Kinetics dataset (Carreira and Zisserman 2017), resulting in limited diversity in visual patterns and limited performance gains. In this work, we aim to improve video representations by leveraging the rich information in natural untrimmed videos. For this purpose, we propose learning a hierarchy of temporal consistencies in videos, i.e., visual consistency and topical consistency, corresponding respectively to clip pairs that tend to be visually similar when separated by a short time span, and clip pairs that share similar topics when separated by a long time span. Specifically, we present a Hierarchical Consistency (HiCo++) learning framework, in which the visually consistent pairs are encouraged to share the same feature representations by contrastive learning, while topically consistent pairs are coupled through a topical classifier that distinguishes whether they are topic-related, i.e., from the same untrimmed video. Additionally, we impose a gradual sampling algorithm for the proposed hierarchical consistency learning, and demonstrate its theoretical superiority. Empirically, we show that HiCo++ can not only generate stronger representations on untrimmed videos, but also improve the representation quality when applied to trimmed videos. This contrasts with standard contrastive learning, which fails to learn powerful representations from untrimmed videos. Source code will be made available here.

9.
IEEE Trans Pattern Anal Mach Intell ; 45(12): 15834-15849, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37607139

ABSTRACT

Visual tracking has made significant improvements in the past few decades. Most existing state-of-the-art trackers 1) merely aim for performance in ideal conditions while overlooking the real-world conditions; 2) adopt the tracking-by-detection paradigm, neglecting rich temporal contexts; 3) only integrate the temporal information into the template, where temporal contexts among consecutive frames are far from being fully utilized. To handle those problems, we propose a two-level framework (TCTrack) that can exploit temporal contexts efficiently. Based on it, we propose a stronger version for real-world visual tracking, i.e., TCTrack++. It boils down to two levels: features and similarity maps. Specifically, for feature extraction, we propose an attention-based temporally adaptive convolution to enhance the spatial features using temporal information, which is achieved by dynamically calibrating the convolution weights. For similarity map refinement, we introduce an adaptive temporal transformer to encode the temporal knowledge efficiently and decode it for the accurate refinement of the similarity map. To further improve the performance, we additionally introduce a curriculum learning strategy. Also, we adopt online evaluation to measure performance in real-world conditions. Exhaustive experiments on 8 well-known benchmarks demonstrate the superiority of TCTrack++. Real-world tests directly verify that TCTrack++ can be readily used in real-world applications.

10.
Heliyon ; 9(8): e18596, 2023 Aug.
Article in English | MEDLINE | ID: mdl-37554817

ABSTRACT

International student exchange programs have gained popularity as a means to increase enrollments, support international academic partnerships, and improve student preparedness for globalized work environments. However, the relationships between English language proficiency, cultural intelligence, teamwork, self-efficacy, academic success, and other factors within these programs are not clear. This study investigates the correlations among international accounting students' English language proficiency, accounting knowledge, and academic performance in a transnational education program in mainland China. Data were obtained from academic records of 104 accounting students enrolled in the program. A quantitative measuring of the Pearson correlation statistical tests were employed to measure the relationships between English language proficiency and academic performance, as well as between previous accounting knowledge and academic success. The results indicate a statistically significant relationship between English language proficiency and academic performance, and between previous accounting knowledge and academic success. This study has significant implications for transnational education programs, academic institutions, and policymakers and provides insights into effective strategies for enhancing the quality of transnational education programs and promoting the internationalization of higher education.

11.
Heliyon ; 9(3): e13811, 2023 Mar.
Article in English | MEDLINE | ID: mdl-36879965

ABSTRACT

Doxorubicin is the most effective anthracycline chemotherapy drug in the treatment of cancer, and it is an effective single agent in the treatment of non-small cell lung cancer (NSCLC). There is a lack of studies on the differentially expressed doxorubicin metabolism-related lncRNAs in NSCLC. In this study, we extracted related genes from the TCGA database and matched them with lncRNAs. Doxorubicin metabolism-related lncRNA-based gene signatures (DMLncSig) were gradually screened from univariate regression, LASSO regression, and multivariate regression analysis, and the risk score model was constructed. These DMLncSig were subjected to a GO/KEGG analysis. We then used the risk model to construct the TME model and analyze drug sensitivity. The IMvigor 210 immunotherapy model was cited for validation. Eventually, we performed tumor stemness index differences, survival, and clinical correlation analyses.

12.
J Hazard Mater ; 451: 131075, 2023 Jun 05.
Article in English | MEDLINE | ID: mdl-36870128

ABSTRACT

The increasing need for sustainable acid mine drainage (AMD) treatment has spurred much attention to strategic development of resource recovery. Along this line, we envisage that a coupled electrochemical system involving anodic Fe(II) oxidation and cathodic alkaline production will facilitate in situ synthesis of schwertmannite from AMD. Multiple physicochemical studies showed the successful formation of electrochemistry-induced schwertmannite, with its surface structure and chemical composition closely related to the applied current. A low current (e.g., 50 mA) led to the formation of schwertmannite having a small specific surface area (SSA) of 122.8 m2 g-1 and containing small amounts of -OH groups (formula Fe8O8(OH)4.49(SO4)1.76), whereas a large current (e.g., 200 mA) led to schwertmannite high in SSA (169.5 m2 g-1) and amounts of -OH groups (formula Fe8O8(OH)5.16(SO4)1.42). Mechanistic studies revealed that the reactive oxygen species (ROS)-mediated pathway, rather than the direct oxidation pathway, plays a dominant role in accelerating Fe(II) oxidation, especially at high currents. The abundance of •OH in the bulk solution, along with the cathodic production of OH-, were the key to obtaining schwertmannite with desirable properties. It was also found to function as a powerful sorbent in removal of arsenic species from the aqueous phase.

13.
Am J Nephrol ; 54(1-2): 62-73, 2023.
Article in English | MEDLINE | ID: mdl-36780877

ABSTRACT

INTRODUCTION: The clinical significance of persistent hematuria degrees has not been expounded in primary IgA nephropathy (IgAN) and requires further research. METHODS: From January 2003 to May 2022, a total of 684 IgAN patients with persistent hematuria were enrolled to conduct a retrospective single-center study. Patients whose hematuria degree at baseline was higher than the second tertiles of the whole were included in the high-degree hematuria cohort (Hh), and the low-degree hematuria cohort (Lh) was constructed with 1:1 matched cases from the rest according to age, gender, and estimated glomerular filtration rate (eGFR) at baseline and follow-up time. Survival was determined using the Kaplan-Meier method (K-M) and generalized linear mixed-effects model (GLMM). Risk factors for survival were determined according to the Cox proportional hazards model. RESULTS: Both the Hh and Lh consisted of 228 cases. While the demographic data and the renal function at baseline were matched, both the K-M (p = 0.02) and GLMM (p = 0.04) proved that the prognosis of the Hh was significantly worse than that of the Lh within 10 years of follow-up. The higher persistent hematuria degree was an independent risk factor (3.93; 95% confidence interval, 1.33-11.6) associated with reaching the endpoint (eGFR decreased from the baseline ≥30% continuously or reached end-stage renal disease [ESRD]). The Hh had a significantly higher proportion of crescent (p = 0.003). The prognosis of the Hh was significantly worse than that of the Lh when accompanied by the crescent and presented an indistinct difference if the crescent was absent. CONCLUSIONS: The clinicopathologic manifestation of IgAN patients with persistent high-degree hematuria was severer, and the prognosis was worse than those with persistent low-degree hematuria.


Subject(s)
Glomerulonephritis, IGA , Humans , Glomerulonephritis, IGA/complications , Glomerulonephritis, IGA/pathology , Retrospective Studies , Hematuria/etiology , Follow-Up Studies , Clinical Relevance , Propensity Score , Prognosis , Disease Progression
14.
Water Res ; 231: 119607, 2023 Mar 01.
Article in English | MEDLINE | ID: mdl-36680820

ABSTRACT

The photoinduced transformation of ferrihydrite is an important process that can predict the geochemical cycle of Fe in anoxic environments as well as the fate of trace elements bonded to Fe minerals. We report that the photooxidation of sulfite by UV irradiation produces hydrated electrons (super-reductants), which significantly promote ferrihydrite reduction to Fe(II), and SO3•- (a moderate oxidant), enabling its further oxidation to more crystalline Fe(III) products. The experimental results show that the concentration of sulfite was key in influencing the rate and extent of surface-bound Fe(II) formation, which ultimately determined the distribution of individual products. For example, fitting of the Mössbauer spectroscopy data revealed that the relative abundances of mineral species after 8 h of treatment in the UV/sulfite systems were 41.9% lepidocrocite and 58.1% ferrihydrite at 2 mM SO32-; 41.8% goethite, 28.2% lepidocrocite, and 29.1% ferrihydrite at 5 mM SO32-; and 100% goethite at 10 mM SO32-. The combined results of the chemical speciation analysis and the Cd K-edge EXAFS characterization provided compelling evidence that Cd was firmly incorporated into the structure of newly formed minerals, particularly at high sulfite concentrations. These findings provide an understanding of the role of UV/sulfite in facilitating ferrihydrite transformation and promoting Cd stabilization in oxygen-deficit soils and aquatic environments.


Subject(s)
Ferric Compounds , Iron , Ferric Compounds/chemistry , Iron/chemistry , Cadmium , Minerals/chemistry , Water , Oxidation-Reduction , Ferrous Compounds
15.
Biomed Pharmacother ; 157: 114036, 2023 Jan.
Article in English | MEDLINE | ID: mdl-36436493

ABSTRACT

Genetic instability can be caused by external factors and may also be associated with intracellular damage. At the same time, there is a large body of research investigating the mechanisms by which genetic instability occurs and demonstrating the relationship between genomic stability and tumors. Nowadays, tumorigenesis development is one of the hottest research areas. It is a vital factor affecting tumor treatment. Mechanisms of genomic stability and tumorigenesis development are relatively complex. Researchers have been working on these aspects of research. To explore the research progress of genomic stability and tumorigenesis, development, and treatment, the authors searched PubMed with the keywords "genome instability" "chromosome instability" "DNA damage" "tumor spread" and "cancer treatment". This extracts the information relevant to this study. Results: This review introduces genomic stability, drivers of tumor development, tumor cell characteristics, tumor metastasis, and tumor treatment. Among them, immunotherapy is more important in tumor treatment, which can effectively inhibit tumor metastasis and kill tumor cells. Breakthroughs in tumorigenesis development studies and discoveries in tumor metastasis will provide new therapeutic techniques. New tumor treatment methods can effectively prevent tumor metastasis and improve the cure rate of tumors.


Subject(s)
Genomic Instability , Neoplasms , Humans , Cell Transformation, Neoplastic/genetics , DNA Damage/genetics , Neoplasms/genetics , Neoplasms/therapy
16.
J Nephrol ; 36(2): 429-440, 2023 03.
Article in English | MEDLINE | ID: mdl-36538201

ABSTRACT

BACKGROUND: The clinical significance of intrarenal vascular lesions has not been elucidated in primary IgA nephropathy (IgAN), especially in non-hypertensive subjects. METHODS: From January 2003 to December 2020, data of 3435 patients with biopsy-proven IgAN were reviewed. Two hundred-forty non-hypertensive patients who met the criteria for IgAN and had intrarenal vascular lesions (IgAN-vas) were selected. The control cohort was constructed with 1:1 matched cases of non-hypertensive IgAN patients without vascular lesions according to age, gender, estimated glomerular filtration rate (eGFR) and follow-up time. RESULTS: The IgAN-vas cohort had significantly higher serum uric acid levels than the control IgAN cohort (P < 0.05); glomerulosclerosis was more common in IgAN-vas patients. Moreover, cluster analysis indicated that the serum uric acid level was associated with serum creatinine (s-Cr) levels in IgAN-vas while it was associated with serum lactate dehydrogenase (LDH) levels in control cases with IgAN. Both Kaplan-Meier analysis and generalized linear mixed-effects models revealed that the prognosis of the IgAN-vas cohort was significantly worse than that of the IgAN cohort after > 5 years of follow-up. Intimal thickening was an independent risk factor associated with reaching the endpoint (eGFR decrease ≥ 30% from the baseline or reaching end-stage renal disease [ESRD] or death). CONCLUSIONS: The prognosis of non-hypertensive patients with IgAN-vas was worse than that of matched individuals with IgAN. The clinicopathologic manifestation of IgAN-vas was more severe, and included a higher proportion of glomerulosclerosis, and a higher serum uric acid level correlated with renal function impairment.


Subject(s)
Glomerulonephritis, IGA , Kidney Failure, Chronic , Humans , Glomerulonephritis, IGA/complications , Glomerulonephritis, IGA/diagnosis , Glomerulonephritis, IGA/pathology , Uric Acid , Clinical Relevance , Kidney Failure, Chronic/complications , Prognosis , Retrospective Studies , Glomerular Filtration Rate , Disease Progression
17.
Inorg Chem ; 61(43): 16981-16985, 2022 Oct 31.
Article in English | MEDLINE | ID: mdl-36251482

ABSTRACT

Metal-organic framework (MOF) glass is a new type of glass material, but it usually lacks sufficient porosity. Thus, regulating the pore structure of MOF glass to improve its adsorption performance is very important. Herein, we found that the porosity of MOF glasses agZIF-62 and agZIF-76 can be regulated via an ammonia-immersion approach. After ammonia immersion, the resulting agZIF-62-NH3 and agZIF-76-NH3 could be maintained in their glass states or converted to their amorphous states, respectively. Their porosity changed according to the gas adsorption experiments. Notably, compared with agZIF-62 and agZIF-76, the iodine uptake capacities for agZIF-62-NH3 and agZIF-76NH3 increased by 12 and 21 times, respectively. This work shows that the subsequent treatment of MOF glass can regulate their adsorption performance.

18.
Front Bioeng Biotechnol ; 10: 914964, 2022.
Article in English | MEDLINE | ID: mdl-36312556

ABSTRACT

To generate and evaluate post-therapeutic optical coherence tomography (OCT) images based on pre-therapeutic images with generative adversarial network (GAN) to predict the short-term response of patients with retinal vein occlusion (RVO) to anti-vascular endothelial growth factor (anti-VEGF) therapy. Real-world imaging data were retrospectively collected from 1 May 2017, to 1 June 2021. A total of 515 pairs of pre-and post-therapeutic OCT images of patients with RVO were included in the training set, while 68 pre-and post-therapeutic OCT images were included in the validation set. A pix2pixHD method was adopted to predict post-therapeutic OCT images in RVO patients after anti-VEGF therapy. The quality and similarity of synthetic OCT images were evaluated by screening and evaluation experiments. We quantitatively and qualitatively assessed the prognostic accuracy of the synthetic post-therapeutic OCT images. The post-therapeutic OCT images generated by the pix2pixHD algorithm were comparable to the actual images in edema resorption response. Retinal specialists found most synthetic images (62/68) difficult to differentiate from the real ones. The mean absolute error (MAE) of the central macular thickness (CMT) between the synthetic and real OCT images was 26.33 ± 15.81 µm. There was no statistical difference in CMT between the synthetic and the real images. In this retrospective study, the application of the pix2pixHD algorithm objectively predicted the short-term response of each patient to anti-VEGF therapy based on OCT images with high accuracy, suggestive of its clinical value, especially for screening patients with relatively poor prognosis and potentially guiding clinical treatment. Importantly, our artificial intelligence-based prediction approach's non-invasiveness, repeatability, and cost-effectiveness can improve compliance and follow-up management of this patient population.

19.
J Hazard Mater ; 438: 129552, 2022 09 15.
Article in English | MEDLINE | ID: mdl-35999726

ABSTRACT

The corrosion of Fe(0) in the presence of O2 in nature can lead to the oxidation of organic compounds, but the efficiency is very limited. Herein, attempts were made to establish a galvanic system that separates the anodic Fe(0) oxidation reaction and the cathodic O2 reduction reaction using an air-breathing cathode. Compared with the chemical Fe(0)/O2 system, it exhibited a substantially higher capability of destroying a variety of pollutants, such as organic dyes (12 types), phenol, nitrobenzene, acetaminophen, phenol, and ethylenediaminetetraacetic acid. The degradation rate constant of a model dye (i.e., Rhodamine B) increased from 0.047 min-1 (chemical) to 1.412 min-1 (galvanic) under the passive air-breathing condition. The electric circuit design promoted Fe(0) dissolution to Fe(II) and triggered electron transfer that drives O2 reduction to H2O2, two important species responsible for the generation of HO• at high abundance. In addition, the galvanic Fe(0)/O2 system produces electricity while destroying pollutants. Tests with real Ni plating wastewater further demonstrated the capability of the system to oxidize complexed organics and phosphite. This study provides a new strategy for boosting the oxidative capacity of the Fe(0)/O2 system, which shows promise for acid wastewater treatment.


Subject(s)
Environmental Pollutants , Water Pollutants, Chemical , Electrodes , Hydrogen Peroxide/chemistry , Iron/chemistry , Oxidation-Reduction , Oxidative Stress , Phenols , Water Pollutants, Chemical/chemistry
20.
IEEE Trans Image Process ; 31: 4693-4706, 2022.
Article in English | MEDLINE | ID: mdl-35793294

ABSTRACT

The understanding of language plays a key role in video grounding, where a target moment is localized according to a text query. From a biological point of view, language is naturally hierarchical, with the main clause (predicate phrase) providing coarse semantics and modifiers providing detailed descriptions. In video grounding, moments described by the main clause may exist in multiple clips of a long video, including both the ground-truth and background clips. Therefore, in order to correctly discriminate the ground-truth clip from the background ones, this co-existence leads to the negligence of the main clause, and concentrate the model on the modifiers that provide discriminative information on distinguishing the target proposal from the others. We first demonstrate this phenomenon empirically, and propose a Hierarchical Language Network (HLN) that exploits the language hierarchy, as well as a new learning approach called Multi-Instance Positive-Unlabelled Learning (MI-PUL) to alleviate the above problem. Specifically, in HLN, the localization is performed on various layers of the language hierarchy, so that the attention can be paid to different parts of the sentences, rather than only discriminative ones. Furthermore, MI-PUL allows the model to localize background clips that can be possibly described by the main clause, even without manual annotations. Therefore, the union of the two proposed components enhances the learning of the main clause, which is of critical importance in video grounding. Finally, we evaluate that our proposed HLN can plug into the current methods and improve their performance. Extensive experiments on challenging datasets show HLN significantly improve the state-of-the-art methods, especially achieving 6.15% gain in terms of [Formula: see text] on the TACoS dataset.


Subject(s)
Language , Semantics , Attention
SELECTION OF CITATIONS
SEARCH DETAIL