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1.
Heliyon ; 10(9): e28993, 2024 May 15.
Article in English | MEDLINE | ID: mdl-38694070

ABSTRACT

Scientists have studied fluid flow over a stretching sheet to explore its potential applications in industries. This study investigates the exponential stretching flow of a bioconvective magnetohydrodynamic (MHD) hybrid nanofluid in porous medium taking into consideration thermal radiations, heat generation, chemical reaction, porosity, and dissipation. Moreover, microorganisms are present in the fluid, so the fluid is more stable, which is crucial in biotechnology, biomicrosystems, and bio-nano coolant systems. Silver and titanium dioxide in a water-based medium are the prototypical nanoparticles. The present study involves a transformation of the governing system into a set of dimensionless, coupled and nonlinear partial differential equations (PDEs) using nonsimilar techniques. The local non-similarity (LNS) technique is used to truncate these equations to ordinary differential equations (ODEs). This technique is also used to estimate transformed equations numerically until the second level of truncation takes place via the bvp4c algorithm, which is a built-in MATLAB solver. Furthermore, tables are provided that presents the drag coefficients, Nusselt numbers, Sherwood numbers, and densities of motile microorganisms. Results show a negative correlation between the velocity and the magnetic field parameter as well as the porosity parameter, as evidenced by a decrease in velocity corresponds to rises in these parameters. The temperature distribution exhibits a positive correlation with the rising values of both radiation parameter and Eckert number. The concentration profiles also exhibit a negative correlation with the increasing values of Lewis and bioconvection Lewis number, chemical reaction parameter, Peclet number and the differences in microbial concentration. This study will improve the future research on hybrid nanofluid regarding industrial applications. There haven't been any previous publications that have investigated the use of this model with the local non-similarity method. The main objective of this article is to enhance the heat transfer performance in a hybrid nanofluid.

2.
Heliyon ; 9(11): e22294, 2023 Nov.
Article in English | MEDLINE | ID: mdl-38027644

ABSTRACT

Nanofluids are a topic of great interest for researchers due to their remarkable performance in most heat transport applications. Williamson fluids have also gained importance due to their numerous uses in many fields. Exponentially stretching sheets with variable thermal conductivity and diffusivity is another topic of importance in fluid mechanics. Moreover, rotating MHD fluids have various applications in the industry. So, in particular, we would study rotating MHD Williamson nanofluid having variable diffusivity and thermal conductivity flowing above an exponentially stretching sheet. In this work, we proposed modified wavelets method to find the solutions of the developed mathematical model of the considered problem. The effectiveness of the developed scheme is certified by the help of tables and graphs. It is worthy to point out that the skin friction coefficient in x and y direction increases gradually against the selection of magnetic field effects and Williamson parameter. Tabular study presented to show that the suggested algorithm is convergent, and it can be extended to more physical models on non-Newtonian type.

3.
PLoS One ; 18(8): e0290867, 2023.
Article in English | MEDLINE | ID: mdl-37651371

ABSTRACT

INTRODUCTION: Medical colleges globally have student organizations that serve to enable students' involvement in research. However, details of their approach and activities are seldom published to serve as learning for student organizations in other settings. The Student Research Forum (SRF), a student organization based at a private medical school in Pakistan aims to facilitate students in acquiring research skills. Following the observation of a downward trajectory of student initiative and interest, SRF leadership restructured the organization and improve its impact. This study describes the development and implementation evaluation of the interventions. METHODOLOGY: The operational framework was revised using the Theory of Change by the core group. Major interventions included enhanced social media and outreach coordination, research workshops, journal clubs, and mentorship to increase research output, mentorship opportunities, and knowledge of medical research; ultimately improving quality in research. The outcomes generated over the course of the study's duration from July 2019 to September 2021 were analyzed using the process metrics of reach, adoption, and efficacy. RESULTS: As a result of the interventions, SRF expanded its reach by conducting a total of 41 events during the duration of the study, facilitated by social media growth on each of SRF's online platforms, with a 300% increase in followers on Facebook, and a nationwide network of 91 student ambassadors. An annual workshop series taught research skills to more than 3800 participants. Students leading their own events, SRF featuring international speakers, and the abstracts submitted to SRF's annual conference, along with the conference's reach of 10,000 students, are seen as improvements in the ToC-informed interventions' adoption. The efficacy of the interventions manifested as the REACH program allocated 56 research projects to vetted applicants. CONCLUSION: The applied interventions have accelerated SRF's progress towards achieving its long-term outcome of increased quality in research as translated by increased research output quantity, mentorship, and knowledge of medical research. Further evaluation is required to assess the success of the ToC. As SRF continues to grow, a continued analysis of the implementation outcomes is imperative to gauge its effectiveness.


Subject(s)
Biomedical Research , Students, Medical , Humans , Benchmarking , Drive , Growth Hormone-Releasing Hormone
4.
Clin Appl Thromb Hemost ; 29: 10760296231181916, 2023.
Article in English | MEDLINE | ID: mdl-37345427

ABSTRACT

Venous thromboembolism (VTE) is a preventable cause of mortality and morbidity. We performed a retrospective analysis of patient records to identify those readmitted with a diagnosis of VTE within 6 months of the primary admission. The records were evaluated to see whether thromboprophylaxis had been provided to patients at high risk for VTE. A total of 360 hospital encounters between August 1, 2018, and August 31, 2019, with VTE, 57 (16%) encounters were readmissions with a primary diagnosis of deep vein thrombosis within 180 days of their primary stay. A high proportion (44%) of these readmissions were within the first 30 days. 3% (n = 9) of patients developed pulmonary embolism; 35 (61%) did not receive thromboprophylaxis on their primary stay. Thromboprophylaxis is often not utilized appropriately in healthcare settings. Our study showed substantial incidence of hospital readmissions due to VTE which is consistent with prior studies conducted globally. A more stringent adherence to the protocol along with risk stratification may lower rates of VTE admission and reduce associated morbidity and mortality.


Subject(s)
Pulmonary Embolism , Venous Thromboembolism , Humans , Venous Thromboembolism/etiology , Retrospective Studies , Anticoagulants/therapeutic use , Patient Readmission , Quality Improvement , Hospitals , Pulmonary Embolism/epidemiology , Risk Factors
5.
J Surg Res ; 290: 188-196, 2023 10.
Article in English | MEDLINE | ID: mdl-37269802

ABSTRACT

INTRODUCTION: Systematic collection and analysis of surgical outcomes data is a cornerstone of surgical quality improvement. Unfortunately, there remains a dearth of surgical outcomes data from low- and middle-income countries (LMICs). To improve surgical outcomes in LMICs, it is essential to have the ability to collect, analyze, and report risk-adjusted postoperative morbidity and mortality data. This study aimed to review the barriers and challenges to developing perioperative registries in LMIC settings. METHODS: We conducted a scoping review of all published literature on barriers to conducting surgical outcomes research in LMICs using PubMed, Embase, Scopus, and GoogleScholar. Keywords included 'surgery', 'outcomes research', 'registries', 'barriers', and synonymous Medical Subject Headings derivatives. Articles found were subsequently reference-mined. All relevant original research and reviews published between 2000 and 2021 were included. The performance of routine information system management framework was used to organize identified barriers into technical, organizational, or behavioral factors. RESULTS: Twelve articles were identified in our search. Ten articles focused specifically on the creation, success, and obstacles faced during the implementation of trauma registries. Technical factors reported by 50% of the articles included limited access to a digital platform for data entry, lack of standardization of forms, and complexity of said forms. 91.7% articles mentioned organizational factors, including the availability of resources, financial constraints, human resources, and lack of consistent electricity. Behavioral factors highlighted by 66.6% of the studies included lack of team commitment, job constraints, and clinical burden, which contributed to poor compliance and dwindling data collection over time. CONCLUSIONS: There is a paucity of published literature on barriers to developing and maintaining perioperative registries in LMICs. There is an immediate need to study and understand barriers and facilitators to the continuous collection of surgical outcomes in LMICs.


Subject(s)
Developing Countries , General Surgery , Treatment Outcome , Humans , Registries
6.
Ann Vasc Surg ; 97: 329-339, 2023 Nov.
Article in English | MEDLINE | ID: mdl-37236530

ABSTRACT

BACKGROUND: Metabolic syndrome (MetS) is a constellation of hypertension, insulin resistance, obesity, and dyslipidemia and is known to increase the risk of postoperative morbidity. This study aimed to assess the impact of MetS on stroke, myocardial infarction, mortality, and other complications following carotid endarterectomy (CEA). METHODS: We analyzed data from the National Surgical Quality Improvement Program. Patients undergoing elective CEA between 2011 and 2020 were included. Patients with American Society of Anesthesiologists status 5, preoperative length of stay (LOS) > 1 day, ventilator dependence, admission from nonhome location, and ipsilateral internal carotid artery stenosis of < 50% or 100% were excluded. A composite cardiovascular outcome for postoperative stroke, myocardial infarction, and mortality was generated. Multivariable binary logistic regression analyses were used to assess the association of MetS with the composite outcome and other perioperative complications. RESULTS: We included 25,226 patients (3,613, 14.3% with MetS). MetS was associated with postoperative stroke, unplanned readmission, and prolonged LOS on bivariate analysis. On multivariable analysis, MetS was significantly associated with the composite cardiovascular outcome (1.320 [1.061-1.642]), stroke (1.387 [1.039-1.852]), unplanned readmission (1.399 [1.210-1.619]), and prolonged LOS (1.378 [1.024-1.853]). Other clinico-demographic factors associated with the cardiovascular outcome included Black race, smoking status, anemia, leukocytosis, physiologic risk factors, symptomatic disease, preoperative beta-blocker use, and operative time ≥ 150 min. CONCLUSIONS: MetS is associated with cardiovascular complications, stroke, prolonged LOS, and unplanned readmissions following CEA. Surgeons should provide optimized care to this high-risk population and strive to reduce operative durations.


Subject(s)
Carotid Stenosis , Endarterectomy, Carotid , Metabolic Syndrome , Myocardial Infarction , Stroke , Humans , Endarterectomy, Carotid/adverse effects , Metabolic Syndrome/complications , Metabolic Syndrome/diagnosis , Metabolic Syndrome/epidemiology , Retrospective Studies , Treatment Outcome , Stroke/etiology , Carotid Stenosis/complications , Carotid Stenosis/diagnostic imaging , Carotid Stenosis/surgery , Risk Factors , Myocardial Infarction/etiology , Postoperative Complications/epidemiology , Postoperative Complications/etiology
7.
Nanomaterials (Basel) ; 12(23)2022 Dec 02.
Article in English | MEDLINE | ID: mdl-36500914

ABSTRACT

Nanofluids have unique features that make them potentially valuable in a variety of medicinal, technical, and industrial sectors. The widespread applications of nanotechnology in modern science have prompted researchers to study nanofluid models from different perspectives. The objective of the current research is to study the flow of non-Newtonian nanofluid over an inclined stretching surface immersed in porous media by employing the Darcy-Forchheimer model. Both titanium oxide (TiO2) and aluminum oxide (Al2O3) are nanoparticles which can be found in blood (based fluid). The consequences of viscous dissipation, thermal radiations, and heat generation are also incorporated. Boundary layer approximations are employed to model the governing system of partial differential equations (PDEs). The governing PDEs with their associated boundary conditions are further altered to a dimensionless form by employing appropriate transformations. The results of the transformed model are collected using local non-similarity approach up to the second level of truncation in association with the built-in finite difference code in MATLAB (bvp4c). Additionally, the impacts of emerging factors on the fluid flow and thermal transport features of the considered flow problem are displayed and analyzed in graphical forms after achieving good agreement between accomplished computational results and published ones. Numerical variations in drag coefficient and Nusselt number are elaborated through the tables. It has been perceived that the enhancement in Casson fluid parameter diminishes the velocity profile. Moreover, it is noted that the porosity parameter and Lorentz's forces reinforce the resulting frictional factor at the inclined stretching surface.

8.
J Funct Biomater ; 14(1)2022 Dec 20.
Article in English | MEDLINE | ID: mdl-36662048

ABSTRACT

Zn-based biodegradable alloys or composites have the potential to be developed to next-generation orthopedic implants as alternatives to conventional implants to avoid revision surgeries and to reduce biocompatibility issues. This review summarizes the current research status on Zn-based biodegradable materials. The biological function of Zn, design criteria for orthopedic implants, and corrosion behavior of biodegradable materials are briefly discussed. The performance of many novel zinc-based biodegradable materials is evaluated in terms of biodegradation, biocompatibility, and mechanical properties. Zn-based materials perform a significant role in bone metabolism and the growth of new cells and show medium degradation without the release of excessive hydrogen. The addition of alloying elements such as Mg, Zr, Mn, Ca, and Li into pure Zn enhances the mechanical properties of Zn alloys. Grain refinement by the application of post-processing techniques is effective for the development of many suitable Zn-based biodegradable materials.

9.
Polymers (Basel) ; 12(2)2020 Feb 04.
Article in English | MEDLINE | ID: mdl-32033140

ABSTRACT

Ultra-High Molecular Weight Polyethylene (UHMWPE) is used in biomedical applications due to its high wear-resistance, ductility, and biocompatibility. A great deal of research in recent decades has focused on further improving its mechanical and tribological performances in order to provide durable implants in patients. Several methods, including irradiation, surface modifications, and reinforcements have been employed to improve the tribological and mechanical performance of UHMWPE. The effect of these modifications on tribological and mechanical performance was discussed in this review.

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