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Dual-acting therapeutic proteins for intraocular use.
Collins, Matthew; Awwad, Sahar; Ibeanu, Nkiru; Khaw, Peng T; Guiliano, David; Brocchini, Steve; Khalili, Hanieh.
Drug Discov Today ; 26(1): 44-55, 2021 01.
Article in English | MEDLINE | ID: mdl-33137484

ABSTRACT

Intravitreally injected antibody-based medicines have revolutionised the treatment of retinal disease. Bispecific and dual-functional antibodies and therapeutic proteins have the potential to further increase the efficacy of intraocular medicines.


Subject(s)
Antibodies, Bispecific/pharmacology , Intravitreal Injections , Retinal Diseases , Angiogenesis Inhibitors/pharmacology , Anti-Inflammatory Agents/pharmacology , Biological Products/pharmacology , Drug Development , Humans , Retinal Diseases/drug therapy , Retinal Diseases/immunology , Retinal Diseases/physiopathology
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