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J Cardiovasc Pharmacol ; 78(5): e722-e728, 2021 11 01.
Article in English | MEDLINE | ID: mdl-34173814

ABSTRACT

ABSTRACT: The open ductus arteriosus (ODA) is the vessel through which the pathological communication between the aorta and the pulmonary artery persists after birth. Clinical manifestations depend on the size of the duct and the stage of hemodynamic disorders. The course of the defect varies from asymptomatic to extremely severe. With large duct sizes, the latter manifests itself from the first week of life with signs of heart failure. The current research is devoted to the choice of the optimal method of medical and surgical treatment in premature newborns with an unaffected ductus arteriosus. Drug therapy for pulmonary hypertension is recommended only for those patients who have irreversible pulmonary hypertension. Surgical closure of the ODA is recommended for overloads of the left heart or signs of pulmonary hypertension in the presence of blood discharge from left to right and after previously suffered endocarditis. The article analyzes current information about the treatment of premature infants with ODA.


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Antihypertensive Agents/therapeutic use , Cardiac Surgical Procedures , Ductus Arteriosus, Patent/therapy , Hypertension, Pulmonary/therapy , Ibuprofen/therapeutic use , Infant, Premature , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Antihypertensive Agents/adverse effects , Cardiac Surgical Procedures/adverse effects , Clinical Decision-Making , Coronary Circulation , Ductus Arteriosus, Patent/complications , Ductus Arteriosus, Patent/physiopathology , Female , Gestational Age , Hemodynamics , Humans , Hypertension, Pulmonary/etiology , Hypertension, Pulmonary/physiopathology , Ibuprofen/adverse effects , Infant, Newborn , Ligation , Male , Pulmonary Circulation , Risk Assessment , Risk Factors , Treatment Outcome , Ventricular Function, Left
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