ABSTRACT
Ixabepilone is a novel microtubule-stabilising agent used as monotherapy or in combination with capecitabine to treat taxane- and anthracycline-refractory breast cancer. We report the case of a patient who experienced an unusual motor neuropathy after the first cycle. This is a very uncommon secondary effect, but it must be taken into account as a possible complication of treatment with ixabepilone.
Subject(s)
Axons/metabolism , Breast Neoplasms/complications , Breast Neoplasms/drug therapy , Epothilones/adverse effects , Neurons, Afferent/drug effects , Neurons, Afferent/metabolism , Peripheral Nervous System Diseases/chemically induced , Fatal Outcome , Female , Humans , Microtubules/metabolism , Middle Aged , Treatment Outcome , Tubulin Modulators/adverse effectsABSTRACT
This study aimed at identifying the ecological characteristics of Triatoma patagonica Del Ponte 1929 (Hemiptera: Reduviidae) and evaluating the epidemiological importance of this species at its southernmost distribution limit. We carried out two surveys in the Province of Chubut, in summer and in spring, 1998. In each survey, we interviewed local health care agents for triatomine recognition and reports of the bugs, followed by entomological searches in houses and peridomestic and silvatic biotopes. The presence of T. patagonica was confirmed in two of the five localities indicated by interview. In agreement with previous studies, all these positive localities were east of the 11ºC isotherm, within the Monte phytogeographic province. Triatomine abundance and infestation levels (in peridomiciles and peridomestic biotopes) were higher in summer than in spring, possibly reflecting adverse environmental conditions such as flood and cold winter weather. In the silvatic environment, we found three adult bugs under rocks in summer. In peridomestic sites bugs were only found associated with chickens, which were also the only blood meal source identified. Infection by Trypanosoma cruzi was not detected. We conclude that T. patagonica at its southernmost distribution limit does not represent a risk to public health due to its low abundance, lack of association with humans, and absence of T. cruzi infection.
Subject(s)
Animals , Female , Humans , Male , Insect Vectors , Triatoma , Argentina , Ecosystem , Feeding Behavior , Housing , Insect Vectors , Population Density , Seasons , TriatomaABSTRACT
This study aimed at identifying the ecological characteristics of Triatoma patagonica Del Ponte 1929 (Hemiptera: Reduviidae) and evaluating the epidemiological importance of this species at its southernmost distribution limit. We carried out two surveys in the Province of Chubut, in summer and in spring, 1998. In each survey, we interviewed local health care agents for triatomine recognition and reports of the bugs, followed by entomological searches in houses and peridomestic and silvatic biotopes. The presence of T. patagonica was confirmed in two of the five localities indicated by interview. In agreement with previous studies, all these positive localities were east of the 11 degrees C isotherm, within the Monte phytogeographic province. Triatomine abundance and infestation levels (in peridomiciles and peridomestic biotopes) were higher in summer than in spring, possibly reflecting adverse environmental conditions such as flood and cold winter weather. In the silvatic environment, we found three adult bugs under rocks in summer. In peridomestic sites bugs were only found associated with chickens, which were also the only blood meal source identified. Infection by Trypanosoma cruzi was not detected. We conclude that T. patagonica at its southernmost distribution limit does not represent a risk to public health due to its low abundance, lack of association with humans, and absence of T. cruzi infection.
Subject(s)
Insect Vectors/physiology , Triatoma/physiology , Animals , Argentina , Ecosystem , Feeding Behavior , Female , Housing , Humans , Insect Vectors/parasitology , Male , Population Density , Seasons , Triatoma/parasitologyABSTRACT
Se presentan los resultados de los programas de control de la hidatidosis efectuados en las cinco jurisdicciones de la Región Patagónica Argentina. Se desglosan las tasas de infección humana (95 x 100.000 en 1983 y 15 x 100.000 en 1988) y ovina (16,6% en 1983 y 2,6% en 1988). Se analizan los factores condicionantes de la endemia en la región
Subject(s)
Dogs , Animals , Humans , Dog Diseases/transmission , Echinococcosis/transmission , Argentina , Dog Diseases/prevention & control , Echinococcosis/prevention & control , Incidence , Praziquantel/therapeutic useABSTRACT
En la República Argentina, la hidatidosis constituye un serio problema que afecta a la salud publica y tiene gráves repercusiones socioeconómicas. Las fuertes corrientes urbanisticas han traido consigo el traslado de algunas costumbres rurales hacia los centros poblados. A partir de ello la hidatidosis en las areas endémicas ha adquirido importancia como zoonosis urbana. Si bien las cifras de infección canina halladas (1.12%) son significativamente inferiores que en las áreas rurales de la misma región, la capacidad potencial de infectar al hombres es muy superior en canes domiciliados en áreas de gran densidad demográfica. Las altas tasas de infección humana halladas son demostrativas de los aspectos señalados
Subject(s)
Dogs , Animals , Dog Diseases/parasitology , Echinococcosis/veterinary , ArgentinaABSTRACT
Se determinó el número de portadores de quistes hidatídicos, y su procedencia, en una muestra selecionada de ciudadanos próximos a ser incorporados al servicio militar en la Provincia del Chubut. El examen de los sueros mediante la prueba de doble difusión arco 5 permitió establecer que el 2.27 por ciento de ellos se encontraba afectado por esta patología. Los hallazgos demuestran la unidad de la encuestas inmunodiagnósticas para la detección precoz de casos y la vigilancia epidemiológica de los programas de control (AU)
Subject(s)
Echinococcosis/diagnosis , Immunodiffusion , Echinococcosis/prevention & control , ArgentinaABSTRACT
Se determinó el número de portadores de quistes hidatídicos, y su procedencia, en una muestra selecionada de ciudadanos próximos a ser incorporados al servicio militar en la Provincia del Chubut. El examen de los sueros mediante la prueba de doble difusión arco 5 permitió establecer que el 2.27 por ciento de ellos se encontraba afectado por esta patología. Los hallazgos demuestran la unidad de la encuestas inmunodiagnósticas para la detección precoz de casos y la vigilancia epidemiológica de los programas de control