ABSTRACT
Traditional corticosteroid and antiinflammatory therapy should be supplemented with new immunocorrective drugs in patients with traumatic uveitis and ocular subatrophy. Immunotherapy is a pathogenetically justified and perspective trend in multiple-modality treatment of patients with injuries to the organ of vision. The authors validate the use of immunocorrectors utilized in general transplantology for preventing rejection crisis. Immunostimulants or immunosuppresants can be added to treatment protocols for patients with traumatic uveitis, depending on the changes in the patient's immune status. New immunotropic drugs affecting all components of immunity are needed.
Subject(s)
Eye Injuries/complications , Immunotherapy/methods , Uveitis/therapy , Adjuvants, Immunologic/therapeutic use , Autoimmunity/drug effects , Eye Injuries/immunology , Humans , Immunosuppressive Agents/therapeutic use , Treatment Outcome , Uveitis/etiology , Uveitis/immunologyABSTRACT
Clinical and morphological examinations of 30 eyes enucleated for relapses of traumatic uveitis and subatrophy caused by grave penetrating wounds involving a complete loss of visual function were carried out and 12 patients were tested for sensitization to tissue antigens by the leukocyte migration inhibition test. Morphological examination revealed cellular reaction in eye membranes, indicating an autoimmune process developing in response to release of the antigenic tissue substances of the eye into the bloodflow and reactive flow of immunocompetent cells towards ocular tissues because of injury to the blood-eye barrier. Detection of sensitization to tissue antigen in the patients confirms this viewpoint. The authors compare the revealed inflammatory process in the injured eye with the graft rejection reaction and find them similar.
Subject(s)
Autoantigens/immunology , Eye Injuries, Penetrating/complications , Eye/pathology , Uveitis/immunology , Adolescent , Adult , Atrophy , Cell Movement , Child , Chronic Disease , Eye/immunology , Eye Enucleation , Eye Injuries, Penetrating/immunology , Humans , Leukocytes/immunology , Leukocytes/pathology , Male , Middle Aged , Recurrence , Uveitis/etiology , Uveitis/pathology , Uveitis/surgeryABSTRACT
Comprehensive morphologic studies (including light microscopy, morphometry, autoradiography) of experimental rabbits have revealed a stimulating effect of fibronectin instillations on healing of central penetrating wounds of the cornea. A polypotent mechanism of the stimulating effect of fibronectin instillations during all the stages of the reparative process in the corneal tissue was proved.