ABSTRACT
The study aims to observe whether subjects with a primary affective disease and manic attacks show modifications of serum concentration of creatine-kinase conferring it the role of a biologic marker. Serum concentration of creatine-kinase was determined for 122 men with mono- and bipolar affective disease during the different stages as well as for schizophrenic men with different clinical forms excepting the affective form. The control group included 60 men. Data indicated that enzyme concentration can constitute a biological marker for a primary affective disease also showing the differences between the different stages of the disease (mania, hypomania, depression and the symptom-free intervals).
Subject(s)
Bipolar Disorder/diagnosis , Clinical Enzyme Tests , Creatine Kinase/blood , Adult , Biomarkers/blood , Humans , Male , Reference Values , Schizophrenia/diagnosisABSTRACT
Carried out on 57 outpatients, the study was aimed to prove the existence of a disgammaglobulinemia in Down's syndrome. The event could not be attributed to hospitalization. Data indicate increased A and G immunoglobulinemias. In agreement with other authors Ig A level was found to be very high especially after the age of 5. Ig M titre in patients was reduced in comparison with that of the controls, regardless of the age group. Increase timing of IgA and Ig G concentrations tends to be more marked for the Ig A fraction. In patients ranging from 0 to 5 years the Ig A serum level is deficient.
Subject(s)
Antibody Formation/immunology , Down Syndrome/immunology , Hospitalization , Adolescent , Age Factors , Child , Child, Preschool , Female , Humans , Immune Tolerance/immunology , Immunoglobulins/analysis , Infant , MaleABSTRACT
Immunoglobulin levels (A, G, M) were measured with Mancini's radial immunodiffusion technique (RID). IgA and IgG levels showed a statistically significant increase in schizoaffective patients compared to normals, and schizophrenics, but no modification in comparison with the affective patients. IgM also showed a statistically significant increase which may constitute a trait marker for the schizoaffective disease.
Subject(s)
Antibody Formation/immunology , Bipolar Disorder/immunology , Depressive Disorder/immunology , Immunoglobulins/analysis , Schizophrenia/immunology , Adolescent , Adult , Bipolar Disorder/diagnosis , Depressive Disorder/diagnosis , Female , Humans , Middle Aged , Schizophrenia/diagnosisABSTRACT
The paper aims at finding whether the serum creatine-kinase activity may be considered as a biological state or a trait-marker in major depression. The study performed in 76 patients (males and females) led to the conclusion that significant increases of the enzymic activity as compared with controls are present in depressive and not in euthymic patients. The same significant increase was found when comparing the depressive and euthymic patients (but not in the group of monopolar depressive females). There were no significant differences between the monopolar and the bipolar form of the disease. The data reported by the authors show that serum creatine-kinase is not a trait-marker in primary affective illness, but it may be taken for a state-marker in this disease. However, the enzyme is not a biochemical discriminant for the type of depression.