Subject(s)
Hair Diseases/pathology , Hair Dyes/pharmacology , Scalp/drug effects , Scalp/pathology , Adult , Aged , Female , Humans , Male , Middle Aged , Reproducibility of Results , Retrospective Studies , Young AdultSubject(s)
Lichen Planus , Ursidae , Alopecia , Animals , Fruit , Hair Follicle , Humans , Lichen Planus/diagnosis , Macrophages , TreesSubject(s)
Glucocorticoids/therapeutic use , Hematologic Neoplasms/drug therapy , Palliative Care/methods , Prednisolone/therapeutic use , Skin Neoplasms/drug therapy , Skin Neoplasms/radiotherapy , Aged, 80 and over , Combined Modality Therapy , Dendritic Cells/pathology , Fatal Outcome , Female , Hematologic Neoplasms/complications , Humans , Skin Neoplasms/etiologyABSTRACT
Electron beam therapy (EBT) is an established treatment for mycosis fungoides (MF), but evidence for the use of EBT in advanced cutaneous conditions is limited, and optimal scheduling of the regimen for such conditions remains unclear. We report the case of a 44-year-old woman diagnosed with MF with widespread cutaneous lesions, including multiple huge tumours in the craniofacial area. Low-dose total skin (TS)EBT and subsequent localized skin (LS)EBT achieved striking improvements in eruptions. Oral etretinate was also administered during therapy. Our experience implies that combined TSEBT and LSEBT may be worth attempting when a patient presents with both widespread lesions and prominent tumours, even when the tumours are extremely large.
Subject(s)
Mycosis Fungoides/radiotherapy , Skin Neoplasms/radiotherapy , Adult , Electrons/therapeutic use , Female , Humans , Mycosis Fungoides/pathology , Radiation Dosage , Radiotherapy/methods , Skin Neoplasms/pathology , Treatment Outcome , Whole-Body Irradiation/methodsABSTRACT
BACKGROUND: Autosomal recessive woolly hair/hypotrichosis (ARWH/H) is caused by mutations in LIPH. Homozygotes for the LIPH c.736T>A (p.C246S) mutation, the most prevalent genotype in Japanese patients, present varying degrees of hair loss; however, determinants of this phenotypic diversity remain elusive. OBJECTIVES: To establish methodologies for quantitative assessment of clinical severity and provide a detailed characterization to elucidate the factors contributing to phenotypic divergence. METHODS: Digital image analyses were conducted to convert clinical severities into numerical values. Eight patients with ARWH/H were classified into three groups (mild, severe, very severe), based on severity scores. Dermoscopic images were collected and assessed for total hair numbers and hair thickness for intergroup comparisons. RESULTS: The image analysis detected a difference in hair thickness but not in total hair numbers, between mild and severe cases. A marked decrease in total hair number was noted in an atypical very severe case. Histopathologically, a patient with a mild case demonstrated hair miniaturization and a high telogen/anagen ratio without a decrease in total hair count, endorsing dermoscopic observations. Two children demonstrated spontaneous improvement without an increase in total hair numbers, and two adults responded well to topical minoxidil with increased total hair numbers and hair thickness. CONCLUSIONS: The difference in the frequency of underdeveloped hairs may be a major factor contributing to the clinical diversity of hair sparseness in LIPH c.736T>A homozygotes with ARWH/H. Hence, pharmacological modification to thicken existing fine hairs may provide a therapeutic strategy.
Subject(s)
Hair Diseases/genetics , Hair/abnormalities , Hair/pathology , Hypotrichosis/genetics , Lipase/genetics , Adult , Child , Child, Preschool , Dermoscopy/methods , Female , Hair Diseases/drug therapy , Hair Diseases/pathology , Hair Preparations/therapeutic use , Homozygote , Humans , Hypotrichosis/drug therapy , Hypotrichosis/pathology , Male , Minoxidil/therapeutic use , Mutation/genetics , PhenotypeSubject(s)
Herpes Zoster/drug therapy , Immunologic Memory/immunology , Lichenoid Eruptions/etiology , T-Lymphocytes/immunology , 2-Aminopurine/administration & dosage , 2-Aminopurine/analogs & derivatives , Antigens, CD/immunology , Antigens, Differentiation, T-Lymphocyte/immunology , Antiviral Agents/administration & dosage , Famciclovir , Herpes Zoster/immunology , Herpes Zoster/pathology , Humans , Lectins, C-Type/immunology , Lichenoid Eruptions/immunology , Lichenoid Eruptions/pathology , Male , Middle Aged , RecurrenceABSTRACT
Genetic defects are a major cause of hearing loss in newborns. Consequently, hearing loss has a profound negative impact on human daily living. Numerous causative genes for genetic hearing loss have been identified. However, presently, there are no truly curative treatments for this condition. There have been several recent reports on successful treatments in mice using embryonic gene therapy, neonatal gene therapy and neonatal antisense oligonucleotide therapy. Herein, we describe state-of-the-art research on genetic hearing loss treatment through gene therapy and discuss the obstacles to overcome in curative treatments of genetic hearing loss in humans.
Subject(s)
Genetic Diseases, Inborn/therapy , Genetic Therapy , Hearing Loss/therapy , Oligonucleotides, Antisense/therapeutic use , Animals , Ear, Inner/anatomy & histology , Ear, Inner/growth & development , Genetic Diseases, Inborn/genetics , Hearing Loss/genetics , HumansABSTRACT
IgG4-related disease (IgG4-RD) is a newly recognized condition that is characterized by raised levels of serum IgG4, tissue infiltration of IgG4-positive plasma cells and presence of fibrosis. It affects multiple organs, including the pancreas, bile duct, and lacrimal and salivary glands. Skin lesions have rarely been reported, and those that have were described as distributed mainly in the head and neck region. We report a case of IgG4-RD with autoimmune pancreatitis and skin lesions on the trunk and limbs. The skin lesions responded well to oral prednisolone (PSL); however, tapering of PSL to 5 mg/day resulted in recurrence. At present, the skin disease is well controlled at a dose of 7 mg/day. Interestingly, IgG4 levels fluctuated with changes in the PSL dose but did not coincide with the severity of the skin disease, implying that the raised levels of IgG4 did not directly influence the skin symptoms.
Subject(s)
Autoimmune Diseases/immunology , Immunoglobulin G/immunology , Pancreatitis/immunology , Skin Diseases/immunology , Autoimmune Diseases/drug therapy , Glucocorticoids/therapeutic use , Humans , Male , Middle Aged , Pancreatitis/drug therapy , Prednisolone/therapeutic use , Recurrence , Skin Diseases/drug therapyABSTRACT
BACKGROUND: An oral adsorbent (AST-120) delays the progression of chronic renal failure (CRF). The aims of the present study are to determine the effects of AST-120 on the localization of indoxyl sulphate in uraemic rat kidneys, and to examine whether AST-120 reduces the renal cortical gene expression of transforming growth factor (TGF)-beta1, tissue inhibitor of metalloproteinase (TIMP)-1 and pro-alpha1(I)collagen, and ameliorates glomerular and tubulointerstitial injuries in uraemic rats. METHODS: Two weeks after 5/6-nephrectomy, 10 rats were divided into pairs such that both rats in each pair exhibited almost the same levels of serum creatinine, blood urea nitrogen and creatinine clearance. One rat from each pair was assigned to a control uraemic group, the other to a uraemic group which received AST-120 everyday for 11 weeks. The localization of indoxyl sulphate was studied by immunohistochemistry using a monoclonal anti-indoxyl sulphate antibody we had developed. The renal cortical gene expression was studied by using northern blotting. RESULTS: Rats treated with AST-120 showed decreased levels of serum creatinine, blood urea nitrogen and urinary protein as well as increased levels of creatinine clearance as compared with control uraemic rats. AST-120 markedly decreased indoxyl sulphate levels in both serum and urine. Immunohistochemistry demonstrated that indoxyl sulphate was localized in the renal proximal tubular epithelial cells, especially of dilated tubules, and that AST-120 markedly reduced the tubular staining of indoxyl sulphate. AST-120 attenuated interstitial fibrosis, tubular injury as well as glomerular sclerosis, and reduced the renal gene expression of TGF-beta1, TIMP-1 and pro-alpha1(I)collagen. CONCLUSIONS: AST-120 reduces the gene expression of TGF-beta1, TIMP-1 and pro-alpha1(I)collagen in the kidneys, and delays the progression of CRF, at least in part, by alleviating the overload of indoxyl sulphate on remnant proximal tubular epithelial cells.
Subject(s)
Carbon/pharmacology , Gene Expression Regulation/physiology , Indican/metabolism , Oxides/pharmacology , Transforming Growth Factor beta/genetics , Uremia/physiopathology , Adsorption , Animals , Blood Urea Nitrogen , Creatinine/metabolism , Gene Expression Regulation/drug effects , Indican/analysis , Male , Nephrectomy , Procollagen/genetics , Rats , Rats, Sprague-Dawley , Tissue Inhibitor of Metalloproteinase-1/genetics , Uremia/geneticsABSTRACT
It has been reported that extramedullary plasmacytoma (EMP) tends to be characterized by an indolent clinical course and lower incidence of progression to multiple myeloma. Primary plasmacytoma of lymph nodes is extremely rare and details of its clinical picture remain unclarified. We recently encountered an unusual case of EMP of lymph nodes that progressed to refractory multiple myeloma only 18 months later. A 74-year-old woman was admitted to our hospital because of a painless swelling in the right inguinal region. A tumor was removed surgically, and a histological diagnosis of EMP of the lymph nodes was made. Bence Jones protein (BJP) was detected in the urine, but there was no other evidence of systemic myelomatosis. The patient received local irradiation, which resulted in the elimination of BJP. Eighteen months later, however, a tumor developed in her right stemo-clavicular joint. A bone survey revealed multiple osteolytic lesions, and many atypical plasma cells were observed in the bone marrow, indicating multiple myeloma. The patient deteriorated despite several regimens of combination chemotherapy, and died four and a half years after the initial diagnosis of EMP.
Subject(s)
Lymph Nodes/pathology , Multiple Myeloma/pathology , Plasmacytoma/pathology , Aged , Drug Resistance, Neoplasm , Female , HumansABSTRACT
BACKGROUND: We have reported that oral sorbent AST-120 (AST) is effective in delaying the induction of dialysis in patients with chronic renal failure (CRF) because of its effect on lipid metabolism. To clarify the precise mechanism of AST in lipid abnormalities in CRF, we examined the effect of AST on plasma lipid profile, total bile acids (TBA), and lipoprotein lipase (LPL) activity in experimental uremic rats. METHODS: Uremic rats were prepared using male Wistar rats by ligating 5/6 of the renal artery. Uremic rats were randomly divided into two groups as follows: a control group in which rats were maintained on the standard diet and an AST group in which rats were maintained on a diet containing 5 g of AST per 100 g of standard diet for 10 weeks. Plasma LPL activity was measured as free fatty acid (FFA) generation after intravenous administration of heparin. RESULTS: Plasma creatinine at 1.5 +/- 0.1 mg/dl was lower in the AST group than the 1.9 +/- 0.5 mg/ml level in the control group. AST significantly decreased plasma total cholesterol from 192 +/- 29 to 142 +/- 25 mg/dl, triglycerides from 198 +/- 71 to 99 +/- 38 mg/dl, and TBA from 19.6 +/- 2.6 mumol/liter to 8.8 +/- 3.5 mumol/ml. Plasma LPL activity at 0.22 +/- 0.01 mumol FFA/min/hr was significantly higher in the AST group than 0.15 +/- 0.03 mumol FFA/min/hr in the control group. CONCLUSIONS: These results suggest that AST may improve plasma lipid abnormalities by binding to bile acids in the intestinal lumen and preventing their reabsorption and inhibiting the reduction of LPL activity in experimental uremic rats.
Subject(s)
Carbon/pharmacology , Lipids/blood , Oxides/pharmacology , Uremia/blood , Administration, Oral , Animals , Bile Acids and Salts/blood , Blood Urea Nitrogen , Body Weight/drug effects , Cholesterol/blood , Creatinine/blood , Lipoprotein Lipase/blood , Lipoprotein Lipase/drug effects , Male , Rats , Rats, Wistar , Reference Values , Triglycerides/bloodSubject(s)
Autoantibodies/immunology , Bulbar Palsy, Progressive/etiology , Gangliosides/immunology , Miller Fisher Syndrome/complications , Miller Fisher Syndrome/immunology , Blood Sedimentation , Child , Chromatography, Thin Layer , Electrophysiology , Enzyme-Linked Immunosorbent Assay , Humans , MaleABSTRACT
A 75-year-old man was admitted because of non-Hodgkin's lymphoma (histology undetermined) of the rib. A complete remission was achieved after CHOP therapy and irradiation. One year later, high fever, thrombocytopenia and liver dysfunction developed. Bone marrow aspirate revealed a hypoplastic marrow with hemophagocytic histiocytes, and a diagnosis of hemophagocytic syndrome (HPS) was made. Although no lymphomatous lesions were detected, HPS due to relapsed lymphoma was strongly suspected. The patient received MEVP therapy including etoposide and prednisolone, but without any improvement. Soon after the initiation of CPT-11 and adriamycin (ADM) therapy, all symptoms of HPS disappeared. This combination chemotherapy was repeated over a three-week span, and the patient remained in partial remission for the next 10 months. In November 1997, a tumor developed in the paranasal sinus, and the patient died three months later. The autopsy disclosed many B lymphoma cells filling the small vessels of almost all organs, and a final diagnosis of intravascular lymphomatosis (IVL) was made. These findings indicate that combination CPT-11 and ADM therapy is effective for cases of IVL accompanied by HPS that are refractory to conventional chemotherapies.
Subject(s)
Antineoplastic Agents, Phytogenic/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Camptothecin/analogs & derivatives , Doxorubicin/administration & dosage , Histiocytosis, Non-Langerhans-Cell/drug therapy , Lymphoma, Non-Hodgkin/complications , Vascular Neoplasms/complications , Aged , Camptothecin/administration & dosage , Histiocytosis, Non-Langerhans-Cell/etiology , Humans , Irinotecan , MaleABSTRACT
We recently reported that the serum levels of indoxyl sulfate, a dietary protein metabolite, are increased in both uremic rats and patients, and that the administration of indoxyl sulfate to uremic rats accelerates the progression of glomerular sclerosis. Thus, we hypothesize that the overload of protein metabolites such as indoxyl sulfate on nephrons promotes the progression of chronic renal failure (CRF). Recent studies revealed that tubulointerstitial injury is of equal or greater importance than glomerular sclerosis in determining whether progressive renal dysfunction will ensue in various renal diseases. In the present study, to clarify the role of indoxyl sulfate in the progression of CRF, the expressions of genes related to tubulointerstitial fibrosis such as transforming growth factor (TGF)-beta 1, tissue inhibitor of metalloproteinases (TIMP-1) and pro-alpha 1(I) collagen were examined in the renal cortex of 5/6-nephrectomized uremic rats given indoxyl sulfate. In the first experiment, the administration of indoxyl sulfate for five weeks significantly increased the mRNA levels of TGF-beta 1, TIMP-1 and pro-alpha 1(I) collagen in the uremic rats given indoxyl sulfate compared with the control uremic rats, accompanied by a significant decline in renal function and worsening of glomerular sclerosis. In the second experiment, the administration of indoxyl sulfate for 2.5 weeks also increased the expression of the mRNA levels with no significant decline in the renal function. In conclusion, these findings indicate that the overload of the protein metabolite indoxyl sulfate on remnant nephrons is involved in the increased bioactivity of TGF-beta 1 in uremic kidneys, which enhances the renal expression of TIMP-1 and type 1 collagen, leading to the progression of CRF.
Subject(s)
Gene Expression/drug effects , Indican/pharmacology , Kidney Cortex/metabolism , Procollagen/biosynthesis , Tissue Inhibitor of Metalloproteinase-1/biosynthesis , Transforming Growth Factor beta/biosynthesis , Uremia/metabolism , Administration, Oral , Animals , Blotting, Northern , DNA Probes/chemistry , Injections, Intraperitoneal , Kidney Cortex/drug effects , Kidney Cortex/pathology , Male , Nephrectomy , Procollagen/genetics , RNA, Messenger/biosynthesis , Rats , Rats, Sprague-Dawley , Tissue Inhibitor of Metalloproteinase-1/genetics , Transforming Growth Factor beta/genetics , Uremia/drug therapy , Uremia/pathologyABSTRACT
We have previously demonstrated that indoxyl sulfate is a stimulating factor for the progression of glomerular sclerosis in uremic rats. In this study we determined if a low-protein diet or oral sorbent (AST-120) could reduce the serum and urine levels of indoxyl sulfate in 5/6-nephrectomized uremic rats and undialyzed uremic patients. The uremic rats were treated by fasting or AST-120 for 2 days. The serum and urine levels of indoxyl sulfate dramatically decreased 1-2 days after fasting or AST-120 treatment. We then measured the serum and urine levels of indoxyl sulfate and calculated protein intake from urinary amounts of urea nitrogen using Maroni's equation in 80 undialyzed uremic patients with creatinine clearance less than 30 ml/min. The serum and urine levels of indoxyl sulfate were significantly lower in the patients on a low-protein diet than in those in the normal-protein diet group. Administration of AST-120 significantly decreased serum and urine levels of indoxyl sulfate in 22 undialyzed uremic patients. In conclusion, a low-protein diet or AST-120 reduced the serum and urine levels of indoxyl sulfate, a stimulating factor for glomerular sclerosis, in both uremic rats and undialyzed uremic patients.
Subject(s)
Carbon/therapeutic use , Dietary Proteins/administration & dosage , Indican/biosynthesis , Oxides/therapeutic use , Renal Insufficiency/therapy , Uremia/therapy , Administration, Oral , Adsorption , Adult , Aged , Animals , Disease Progression , Fasting/metabolism , Female , Humans , Male , Microspheres , Middle Aged , Rats , Rats, Sprague-Dawley , Renal Dialysis , Renal Insufficiency/metabolism , Uremia/etiologyABSTRACT
We recently demonstrated that the administration of indoxyl sulfate (dietary protein metabolite) to 5/6-nephrectomized rats accelerated the progression of chronic renal failure by increasing the transforming growth factor (TGF)-beta 1 synthesis in the kidneys, which enhanced the renal expressions of tissue inhibitor of metalloproteinase (TIMP)-1 and type 1 collagen, leading to renal fibrosis. The aim of the present study was to clarify the mechanism by which the administration of indoxyl sulfate increases TGF-beta 1 in the kidneys of uremic rats. Since infiltrative monocytes are suggested to be an important source of TGF-beta 1 in tubulointerstitial fibrosis, we examined the effect of indoxyl sulfate administration to uremic rats on the renal gene expression of intercellular adhesion molecule (ICAM)-1, which is involved in the infiltration of monocytes to kidneys. Indoxyl sulfate administration was observed to enhance the mRNA levels of ICAM-1 as well as those of TGF-beta 1, TIMP-1 and pro alpha 1 (I) collagen in the renal cortex of 5/6-nephrectomized uremic rats. In addition, we demonstrated in vitro that the addition of indoxyl sulfate significantly increased the synthesis of TGF-beta 1 in cultured proximal tubular cells. Thus, the overload of indoxyl sulfate in uremic kidneys increased the infiltration of monocytes and directly increased the synthesis of TGF-beta 1 in proximal tubular cells.
Subject(s)
Indican/pharmacology , Kidney Failure, Chronic/pathology , Kidney/metabolism , Transforming Growth Factor beta/biosynthesis , Animals , Cells, Cultured , Disease Progression , Enzyme-Linked Immunosorbent Assay , Gene Expression Regulation/drug effects , Intercellular Adhesion Molecule-1/biosynthesis , Intercellular Adhesion Molecule-1/genetics , Kidney/drug effects , Kidney/pathology , RNA, Messenger/biosynthesis , Rats , SwineABSTRACT
We investigated the cholinergic modulation of hippocampal rhythmical slow activity (or theta activity), long-term potentiation and a behavioral memory task. The intravenous administration of the muscarinic receptor agonists, AF102B ((+/-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3') quinuclidine hydrochloride hemihidrate) and oxotremorine, induced rhythmical slow activity at doses of 1.0 mg/kg and 0.01 mg/kg, respectively. Long-term potentiation of population spike amplitude in the hippocampal CA1, which was induced by tetanic stimulation to the Schaffer collateral/commissural fiber, was increased by AF102B (1.0 mg/kg i.v.) and oxotremorine (0.01 mg/kg i.v.). Oral administration of AF102B and oxotremorine improved scopolamine-induced memory deficits in a passive avoidance task in mice at doses of 1.0 mg/kg and 0.2 mg/kg, respectively. The correspondence of the effective doses of muscarinic receptor agonists in these three experiments suggested the cholinergic correlation of rhythmical slow activity, long-term potentiation and memory.
Subject(s)
Long-Term Potentiation/drug effects , Memory/drug effects , Muscarinic Agonists/pharmacology , Theta Rhythm/drug effects , Thiophenes , Administration, Oral , Animals , Avoidance Learning/drug effects , Dose-Response Relationship, Drug , Electric Stimulation , Electroencephalography/drug effects , Hippocampus/drug effects , Hippocampus/physiology , Male , Mice , Mice, Inbred Strains , Oxotremorine/administration & dosage , Oxotremorine/pharmacology , Quinuclidines/administration & dosage , Quinuclidines/pharmacology , Rats , Rats, Wistar , Scopolamine/pharmacology , Synaptic Transmission/drug effectsABSTRACT
To determine the role of indoxyl sulfate in the progression of glomerular sclerosis, the serum level of indoxyl sulfate was measured in patients with uremia, and the effect of oral administration of indoxyl sulfate on renal function and renal histology was studied in subtotally nephrectomized uremic rats. Further, the effects of a low-protein diet and oral sorbent (AST-120) administration on the serum and urine levels of indoxyl sulfate were studied in different groups of subtotally nephrectomized uremic rats. We noted a marked elevation of serum level of indoxyl sulfate in the patients with uremia. The oral administration of indoxyl sulfate to the uremic rats increased the serum creatinine and blood urea nitrogen levels and decreased creatinine clearance, inulin clearance, and p-aminohippuric acid clearance. The glomerular sclerosis index in the indoxyl sulfate-administered uremic rats was higher than in the control uremic rats. A low-protein diet and AST-120 administration decreased the serum and urine levels of indoxyl sulfate, the blood urea nitrogen level, the urinary protein level, and the glomerular sclerosis index in the uremic rats as compared with those on a high-protein diet. Thus, indoxyl sulfate, a circulating uremic toxin, stimulated the progression of glomerular sclerosis in the uremic model. A low-protein diet and AST-120 reduced the serum and urine levels of indoxyl sulfate and suppressed the progression of glomerular sclerosis.
Subject(s)
Glomerulosclerosis, Focal Segmental/pathology , Indican/pharmacology , Uremia/blood , Aged , Animals , Carbon/pharmacology , Dietary Proteins/pharmacology , Female , Humans , Indican/urine , Kidney/drug effects , Kidney/pathology , Male , Middle Aged , Oxides/pharmacology , Rats , Rats, Sprague-DawleyABSTRACT
In uremia there is a marked elevation of serum levels of indoxyl sulfate due to its decreased renal clearance. Indoxyl sulfate is synthesized in the liver from indole which is produced by bacteria in the intestines. To determine the role of indoxyl sulfate in the progression of chronic renal failure, we administered indole, the precursor of indoxyl sulfate, to subtotally nephrectomized uremic rats. The oral administration of indole increased the serum levels of creatinine and blood urea nitrogen and decreased creatinine, inulin, and p-aminohippuric acid clearances. The glomerular sclerosis index in the indole-treated rats was higher than in the control uremic rats. After oral administration, indole could not be detected in the urine, but large amounts of its metabolite, indoxyl sulfate. Thus, indole administration stimulated glomerular sclerosis in a uremic model through the production of indoxyl sulfate.
Subject(s)
Glomerulosclerosis, Focal Segmental/pathology , Indican/metabolism , Indican/pharmacology , Indoles/metabolism , Indoles/pharmacology , Kidney Glomerulus/pathology , Uremia/pathology , Animals , Male , Nephrectomy , Rats , Rats, Sprague-Dawley , Tryptophan/pharmacologyABSTRACT
Serum p-cresol and phenol are markedly accumulated in uremic patients. To determine if an oral sorbent (AST-120) can decrease their serum concentrations in the uremic state, an oral sorbent was administered to experimental nephrectomized uremic rats. In uremic rats fed with oral sorbent, the serum concentration and the urinary excretion of p-cresol were markedly and significantly lower than those in control uremic rats, while those of phenol tended to be low in the uremic rats with oral sorbent as compared with control uremic rats. The concentrations of serum creatinine and blood urea nitrogen were significantly decreased in the uremic rats with oral sorbent. These findings demonstrate that oral sorbent adsorbs especially p-cresol in the intestine and prevents the accumulation of p-cresol in the serum of uremic rats.