ABSTRACT
A solitary mass, 2.5 cm x 2.5 cm x 2.0 cm in size, was found in the subcutis adjacent to the ischial tuberosity of an 8-year-old male German shepherd dog. The excised mass was not encapsulated and the cut surface was solid, grey-white and had multiple red areas suggestive of haemorrhage. Microscopically, the neoplasm was composed of epithelioid cells interspersed with venous vessels of various sizes and irregular bundles of spindle-shaped tumour cells with mucinous stroma. The nuclei showed anisokaryosis and many mitotic figures were noted. Immunohistochemically, the majority of tumour cells were positive for alpha smooth-muscle actin and vimentin, but negative for cytokeratin, desmin, S-100 and factor VIII-related antigen. Ultrastructurally, the tumour cells contained irregular nuclei, few mitochondria, few rough endoplasmic reticulum, cytoplasmic myofilaments of intermediate density, pinocytotic vesicles and distinct basal lamina. Based on these pathological findings, the diagnosis was malignant glomus tumour.
Subject(s)
Dog Diseases/pathology , Glomus Tumor/veterinary , Skin Neoplasms/veterinary , Animals , Dogs , Glomus Tumor/pathology , Male , Skin Neoplasms/pathologySubject(s)
Gastrointestinal Stromal Tumors/diagnosis , Aged , Aged, 80 and over , Biomarkers, Tumor/genetics , Biopsy, Fine-Needle , Fatal Outcome , Gastrointestinal Stromal Tumors/genetics , Gastrointestinal Stromal Tumors/metabolism , Humans , Magnetic Resonance Imaging , Male , Pelvis , Tomography, X-Ray ComputedSubject(s)
Anemia, Aplastic/virology , Anemia, Refractory/virology , Hepatitis B/complications , Female , Humans , Middle AgedABSTRACT
An 88-year-old man developed pneumothorax and pleural effusion. After the finding of ingesta in the pleural effusion, a gastropleural fistula was diagnosed. A biopsy specimen of the stomach revealed non-Hodgkin lymphoma, diffuse large-cell, B-cell type. Autopsy examination demonstrated that the malignant lymphoma had originated from high-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Gastropleural fistula is an uncommon condition, as the diaphragm forms a thick barrier between the stomach and the thoracic cavity. We review 25 reported cases of gastropleural fistula found in a MEDLINE search from 1966 to 2000. In only 3 of the 25 patients was malignant lymphoma reported to have caused the gastropleural fistula.