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1.
Sci Rep ; 14(1): 19000, 2024 Aug 16.
Article in English | MEDLINE | ID: mdl-39152247

ABSTRACT

This article presents a compact, wide-angle, polarization-insensitive metamaterial harvester that can efficiently harvest electromagnetic (EM) energy in the S, C, X, and Ku bands. The harvester's unit cell consists of a split ring resonator, two strip lines, and two split strip lines, giving it a total size of (10 × 10) mm2. Each split gap is filled with a 50 Ω resistive load. The input impedance of the harvester is precisely designed to match that of free space, allowing for efficient absorption of EM power and appropriate redirection towards the resistive loads. The harvester's performance is also evaluated for various polarization and incident angles, considering the Transverse Electric and Transverse Magnetic modes. The simulation results reveal that the proposed harvester exhibits a notably greater conversion efficiency of around > 95%. The simulation outcomes were carefully validated through experimental tests conducted in an anechoic chamber using a 3 × 3 cell array of the proposed design. This ensured the accuracy and reliability of the results. The strong correlation between the experimental data and the full-wave simulations strongly supports the effectiveness of the proposed harvester. Therefore, the demonstrated efficiency and compact size make it a perfect fit for energy harvesting systems in wireless sensor networks.

2.
PLoS One ; 19(8): e0303461, 2024.
Article in English | MEDLINE | ID: mdl-39088511

ABSTRACT

BACKGROUND: Participating in physical exercise is advantageous for maintaining optimum health, improving physical capacity, decreasing the likelihood of chronic diseases, and promoting overall wellbeing. AIM: This study aimed to find out the prevalence and factors that contribute to musculoskeletal injuries among individuals who participated in fitness activities at the gym. METHODS: This cross-sectional study included 1123 gym members, both male and female, aged between 18 and 50 years, from selected fitness centers in Bangladesh. Musculoskeletal injuries were assessed using the Nordic musculoskeletal disorder questionnaire. Binary logistic regression identified the gym members' predictors of musculoskeletal injuries. RESULTS: The highest prevalence of musculoskeletal injuries at the low back (36.6%) was seen among the eight body sites, followed by the shoulder (24.7%) and knee (17.1%). Males (aOR 2.589, CI 1.18 to 5.65) and those who go to the gym to lose weight (aOR 3.859, CI 0.91 to 16.33) and for physical fitness (aOR 1.895, CI 1.07 to 3.35) had a greater risk of musculoskeletal injury. Participants who carried out strength training exercises (aOR 4.10, CI 2.74 to 6.19) had a four-fold increased risk of musculoskeletal injuries than those who did not. Furthermore, higher adjusted odds of musculoskeletal injuries were found for the potential causes of injuries in incorrect holding (aOR 1.69, CI 1.10 to 2.60), overweight lifting (aOR 2.00, CI 1.30 to 3.08), lack of workout knowledge (aOR 3.56, CI 2.09 to 5.85), and insufficient information from the trainer (aOR 5.66, CI 1.84 to 17.39). CONCLUSION: Musculoskeletal injuries are highly prevalent among gym-goers in Bangladesh. The back was the most often injured area, followed by the shoulder and knee. It is important to exhibit caution and take extra care while doing strength training activities in order to avoid injury. Prior to engaging in gym-based activities, it is essential to have a thorough understanding of proper exercise knowledge.


Subject(s)
Exercise , Humans , Male , Female , Bangladesh/epidemiology , Adult , Cross-Sectional Studies , Middle Aged , Prevalence , Adolescent , Young Adult , Risk Factors , Physical Fitness , Surveys and Questionnaires , Musculoskeletal Diseases/epidemiology
3.
Sci Rep ; 14(1): 18561, 2024 08 09.
Article in English | MEDLINE | ID: mdl-39122809

ABSTRACT

Field pea (Pisum sativum L.) needs improvement to increase productivity due to its high price and demand. However, the incidence of powdery mildew (PM) disease limits its production. This study aimed to analyze the diversity of qualitative and quantitative traits against powdery mildew resistance by utilizing cluster and principal component analysis to explore PM resistance high-yield potential field peas. Shannon-Weaver's diversity index (H') displayed high intra-genotype diversity for quantitative and qualitative aspects. Heterogeneity was identified for resistance against powdery mildew infections. Eighty-five genotypes were divided into five groups using Mohalanobis generalized distance (D2) statistics. The highest inter-cluster D2 value was observed between clusters 2 and 3 (11.89) while the lowest value was found between clusters 3 and 4 (2.06). Most of the genotypes had noticeable differences, so these could be employed in a crossing scheme. Twelve genotypes were extremely resistant, 29 genotypes were resistant, 25 genotypes were moderately resistant, 18 genotypes were fairly susceptible, and 1 genotype was susceptible to powdery mildew disease. Among 29 resistant genotypes, BFP77, BFP74, BFP63, BFP62, BFP43, and BFP80 were high yielders and, could be used directly and/or transferred through hybridization to high-yielding disease-susceptible genotypes. Among the 25 moderately resistant genotypes, BFP78, BFP45, BFP79, and BFP48 were found to be high yielders. In principal component analysis (PCA), the first four PCs with Eigen values > 1 accounted for 88.4% variability for quantitative traits. Clustering sorted genotypes into five groups, where groups 1 to 5 assembled 37, 28, 1, 8, and 11 genotypes, respectively. Genotypes of cluster 4 were identified as high yielders with its attributes. Pearson correlation significantly and positively correlated across all traits except for PM. This variation suggested that there is a mechanism to select promising genotypes for field pea breeding. Considering all features, BFP78, BFP77, BFP74, BFP63, BFP62, BFP45, BFP79, and BFP80 could be preferred as high yielders and PM resistance owing to longer pod lengths, seeds per pod and pods per plant.


Subject(s)
Disease Resistance , Genotype , Phenotype , Pisum sativum , Plant Diseases , Pisum sativum/genetics , Pisum sativum/microbiology , Plant Diseases/microbiology , Plant Diseases/genetics , Disease Resistance/genetics , Ascomycota/genetics , Plant Breeding/methods , Principal Component Analysis , Quantitative Trait, Heritable , Genetic Variation
4.
Eur J Case Rep Intern Med ; 11(8): 004729, 2024.
Article in English | MEDLINE | ID: mdl-39130070

ABSTRACT

Background: While the use of immunotherapy has revolutionised the treatment of various cancers, it is often associated with a myriad of immune-related adverse effects. Case Presentation: In this article, we report a rare case of durvalumab-induced triple-M syndrome in a 69-year-old woman with stage III lung adenocarcinoma. She was admitted with profound generalised muscle weakness, myalgia, and exertional breathlessness, about a week into her second cycle of durvalumab, an immune checkpoint inhibitor. She had clinicopathological features of myositis, myasthenia and myocarditis with acute onset symptomatic tri-fascicular block on electrocardiogram, requiring urgent cardiology intervention. Durvalumab was discontinued and she was treated with a combination of high-dose steroids and intravenous immunoglobulin after which she had clinical and biochemical improvement, albeit with residual muscle weakness. Conclusion: Myocarditis-myositis-myasthenia complex is a rare side effect of immunotherapy which has been reported in other immune checkpoint inhibitors, but less so with durvalumab. We report this clinical case to raise awareness of this rare and potentially life-threatening adverse effect of this agent. LEARNING POINTS: Triple-M syndrome is a rare immune-related adverse effect, which has been noted in other immune checkpoint inhibitors, but less so with durvalumab specifically.Immunotherapy-induced myositis, myocarditis and myasthenia can occur in isolation or, rarely, in association as a syndrome.This case demonstrates the potentially life-threatening nature of this entity, the need for early recognition, and multi-specialist teamwork to ensure good outcome.

5.
Nat Sci Sleep ; 16: 1131-1139, 2024.
Article in English | MEDLINE | ID: mdl-39109265

ABSTRACT

Purpose: Clinical management decisions often rely on a patient's SpO2 level and desaturation rate. Limitations include that measurements depend on the averaging time (AVT) used, which is particularly relevant to sleep medicine, but has yet received little attention. Methods: Cross-sectional review of studies reporting pulse oximeter saturation (SpO2) measurements published in 5 leading sleep medicine journals. All papers published between 2017 and 2023 reporting SpO2 measurements were screened regarding the AVT used. Results: Of 193 papers identified, 151 were included; of these, only 9 studies mentioned the AVT, 4 of these were published in one journal. The AVT ranged from zero (beat-to-beat-mode) to 10s, with 3s being used most often (33.3%), followed by 2s (22.2%). Conclusion: The AVT is only rarely mentioned in sleep medicine papers, despite its influence on sleep study results. Reported AVTs were heterogenous. Further research is warranted to set up guidelines for using or reporting the AVT.

6.
Health Sci Rep ; 7(8): e2274, 2024 Aug.
Article in English | MEDLINE | ID: mdl-39100714

ABSTRACT

Background: Effective communication skill of physicians is an important component of high-quality healthcare delivery and safe patient care. Communication is embedded in the social and cultural contexts where it takes place. An understanding of medical students' attitudes and learning communication skills would help to design and deliver culturally appropriate medical education. The Communication Skills Attitude Scale (CSAS) is a widely used and validated tool to measure the attitude of medical students toward learning communication skills in different populations, settings, and countries. However, there is no culturally adapted and validated scale in Bangla in the Bangladesh context. This study aims to culturally adapt the CSAS into Bangla, and validate it in a cohort of medical students in Bangladesh. Methods: This study used a cross-sectional survey design to collect data from purposively selected 566 undergraduate medical students from the Rajshahi division. The survey was conducted from January to December 2023. Descriptive statistics like frequency distribution and measures of central tendency were used to measure perception regarding communication skills. The sample adequacy was measured through the Kaiser-Meyer-Olkin test. The internal consistency of the items was identified using Cronbach's alpha (α) coefficients. Result: The results of the study show that the Bangla version of the scale is feasible, valid, and internally consistent in the context of a developing country, Bangladesh. The overall internal consistency of the Bangla version is good since the value of Cronbach's alpha (α) is 0.882. For PAS, the internal consistency is 0.933. While, for NAS, the value is 0.719. The item-wise average scores in the PAS indicate that female medical students are more willing to learn communication skills compared with male students (α = 0.933). While, the scores in the NAS indicate that the male students tend to have more negative attitude toward learning communication skills compared with female students (α = 0.719). Conclusion: The CSAS-Bangla is a valid and reliable tool for assessing communication skill attitudes among Bangla speaking medical students. This scale can be used in future studies to measure the attitude of students, designing and evaluating communication skills training programs in medical colleges.

8.
Ophthalmol Sci ; 4(6): 100544, 2024.
Article in English | MEDLINE | ID: mdl-39139547

ABSTRACT

Purpose: To develop a 3-dimensional corneal construct suitable for in vitro studies of disease conditions and therapies. Design: In vitro human corneal constructs were created using chemically crosslinked collagen and chondroitin sulfate extracellular matrix and seeded with 3 human corneal cell types (epithelial, stromal, and endothelial) together with neural cells. The neural cells were derived from hybrid neuroblastoma cells and the other cells used from immortalized human corneal cell lines. To check the feasibility and characterize the constructs, cytotoxicity, cell proliferation, histology, and protein expression studies were performed. Results: Optimized culture condition permitted synchronized viability across the cell types within the construct. The construct showed a typical appearance for different cellular layers, including healthy appearing, phenotypically differentiated neurons. The expected protein expression profiles for specific cell types within the construct were confirmed with western blotting. Conclusions: An in vitro corneal construct was successfully developed with maintenance of individual cell phenotypes with anatomically correct cellular loci. The construct may be useful in evaluation of specific corneal disorders and in developing different corneal disease models. Additionally, the construct can be used in evaluating drug targeting and/or penetration to individual corneal layers, testing novel therapeutics for corneal diseases, and potentially reducing the necessity for animals in corneal research at the early stages of investigation. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

9.
Sci Rep ; 14(1): 19133, 2024 08 19.
Article in English | MEDLINE | ID: mdl-39160196

ABSTRACT

Type 2 diabetes (T2D) and Clear-cell renal cell carcinoma (ccRCC) are both complicated diseases which incidence rates gradually increasing. Population based studies show that severity of ccRCC might be associated with T2D. However, so far, no researcher yet investigated about the molecular mechanisms of their association. This study explored T2D and ccRCC causing shared key genes (sKGs) from multiple transcriptomics profiles to investigate their common pathogenetic processes and associated drug molecules. We identified 259 shared differentially expressed genes (sDEGs) that can separate both T2D and ccRCC patients from control samples. Local correlation analysis based on the expressions of sDEGs indicated significant association between T2D and ccRCC. Then ten sDEGs (CDC42, SCARB1, GOT2, CXCL8, FN1, IL1B, JUN, TLR2, TLR4, and VIM) were selected as the sKGs through the protein-protein interaction (PPI) network analysis. These sKGs were found significantly associated with different CpG sites of DNA methylation that might be the cause of ccRCC. The sKGs-set enrichment analysis with Gene Ontology (GO) terms and KEGG pathways revealed some crucial shared molecular functions, biological process, cellular components and KEGG pathways that might be associated with development of both T2D and ccRCC. The regulatory network analysis of sKGs identified six post-transcriptional regulators (hsa-mir-93-5p, hsa-mir-203a-3p, hsa-mir-204-5p, hsa-mir-335-5p, hsa-mir-26b-5p, and hsa-mir-1-3p) and five transcriptional regulators (YY1, FOXL1, FOXC1, NR2F1 and GATA2) of sKGs. Finally, sKGs-guided top-ranked three repurposable drug molecules (Digoxin, Imatinib, and Dovitinib) were recommended as the common treatment for both T2D and ccRCC by molecular docking and ADME/T analysis. Therefore, the results of this study may be useful for diagnosis and therapies of ccRCC patients who are also suffering from T2D.


Subject(s)
Carcinoma, Renal Cell , Computational Biology , Diabetes Mellitus, Type 2 , Kidney Neoplasms , Protein Interaction Maps , Humans , Carcinoma, Renal Cell/genetics , Carcinoma, Renal Cell/metabolism , Carcinoma, Renal Cell/pathology , Diabetes Mellitus, Type 2/genetics , Diabetes Mellitus, Type 2/metabolism , Computational Biology/methods , Kidney Neoplasms/genetics , Kidney Neoplasms/metabolism , Kidney Neoplasms/pathology , Gene Expression Regulation, Neoplastic , DNA Methylation , Gene Expression Profiling , Gene Regulatory Networks , Transcriptome
10.
RSC Med Chem ; 15(8): 2937-2958, 2024 Aug 14.
Article in English | MEDLINE | ID: mdl-39149093

ABSTRACT

The unique structure of spirooxindoles and their ability to feature various pharmacophoric motifs render them privileged scaffolds for tailoring new multitarget anticancer agents. Herein, a stereoselective multicomponent reaction was utilized to generate a small combinatorial library of pyrazole-tethered spirooxindoles targeting DNA and CDK2 with free radical scavenging potential as an extra bonus. The designed spirooxindoles were directed to combat NSCLC via inducing apoptosis and alleviating oxidative stress. The series' absolute configuration was assigned by X-ray diffraction analysis. Cytotoxicity screening of the developed spirooxindoles against NSCLC A549 and H460 cells compared to normal lung fibroblasts Wi-38 revealed the sensitivity of A549 cells to the compounds and raised 6e and 6h as the study hits (IC50 ∼ 0.09 µM and SI > 3). They damaged DNA at 24.6 and 35.3 nM, and surpassed roscovitine as CDK2 inhibitors (IC50 = 75.6 and 80.2 nM). Docking and MDs simulations postulated their receptors binding modes. The most potent derivative, 6e, induced A549 apoptosis by 40.85% arresting cell cycle at G2/M phase, and exhibited antioxidant activity in a dose-dependent manner compared to Trolox as indicated by DPPH scavenging assay. Finally, in silico ADMET analysis predicted the drug-likeness properties of 6e.

11.
Data Brief ; 55: 110712, 2024 Aug.
Article in English | MEDLINE | ID: mdl-39081491

ABSTRACT

The utilization of computer vision techniques has significantly enhanced the automation processes across various industries, including textile manufacturing, agriculture, and information technology. Specifically, in the domain of textile manufacturing, these techniques have revolutionized the detection of fiber defects and the quantification of cotton content in fabrics. Traditionally, the assessment of cotton percentages was a labor-intensive and time-consuming process that relied heavily on manual testing methods. However, the adoption of computer vision approaches requires a comprehensive dataset of fabric samples, each with a known cotton percentage, to serve as training data for machine learning models. This paper introduces a novel dataset comprising 1300 original images, covering a wide range of cotton percentages across thirteen distinct categories, from 30% to 99%. By employing image augmentation techniques, such as- rotation, horizontal flip, vertical flip, width shift, height shift, shear range, and zooming, this dataset has been expanded to include a total of 27,300 images, thereby enhancing its utility for training and validating computer vision models aimed at accurately determining cotton content in fabrics. Through the extraction of pertinent features from the images of fabrics, this dataset holds the potential to significantly improve the accuracy and efficiency of computer vision-based cotton percentage detection.

13.
Heliyon ; 10(13): e33224, 2024 Jul 15.
Article in English | MEDLINE | ID: mdl-39027546

ABSTRACT

Photonic Crystal Fibers (PCF) effectiveness in practice decreases if the fabrication of the sensor becomes too complex. Keeping this in mind, we propose a one-of-a-kind wheel shaped PCF sensor with an exposed core containing only three air holes with exceptional sensing features. The sensor is equipped with dual plasmonic layers, Indium Tin Oxide (ITO, 10 % wt) and silver (Ag) with a coating of TiO2 to enhance the sensing capabilities and provide protection against oxidation. The sensor's distinctive configuration enables it to exhibit two distinct peaks within a range of refractive index from 1.32 to 1.38 for y-polarization and from 1.35 to 1.38 for x-polarization. The sensor specifications have been optimized to achieve the maximum levels of wavelength sensitivity (WS) and double peak shift sensitivity (DPSS). The sensor portrays a WS of 50,652 nm/RIU and the highest DPSS ever recorded, measuring 50,000 nm/RIU. Additionally, the sensor exhibits a significantly high scale of amplitude sensitivity (AS) of 1668.34 RIU-1 which is a very remarkable value considering silver as plasmonic material along with an outstanding figure of merit (FOM) of 1017.11 RIU-1. In addition, our sensor is able to manifest resolutions in the order of 10-6, demonstrating a resolution of 5.94 × 10-6 RIU with the deployment of amplitude interrogation method and 1.97 × 10-6 RIU with the wavelength interrogation method. The design spans an extensive spectrum, covering ultraviolet to mid-infrared wavelengths, enabling detection of biomolecules and biochemicals, along with operation in the optical communication band.

14.
Article in English | MEDLINE | ID: mdl-38967713

ABSTRACT

PURPOSE OF REVIEW: The elderly population typically suffer from a variety of diseases that mostly reflect the degenerative changes linked with the aging process. These diseases may be exacerbated by acute pain or by an abrupt aggravation of previously stable chronic pain. RECENT FINDINGS: Physical and psychological changes associated with aging may influence one's experience of pain and, as a result, the severity of pain. Pain treatment in the elderly can be complex and is often a budgetary burden on the nation's health care system. These difficulties arise, in part, because of unanticipated pharmacodynamics, changed pharmacokinetics, and polypharmacy interactions. Therefore, it is critical to integrate a multidisciplinary team to develop a management strategy that incorporates medical, psychological, and surgical methods to control persistent pain conditions. It is in this critical process that pain prediction models can be of great use. The purpose of pain prediction models for the elderly is the use of mathematical models to predict the occurrence and intensity of pain and pain-related conditions. These mathematical models employ a vast quantity of data to ascertain the many risk factors for the development of pain problems in the elderly, whether said risks are adjustable or not. These models will pave the way for more informed medical decision making that are based on the findings of thousands of patients who have previously experienced the same illness and related pain conditions. However, future additional research needs to be undertaken to build prediction models that are not constrained by substantial legal or methodological limitations.

15.
Ann Glob Health ; 90(1): 41, 2024.
Article in English | MEDLINE | ID: mdl-39005643

ABSTRACT

A healthy ocean is essential for human health, and yet the links between the ocean and human health are often overlooked. By providing new medicines, technologies, energy, foods, recreation, and inspiration, the ocean has the potential to enhance human health and wellbeing. However, climate change, pollution, biodiversity loss, and inequity threaten both ocean and human health. Sustainable realisation of the ocean's health benefits will require overcoming these challenges through equitable partnerships, enforcement of laws and treaties, robust monitoring, and use of metrics that assess both the ocean's natural capital and human wellbeing. Achieving this will require an explicit focus on human rights, equity, sustainability, and social justice. In addition to highlighting the potential unique role of the healthcare sector, we offer science-based recommendations to protect both ocean health and human health, and we highlight the unique potential of the healthcare sector tolead this effort.


Subject(s)
Climate Change , Oceans and Seas , Humans , Biodiversity , Conservation of Natural Resources , Health Care Sector , Human Rights , Social Justice , Sustainable Development
16.
Chem Biodivers ; : e202400897, 2024 Jul 06.
Article in English | MEDLINE | ID: mdl-38970566

ABSTRACT

Cancer is one of the leading causes of mortality worldwide. Despite the advancement of cancer treatment by various means including surgery, chemotherapy, etc., cancer is still a challenging disease to manage. This study was undertaken to investigate extraction, purification, structural elucidation, and the potential anti-cancer effects of Pleurotus ostreatus polysaccharide (POP). The anti-cancer activities were performed on the Ehrlich Ascites Carcinoma Cell Line. The results demonstrated that the MW of  POP was154649.8 Da with homopolysaccharide composed of D-glucose units, featuring (1→6)-α-D-Glcp backbone with O-6 branches and T-α-D-Glcp terminations. and the yield was 6.27%. was 6.27%, The antitumor activity assessment demonstrated significant cytotoxicity of POP against Ehrlich Ascites Carcinoma (EAC) cells, with an IC50 of 121.801 µg/mL, supported by LDH release analysis. POP inhibited cell migration, invasion, and colony formation, indicating its potential as an anti-cancer agent. POP elicited the apoptotic activity with the upregulation of Caspase-9 and Bax, and downregulation of Bcl-2. The DNA fragmentation assay further confirmed apoptosis-mediated DNA degradations. Additionally, POP-induced cell cycle arrest at the G0/G1 phase, by altering the expression of p53, Cyclin D, and Cdk4 proteins. So, Pleurotus ostreatus polysaccharide (POP) showed significant cytotoxicity on Ehrlich Ascites Carcinoma cells, indicating potential as an anti-cancer agent.

17.
Article in English | MEDLINE | ID: mdl-39012380

ABSTRACT

PURPOSE: Cyclophosphamide, Epirubicin/Doxorubicin, 5-fluorouracil (CEF or CAF) chemotherapy has long been a standard first-line treatment for breast cancer. The genetic variations of enzymes that are responsible for the metabolism of these drugs have been linked to altered treatment response and toxicity. Two drug-metabolizing enzymes ALDH1A1 and NQO1 are critically involved in the pathways of CEF/CAF metabolism. This study aimed to evaluate the effect of ALDH1A1 (rs13959) and NQO1 (rs1800566) polymorphisms on treatment response and toxicities caused by adjuvant (ACT) and neoadjuvant chemotherapy (NACT) where CEF/CAF combination was used to treat Bangladeshi breast cancer patients. METHODS: A total of 330 patients were recruited from various hospitals, with 150 receiving neoadjuvant chemotherapy and 180 receiving adjuvant chemotherapy. To extract genomic DNA, a non-enzymatic simple salting out approach was adopted. The polymerase chain reaction-restriction fragment length polymorphism method was used to detect genetic polymorphisms. Unconditional logistic regression was used to derive odds ratios (ORs) with 95% confidence intervals (CIs) to study the association between genetic polymorphisms and clinical outcome and toxicity. RESULTS: A statistically significant association was observed between ALDH1A1 (rs13959) polymorphism and treatment response (TT vs. CC: aOR = 6.40, p = 0.007; recessive model: aOR = 6.38, p = 0.002; allele model: p = 0.032). Patients with the genotypes TT and CT + TT of the NQO1 (rs1800566) polymorphism had a significantly higher risk of toxicities such as anemia (aOR = 0.34, p = 0.006 and aOR = 0.58, p = 0.021), neutropenia (aOR = 0.42, p = 0.044 and aOR = 0.57, p = 0.027), leukopenia (aOR = 0.33, p = 0.010 and aOR = 0.46, p = 0.005), and gastrointestinal toxicity (aOR = 0.30, p = 0.02 and aOR = 0.38, p = 0.006) when compared to the wild CC genotype, while patients with the genotype CT had a significant association with gastrointestinal toxicity (aOR = 0.42, p = 0.02) and leukopenia (aOR = 0.52, p = 0.010). The TT and CT + TT genotypes of rs13959 had a significantly higher risk of anemia (aOR = 2.00, p = 0.037 and aOR = 1.68, p = 0.029). There was no significant association between rs1800566 polymorphism and treatment response. CONCLUSION: Polymorphisms in ALDH1A1 (rs13959) and NQO1 (rs1800566) may be useful in predicting the probability of treatment response and adverse effects from CEF or CAF-based chemotherapy in breast cancer patients.

18.
Future Med Chem ; 16(12): 1185-1203, 2024.
Article in English | MEDLINE | ID: mdl-38989989

ABSTRACT

Aim: Synthesis of novel bis-Schiff bases having potent inhibitory activity against phosphodiesterase (PDE-1 and -3) enzymes, potentially offering therapeutic implications for various conditions. Methods: Bis-Schiff bases were synthesized by refluxing 2,4-dihydroxyacetophenone with hydrazine hydrate, followed by treatment of substituted aldehydes with the resulting hydrazone to obtain the product compounds. After structural confirmation, the compounds were screened for their in vitro PDE-1 and -3 inhibitory activities. Results: The prepared compounds exhibited noteworthy inhibitory efficacy against PDE-1 and -3 enzymes by comparing with suramin standard. To clarify the binding interactions between the drugs, PDE-1 and -3 active sites, molecular docking studies were carried out. Conclusion: The potent compounds discovered in this study may be good candidates for drug development.


[Box: see text].


Subject(s)
Acetophenones , Cyclic Nucleotide Phosphodiesterases, Type 1 , Molecular Docking Simulation , Phosphodiesterase Inhibitors , Acetophenones/chemistry , Acetophenones/pharmacology , Acetophenones/chemical synthesis , Phosphodiesterase Inhibitors/pharmacology , Phosphodiesterase Inhibitors/chemical synthesis , Phosphodiesterase Inhibitors/chemistry , Humans , Cyclic Nucleotide Phosphodiesterases, Type 1/antagonists & inhibitors , Cyclic Nucleotide Phosphodiesterases, Type 1/metabolism , Structure-Activity Relationship , Molecular Structure , Schiff Bases/chemistry , Schiff Bases/pharmacology , Schiff Bases/chemical synthesis , Catalytic Domain
19.
ACS Omega ; 9(27): 29751-29755, 2024 Jul 09.
Article in English | MEDLINE | ID: mdl-39005837

ABSTRACT

In this study, we investigate the scope of molybdenum disulfide (MoS2) as an electric field sensor. We show that MoS2 sensors can be used to identify the polarity as well as to detect the magnitude of the electric field. The response of the sensor is recorded as the change in the drain current when the electric field is applied. The sensitivity, defined as the percentage change in the drain current, reveals that it has a linear relation with the magnitude of the electric field. Furthermore, the sensitivity is highly dependent on the layer thickness, with the single-layer device being highly sensitive and the sensitivity decreasing with the thickness. We have also compared the electric field sensitivity of MoS2 devices to that of previously studied graphene devices and found the former to be exceptionally sensitive than the latter for a given electric field magnitude.

20.
Mar Pollut Bull ; 206: 116694, 2024 Sep.
Article in English | MEDLINE | ID: mdl-39002213

ABSTRACT

This study explored the alteration of naturally occurring radioactive materials (NORMs: 226Ra (≈238U), 232Th, 40K) in an anthropogenically disrupted urban river-basin (Turag, Bangladesh) in terms of constitutional substances (Sc, Ti, V, Fe, La, Ce, Sm, Eu, Tb, Dy, Ho, Yb, Lu, Hf, Ta, W, Th, U) of heavy-minerals. Average activity concentrations of 226Ra (≈238U), 232Th, and 40K were 41.5 ± 12.9, 72.1 ± 27.1, and 639 ± 100 Bqkg-1, respectively which were relatively higher compared to crustal origin. ∑REEs, Ta, W, Th, and U were ~2 times higher compared to crustal values with Ce and Eu-anomalies. APCS-MLR and PMF receptor models were used to determine the various anthropogenic and/or geogenic sources of NORMs and elements. Layer-wise variations of NORMs and elements were observed to trace the response of sedimentary processes towards the incoming pollution load. Presence of REEs indicates moderate degree of ecological risk to aquatic biota. However, carcinogenic risk (3.84 × 10-4 Sv-1) were significantly higher than threshold limit.


Subject(s)
Radiation Monitoring , Rivers , Rivers/chemistry , Risk Assessment , Bangladesh , Water Pollutants, Radioactive/analysis , Thorium/analysis , Minerals/analysis , Potassium Radioisotopes/analysis , Radium
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