ABSTRACT
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease that combines various clinical manifestations and pathophysiological mechanisms. It underlies the separation of patients with COPD by phenotypes, endotypes and a personalized therapy of this disease. The implementation of this approach is possible only with the use of appropriate biomarkers. One of the most important biomarkers of COPD is eosinophilia of blood and/or sputum, which is considered as a predictor of frequent exacerbations and the effectiveness of inhaled glucocorticosteroids in patients with COPD. The literature discusses the impact of eosinophilic inflammation on the prognosis, clinical and functional parameters in COPD, and the role of the targeted therapy in the treatment of eosinophilic COPD.
Subject(s)
Eosinophilia , Pulmonary Disease, Chronic Obstructive , Biomarkers , Eosinophils , Humans , Inflammation , SputumABSTRACT
The authors view results of conservative and surgical treatment of constant tooth chronic periodontitis in 90 children and adolescents aged 7-18 20 hemisections, 45 apicoectomies, 10 radix amputations were performed. The patients were followed up 6 months to 5 years. X-ray films show osseous restoration on the maxilla tooth to complete in 5-6 months, on the mandible tooth in over 8 months. The authors describe indications and contraindications to such kind.
Subject(s)
Aggressive Periodontitis/therapy , Dentition , Adolescent , Aggressive Periodontitis/diagnostic imaging , Apicoectomy , Child , Chronic Disease , Endodontics/methods , Female , Follow-Up Studies , Humans , Male , Mandible , Maxilla , Radiography , Tooth Root/surgeryABSTRACT
A high incidence of complications developing during and after removal of teeth with chronic periodontitis and radicular cysts has made the dentists resort to conservative surgical methods of treatment of such conditions. These methods are replantation, resection of radical apex, hemisection, radicular amputation, granulectomy, crown-radicular separation, crown-radicular amputation, hemireplantation, and inter-radicular granulectomy. The technique of such treatment is described in detail. Conservative surgical methods of treatment include the following stages: (1) conservative therapy; (2) surgical treatment; (3) orthodontic treatment; (4) dynamic follow-up till complete recovery of osseous tissue. The recommended modalities are not difficult but rather effective and may be performed at pedodontic clinics.
Subject(s)
Aggressive Periodontitis/surgery , Dentition , Radicular Cyst/surgery , Tooth/surgery , Adolescent , Apicoectomy/methods , Child , Chronic Disease , Female , Humans , Male , Tooth Replantation/methodsABSTRACT
Chronic granulating and granulomatous periodontitis of 250 permanent teeth was treated in children and adolescents aged 7 to 17, surgery had to be resorted to in 44 (18%) cases. Three groups of indications for radical treatment of chronic periodontitis in children were distinguished: difficulties in or impossibility of conservative treatment, inefficacy of conservative treatment, and somatic indications. The conservative and surgical methods together are most often indicated for patients in whom the adverse conditions of treatment (the first group of indications) are associated with an aggravated somatic status. Radical methods of treatment helped attain bone tissue recovery sooner (in 5-6 months) than after conservative therapy alone (in 8-9 months) and completely liquidate chronic foci of odontogenic infection.