ABSTRACT
Examining responses of the local immune system of the brain in neurocancer patients suggests that the immune system is involved in the neuroimmune interaction of both physiological and pathological conditions in the central nervous system (CNS). The setting off the local immune system of the brain is of functional nature, similar to functional analogy with the local system of the mucosae. By functional analogy, the aggregate of immune responses in the nervous tissue and cerebrospinal fluid should be called local and the system that includes these responses should named the local immune system of the brain. Due to the fact that nervous, endocrine, and immune regulatory pathways intersect in the CNS (hypothalamus), it is expedient to call this aggregate of defensive factors and mechanisms in CNS more broadly--the neuroimmune system.
Subject(s)
Astrocytoma/immunology , Brain Neoplasms/immunology , Brain Neoplasms/surgery , Brain/immunology , Glioblastoma/immunology , Meningioma/immunology , Meningioma/surgery , Albumins/analysis , Astrocytoma/pathology , Astrocytoma/surgery , Brain Neoplasms/pathology , Female , Glioblastoma/pathology , Glioblastoma/surgery , Humans , Immunoglobulin A/analysis , Immunoglobulin G/analysis , Meningioma/pathology , Reference Values , Transferrin/analysisABSTRACT
Biochemical reactions of the liquor were investigated in 68 patients with gunshot wounds of the skull and brain and in closed treatment of the brain wound. The reactivity of biochemical system plays a certain role in the development of infectious complications. In dead people the developing pathogenetical biochemical syndromes having a sanogenic role of clearance from antigens of the injured tissues turn pathogenesis into thanatogenesis.
Subject(s)
Brain Concussion/cerebrospinal fluid , Skull Fractures/cerebrospinal fluid , Wounds, Gunshot/cerebrospinal fluid , Afghanistan , Brain Concussion/surgery , Humans , Military Personnel , Skull Fractures/surgery , Time Factors , Treatment Outcome , USSR , Warfare , Wounds, Gunshot/surgerySubject(s)
Arachnoiditis/cerebrospinal fluid , Electric Stimulation Therapy , Optic Chiasm , Optic Nerve , Adolescent , Adult , Arachnoiditis/immunology , Arachnoiditis/therapy , Brain/immunology , Cerebrospinal Fluid/chemistry , Cerebrospinal Fluid/immunology , Chronic Disease , Humans , Middle Aged , Postoperative Period , Remission InductionABSTRACT
The paper shows the formation of immunopathological syndromes in the cerebrospinal fluid in the victims with gunshot wounds in relation to the policy and outcome of treatment. Suturing the dura mater during a primary surgical treatment should be regarded as a protective process to limit antigen release, the development of immunological paralysis and autoimmunization. Deaths are caused by the neurogenic immune dysfunction induced by the inadequate functioning of the psychoneuroimmunoendocrine connections of the whole body.
Subject(s)
Antigen-Antibody Reactions , Brain Injuries/cerebrospinal fluid , Brain Injuries/immunology , Skull/injuries , Wounds, Gunshot/cerebrospinal fluid , Wounds, Gunshot/immunology , Afghanistan , Brain Injuries/surgery , Cerebrospinal Fluid/chemistry , Cerebrospinal Fluid/immunology , Humans , Military Personnel , Skull/surgery , Time Factors , Treatment Outcome , USSR , Warfare , Wounds, Gunshot/surgeryABSTRACT
An ATPase activity of myosin was decreased in the ischemic zone of myocardium within 24 hrs after experimental infarction in dogs. The intensity of Ca2+-dependent phosphorylation of the myosin preparation was also decreased and the rate of phosphorylation in the light chain (with molecular mass 18,000) was increased. These alterations found in the ATPase properties and phosphorylation of myosin are important for studies of pathogenetic alterations in myofibril contractile function in acute ischemia of myocardium.
Subject(s)
Adenosine Triphosphatases/metabolism , Calcium/metabolism , Myocardial Infarction/metabolism , Myocardium/metabolism , Myosins/metabolism , Animals , Dogs , Electrophoresis, Polyacrylamide Gel , In Vitro Techniques , Myocardial Infarction/enzymology , Myocardium/enzymology , PhosphorylationABSTRACT
Ca2+ ions at low concentration (10(-4)-10(-5) M) when added to ultracentrifugates of sarcoplasmic proteins with minimal content of sarcoplasmic reticulum fragments completely prevent protein gelatinization or gels, formed in these conditions, quickly dilute. Ca2+ ions at the concentration of 10(-3) M prevented in these conditions gelatinization in all the cases studied. Strong gels of sarcoplasmic proteins are formed afterwards in weak acid (pH 6.1-6.75), neutral (pH 7.0) and weak alkaline (pH 7.25-7.45 and higher) media. It is suggested that gelatinization of sarcoplasmic proteins is closely related with the development of plastic tonus, obturatory muscle function and viscous after-effect.
