Esoteric beliefs and CAM impact SARS-CoV-2 immunization drivers, uptake and pediatric immunization views in Germany.

Recent studies demonstrate that sociopolitical attitudes partially explain variance in (SARS-CoV-2) vaccine hesitancy and uptake. Other attitudes, such as those towards esoteric beliefs, complementary and alternative medicine (CAM), and religion, have also been proposed. However, pertinent studies provide limited direction for public health efforts, as the impact of such attitudes has been tested in isolation or on different outcomes. Moreover, related associations between SARS-CoV-2 immunization drivers as well as views towards other modes of immunization (e.g., routine pediatric immunization), remain unclear. Based on a sample of ~7400 survey participants (Germany), where esoteric belief systems and CAM (Waldorf, homeopathy) are rather prevalent, and controlling for other sociological factors, we found that (i) individuals with positive attitudes towards Waldorf education and homeopathy are significantly less likely to have received a (further) dose of SARS-CoV-2 vaccine compared to those with positive views of mainstream medicine; (ii) for the former, immunization decisions are primarily driven by external pressures, and for the latter overwhelmingly by voluntary considerations; (iii) attitudes influencing adult SARS-CoV-2 vaccine uptake similarly influence views towards routine pediatric immunization. Our findings provide significant evidence informing a more nuanced design of public health and communication campaigns, and pertinent policies.

Particularly in Highly Developed and More Gender Egalitarian Societies: Sex Differences in Attitudes Towards Homosexuality.

Time and again, research has shown that men are less accepting of homosexuality than women. Studies on such attitudinal sex differences have been overwhelmingly conducted in Western democracies, however, with a special focus on the U.S. Whether the sex difference in attitudes towards homosexuality is a worldwide phenomenon has not yet been investigated. Using data from the seventh wave of the World Values Survey (2017-2021), this article provides evidence that the sex difference is not universal, but limited almost exclusively to Europe and the Americas, indicating the need to replicate studies conducted in these societies in global cross-country comparisons. Contrary to predictions of the social role theory or biosocial construction theory, but in line with predictions from evolutionary psychology and a growing number of empirical studies in this field, the sex difference in attitudes towards homosexuality widens with rising gender equality and development, especially when the two coincide.

Left-Right-Position, party affiliation and regional differences explain low COVID-19 vaccination rates in Germany.

Established vaccine hesitancy measurement instruments, such as the Vaccine Hesitancy Determinants Matrix, are not sufficiently equipped to adequately and consistently measure political and ideological attitudes. Focusing on Germany, which is a particularly interesting case since it witnessed the establishment of the by far most well-organized and sustained 'anti-Covid' movement in Europe, this quantitative study explores the impact of political ideology and partisanship on the degree of vaccine hesitancy based on four surveys (February-October 2021) among more than 30,000 individuals. We demonstrate that party affiliation, political ideology and region of residence all impact vaccine hesitancy. In fact, they turn out to have a greater impact than two factors often analysed with respect to vaccine hesitancy: gender and educational background. Further interaction models show that the effect of political ideology on vaccine hesitancy is moderated by age, gender and region of residency. For instance, while the more rightwing a young individual is, the more hesitant they are towards SARS-CoV-2 vaccination-for older individuals, this is not the case. Our findings are relevant for future investigators measuring vaccine hesitancy and policy makers contemplating the differential impact of complex public health interventions: as the impact of political and ideological attitudes on vaccine hesitancy are not adequately captured by established vaccine hesitancy measurement instruments, we recommend its modification to include a clear and harmonised definition of the political-ideological dimension of vaccine hesitancy together with pre-validated measurement items that improve future studies. In addition, we reason that vaccine hesitancy, while being an outcome of complex socio-political factors, is in itself an indicator for societal cohesion and anomie, the degree of which is associated with trust in (health) policy makers, (public) health authorities, health service providers, etc. Therefore, we further recommend that vaccine hesitancy questions should be integrated in pertinent national surveys.

Boosting the Understanding and Approval of Anti-Corona Measures-Reducing Exponential Growth Bias and its Effects through Educational Nudges.

One major problem of compliance with anti-coronavirus measures originates from the so-called exponential growth bias, i.e. the cognitive distortion of systematically underestimating exponential growth and its consequences. We replicate an Amazon MTurk experiment regarding the spread of SARS-CoV-2 that was conducted in the general US population during the first wave of the pandemic in March 2020 dealing with this bias. Using a least-likely-design-approach, we find a similarly strong bias in our sample of German students in November 2020. Nevertheless, this bias can be reduced by one simple educational intervention. Furthermore, participants who received these educational nudges showed a considerably higher approval rating for contact restrictions. This effect is robust to different analytical techniques and the inclusion of controls. Complementing political statements about the exponential spread of the virus - which often only mention the name of the phenomenon - with simple educational nudges could help the public better understand the need for encroachments on personal liberties.

La sous­estimation systématique de la croissance exponentielle et de ses conséquences, que l'on appelle « exponential growth bias ¼, figure parmi les problèmes majeurs dans le respect des mesures anti­Covid. Cette note de recherche reproduit une expérience au sujet de cette erreur qui a été conduite à l'aide de Amazon MTurk aux États­Unis pendant la première vague du Covid­19, en mars 2020. Suivant une logique du « least likely case ¼, nous trouvons une sous­estimation similaire dans notre échantillon d'étudiants allemands en novembre 2020. Or, cette erreur peut être réduite par le biais d'une simple intervention pédagogique. De plus, les participants ayant reçu une incitation pédagogique (« nudge ¼) montrent une plus forte adhésion à la réduction des contacts. Cet effet résiste à l'application de différentes méthodes d'analyse et aux contrôles. Une approche de « nudging ¼ pédagogique, qui irait au­delà d'une simple mention de la croissance exponentielle, pourrait donc contribuer à mieux démontrer les dangers de la propagation exponentielle du virus et à convaincre la population de la nécessité d'atteintes à la liberté individuelle.

[Left atrial appendage clusure in nonvalvular atrial fibrillation : Clinical evidence 2017]. / Der Verschluss des linken Vorhofohrs bei nichtvalvulärem Vorhofflimmern zur Prophylaxe von Tod, Schlaganfall und Blutungen : Klinische Evidenz 2017.

Nonvalvular atrial fibrillation (AF) is the most common arrhythmia with a prevalence of 1-2% and affects approximately 15-20% of all octogenarians. Patients are at increased risk of thromboembolic stroke, with an overall risk of 5% per year. Thrombi form almost exclusively in the left atrial appendage (LAA), a blind sac-like heterogeneous structure trabeculated by pectinate muscles. In the past five decades, life-long oral anticoagulation (OAC) with vitamin K antagonists (VKA) has been the state-of-the art treatment to prevent stroke and systemic embolism from thrombi in AF. In the last decade, nonvitamin K dependent oral anticoagulants (NOAC) have been shown to be superior to VKA. Given the safety issues of indefinite OAC with either VKA or NOAC, it is plausible to consider left atrial appendage closure (LAAC) as an alternative strategy to prevent death, stroke or other systemic embolization, and bleeding. In recent years, LAAC has been compared to VKA in prospective randomized trials, yielding superior results regarding efficacy and noninferiority regarding safety in the mid-term. This review provides an update on the current state of LAAC in the field of prevention of death, stroke, and bleedings in patients suffering from nonvalvular AF. We elucidate the evidence and limitations of anticoagulation as the classical treatment paradigm, and review devices and techniques for LAAC. Most importantly, the current clinical evidence on efficacy and safety is outlined.

Religion, religiosity, and the attitudes toward homosexuality--a multilevel analysis of 79 countries.

Although attitudes toward homosexuality have become more liberal, particularly in industrialized Western countries, there is still a great deal of variance in terms of worldwide levels of homonegativity. Using data from the two most recent waves of the World Values Survey (1999-2004, 2005-2009), this article seeks to explain this variance by means of a multilevel analysis of 79 countries. We include characteristics on the individual level, as age or gender, as well as aggregate variables linked to specificities of the nation-states. In particular, we focus on the religious denomination of a person and her religiosity to explain her attitude toward homosexuality. We find clear differences in levels of homonegativity among the followers of the individual religions.

MRI and implantable cardiac electronic devices.

PURPOSE OF REVIEW: To assess the current knowledge about the potential hazard from MRI in patients with devices such as pacemakers and implantable cardioverter defibrillators (ICDs). RECENT FINDINGS: Most data concern 'MRI unsafe' devices, with only a few studies on 'MRI conditional' devices. No 'MRI safe' cardiac devices are currently available. Studies on 'MRI unsafe' devices tend to be small scale and reflect the experience of individual centres; few provide long-term follow-up data. Many newer devices are approved as 'MRI conditional' based on technical simulations or postmarket surveillance studies. With adequate measures taken before performing an MRI scan, reported complication rates are generally low, but there is a nonnegligible residual risk for power-on reset and lead heating. The presence of abandoned, older leads may affect the propensity for lead heating during MRI with newer devices, including those designated 'MRI conditional'. Very little research has been carried out on the hazard from MRI scans in patients with ICDs, but registry data indicate more events with ICDs than with pacemakers. SUMMARY: The limited available data indicate a manageable but not negligible MRI-associated hazard in patients with implantable cardiac devices. Further controlled studies and large, independent registries, particularly in Europe, are needed to provide important safety information.

Comparison of cardiogoniometry and electrocardiography with perfusion cardiac magnetic resonance imaging and late gadolinium enhancement.

AIMS: Cardiogoniometry (CGM) is a spatio-temporal five-lead resting electrocardiographic method utilizing automated analysis. The purpose of this study was to determine CGM's and electrocardiography (ECG)'s accuracy for detecting myocardial ischaemia and/or lesions in comparison with perfusion cardiac magnetic resonance imaging (CMRI) and late gadolinium enhancement (LGE). METHODS AND RESULTS: Forty (n= 40) patients with suspected or known stable coronary artery disease were examined by CGM and resting ECG directly prior to CMRI including adenosine stress perfusion (ASP) and LGE. The investigators visually reading the CMRI were blinded to the CGM and ECG results. Half of the patients (n= 20) had a normal CMRI while the other half presented with either abnormal ASP and/or detectable LGE. Cardiogoniometry yielded an accuracy of 83% (sensitivity 70%) and ECG of 63% (sensitivity 35%) compared with CMRI. CONCLUSIONS: In this pilot study CGM compares more favourably than ECG with the detection of ischaemia and/or structural myocardial lesions on CMRI.

Safe magnetic resonance image scanning of the pacemaker patient: current technologies and future directions.

Magnetic resonance imaging (MRI) is the imaging modality of choice in many clinical situations, and its use is likely to grow due to expanding indications and an ageing population. Many patients with implantable devices are denied MRI except in cases of urgent need, and when scans must be performed they are complicated by the need for burdensome and costly personnel and monitoring requirements that have the net effect of restricting access to scans. Several small studies, enrolling a total of 344 patients, suggest that some patients with conventional systems may undergo MR examinations without clinically overt adverse events. However, a number of potential interactions exist between implantable cardiac devices and the static and gradient magnetic fields and modulated radio frequency (RF) fields generated during MR scans; nearly all studies have reported pacing capture threshold changes, troponin elevations, ectopy, unpredictable reed switch behaviour, and other 'subclinical' issues with pacemakers and implantable cardioverter-defibrillators (ICDs) in patients who have undergone MRI. Attention has turned to devices that are specifically designed to be safe in the MRI environment. A clinical study of one such device documented its ability to be exposed to MRI in a 1.5 T scanner without adverse impact on patient outcomes or pacemaker system function. Such new technologies may enable scanning of pacemaker and ICD patients with reduced concerns regarding the short- and long-term effects of MRI. As importantly, these devices may increase the number of centres that are able to safely perform MRI and, thus, expand access to scans for patients with these devices.

Initial experience with magnetic resonance imaging-safe pacemakers : a review.

Due of its superior soft tissue imaging capabilities, magnetic resonance imaging (MRI) has become the imaging modality of choice in many clinical situations, as illustrated by the tremendous growth in the number of MRIs performed over the past 2 decades. In parallel, the number of patients who require pacemakers or implantable cardiac defibrillators is increasing as indications for these devices broaden and the population ages. Taken together, these phenomena present an important clinical issue, as MR scans are generally contraindicated-except in urgent situations-in patients who have implanted cardiovascular devices. Potentially deleterious interactions between the magnetic fields and radio frequency (RF) energy produced by MR equipment and implantable devices have been identified, including inhibition of pacing, asynchronous/high-rate pacing, lead tip heating, and loss of capture. New devices that incorporate technologies to improve MR safety in patients with pacemakers have recently received approval in Europe and are under evaluation in the United States. Initial data from these devices suggest that these devices are safe in the MRI environment.

Persistent iatrogenic atrial septal defect after a single-puncture, double-transseptal approach for pulmonary vein isolation using a remote robotic navigation system: results from a prospective study.

AIMS: Persistent iatrogenic atrial septal defect (iASD) after transseptal puncture for pulmonary vein isolation (PVI) has been described recently as a complication of PVI. No data exists evaluating systematically the incidence and clinical implications of iASDs after PVI using a remote robotic navigation system (RNS) with sheaths with a distinct larger outer diameter. METHODS AND RESULTS: In this prospective study, 40 patients with either paroxysmal (n = 22, 55%) or persistent symptomatic atrial fibrillation were treated with circumferential PVI using an RNS. In all patients, a single-puncture, double-transseptal approach was used to access the left atrium. Transoesophageal echocardiography was performed before and the day after PVI as well as after a 3 and 6 months follow-up (FU). The day after ablation an iASD was detected in 38 of 40 (95%) patients with a mean diameter of 3.45 +/- 1.5 mm. At 6-month FU, the iASDs were closed in 30 of 39 (78.9%) patients. During the 6-month FU period, no patient died or suffered from cerebral or cardiac embolism. CONCLUSION: After a single-puncture, double-transseptal approach for PVI using the RNS, iASDs show a high spontaneous closure rate of 78.9% after a 6-month FU period. Persistent iASDs following PVI with the RNS are not associated with an increased rate of paradoxical embolism or with relevant shunting.

Importance of cardiac troponins I and T in risk stratification of patients with acute pulmonary embolism.

BACKGROUND: Assessment of risk and appropriate management of patients with acute pulmonary embolism (PE) remains a challenge. Cardiac troponins I (cTnI) and T (cTnT) are reliable indicators of myocardial injury and may be associated with right ventricular dysfunction in PE. METHODS AND RESULTS: The present prospective study included 106 consecutive patients with confirmed acute PE. cTnI was elevated (> or =0.07 ng/mL) in 43 patients (41%), and cTnT (> or =0.04 ng/mL) was elevated in 39 (37%). Elevation of cTnI or cTnT was significantly associated with echocardiographically detected right ventricular dysfunction (P=0.001 and P<0.05, respectively). Moreover, a significant correlation was found between elevation of cTnI or cTnT and the two major end points overall mortality and complicated in-hospital course. The negative predictive value of cardiac troponins for major clinical events was 92% to 93%. Importantly, there was obvious escalation of in-hospital mortality, the rate of complications, and the incidence of recurrent PE, when patients with high troponin concentrations (cTnI >1.5; cTnT >0.1 ng/mL) were compared with those with only moderately elevated levels (cTnI, 0.07 to 1.5; cTnT, 0.04 to 0.1 ng/mL). Logistic regression analysis confirmed that the mortality risk (OR) was significantly elevated only in patients with high cTnI (P=0.019) or cTnT (P=0.038) levels. Furthermore, the risk of a complicated in-hospital course was almost 5 times higher (15.47 versus 3.16) in the high-cTnI group compared with patients with moderate cTnI elevation. CONCLUSIONS: Our results indicate that cTnI and cTnT may be a novel, particularly useful tool for optimizing the management strategy in patients with acute PE.