ABSTRACT
Although peripheral vascular thrombic events are recognized as a serious extra-intestinal complication of inflammatory bowel disease, the occurrence of cerebral vascular events in association with acute exacerbations of this group of diseases is rare. In this article, relevant literature is reviewed and three children, 5, 12, and 13 years of age, who presented with clinical and magnetic resonance imaging evidence of an acute cerebrovascular event in association with an acute exacerbation of their inflammatory bowel disease are described. Except for the presence of anemia, hematologic and coagulation studies were unremarkable, and a search for evidence of a systemic vasculitis proved negative.
Subject(s)
Cerebrovascular Disorders/diagnosis , Cerebrovascular Disorders/etiology , Colitis, Ulcerative/complications , Colitis, Ulcerative/diagnosis , Adolescent , Brain/pathology , Child , Child, Preschool , Female , Humans , Magnetic Resonance Imaging , MaleABSTRACT
There has been renewed interest in the ketogenic diet in the treatment of medically refractory seizure disorders in childhood. This article reports the results of a retrospective chart review of 52 patients who were treated with the ketogenic diet. The vast majority (49 of 52) were treated with the classic 4:1 diet. Seizure control improved in 67.3% of patients with complete abolition of seizures in six. Adverse reactions were uncommon and included the development of renal stones, gall bladder stones, and hypoproteinemia in one patient each. Routine biochemical screening during the diet did not identify or prevent adverse events. The authors' experiences with the diet emphasize the need for close ongoing medical and dietary supervision.
Subject(s)
Diet Therapy/adverse effects , Epilepsy/diet therapy , Ketosis , Adolescent , Child , Child, Preschool , Female , Humans , Kidney Calculi/etiology , Male , Retrospective Studies , Urinary Bladder Calculi/etiologyABSTRACT
All records of primary liver cancer reported to the tumor registry of the Province of Québec from 1969 to 1972 were collected and were classified according to sex, age and place of residence. Men had higher incidence of primary liver cancer and the disease developed at an earlier age in men than it did in women. There was a noticeable difference in the number of cases in rural and urban areas, and a significant difference in the incidence in the 10 districts of the province. Cases in urban areas were clustered in a few industrialized cities. Our findings are in agreement with previous reports that show a relationship between primary cancer of the liver and the presence of chemicals in the environment.
