ABSTRACT
Ticagrelor is an antiplatelet agent used for treatment of coronary artery disease via inhibition of the P2Y12 receptor. Based on limited literature the safety of intravenous thrombolysis for ischemic stroke in patients with ticagrelor pretreatment is unknown. We present two patients established on ticagrelor treated with intravenous thrombolysis for acute ischemic stroke complicating coronary intervention.
Subject(s)
Cardiovascular Surgical Procedures/adverse effects , Coronary Artery Disease/drug therapy , Coronary Artery Disease/surgery , Stroke/etiology , Ticagrelor/therapeutic use , Aged , Humans , Male , Middle Aged , Platelet Aggregation Inhibitors/therapeutic use , Stroke/drug therapy , Thrombolytic Therapy/methods , Treatment OutcomeABSTRACT
BACKGROUND: Spontaneous coronary artery dissection (SCAD) has gained attention as an important cause of acute coronary syndrome and sudden cardiac death (SCD) among women. Management strategies of SCAD differ from those of atherosclerotic disease. There is an elevated risk of complications and suboptimal outcomes in patients with SCAD undergoing percutaneous coronary interventions (PCIs). CASE SUMMARY: A 48-year-old woman without any traditional cardiovascular risk factors was admitted with severe central chest pain with associated dyspnoea and diaphoresis. The patient had a strong family history of SCD, affecting three female members in their 40s and 50s. Cardiac troponins were elevated. Coronary angiogram showed moderate to severe stenosis of the proximal circumflex coronary artery. Optical coherence tomography confirmed SCAD with sub-intimal haematoma. Despite significant stenosis in the proximal segment of a relatively large artery, a decision was made not to proceed with PCI. The follow-up angiogram demonstrated normal coronaries. Magnetic resonance imaging of renal arteries showed features suggestive of fibromuscular dysplasia affecting the right renal artery. Subsequent genetic counselling and gene testing were unremarkable. DISCUSSION: Conservative management of SCAD is recommended because the large majority of SCAD lesions heal naturally, whereas PCI is associated with increased risk of complications and adverse outcomes. Whether SCAD is associated with the sudden death events in our patient's family remains unclear. It certainly raises concerns as to an inheritable condition. In the absence of post-mortem findings in her family members, we can only speculate about this representing a possible inheritable form of SCAD.
ABSTRACT
Percutaneous coronary intervention (PCI) of heavily calcified stenoses remains a significant challenge to interventional cardiologists. Over the last years, high-pressure balloons, cutting balloons as well as atherectomy devices have been used to tackle such lesions. Lithoplasty is a method of lesion modification using intravascular lithotripsy (IVL, shockwave) to treat particularly calcified coronary lesions. A 55-year-old male without previous cardiac history reported chest pain and was found to have ECG changes anterolaterally and significantly elevated troponins. Coronary angiogram showed heavily calcified severe proximal left anterior descending (LAD) stenosis. The attempts to predilate the lesion with semi-compliant and non-compliant balloons at high pressures were unsuccessful so the decision was made to use a shockwave balloon. Subsequently a drug-eluting stent was successfully implanted and post-dilated at high pressure. Final angiography showed an excellent result, also confirmed in optical coherence tomography (OCT).
Subject(s)
Coronary Stenosis/therapy , Drug-Eluting Stents , Lithotripsy/methods , Vascular Calcification/therapy , Coronary Angiography/methods , Coronary Stenosis/complications , Coronary Stenosis/diagnostic imaging , Coronary Stenosis/pathology , Coronary Vessels/pathology , Humans , Male , Middle Aged , Treatment Outcome , Vascular Calcification/complications , Vascular Calcification/diagnostic imaging , Vascular Calcification/pathologyABSTRACT
Severe stenosis or occlusion of the subclavian artery is a rare clinical finding, even more so for bilateral existence of the condition. Subclavian artery stenosis and occlusion leads to erroneously low blood pressure values when measured at the brachial artery on the ipsilateral side. Widespread clinical reliance on a sole brachial measurement of blood pressure, particularly in the emergency room setting, may result in inappropriate clinical management in patients with conditions that alter brachial blood pressure. Currently, there is no published English-language literature on the implications of bilateral subclavian artery stenosis and occlusion in heart failure. A case of an apparently hypotensive patient with frequent emergency room visits for symptoms of heart failure exacerbation is presented.
Subject(s)
Heart Failure, Diastolic/etiology , Hypertension/complications , Subclavian Artery/pathology , Subclavian Steal Syndrome/complications , Aged , Blood Pressure , Female , Heart Failure, Diastolic/physiopathology , Humans , Hypertension/physiopathology , Subclavian Steal Syndrome/physiopathologyABSTRACT
The epidemiology and clinical picture in human immunodeficiency virus (HIV) infection has evolved tremendously over the years, leaving health-care professionals having to cope with continuously transforming challenges in the management of HIV-infected patients.